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A potential impact of A Disintegrin and Metalloproteinase Domain-Like Protein Decysin-1(ADAMDEC1)on clear cell renal cell carcinoma propagation

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BIOCELL 2022年第8期46卷 1893-1901页

作者： magdalena RUDZIŃSKA-RADECKA Foundation of Research and Science Development Warsaw01-793Poland

Clear cell renal cell carcinoma(KIRC)is the most common and aggressivemalignancy subtype of renal neoplasm that arises from proximal convoluted *** is characterized by poor clinical outcomes and high mortality of patients due to the lack of specific biomarkers for varying stages of the disease and no effective *** are associated with the development of several malignant tumors in humans by their ability to degrade extracellular matrices,facilitating ***,differentially expressed genes in KIRC cases compared to healthy kidneys were screened out from the Gene Expression Profiling Interactive Analysis(GEPIA)*** data was applied to determine the most elevated protease in KIRC and as a result,A Disintegrin and Metalloproteinase Domain-Like Protein Decysin-1(ADAMDEC1)was *** expression pattern was exclusive for KIRC and not observed for papillary and chromophobe renal cell carcinomas,in which ADAMDEC1 was at the same level in tumors and non-cancer ***,the ADAMDEC1 significant increase was detected in the fourteen other human malignancies compared to healthy samples,which suggested its strong involvement in cancer ***,GEPIA and Pathology Atlas correlated ADAMDEC1 high expression with more advanced tumor grade and shorter survival of KIRC *** Functional Genomics Explorer presented that ADAMDEC1 could be hypermethylated in some tumor cases and one somatic mutation in the gene sequence was ***,a Search Tool for the Retrieval of Interacting Genes/Proteins;STRING base was utilized to predict the interactions of ADAMDEC1 with other molecules and construct the signaling *** summary,ADAMDEC1 showed the tremendous potential to be the predictive marker for the KIRC and its ***,this review with data analysis can be a good base for further in vitro and in vivo research that experimentally can confirm the ADAMDEC1 as prognostic biomarkers and therapeuti

关键词： A Disintegrin and Metalloproteinase Domain-Like Protein Decysin-1 ADAMDEC1 Clear cell renal cell carcinoma Patient specimens Databases

Discriminating the HTM and MLRSM models in collider studies via doubly charged Higgs boson pair production and the subsequent leptonic decays

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Chinese Physics C 2021年第7期45卷 151-182页

作者： Janusz Gluza magdalena Kordiaczynska Tripurari Srivastava Institute of Physics University of SilesiaKatowicePoland Faculty of Science University of Hradec KrálovéCzech Republic Theoretical Physics Division Physical Research LaboratoryAhmedabad-380009India

We present a case study for the doubly charged Higgs boson H^(±±)pair production ine^(+)+e^(-)and pp colliders with their subsequent decays to four charged *** consider the Higgs Triplet Model(HTM),which is not restricted by the custodial symmetry,and the Minimal Left-Right Symmetric Model(MLRSM).These models include scalar triplets with different complexities of scalar potentials and,because of experimental restrictions,completely different scales of non-standard triplet vacuum expectation *** both models,a doubly charged Higgs bosonH^(±±)can acquire a mass of hundreds of gigaelectronvolts,which can be probed at the HL-LHC,futuree^(+)+e^(-),and hadron *** take into account a comprehensive set of constraints on the parameters of both models coming from neutrino oscillations,LHC,e^(+)+e^(-),and low-energy lepton flavor violating data and assume the same mass ofH^(±±).Our finding is that theH^(±±)pair production in lepton and hadron colliders is comparable in both models,though more pronounced in the *** show that the decay branching ratios can be different within both models,leading to distinguishable four-lepton signals,and that the strongest are 4μevents yielded by ***,we find that the MLRSM signals are one order of magnitude larger those in *** example,the pp→to 4μMLRSM signal for 1 TeVH^(±±)mass results in a clearly detectable significance of S■11for the HL-LHC and S≥290 for the ***,we provide quantitative predictions for the dilepton invariant mass distributions and lepton separations,which help to identify non-standard signals.

关键词： BSM Higgs triplet model left right symmetric model

Starting life in space

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National Science Review 2020年第9期7卷 1447-1448页

作者： Jake Cornwall-Scoones magdalena Zernicka-Goetz Division of Biology and Biological Engineering Californian Institute of Technology

As far as we know, animal development is a process that is unique to our planet. That does not mean, however, that development beyond our realm is impossible. As it starts to become feasible for us to look to the sky for another place to call home, we may start to appreciate the gravity of this *** this issue, Lei et al. investigate for the first time the repercussions of space travel on the first decisions made by mouse embryos.

