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The impact of chemotherapy-naïve open radical cystectomy delay and perioperative transfusion on the recurrence-free survival: A perioperative parameters-based nomogram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： Ahmed m.harraz Ahmed Elkarta mohamed H.Zahran Ahmed mosbah Atallah A.Shaaban Hassan Abol-Enein Urology and Nephrology Center Mansoura UniversityEgypt

Objective: To develop and internally validate a nomogram to predict recurrence-free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (n=948) and validating (n=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nomogram. Discrimination, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On multivariate analysis, independent predictors were TTC (hazards ratio [HR] 1.07, 95% confidence interval [CI] 1.05-1.08, pmore units: HR 1.72, 95% CI 1.29-2.29, pmous cell carcinoma (HR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (HR 1.77, 95% CI 1.41-2.22, pmph node status (HR 1.53, 95% CI 1.21-1.95, pmphovascular invasion (HR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nomogram with good discrimination, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectomy Blood transfusion Time to radical cystectomy Survival Nomogram

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Band Gap Control for （Fe, Ti）-Containing mesoporous Silica Nanoparticles Using the Photo-Assisted Deposition Technique

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Journal of Environmental Science and Engineering 2010年第7期4卷 36-40页

作者： R.m. mohamed A.m. El-Toni F.A. harraz I.A. Ibrahim Advanced materials Technology Department Central Metallurgical Research and Development Institute （CMRDI） Helwan Cairo11421 Egypt

It is a great advantage to design advanced materials with outstanding porosity and controllable band gab. In this study, （Fe, Ti）-containing mesoporous silica （x Fe/Ti-HmS） nanoparticles were prepared by a photo-assisted deposition PAD technique, where x is a nominal composition ofFe （l to 4 wt%））. The prepared samples were characterized by DR-UV, XRD, and TEm techniques. The results showed the insertion of Fe into intra-framework of Ti-HmS resulted in a gradual narrowing of the band gap of Ti-HmS samples with increment of Fe wt%. TEm observations reveal that Fe nanoparticles are evenly distributed within Ti-HSm matrix at different Fe wt%. Such results indicate the possibility to control the band gap of a single-site photocatalyst （Ti-HmS） by coupling it with the conventional nano-sized Fe catalysts.

关键词： Nanomaterials single-site photocatalyst Fe/Ti-HmS

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Fat,oil,and grease as new feedstock towards bioelectrogenesis in microbial fuel cells:microbial diversity,metabolic pathways,and key enzymes

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Journal of Energy Chemistry 2023年第10期85卷 418-429,I0011页

作者： monika Sharma mohammed Jalalah Saeed AAlsareii Farid Aharraz Abdulrhman AAlmadiy Nandini Thakur El-Sayed Salama Xiangkai Li mOE Key Laboratory of Cell Activities and Stress AdaptationsSchool of Life SciencesLanzhou UniversityLanzhou 730000GansuChina Promising Centre for Sensors and Electronic Devices(PCSED) Advanced Materials and Nano-Research CentreNajran UniversityP.O.Box:1988Najran 11001Saudi Arabia Department of Electrical Engineering College of EngineeringNajran UniversityNajran 11001Saudi Arabia Department of Surgery College of MedicineNajran UniversityNajran 11001Saudi Arabia Department of Chemistry Faculty of Science and Arts at SharurahNajran UniversitySharurah 68342Saudi Arabia Department of Biology Faculty of Arts and SciencesNajran University1988 NajranSaudi Arabia Department of Occupational and Environmental Health School of Public HealthLanzhou UniversityLanzhou 730000GansuChina

microbial fuel cells(mFCs)are a well-known technology used for bioelectricity production from the decomposition of organic waste via electroactive ***,oil,and grease(FOG)as a new substrate in the anode and microalgae in the cathode were added to accelerate the *** effect of FOG concentrations(0.1%,0.5%,1%,and 1.5%)on the anode chamber was *** FOG degradation,volatile fatty acid(VFAs)production,and soluble chemical oxygen demand along with voltage output kinetics were ***,the microbial community analysis and active functional enzymes were also *** maximum power and current density were observed at 0.5%FOG which accounts for 96 mW m^(-2)(8-folds enhancement)and 560 mA m^(-2)(3.7-folds enhancement),*** daily voltage output enhanced upto 2.3-folds with 77.08%coulombic efficiency under 0.5%FOG,which was the highest among all the *** 0.5%FOG was degraded>85%,followed by a 1%FOG-loaded *** chief enzymes inβ-oxidation and electrogenesis were acetyl-CoA C-acetyltransferase,riboflavin synthase,and riboflavin *** identified enzymes symbolize the presence of Clostridium sp.(>15%)and Pseudomonas(>10%)which served as electrochemical active bacteria(EAB).The major metabolic pathways involved in electrogenesis and FOG degradation were fatty acid biosynthesis and glycerophospholipid *** of lipidic-waste(such as FOG)in mFCs could be a potential approach for simultaneous biowaste utilization and bioenergy generation.

