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Impact of Gender Difference on Characteristics and Outcome of Chronic Hepatitis C

Open Journal of Gastroenterology 2020年第11期10卷 281-294页

作者： Mahmoud Saif-Al-Islam Hamdy Saad mohamed Mustafa Adel Younis Mahmoud Yosef Abdelhamid magda mohamed ali Safaa Khalaf Departments of Tropical Medicine and Gastroenterology Sohag University Hospital Sohag Egypt Departments of Internal Medicine Sohag University Hospital Sohag Egypt Departments of Clinical Pathology Sohag University Hospital Sohag Egypt Departments of Radiology Sohag University Hospital Sohag Egypt Departments of Community Medicine Sohag University Hospital Sohag Egypt

Gender difference in chronic hepatitis C (CHC) infection is not previously well studied. We aimed to analyze the effect of gender difference on the risk factors of CHC, disease progression, and outcome after oral direct acting antiviral (DAA) therapy. The study was conducted at Tropical Medicine and Gastroenterology Department, Sohag University, Egypt, in the period between 2018 and 2020. 775 patients were evaluated for hepatitis C virus (HCV) risk factors. Laboratory investigations, abdominal ultrasound and liver Shear wave elastography (SWE) were done. The patients were given antiviral therapy and followed up to assess the response and side effects of DAA therapy. 434 (56%) of study patients were males and 341 (44%) were females. Catching infection from blood transfusion and intravenous (IV) injection of tarter emetic was significantly higher in males, while catching infection from surgical operation was significantly higher in females. Hepatic fibrosis was significantly more extensive in males. Side effects were reported more in females. Sustained virological response (SVR) 12 was reported in 98.6%. Females had a slightly better SVR12 than males (99.4% versus 97.9%). In conclusion males were different from females in exposure to HCV risk factors. After introduction of blood screening and

关键词： Chronic HCV Risk Factors Gender Difference DAA Therapy

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Summary of the current guidelines for managing iatrogenic colorectal perforations and the evolving role of endoluminal vacuum therapy

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World Journal of Clinical Cases 2025年第6期13卷 1-8页

作者： Ahmed Tawheed Ibrahim Halil Bahcecioglu Mehmet Yalniz Mubin Ozercan ali Cagri Oral mohamed El-Kassas Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Gastroenterology Firat UniversityElazig 23119Türkiye Liver Disease Research Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

Colonoscopy represents a safe procedure that is widely used in medical practice either to diagnose or treat various gastrointestinal *** the last few years,the incidence rate of perforations in colonoscopic procedures has increased,especially in therapeutic *** recent advancements in endoscopic techniques and gastrointestinal tumoral resection procedures such as endoscopic mucosal resection,endoscopic full-thickness resection,and endoscopic submucosal dissection(ESD)could be a risk factor for this increased *** incidence rate of mortality of serious colonoscopic perforations is 7.1%.The management plan for these perforations starts with conservative treatment in mild cases,endoscopic closure,and surgical management in severe ***,endoluminal vacuum therapy was found to be effective in the management of colorectal perforations and this has been reported in multiple case *** editorial provides an overview of the current guidelines for the management of iatrogenic colorectal *** insights are from the perspectives of endoscopists and *** also present a management algorithm based on the guidelines of the European Society of Gastrointestinal Endoscopy,the American Gastroenterological Association,and the World Society of Emergency *** also discussed in brief the use of endoluminal vacuum therapy in colorectal perforations.

关键词： Colon Rectum Iatrogenic colonic perforation Colonoscopy Guidelines Endovacuum Endolumical vacuum therapy Endoscopic management

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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli ali mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Salt response of the freshwater microalga Scenedesmus obliquus(Turp.)Kutz is modulated by the algal growth phase

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Journal of Oceanology and Limnology 2020年第3期38卷 802-815页

作者： Taha mohamed EL-KATONY magda Faiz EL-ADL Department of Botany and Microbiology Faculty of ScienceDamietta UniversityNew Damietta City 34517Egypt

Growth and biochemical responses of the coenobial green alga Scenedesmus obliquus to salinity stress were monitored across different phases of *** alga was cultured on BG11 growth medium and subjected to 0,30,100,and 200 mmol/L NaCl for a period of 20 d,during which algal cultures were harvested at 4-d *** salinity-induced inhibition of algal growth was accompanied with prolongation of timing of the different growth *** sharp and progressive salinity-induced inhibition of algal growth rate during the early phase of growth points to salt shock but moderation of inhibition at the subsequent stages of growth means algal acclimation to *** concentrations of chlorophylls a and b,soluble sugars,proteins as well as those of K+and Na+in the alga exhibited peaks at the initiation of the exponential phase of growth,with increasing magnitude in proportion to the increase in the level of ***,whereas soluble sugars of the alga peaked at initiation of the exponential phase,starch concentration progressively increased with culture age,reaching saturation towards the stationary *** the salinity-induced increase in soluble sugars was most evident at the early stages of growth the reverse was true for *** present results point to fast acclimation of *** to salt stress post a brief salt shock,utilizing soluble sugars,K+and Na+for osmotic *** salinity from 0 to 200 mmol/L NaCl led to progressive increase in soluble sugars,proteins,K+and Na+concentrations of the algal cells,particularly at the early stages of ***,the salinity-induced increase in chlorophyll concentration approached a limit at 100 mmol/L NaCl whereas that in starch concentration was more evident at the later stages of growth.

