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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Zubair Lomax Distribution:Properties and Estimation Based on Ranked set sampling

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Computers, Materials & Continua 2020年第12期65卷 2169-2187页

作者： Rashad Bantan Amal s.Hassan mahmoud Elsehetry Deanship of scientific Research King AbdulAziz UniversityJeddah21589Saudi Arabia Faculty of Graduate studies for statistical Research Cairo UniversityCairo11865Egypt Deanship of Information Technology King AbdulAziz UniversityJeddah21589Saudi Arabia

In this article,we offer a new adapted model with three parameters,called Zubair Lomax *** new model can be very useful in analyzing and modeling real data and provides better fits than some others new *** properties of the Zubair Lomax model are determined by moments,probability weighted moments,Renyi entropy,quantile function and stochastic ordering,among *** likelihood method is used to estimate the population parameters,owing to simple random sample and ranked set sampling *** behavior of the maximum likelihood estimates for the model parameters is studied using Monte Carlo *** measures including biases,mean square errors and relative efficiencies are used to compare *** the simulation study,we observe that the estimates based on ranked set sampling are more efficient compared to the estimates based on simple random *** importance and flexibility of Zubair Lomax are validated empirically in modeling two types of lifetime data.

关键词： Lomax distribution Zubair-g family moments maximum likelihood estimation ranked set sampling

Generalized Marshall Olkin Inverse Lindley Distribution with Applications

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Computers, Materials & Continua 2020年第9期64卷 1505-1526页

In this article,a new generalization of the inverse Lindley distribution is introduced based on Marshall-Olkin family of *** call the new distribution,the generalized Marshall-Olkin inverse Lindley distribution which offers more flexibility for modeling lifetime *** new distribution includes the inverse Lindley and the Marshall-Olkin inverse Lindley as special *** properties of the generalized Marshall-Olkin inverse Lindley distribution are discussed and investigated including,quantile function,ordinary moments,incomplete moments,moments of residual and stochastic *** likelihood method of estimation is considered under complete,Type-I censoring and Type-II *** likelihood estimators as well as approximate confidence intervals of the population parameters are discussed.A comprehensive simulation study is done to assess the performance of estimates based on their biases and mean square *** notability of the generalized Marshall-Olkin inverse Lindley model is clarified by means of two real data *** results showed the fact that the generalized Marshall-Olkin inverse Lindley model can produce better fits than power Lindley,extended Lindley,alpha power transmuted Lindley,alpha power extended exponential and Lindley distributions.

关键词： Generalized Marshal-Olkin family inverse Lindley distribution maximum likelihood estimation

Influence of magnetic field on free vibrations in elastodynamic problem of orthotropic hollow sphere

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Applied Mathematics and Mechanics(English Edition) 2014年第8期35卷 1051-1066页

作者： s.R.mahmoud A.M.ABD-ALLA Department of Mathematics Science FacultyKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics Science FacultySohag UniversitySohag 82524Egypt

The effect of magnetic field on the plane vibrations for an elastodynamic orthotropic sphere is studied. Equations of elastodynamic problems of the orthotropic hollow sphere in terms of displacement are solved. The numerical results of the frequency equations in the presence of magnetic field are discussed and shown graphically. Compar-isons are made with the result in the presence and absence of magnetic field in the case of orthotropic sphere. The results show that the effect of magnetic field is very pronounced.

关键词： magnetic field elastodynamic orthotropic free vibration hollow sphere

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGs6-expressing ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying RGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGs6)

Diffusion Monte Carlo calculations on LaB molecule

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Chinese Physics B 2018年第9期27卷 241-246页

作者： Nagat Elkahwagy Atif Ismail s M A Maizet K R mahmoud Department of Physics Faculty of Science Kafrelsheikh University Kafr El-Sheikh Egypt Department of Physics Faculty of Applied Sciences Umm AI Qura University Makkah Saudi Arabia Department of Physics Faculty of Science Menoufia University Shebin EI-Kom Egypt

