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Journal of Integrative Medicine 2024年第1期22卷 1-11页

作者： Maria younes Ghady Loubnane Christopher Sleiman Sandra Rizk Department of Natural Sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as *** incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical *** literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular proliferation,apoptosis,angiogenesis and ***/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

Performance Assessment of a Real PV System Connected to a Low-Voltage Grid

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Energy Engineering 2024年第1期121卷 13-26页

作者： Gaber magdy Mostafa Metwally Adel A.Elbaset Esam Zaki Electrical Engineering Department Faculty of Energy EngineeringAswan UniversityAswanEgypt `2Faculty of Engineering King Salman International UniversityEl-Tor46511Egypt Electrical Engineering Department Faculty of EngineeringMinia UniversityMiniaEgypt Department of Electromechanics Engineering Faculty of EngineeringHeliopolis UniversityCairoEgypt Computer Department Faculty of EngineeringModern Academy of Engineering&TechnologyCairoEgypt

The generation of photovoltaic(PV)solar energy is increasing continuously because it is renewable,unlimited,and clean *** the past,generation systems depended on non-renewable sources such as oil,coal,and ***,this paper assesses the performance of a 51 kW PV solar power plant connected to a low-voltage grid to feed an administrative building in the 6th of October City,*** performance analysis of the considered grid-connected PV system is carried out using power system simulator for Engineering(PSS/E)*** the PSS/E program,monitors and uses the power analyzer that displays the parameters and measures some parameters such as current,voltage,total power,power factor,frequency,and current and voltage harmonics,the used inverter from the type of grid inverter for the considered *** results conclude that when the maximum solar radiation is reached,the maximum current can be obtained from the solar panels,thus obtaining the maximum power and power *** total voltage harmonic distortion,a current harmonic distortion within permissible limits using active harmonic distortion because this type is fast in processing up to 300 *** connection between solar stations and the national grid makes the system more efficient.

关键词： Low-voltage grid photovoltaic(PV)system total harmonic distortion grid-connected PV system

Integrated hazard assessment of rockfall incidents in the Cap Aokas Cliff Region

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Journal of Mountain Science 2024年第6期21卷 1916-1929页

作者： Zohra LADJEL Farid ZAHRI Riheb HADJI younes HAMED Karim ZIGHMI Kaddour BENMARCE Department of Earth Sciences Institute of Architecture and Earth SciencesFerhat Abbas UniversitySetif 19137Algeria Unit of Emerging Materials Research Ferhat Abbes UniversitySétif 19137Algeria Laboratory of Applied Research in Engineering Geology GeotechnicsWater Sciencesand EnvironmentFerhat Abbas UniversitySetif 19137Algeria International Association of Water Resources in the Southern Mediterranean Basin Gafsa 2112Tunisia Department of Earth Sciences Faculty of SciencesUniversity of GafsaGafsa 2112Tunisia

Rock fall accidents in mountainous cliff areas have significant consequences for human life and *** study aimed to evaluate the rockfall hazard in the Cap Aokas cliff region located along the northeast coast of Algeria by identifying the key factors contributing to rockfall *** employed a combination of kinematic analysis,Matterocking method,and 3D trajectory simulations to determine zones that are susceptible to rockfall *** using a probabilistic and structural approach in conjunction with photogrammetry,we identified the controlling *** kinematic analysis revealed the presence of five discontinuity families,which indicated both plane and wedge failure *** 3D trajectory simulations demonstrated that the falling blocks followed the stream *** then validated the susceptibility maps generated from the analysis using aerial photos and historical rockfall *** findings of this study enhance our understanding of rockfall phenomena and provide valuable insights for the development of effective strategies to mitigate rockfall hazards.

关键词： Trajectory simulations Probabilistic analysis Structural approach Rockfall hazard Cap Aokas cliff

The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL magdy MYOUSSEF AHMED EL-SEBAIE SHERIF REFAAT AFAF EL-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,p<0.001)and dominant(GT+TT ***,OR=5.4,p<0.001)*** cyclophosphamide chemotherapy,we found that the patients with variant genotypes(GT+TT)were less likely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

Overall Assessment of Heat Transfer for a Rarefied Flow in a Microchannel with Obstacles Using Lattice Boltzmann Method

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工程与科学中的计算机建模(英文) 2024年第1期138卷 273-299页

作者： Siham Hammid Khatir Naima Omolayo M.Ikumapayi Cheikh Kezrane Abdelkrim Liazid Jihad Asad Mokdad Hayawi Rahman Farhan Lafta Rashid Naseer Ali Hussien younes Menni Laboratory of Development in Mechanics and Materials(LDMM) Zian Achour UniversityDjelfaPB 3117Algeria Department of Technology University Center Salhi Ahmed Naama(Ctr.Univ.Naama)P.O.Box 66Naama45000Algeria Department of Mechanical and Mechatronics Engineering Afe Babalola University Ado Ekiti360101Nigeria Departement of Physics Faculty of ScienceAbou Bekr Belkaid UniversityTlemcen13000Algeria Department of Physics Faculty of Applied SciencesPalestine Technical University-KadoorieTulkarmPalestine Aeronautical Technical Engineering Al-Farahidi UniversityBaghdad10011Iraq Mechanical Engineering Department University of KerbalaKarbala56001Iraq Information and Communication Technology Research Group Scientific Research CenterAl-Ayen UniversityThi-QarIraq National University of Science and Technology Dhi QarIraq