关键词： BLASTOMERES

Analysis of solid sorbents for control and removal processes for elemental mercury from gas streams:a review

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International Journal of Coal Science & Technology 2021年第1期8卷 23-46页

作者： Piotr Kunecki Dorota Czarna-Juszkiewicz magdalena Wdowin Mineral and Energy Economy Research Institute Polish Academy of SciencesWybickiego 7a31-261KrakówPoland

Due to the restriction such as the Minamata Convention as well as the IED of the European Commission,mercury removal from flue gases of coal-fired power plants(CPP)is an increasingly important environmental *** makes this topic very crucial for both the energy industry and *** paper shows how mercury arises from natural resources,i.e.,coals,through their combustion processes in CPP and considers the issue of mercury content in flue gases and solid-state coal combustion *** main part of this paper presents a review of the solid sorbents available for elemental mercury control and removal processes,tested on a laboratory *** described solutions have a potential for wider usage in exhaust gas treatment processes in the energy production *** solutions represent the latest developments in the field of elemental mercury removal from *** authors present an overview of the wide range of solid sorbents and their modifications intended to increase affinity for Hg^(0).Among the presented sorbents are the wellknown activated carbon solutions but also novel modifications to these and other innovative sorbent proposals based on,e.g.,zeolites,biochars,other carbon-based materials,metal-organic *** paper presents a wide range of characteristics of the described sorbents,as well as the conditions for the Hg^(0) removal experiments summarizing the compendium of novel solid sorbent solutions dedicated to the removal of elemental mercury from gases.

关键词： Solid sorbents Textural properties Elemental mercury removal Flue gas Gas stream

Effect of spot burning of logging residues on the properties of mountain forest soils and the occurrence of ground beetles(Coleoptera, Carabidae)

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Journal of Mountain Science 2020年第1期17卷 31-41页

作者： magdalena KACPRZYK Ewa BLONSKA Jaroslaw LASOTA Department of Forest Protection Entomology and Forest ClimatologyUniversity of AgricultureAl.29 Listopada 4631-425 KrakowPoland Department of Forest Soil Science University of AgricultureAl.29 Listopada 4631-425 KrakowPoland

We investigated the relationships between dehydrogenase activity and the physicochemical properties of mountain soils over three and five years from Norway spruce(Picea abies L. Karst) logging residue spot burning and the occurrence of epigeic carabid beetles. Six study sites were utilised, including18 study plots(nine plots in a mixed coniferous mountain forest site and nine plots in a mixed broadleaf mountain forest site), with five replicate pitfall traps at each site located in southern *** samples from the organic horizon were taken for p H, organic carbon, nitrogen, base cation content,acidity and dehydrogenase activity *** beetles were monitored in weekly intervals during the period of July to August 2016. The burning of logging residues led to modified soil properties,especially the dehydrogenase activity. In all the tested variants, the activity was higher in soil samples after the burning in comparison to the control variants. We show no positive correlation between dehydrogenase activity and the number of carabid specimens. The preferences of dominant predatory hygrophilous carabids to acid habitats with weakly decomposed organic matter were proven. Simultaneously, the soil organic matter content was positively related to the carabid abundance. The significant impact of forest site conditions and the date of logging residue burning on the number of caught specimens were confirmed. In contrast, no relationships between the species richness, species diversity, mean individual biomass and spot burning effect were found. This work supports the recommendation of spruce fine woody debris utilisation by spot burning on mountain regions with rich habitats presenting moderate wet conditions and small land falls.

关键词： Fine woody debris Combustion Soil organic matter Enzyme activities Epigeic carabid beetles

Free-surface long wave propagation over linear and parabolic transition shelves

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Water Science and Engineering 2018年第4期11卷 318-327页

作者： Ikha magdalena Iryanto Dominic E.Reeve Faculty of Mathematics and Natural Sciences Bandung Institute of Technology Informatics Department Indramayu State Polytechnic College of Engineering Swansea UniversityBay Campus

Long-period waves pose a threat to coastal communities as they propagate from deep ocean to shallow coastal waters. At the coastline, such waves have a greater height and longer period in comparison with local storm waves, and can cause severe inundation and damage. In this study,we considered linear long waves in a two-dimensional(vertical-horizontal) domain propagating towards a shoreline over a shallowing *** solutions to the linear shallow water equations were found, through the separation of variables, for two forms of transition shelf morphology: deep water and shallow coastal water horizontal shelves connected by linear and parabolic transition, respectively. Expressions for the transmission and reflection coefficients are presented for each case. The analytical solutions were used to test the results from a novel computational scheme, which was then applied to extending the existing results relating to the reflected and transmitted components of an incident wave. The solutions and computational package provide new tools for coastal managers to formulate improved defence and riskmitigation strategies.