关键词： carbohydrates growth phase minerals protein salt stress Scenedesmus obliquus

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Anti-wear properties evaluation of frictional sliding interfaces in automobile engines lubricated by copper/graphene nanolubricants

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Friction 2020年第5期8卷 905-916页

作者： mohamed Kamal Ahmed ali Xianjun HOU mohamed AAABDELKAREEM Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Automotive and Tractors Engineering Department Faculty of EngineeringMinia UniversityEl-Minia 61111Egypt Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China

Owing to the significance of improving fuel economy, reducing emissions, and extending the durability of engine components, this study focused on the tribological performance of nano-additives. In this study, copper (Cu) and graphene (Gr) nanomaterials were dispersed in a fully formulated engine oil (5W-30) with different concentrations. The tribological trials were investigated under various speeds and loads, utilizing a reciprocating tribometer to mimic the ring/liner interfaces in the engine. The frictional surface morphologies were com-prehensively analyzed using electron probe X-ray microanalysis (EPMA), field emission scanning electron microscopy (FESEM), energy dispersive spectrometer (EDS), and three dimensional (3D) surface profilometry to explore the mechanisms responsible for improving the tribological performance of the frictional sliding parts in the engine. The tribological test results illustrated that lubrication by nano-additives reduced the wear rate (WR) and friction coefficient (COF) by 25%–30% and 26.5%–32.6%, respectively, as compared with 5W-30. The results showed that this is a promising approach for increasing the durability and lifespan of frictional sliding components and fuel economy in automobile engines.

关键词： engine tribology nanomaterial nanolubricant friction wear tribofilm

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Machine learning-based seismic assessment of framed structures with soil-structure interaction

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 205-223页

作者： mohamed NOURELDIN Tabish ali Jinkoo KIM Department of Global Smart City Sungkyunkwan UniversitySuwon 16419Korea

The objective of the current study is to propose an expert system framework based on a supervised machine learning technique(MLT)to predict the seismic performance of low-to mid-rise frame structures considering soil-structure interaction(SSI).The methodology of the framework is based on examining different MLTs to obtain the highest possible accuracy for *** the MLT,a sensitivity analysis was conducted on the main SSI parameters to select the most effective input *** limit state criteria were used for the seismic evaluation within the process.A new global seismic assessment ratio was introduced that considers both serviceability and strength aspects by utilizing three different engineering demand parameters(EDPs).The proposed framework is novel because it enables the designer to seismically assess the structure,while simultaneously considering different EDPs and multiple limit ***,the framework provides recommendations for building component design based on the newly introduced global seismic assessment ratio,which considers different levels of seismic *** proposed framework was validated through comparison using non-linear time history(NLTH)*** results show that the proposed framework provides more accurate results than conventional ***,the generalization potential of the proposed framework was tested by investigating two different types of structural irregularities,namely,stiffness and mass *** results from the framework were in good agreement with the NLTH analysis results for the selected case studies,and peak ground acceleration(PGA)was found to be the most influential input parameter in the assessment process for the case study models *** proposed framework shows high generalization potential for low-to mid-rise structures.

关键词： seismic hazard artificial neural network soil-structure interaction seismic analysis

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Robust Output Practical Stability of Time-Varying Nonlinear Control Systems via Indefinite Lyapunov Functions

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Journal of Systems Science & Complexity 2024年第6期37卷 2595-2613页

作者： DAMAK Hanen ABOTHHER Amal HAMMAMI mohamed ali Department of Mathematics University of SfacPreparatory Engineering Institute of SfaxSfax 3047Tunisia Department of Mathematics University of ZawiaFaculty of education Abu EssaZawia 16418Libya Department of Mathematics University of SfacFaculty of Sciences of SfaxSfax 3047Tunisia

This paper focuses on studying the problem of robust output practical stability of timevarying nonlinear control systems. The main innovation lies in the fact that the proposed approach for stability analysis allows for the computation of bounds that characterize the asymptotic convergence of solutions to a small ball centered at the origin using a Lyapunov method with a definite *** different conditions on the perturbation, the authors demonstrate that the system can be globally robustly asymptotically output stable by designing a candidate feedback controller. Finally, three examples are given to illustrate the practical implications and significance of the theoretical results.

