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Computational Chemistry 2014年第2期2卷 22-30页

作者： magda S. Saleh Ahmed K. Youssef Elham Y. Hashem Doaa A. Abdel-Kader Chemistry Department Faculty of Science Assiut University Assiut Egypt

A highly simple, rapid, sensitive and selective method is developed for spectrophotometric determination of gabapentin in pure form as well as in pharmaceutical formulations. The method is based on the formation of a yellow Schiff base derived from the condensation of gabapentin drug (1-amino methyl) cyclo hexane acetic acid and 2,5-dihydroxybenzaldehyde (DHBA) exhibiting a maximum absorbance at 445 nm. The composition, molar absorptivity and effect of different excipient have been determined spectrophotometrically. Under optimized experimental conditions, Beer’s law is obeyed in the concentration range 2.57 - 37.25 μg/ml. The method is validated with respect to accuracy, precision, limit of detection and limit of quantification. The Sandell sensitivity, correlation coefficient and regression equation are calculated. The equilibrium constant and free energy change using Benesi-Hildebrand plot are also determined. The Schiff base derived from condensation of gabapentin with DHBA is also synthesized and characterized. The condensation reaction mechanism has been proposed.

关键词： Gabapentin 2 5-Dihydroxybenzaldehyde Pharmaceutical Formulations Spectrophotometric Analysis

Discharge Policy Analysis in Prince Hamzah Hospital

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Health 2014年第21期6卷 3022-3029页

作者： Hamzah M. Alghzawi Rudaina A. Hourani Baraa M. Alrashaida Ayman Hamdan-Mansour magda Bayomi Department of Community Health Nursing Al Farabi College Riyadh KSA Medical Department Prince Hamzah Hospital Amman Jordan

A discharge policy is intended to ensure provision of fit, timely discharge arrangements to an appropriate safe environment for all patients on completion of their hospital care. This paper analyzes the current discharge policy in Prince Hamzah Hospital, to discover if it can be made more effective. The analysis is based on Patton and Sawicki’s six-step model of policy analysis. According to Patton and Sawicki’s six-step model of policy analysis, the process involves problem identification, determining policy objectives, establishing evaluation criteria, suggesting and assessing possible alternatives, and implementing, monitoring, and evaluating the policy after modification. It was concluded that the policy should remain a live document that could be refined, updated and expanded as appropriate.

关键词： Discharge Policy Analysis Patient

ZIP1和 ZIP2不同程度激活PKC对钾离子通道的磷酸化

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第一军医大学学报 2000年第1期20卷 1-6页

作者：龚剑平徐嘉 magda lena Bezanilla Rika van Huizen Rechel Derin 利民约翰.霍普金斯大学医学院生理神经科学系

蛋白修饰酶的定向修饰反应是蛋白合成后进行特异、有效修饰的一个关键步骤。ＺＩＰ１和ＰＩＰ２是两个互为剪切异构体的蛋白，它们既与钾离子通道的Ｋｖβ２亚基结合，又与蛋白激酶ｃ（ｐｋｃζ）结合。由于它们的联结作用，使三者形成... 详细信息

蛋白修饰酶的定向修饰反应是蛋白合成后进行特异、有效修饰的一个关键步骤。ＺＩＰ１和ＰＩＰ２是两个互为剪切异构体的蛋白，它们既与钾离子通道的Ｋｖβ２亚基结合，又与蛋白激酶ｃ（ｐｋｃζ）结合。由于它们的联结作用，使三者形成一个复合物。而ＺＩＰ１和ＺＩＰ２可不同程度激活ｐｋｃζ对钾离子通道的磷酸化，且二者可以相互结合，形成异型多聚体，这就使它们对ｐｋｃζ的刺激复杂多变。另外，ＺＩＰ１和ＺＩＰ２共存于同一种细胞中，并且经神经生长因子刺激后，升高的程度各不相同。这些实验结果提示了ｐｋｃζ定向磷酸化的特异性和调控性的分子机理。

关键词：蛋白修饰酶蛋白激酶钾离子通道磷酸化 PKC

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对话字母

室内设计与装修 2020年第9期 138-140页

作者： [波兰]magda Jurek 麦子(编译) 不详

波兰设计师magda Jurek毕业于华沙美术学院绘画专业,之后创办了自己的产品品牌Pani Jurek。此次最新的TRN系列共有3个类别,包括5款边桌、4款镜子和1组陶瓷吊灯。TRN系列的主旨是向波兰著名画家、平面设计师、插画师Jan Tarasin(1926—20... 详细信息