关键词： Shallow water equation Long-period wave Shoaling Analytical solution Numerical solution Reflection coefficient Transmission coefficient

以不同聚合物和有机前驱体模板法制备纳米孔炭及其热性能(英文)

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新型炭材料 2012年第5期27卷 337-343页

作者： magdalena Sobiesiak Faculty of Chemistry MCS University

以糠醇(FA)、4,4-双马来酰亚胺二苯基甲醇(BM)、BM与二乙烯基苯共聚物(BM-DVB)和蔗糖(S)为炭前驱体,硅胶为硬模板制备了六种纳米孔炭。在氦气气氛中800℃～1 000℃炭化30 min,炭化后利用质量分数40%HF脱除模板。利用元素分析、氮气吸附... 详细信息

以糠醇(FA)、4,4-双马来酰亚胺二苯基甲醇(BM)、BM与二乙烯基苯共聚物(BM-DVB)和蔗糖(S)为炭前驱体,硅胶为硬模板制备了六种纳米孔炭。在氦气气氛中800℃～1 000℃炭化30 min,炭化后利用质量分数40%HF脱除模板。利用元素分析、氮气吸附、热分析和漫反射红外表征产物的孔结构和化学结构及它们对多孔炭热性能的影响。结果表明,前驱体对多孔炭的性能有一定的影响。前驱体的化学结构和热处理条件对炭的孔隙结构,亲水性和热稳定性都有影响。最稳定的产物中含有氮和磷元素。

关键词：多孔炭模板法孔结构表面化学

Relationships between serum lipid,lipoprotein,triglyceride-rich lipoprotein,and high-density lipoprotein particle concentrations in post-renal transplant patients

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第4期11卷 249-257页

作者： ElZbieta KIMAK magdalena HALABI Iwona BARANOWICZ-GASZCZYK Department of Laboratory Diagnostics Medical University of Lublinul. Chod■ki 120-093 LublinPoland Department of Nephrology Medical University of LublinJaczewskiego 820-093 LublinPoland

Objective:Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. Methods:Serum levels of lipids,lipoprotein,triglyceride-rich lipoproteins (TRLs),and high-density lipoprotein (HDL) particles were determined,lipid and lipoprotein ratios were calculated,and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx patients and 89 healthy subjects. HDL particle levels were de-termined by enzyme-linked immunosorbent assay (ELISA). Results:Tx patients had disturbed concentration,com-position,and metabolism of TRLs and HDL particles. Multivariance analysis showed significant and positive correlation between HDL cholesterol/apoAI (HDL-C/apoAI) and HDL-C/HDL ratios,which indicates that both ratios could sensi-tively reflect changes in the HDL subclasses and their distribution into smaller size particles. In Tx patients,the de-creased HDL-C/apoAI ratio indicates that,along with the decreased apoAI concentration,the HDL-C level is de-creased. However,a low HDL-C/HDL ratio indicates that HDL particles in Tx patients transport lesser content of HDL-C but more triglyceride (TG) (high TG/HDL ratio),and thus are hypercatabolized and removed; therefore,con-centration of HDL particles in serum was decreased. Conclusion:The decrease of HDL-C/apoAI ratio seems to be a good marker of HDL subclass distribution into smaller size particles.

关键词： Lipid Lipoprotein High-density lipoprotein particle Triglyceride-rich lipoprotein Renal transplantation

Microelectrona cladara *** ***.:A New Protodikraneurini from the Eocene Baltic Amber(Hemiptera:Cicadomorpha:Cicadellidae:Typhlocybinae)

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 696-704页

作者： Jacek SZWEDO Cezary GEBICKI magdalena KOWALEWSKA Museum and Institute of Zoology Polish Academy of SciencesWarsawPoland Department of Ecology and Environment Protection Jan Dlugosz University of CzestochowaCzestochowaPoland

A new genus Microelectrona gen. nov. and species Microelectrona cladara sp. nov. of the extinct tribe Protodikraneurini of the leafhoppers （Cicadellidae： Typhlocybinae） from the Eocene Baltic amber is described. The piece of amber containing leafhopper inclusion is broken, unveiling some of the morphological structures, and enabling their studies using scanning electron microscopy.

关键词： Microelectrona gen. nov. Microelectrona cladara sp. nov. Protodikraneurini Typhlocybinae,leafhoppers Baltic amber Eocene fossil morphological structure scanning electron microscopy