Potential energy curves for the lowest electronic states of LaB and LaB- have been calculated by ab initio *** diffusion Monte Carlo method has been employed in combination with three different trial functions. spectroscopic constants have also been numerically derived for the neutral molecule and compared with the only available theoretical work;^（[19]） however, predictions are provided for the corresponding constants for the anionic species which have not been reported yet. Our calculations suggest the high spin quintet state of LaB as the ground state with the triplet state higher in energy irrespective of the type of the functional used. This suggestion is in good accordance with the previous theoretical results calculated at B3LYP/LANL2DZ level of theory, whereas it contradicts with the prediction based upon B3LYP/sDD calculations in the same study. Moreover, variations of the permanent dipole moments as a function of the internuclear separations for the two electronic states of the neutral molecule have been studied and analyzed.

关键词： potential energy curve lanthanum boride diffusion Monte Carlo dipole moment

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

silicothermic reduction of MgO using diode laser:Experimental and kinetic study

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Journal of Magnesium and Alloys 2017年第4期5卷 430-438页

作者： M.s.mahmoud T.Yabe Chemical Engineering Department Faculty of EngineeringMinia UniversityMinia61516Egypt Engineering Department Collage of Applied ScienceSuhar311Oman Mechanical Engineering Department Tokyo Institute of Technology2-12-1 O-okayamaMeguroTokyo 152-8552Japan Energy Genesis Cycle 405 East Wing3-2-1 SakadoTakatsukuKawasaki CityKanagawa 213-0012Japan

As a step toward realizing magnesium civilization,which needs a sustainable Mg production process,the reduction of MgO to Mg has been *** diode laser(DDL)produces high power and continuous beam in tiny *** laser with energy density up to 83*10^(5) W/cm^(2) is focused on MgO/si target inside the vacuum chamber,creating the high temperature zone,which stimulates the Mg production *** vapor is collected on the copper plate;and then,analyzed chemically in terms of Mg production *** largest reduction and energy efficiencies in Ar atmosphere were 41%and 15.3 mg kJ^(−1),while in the vacuum,13.5%and 15.8 mg kJ^(−1) were *** reactions of MgO and si have been *** revealed that the MgO reduction with si proceeds as heterogeneous *** rate of reaction of si with MgO is faster than the rate of MgO evaporation and Mg vapor deposition.

关键词： Diode laser Magnesium oxide Magnesium Reduction silicon

Optimal and Memristor-Based Control of A Nonlinear Fractional Tumor-Immune Model

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Computers, Materials & Continua 2021年第6期67卷 3463-3486页

作者： Amr M.s.Mahdy mahmoud Higazy Mohamed s.Mohamed Department of Mathematics College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Mathematics Faculty of ScienceZagazig UniversityZagazig44519Egypt Department of Physics and Engineering Mathematics Faculty of Electronic engineeringMenoufia UniversityMenouf32952Egypt Department of Mathematics Faculty of ScienceAl-Azher UniversityNasr City11884Egypt

In this article,the reduced differential transform method is introduced to solve the nonlinear fractional model of *** fractional derivatives are described in the Caputo *** solutions derived using this method are easy and very *** model is given by its signal flow ***,a simulation of the system by the simulink of MATLAB is *** disease-free equilibrium and stability of the equilibrium point are *** of a fractional optimal control for the cancer model is *** addition,to control the system,we propose a novel modification of its *** modification is based on converting the model to a memristive one,which is a first time in the literature that such idea is used to control this type of ***,we study the system’s stability via the Lyapunov exponents and Poincare maps before and after *** order differential equations(FDEs)are commonly utilized to model systems that have memory,and exist in several physical phenomena,models in thermoelasticity field,and biological *** have been utilized to model the realistic biphasic decline manner of elastic systems and infection of diseases with a slower rate of *** are more useful than integer-order in modeling sophisticated models that contain physical phenomena.

关键词： RDTM tumor-immune optimal control caputo derivative signal flow simulink disease-free equilibrium stability memristive lyapunov exponents poincare map