The objective of this investigation is to assess the effect of obstacles on numerical heat transfer and fluid flow momentum in a rectangular microchannel(MC).Two distinct configurations were studied:one without obstacles and the other with alternating obstacles placed on the upper and lower *** research utilized the thermal lattice Boltzmann method(LBM),which solves the energy and momentum equations of fluids with the BGK approximation,implemented in a Python coding *** jump and slip velocity conditions were utilized in the simulation for the MC and extended to all obstacle *** study aims to analyze the rarefaction effect,with Knudsen numbers(Kn)of 0.012,0.02,and *** outcomes indicate that rarefaction has a significant impact on the velocity and temperature *** presence of nine obstacles led to slower fluid movement inside the microchannel MC,resulting in faster cooling at the *** MCs with obstacles,the rarefaction effect plays a crucial role in decreasing the Nusselt number(Nu)and skin friction coefficient(Cf).Furthermore,the study demonstrated that the obstacles played a crucial role in boosting fluid flow and heat transfer in the *** findings suggest that the examined configurations could have potential applications as cooling technologies in micro-electro-mechanical systems and microdevice applications.

关键词： Microfluid rarefied flow LBM microchannel Knudsen number numerical simulation

Enable Excel-Based Basic Cybersecurity Features for End Users by Using Python-Excel Integration

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Journal of Software Engineering and Applications 2024年第6期17卷 522-529页

作者： Mohamed Breik Osama magdy Essam Amin Tarek Aly Mervat Gheith Software Engineering Department Faculty of Graduate Studies for Statistical Research Cairo University Cairo Egypt

In the digital age, the global character of the Internet has significantly improved our daily lives by providing access to large amounts of knowledge and allowing for seamless connections. However, this enormously interconnected world is not without its risks. Malicious URLs are a powerful menace, masquerading as legitimate links while holding the intent to hack computer systems or steal sensitive personal information. As the sophistication and frequency of cyberattacks increase, identifying bad URLs has emerged as a critical aspect of cybersecurity. This study presents a new approach that enables the average end-user to check URL safety using Microsoft Excel. Using the powerful VirusTotal API for URL inspections, this study creates an Excel add-in that integrates Python and Excel to deliver a seamless, user-friendly interface. Furthermore, the study improves Excel’s capabilities by allowing users to encrypt and decrypt text communications directly in the spreadsheet. Users may easily encrypt their conversations by simply typing a key and the required text into predefined cells, enhancing their personal cybersecurity with a layer of cryptographic secrecy. This strategy democratizes access to advanced cybersecurity solutions, making attentive digital integrity a feature rather than a daunting burden.

关键词： Python End-User Approach Excel Excel Add-In Cybersecurity URL Check API Virustotal API Encryption Decryption Vigenère Cipher Python-Excel Integration

Enhancing Data Analysis and Automation: Integrating Python with Microsoft Excel for Non-Programmers

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Journal of Software Engineering and Applications 2024年第6期17卷 530-540页

作者： Osama magdy Ali Mohamed Breik Tarek Aly Atef Tayh Nour El-Din Raslan Mervat Gheith Software Engineering Department Faculty of Graduate Studies for Statistical Research Cairo University Giza Egypt

Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.

关键词： Python End-User Approach Microsoft Excel Data Analysis Integration Spreadsheet Programming Data Visualization

Heritability of Heart Rate Response to Arousals in Twins

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Heritability of Heart Rate Response to Arousals in Twins

Heritability of Heart Rate Response to Arousals in Twins

中国睡眠研究会第九届学术年会

作者： Xiaoling Gao Ali Azarbarzin Brendan T.Keenan Michele Ostrowski Frances M.Pack Bethany Staley Greg Maislin Allan I.Pack magdy younes Samuel T.Kuna Department of Medicine and Center for Sleep and Circadian Neurobiology University of Pennsylvania Department of Respiration The second Hospital of Shanxi Medical University Sleep Disorders Centre University of Manitoba