波兰设计师magda Jurek毕业于华沙美术学院绘画专业,之后创办了自己的产品品牌Pani Jurek。此次最新的TRN系列共有3个类别,包括5款边桌、4款镜子和1组陶瓷吊灯。TRN系列的主旨是向波兰著名画家、平面设计师、插画师Jan Tarasin(1926—2009)致敬,对其绘画和图形创作的迷恋是设计师创作TRN系列的起源。Jan Tar⁃asin是一个对世界充满好奇的人,他热衷于用艺术的方式记录真实世界中的各种物体,并将其简化、抽象为各种符号。而magda Jurek则将整个过程完全颠倒,将抽象表意的符号、文字转而成为具体物件,在她设计的三维物件中均有简单的、文字笔画的元素。因此,该系列中的每件产品都像似字母表中的一个字母,仿佛可以形成相互对话的关系。

关键词：平面设计师绘画专业美术学院真实世界插画师字母表符号

A Case of Sinonasal Extranodal NK/T-Cell Lymphoma with Indolent Behaviour and Low-Grade Morphology

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Case Reports in Clinical Medicine 2014年第11期3卷 596-600页

作者： Valentina Tabanelli Riccardo Valli magda Zanelli Simona Righi Anna Gazzola Claudia Mannu Stefano Pileri Elena Sabattini Hematopathology and Haematology Sections Department of Experimental Diagnostic and Specialty Medicine S. Orsola-Malpighi Hospital University of Bologna Bologna Italy Anatomic Pathology Unit IRCSS Santa Maria Nuova Hospital Reggio Emilia Italy

Extranodal NK/T-cell lymphoma, nasal type (ENKL), is an uncommon subtype of EBV associated lymphoma usually characterized by aggressive clinical course. We report an atypical sinonasal ENKL case with long-lasting indolent behaviour, developed in the setting of a polymorphic EBV-associated lymphoproliferative disorder (LPD). A 52-year-old woman had suffered from chronic sinusitis and nasal obstruction since 2000, moderately worsened during the last years (marked enlargement of the sino-nasal mucosa at MRI in 2011) with elevated anti-VCA IgG and IgM titers. Three subsequent biopsies revealed slightly increasing morphophenotypic atypia, ranging from a polymorphic B- and T-cell EBV positive proliferation (diagnosed in 2011, but not fulfilling CAEBV diagnostic criteria) to an overt monomorphic mildly atypical T LPD without necrosis and angiocentricty diagnosed as ENKL in 2013 upon immunophenotype and TCR-γ gene clonal rearrangement. Clinically indolent ENKL with low-grade morphology is extremely rare and diagnostically challenging;while the few reports in the literature describe long-survival in ENKL treated patients comparing histologically neoplastic lesions at onset and recurrences, no reports are published on the slow progression from a polymorphic EBV-related T/NK proliferation to a histologically overt clinically indolent ENKL in an untreated patient who only received occasional steroid administration.

关键词： ENKL Indolent CAEBV EBV

Perceived Stress, Anxiety and Insomnia among Nursing Staff in Saudi Arabia during the 2019 Novel Coronavirus Disease Pandemic

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Open Journal of Nursing 2022年第1期12卷 1-11页

作者： magda M. Agameel Sahar A. Abd-El Mohsen Nagda A. Dyab Amal Yousef Abdelwahed Razan Adel Fakieh Department of Nursing College of Applied Medical Sciences Prince Sattam Bin Abdulaziz University Wadi Eldawaser Saudi Arabia Department of Gerontolgical Nursing Faculty of Nursing Damanhour University Damanhour Egypt Department of Medical Surgical Nursing Faculty of Nursing Asyut University Asyut Egypt Department of Nursing Alghad International College for Applied Medical Science Abha Saudi Arabia Department of Community Health Nursing Faculty of Nursing South Valley University Qena Egypt Department of Public Health College of Health Sciences Saudi Electronic University Dammam Saudi Arabia Department of Community Health Nursing Faculty of Nursing Damanhour University Damanhour Egypt