关键词： Control theory global robust practical asymptotic output stability(GRPAOS) Lyapunov method time-varying control systems

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A Multi-Level Selective Maintenance Strategy Combined to Data Mining Approach for Multi-Component System Subject to Propagated Failures

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Journal of Systems Science and Systems Engineering 2022年第3期31卷 313-337页

作者： mohamed ali Kammoun Zied Hajej Nidhal Rezg Universite de Lorraine LGIPMF-57000 MetzFrance Ecole poly technique du Groupe Honoris United Universities-Tunisia

In several industrial fields like air transport,energy industry and military domain,maintenance actions are carried out during downtimes in order to maintain the reliability and availability of production *** such a circumstance,selective maintenance strategy is considered the reliable solution for selecting the faulty components to achieve the next mission without *** this paper,a novel multi-level decision making approach based on data mining techniques is investigated to determine an optimal selective maintenance *** the first-level,the age acceleration factor and its impact on the component nominal age are used to establish the local *** first decision making employed K-means clustering algorithm that exploited the historical maintenance *** on the first-level intervention plan,the remaining-levels identify the stochastic dependence among components by relying upon Apriori association rules algorithm,which allows to discover of the failure occurrence *** addition,at each decision making level,an optimization model combined to a set of exclusion rules are called to supply the optimal selective maintenance plan within a reasonable time,minimizing the total maintenance cost under a required reliability *** illustrate the robustness of the proposed strategy,numerical examples and a FMS real study case have been solved.

关键词： Selective maintenance stochastic dependence age acceleration factor data mining flexible manufacturing system

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Thermal degradation of diethanolamine at stripper condition for CO2 capture: Product types and reaction mechanisms

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Chinese Journal of Chemical Engineering 2019年第12期27卷 2900-2908页

作者： Idris mohamed Saeed Brahim Si ali Badrul mohamed Jan Wan Jefrey Basirun Shaukat ali Mazari Ibrahim ali Obid Birima Department of Chemistry Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Department of Chemical Engineering Faculty of EngineeringDawood University of Engineering and TechnologyMA Jinnah RoadKarachi 74800Pakistan

Amine-based absorption/stripping is one of the promising technology for CO2 capture from natural and industrial gas *** the process,amines and CO2 undergo irreversible reactions to produce undesired compounds,which cause corrosion,foaming,increased viscosity and breakdown of equipment,ultimately contributing to the economic loss and environmental *** this study,the thermal degradation of aqueous diethanolamine in the presence and absence of dissolved CO2 was *** experiments were performed in stainless steel *** results show that thermal degradation in the absence of CO2 was a slow process;triethanolamine,and tris(2-aminoethyl)amine were only the degradation products identified in the mixture In addition,the rate of degradation was very low,only 3%degradation was observed after 4 *** in the presence of CO2,sixteen degradation products were identified,nine of which were new degradation products reported for the first time in this *** 3-(2-hydroxyethyl)-2-oxazolidinone,1,4-bis(2-hydroxyethyl)piperazine and triethanolamine were the most abundant degradation *** remaining DEA concentration after 4 weeks was about 20%of the total amine *** most probable degradation reactions and their mechanisms are also proposed.

关键词： Diethanolamine CO2 capture Degradation Mechanism

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Exploration of structural,optical,and photoluminescent properties of (1-x)NiCo_(2)O_(4)/xPbS nanocomposites for optoelectronic applications

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Chinese Physics B 2022年第6期31卷 663-670页

作者： Zein K Heiba mohamed Bakr mohamed Noura M Farag ali Badawi Physics Department Faculty of ScienceAin Shams UniversityCairoEgypt Physics Department Faculty of ScienceTaibah UniversityAl-Madina al MunawarahSaudi Arabia Department of Physics College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Physics University College of TurabahTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

The(1-x)NiCo_(2)O_(4)/x PbS(0≤x≤0.2)nanocomposite samples are synthesized using the hydrothermal and thermolysis *** different phases developed in the obtained nanocomposite samples are accurately determined using the x-ray diffraction technique equipped with a *** percentage of the formed phases(NiCo_(2)O_(4)(NCO),PbS,PbSO_(4)),structural and microstructure parameters are determined using Rietveld quantitative phase *** transmission electron microscope(TEM)images and Rietveld analysis reveal almost isotropic particle size in the nano range with a very narrow size *** obtained phase percentage of PbS and PbSO4are smaller than nominated values(x)suggesting dissolving of some Pb and S ions into NCO which is then confirmed by the analysis of Fourier-transform infrared(FTIR)spectra of nanocomposite *** absorption spectra are modified upon doping NCO with *** optical band gaps of the nanocomposites increase as the amount of PbS *** effect of alloying on extinction coefficient,refractive index,dielectric constant,optical conductivity,the intensity,and emitted color from the photoluminescence of the nanocomposite samples are also *** refractive index value of NCO and NCO-PbS nanocomposite samples exhibit normal *** photoluminescent measurements reveal that the NCO-PbS nanocomposites can emit a violet *** improvement in the values of the nonlinear optical(NLO)parameters of pristine NCO at high frequencies or the nanocomposite samples at low frequencies,are made them used in NLO photonic devices.

关键词： Co_(2)O_(4)and PbS nanocomposite FTIR optical photoluminescence

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