Study Objectives:To determine if the large and highly reproducible inter-individual differences in heart rate(HR) response to arousals during non-REM sleep arise from a heritable ***:Post-hoc analysis of polysomnograms of same-sex monozygotic and dizygotic twin ***:Academic medical center and Research and Development Laboratory(YRT Limited).Participants:55 monozygotic(mean[±SD]age 29.2±6.9 years;14 male and 41 female pairs) and 36dizygotic(mean age 26.217.5 years;15 male and 21 female pairs) twin pairs with a normal ***:None Measurements and Results:Arousals were scored using the 2007 American Academy of Sleep Medicine *** intensity was scaled(between 0 and 9) using an automatic algorithm based on the change in EEG time and frequency characteristics and a training data *** rate response to arousal(AHR) was determined and averaged at each arousal intensity per *** calculated the average arousal duration,average arousal intensity,average AHR,AHR at a given arousal intensity,rate of AHR per arousal intensity,and arousal intensity threshold of *** the classical approach to assess broad sense heritability(h),the arousal intensity threshold of AHR(h=0.94) and average arousal intensity(h=1.05) showed the strongest evidence for heritability after age and sex *** was supported by a maximum likelihood based variance components estimation approach,with h(95%CI) estimates of 0.38(0.13,0.62) for arousal intensity threshold of AHR and 0.64(0.48,0.80) for average arousal *** approach also suggested significant additive genetic effects for the number of arousals,average arousal duration,and the average ***:Genetic factors explain a significant fraction of the phenotypic variability for the threshold of AHR to arousal and average arousal *** also suggest that the number and duration of arousals and the average AHR may be heritable traits.

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Heritability of Heart Rate Response to Arousals in Twins

Effective Control of Smart Hybrid Power Systems:Cooperation of Robust LFC and Virtual Inertia Control Systems

中国睡眠研究会第十届全国学术年会

作者： Xiaoling Gao Ali Azarbarzin Brendan T.Keenan Michele Ostrowski Frances M.Pack Bethany Staley Greg Maislin Allan I.Pack magdy younes Samuel T.Kuna Department of Medicine and Center for Sleep and Circadian Neurobiology University of Pennsylvania Department of Respiration The Second Hospital of Shanxi Medical University Division of Sleep Medicine Brigham and Women’s Hospital and Harvard Medical School Sleep Disorders Centre University of Manitoba

Objectives: To determine if the large and highly reproducible interindividual differences in arousal intensity and heart rate response to arousal（ΔHR） during non-REM sleep are ***: Polysomnograms of 55 monozygotic（14 male and 41 female pairs） and 36 dizygotic（15 male and 21 female pairs） same-sex twin pairs were *** were scored using the 2012 American Academy of Sleep Medicine *** intensity was scaled（between 0 and 9） using an automatic algorithm based on the change in electroencephalogram time and frequency *** ΔHR was determined at each *** calculated average arousal duration,average arousal intensity,average overall ΔHR,average ΔHR at a given arousal intensity,slope of ΔHR per arousal intensity,and arousal intensity threshold of Δ***: The intraclass correlations among monozygotic and dizygotic twin pairs were 0.663 and 0.146,respectively,for average arousal intensity,and 0.449 and 0,respectively,for arousal intensity threshold of ΔHR controlling for age,sex,and *** values imply large broad sense heritability（H2） for these *** evidence was confirmed by a robust maximum likelihood-based variance components estimation approach,with an additive genetic heritability of 0.64（95% confidence interval: 0.48 to 0.80） for average arousal intensity and a combined additive and dominance genetic heritability and of 0.46（0.25 to 0.68） for arousal intensity threshold of Δ*** also suggested significant additive genetic effects for average arousal duration,ΔHR at arousal intensity scale 4 and the overall average Δ***: Genetic factors explain a significant fraction of the phenotypic variability for average arousal intensity and arousal intensity threshold of Δ*** suggest that the duration of arousals and specific average ΔHR values may also be heritable traits.

关键词： polysomnogram monozygotic dizygotic

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CSEE Journal of Power and Energy Systems 2022年第6期8卷 1583-1593页

作者： Gaber magdy Hossam Ali Dianguo Xu Electrical Engineering Department Faculty of Energy EngineeringAswan UniversityAswan 81528Egypt Institute of Technology HarbinHeilongjiang 150001Chinaand Electrical Engineering DepartmentFaculty of Energy EngineeringAswan UniversityAswan 81528Egypt Harbin Institute of Technology HarbinHeilongjiang 150001China

A modern power system is expected to consist primarily of renewables,which either lack or have less rotating masses(i.e.,source of inertia)compared to the traditional generation ***,the growth of renewables generation,based on power electronics,can substantially decrease the inertia levels of renewable power grids,which can create several frequency stability issues,resulting in power system *** address this issue,this paper presents a recent virtual inertia scheme predicated on electric vehicles(EVs)to mimic the necessary inertia power in low-inertia smart hybrid power systems(SHPSs),thus regulating the system frequency and avoiding system ***,to guarantee robust performance and more stability for SHPSs against multiple perturbations,system uncertainties,and physical constraints,this paper also proposes a robust control strategy relying on a coefficient diagram method(CDM)for the load frequency control(LFC)of SHPSs considering high renewables penetration and *** efficacy of the proposed system(i.e.,robust LFC with the proposed VIC strategy)is validated by comparison with a conventional LFC with/without the proposed VIC *** addition,the simulation outcomes show that the proposed system can considerably support smart low-inertia hybrid power systems for many different contingencies.

关键词： Electric vehicles renewable energy sources robust frequency control smart hybrid power system virtual inertia control