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Th. Possible Role of th. Incretin Enh.ncer Sitaglipten, in Renal Isch.mic Reperfusion Injury in Type 2 Diabetes Mellitus

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Open Journal of Endocrine and Metabolic Diseases 2014年第7期4卷 181-196页

作者： Mervat E. Moh.med Sammy h. h.mmadi magda h. abd-el hamid Department of Ph.rmacology & Toxicology and Path.logy Faculty of Medicine Umm Al-Qura University Makkah Saudi Arabia

Background: Diabetes mellitus (DM) especially type 2 is a major h.alth.problem and diabetic neph.opath. is th. main cause of end stage renal disease (ESRD). Renal isch.mia/reperfusion (I/R) injury is common in diabetic patients. Recent studies reported increased vulnerability of kidneys to I/R injury in diabetic rats. In view of th. reported efficacy of incretin enh.ncer on I/R injury. Aim: Th.s study was designed to assess th. effect of sitaglipten on renal I/R in type 2 diabetes mellitus . Meth.ds: Type 2 DM in rats were induced by administration of nicotinamide (230 mg/kg, i.p.), 15 min prior to th. single dose of streptozotocin (65 mg/kg, i.p.). Renal I/R were performed in both.diabetic and normal rats. Results: Th. lipid peroxidation, xanth.ne oxidase activity, and nitric oxide levels were significantly increased after I/R in diabetic rats compared to I/R in normal rats. Antioxidant enzymes such.as glutath.one, superoxide dismutase, catalase, and glutath.one peroxidase were significantly reduced after I/R in diabetic rats compared to normal rats. Sitaglipten treatment significantly normalized th.se bioch.mical parameters compared to diabetic I/R rats. Serum TNF-α level and myeloperoxidase activity were also significantly normalized after administration of sitaglipten. Furth.rmore, treatment with.sitaglipten (10 mcg/kg) h.d preserved th. normal morph.logy of th. kidney compared to I/R performed in diabetic rats. Conclusion: Sitaglipten protects exaggerated renal I/R injury in type 2 DM. Th.se findings h.ve major implication in th. treatment of isch.mic injury th.t is prone to develop in DM.

关键词： Type 2 Diabetes Mellitus Dipeptidyl Peptidase-IV Glucagon-Like Peptide-1 Sitaglipten Inflammation Isch.mia Reperfusion Kidney Oxidative Stress

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Plastic Deformation Evaluation of 6201 Alloy by Using Positron Annih.lation Lifetime Tech.ique

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材料科学与工程（中英文A版） 2013年第1期3卷 14-21页

作者： Amira.Nassar magda abd el-Wah.b Eman abd el hamid Zeinab Yousef Metal Ph.sics Lab. Solid State Physics Department National Research Center Dokki Cairo P.O. 1231 I Egypt Ph.sics Department Faculty of Women for Arts Science and Education A in Shams University Heliopolis Cairo 1175 7 Egypt

Th. effect of cold drawn on th. mech.nical properties and structural defects of 6201 alloy used as conductor cables was studied. Th. effect of h.at treatment at 350 and 500 °C after deformation as well as deformed at room temperature (RT) was investigated in order to identify an optimized h.at treatment for different cold drawn samples. Th. mech.nical properties and microstructure were determined by using Vickers micro h.rdness (h.) and scanning electron microscopy (SEM), respectively. Th. Evaluation of th.ee distinguish.d stages observed in th.s investigation was discussed by using positron annih.lation lifetime (PAL) tech.ique. Th. present work demonstrates th.t PAL can provide valuable information about th. microstructure of cold drawn 6201 alloy.

关键词：正电子湮没寿命塑性变形技术评价合金扫描电子显微镜微观结构结构缺陷机械性能

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