关键词： Lipidic-waste microalgae Electrogenesis microbial community Functional enzymes

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Science:研究鉴定出导致脑细胞死亡的罪魁祸首

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现代生物医学进展 2017年第4期17卷 I0001-I0001页

作者： Yingfei Wang Ran An George K Umanah Hyejin Park Kalyani Nambiar Stephen m Eacker BongWoo Kim Lei Bao mage..m harraz Calvin Chang Rong Chen Jennifer E Wang TaeIn Kam Jun Seop Jeong Zhi Xie Stewart Neifert Jiang Qian Shaida A Andrabi Seth Blackshaw Heng Zhu Hongjun Song GuoLi ming Valina L Dawson Ted m Dawson Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. tdawson@jhmi.edu vdawson1@jhmi.edu yingfei.wang@utsouthwestern.edu. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pathology University of Texas Southwestern Medical Center Dallas TX 75390 USA. Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX 75390 USA. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology of Huashan Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China. Adrienne Helis malvin medical Research Foundation New Orleans LA 70130-2685 USA. Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pharmacology and molecular Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Center for High-Throughput Biology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Physiology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋... 详细信息

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋白。即一种通过切割细胞的DNA给予致命性打击的蛋白。他们说，这一发现潜在地为开发预防、阻止或削弱这一过程的药物打开新的大门。相关研究结果发表在Science期刊上。

关键词：细胞死亡脑损伤神经退行性疾病鉴定阿尔茨海默病分子事件研究人员致命性

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喷水推进混流泵叶片径向力

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排灌机械工程学报 2012年第6期30卷 636-640页

作者：成立 Bart P.m.van Esch 刘超周济人金燕扬州大学水利科学与工程学院江苏扬州225009 埃因霍温理工大学机械工程系

水力机械内的水压力脉动常常导致叶片的疲劳破坏及共振,为了研究叶片旋转交互作用引起的流体诱导水压力,基于CFD计算和模型试验开展导叶式喷水推进混流泵叶片交互作用径向力研究.建立了一个闭式的混流泵试验循环系统,在叶轮和泵轴内内... 详细信息

水力机械内的水压力脉动常常导致叶片的疲劳破坏及共振,为了研究叶片旋转交互作用引起的流体诱导水压力,基于CFD计算和模型试验开展导叶式喷水推进混流泵叶片交互作用径向力研究.建立了一个闭式的混流泵试验循环系统,在叶轮和泵轴内内置同步旋转测力计测量叶轮上的瞬时力和转矩.通过大量的标定确定试验轴系的动态特性.采用Fluent软件进行非定常数值模拟,并将模拟结果与试验结果进行了比较,分析了产生偏差的原因.结果表明:叶片旋转经过时的轴上径向作用力的频率与工况有关,同时叶片激发的径向力导致叶轮有与轴旋转方向相反旋转的趋势;计算的推进泵外特性与试验吻合较好,同时叶片交互作用径向力的量级也有较好的吻合度;从小流量到大流量工况,计算结果的变化趋势与试验结果一致.

关键词：混流泵喷水推进径向力非定常数值模拟试验

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癌症睾丸抗原可能有助于黑素瘤的诊断

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 15-16页

作者： Luftl m. S■huler G. Jungbluth A.A. 牛新武 Department of Dermatology Universit y Hospital of Erlangen Hartmannstr. 14 D-91052 Erlangen Germany

Background:Cancer testis antigens (CTAs) are expressed in a variety of malign ant tumours. No CTA expression is found in normal adult tissues, except in male germ cells and occasionally placenta. To date, more than 20 CTAs or antigen fami lies have been identified. Objectives:Owing to their tumour-associated express ion pattern, CTAs may be useful for making a distinction between benign and mali gnant neoplasms. The present study was done to analyse the value of CTAs for the discrimination of cutaneous melanoma and naevi. Patients and methods:Primary m elanomas (38) and 19 naevi were analysed for their expression of CTAs by immunoh istochemistry using the following monoclonal antibodies (mAb) to the following a ntigens (mAb/antigen):mA454/mage-A1, 57B/mage-A4, ES121/NY-ESO-1. In a subs et of melanomas (n=26), the CTA panel was extended to three additional CTAs (mAb /antigen):CT7-33/mage-C1, m3H67/mage-A3 and GAGE/GAGE. Results:All 19 naevi were negative for the mAbs mA454, m3H67, 57B, ES121, CT7-33 and GAGE. In melan oma, the immunoreactivity was as follows:mA454:8/38 (21%), 57B 11/38 (29%), ES121 9/38 (24%). However, 19/38 (50%) were positive for at least one CTA. When 26 melanomas we re tested for the expression of six different CTAs 20/26 (77%) were positive fo r at least one CTA. Conclusions:CTAs may be useful in the determination of susp ected malignancy in cutaneous melanomas. The low incidence of particular CTAs ca n be overcome by increasing the number of CTAs analysed.

关键词：黑素瘤黑色素瘤良恶性肿瘤单克隆抗体免疫反应性成人组织胎盘组织男性生殖免疫组织化学性表达

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湖南省水稻三化螟发生规律的研究——Ⅰ.地理分布

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昆虫学报 1965年第2期 118-127页

作者：陈常铭刘仕龙曾雄俊湖南农学院

1962—1963年,在湘南、湖中、湘东和湘西等山区调查,得知湖南省水稻三化螟垂直分布最高为海拔1,025米。但不同山系的最高分布不一,一般都止于海拔800米以下。气候因素是影响垂直分布的主导因素。从湖南省三化螟的平面分布看来,它的踪... 详细信息

1962—1963年,在湘南、湖中、湘东和湘西等山区调查,得知湖南省水稻三化螟垂直分布最高为海拔1,025米。但不同山系的最高分布不一,一般都止于海拔800米以下。气候因素是影响垂直分布的主导因素。从湖南省三化螟的平面分布看来,它的踪迹遍及全省,但根据它们的发生动态,可划分为五个发生区:(1)第3—4代经常猖獗区:(2)第3—4代间歇猖獗区:(3)第3代经常猖獗区;(4)第3代间歇猖獗区:(5)轻微发生区。我们认为,水稻种植制度和气候条件是左右平面分布猖獗程度的因素。讨论了三化螟的预测预报和大田防治应有重点,在海拔700米以上地区,不必进行;400—700米的地区,视种植制度复杂与否来决定;400米以下地区,若双季稻或迟熟中稻面积较大,则必须着重进行。猖獗区要注意防治,轻微区要总结原因,找出根治螟害的途径。

关键词：水稻三化螟陈常铭垂直分布生态分布湖南省地理分布

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*** the link between reduced reading ability and cognitive decline in older adults with acquired vision impairment:a feasibility study

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Annals of Eye Science 2019年第1期 204-204页

作者： Swaathi Balaji Karine Elalouf Andrea Urqueta-Alfaro Julie-Andrée marinier Aaron Johnson Natalie Phillips Eva Kehayia m.Kathy Pichora-Fuller Walter Wittich École d'Optométrie Universitéde MontréalMontréalQCCanada Centre de recherche interdisciplinaire en réadaptation du montréal métropolitain MontrealQCCanada Department of Psychology Concordia UniversityMontréalQCCanada School of Physical and Occupational Therapy McGill UniveristyMontréalQCCanada Department of Psychology University of Toronto at MississaugaMississaugaOntarioCanada

Background:Reading enables us to obtain information,to engage in leisure,educational,business and other activities,and fosters cognitive *** vision loss can have a negative effect on an individual’s ability to read,and,by extension,reduce overall quality of *** addition,a growing body of research on the association between reading and cognition has linked a decrease in reading ability with negative changes in cognitive ***,the purpose of the current study is to test the feasibility of a research protocol that will be used to study the association between reduced reading ability and cognitive impairment,specifically in older adults with acquired vision ***:Seven participants(age range,27-60 years,mage=44,4 males)completed a series of questionnaires and assessments that measured their cognitive,hearing,and reading *** participants had normal hearing,vision and cognition,with the exception of one(two pre-existing hearing conditions).Cognition was tested using the Rey Auditory Verbal Learning Test(RAVLT),the RAVLT 50-word Recognition test,the Verbal Fluency Test,an auditory Trail-making task,and an auditory 1-N-back memory *** was used to assess ear health,and hearing was measured with self-administered computerized audiometry(Home Hearing Test)and a speech-in-noise test(Canadian Digit Triplet Test).Questionnaires included the Hearing Handicap Inventory for the Elderly,and a multiple-choice questionnaire on subjective reading ability and reading ***,reading acuity,speed and comprehension were assessed using the International Reading Speed Texts and the ***:In testing the feasibility of this protocol,the uninterrupted length of testing time,including obtaining consent,was determined to be between 60-90 *** of the assessments and tests(RAVLT,mNRead,audiogram)were reported to be mentally ***,all pilot participants were able to complete all *** the exception of s

关键词： Cognition vision impairment reading rehabilitation

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