Background: Nursing staff exposed to 2019 novel coronavirus disease which might be at the increased risk of development mental health problems such as stress, anxiety and insomnia. Objectives: To estimate the spread of stress, anxiety and insomnia among the nursing staff who are working at Asir central hospital, Kingdom of Saudi Arabia. Methods: This study was a descriptive cross-sectional study, that involved with a 53 (44 Female and 9 Male) nurses who are working at Asir central hospital, Kingdom of Saudi Arabia. A convenient sampling technique was used to select the participants during the period from October to the mid of November 2020. A structured closed-ended questionnaire was used related with three standard tools (The Perceived Stress Scale, Generalized Anxiety Disorder and the Insomnia severity index). Results: The results revealed that 90.6% of participants had moderate stress and 7.5% showed low stress. Regarding anxiety, 37% of nurses had mild anxiety, 28.3% and 34% had moderate and severe anxiety, respectively. Moreover, sub-threshold insomnia was observed in 60.4% and clinical insomnia in 15% of study candidates. Additionally, a statistically significant association was found between levels of stress, anxiety and insomnia and the age of the studied nurses (P = 0.00). Conclusion: The results of this study showed that the spread of stress, anxiety and insomnia, was higher than some studies which have been reported in the previous researches. Significant difference was observed between mental distress and age of nurses, while there was no significant difference between the studied mental health problems and gender.

关键词： Anxiety COVID-19 Nursing Staff Insomnia Stress

Impact of Gender Difference on Characteristics and Outcome of Chronic Hepatitis C

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Open Journal of Gastroenterology 2020年第11期10卷 281-294页

作者： Mahmoud Saif-Al-Islam Hamdy Saad Mohamed Mustafa Adel Younis Mahmoud Yosef Abdelhamid magda Mohamed Ali Safaa Khalaf Departments of Tropical Medicine and Gastroenterology Sohag University Hospital Sohag Egypt Departments of Internal Medicine Sohag University Hospital Sohag Egypt Departments of Clinical Pathology Sohag University Hospital Sohag Egypt Departments of Radiology Sohag University Hospital Sohag Egypt Departments of Community Medicine Sohag University Hospital Sohag Egypt

Gender difference in chronic hepatitis C (CHC) infection is not previously well studied. We aimed to analyze the effect of gender difference on the risk factors of CHC, disease progression, and outcome after oral direct acting antiviral (DAA) therapy. The study was conducted at Tropical Medicine and Gastroenterology Department, Sohag University, Egypt, in the period between 2018 and 2020. 775 patients were evaluated for hepatitis C virus (HCV) risk factors. Laboratory investigations, abdominal ultrasound and liver Shear wave elastography (SWE) were done. The patients were given antiviral therapy and followed up to assess the response and side effects of DAA therapy. 434 (56%) of study patients were males and 341 (44%) were females. Catching infection from blood transfusion and intravenous (IV) injection of tarter emetic was significantly higher in males, while catching infection from surgical operation was significantly higher in females. Hepatic fibrosis was significantly more extensive in males. Side effects were reported more in females. Sustained virological response (SVR) 12 was reported in 98.6%. Females had a slightly better SVR12 than males (99.4% versus 97.9%). In conclusion males were different from females in exposure to HCV risk factors. After introduction of blood screening and

关键词： Chronic HCV Risk Factors Gender Difference DAA Therapy

监测国际人用药品注册技术协调会(ICH)指南的执行和落实情况——2021年项目报告

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中国食品药品监管 2022年第6期 92-107页

作者： Juan Lara magda Bujar 曾亚莉国际监管科学创新研究中心(CIRS) 科睿唯安信息服务(北京)有限公司

本研究通过国际监管科学创新中心(CIRS)与国际人用药品注册技术协调会(ICH)合作开发并定义的在线调研问卷,监测并评估ICH非常任、非创始的监管机构成员对ICH二、三级指南,以及ICH观察员对ICH一级指南的执行和落实情况,重点介绍ICH指南... 详细信息

本研究通过国际监管科学创新中心(CIRS)与国际人用药品注册技术协调会(ICH)合作开发并定义的在线调研问卷,监测并评估ICH非常任、非创始的监管机构成员对ICH二、三级指南,以及ICH观察员对ICH一级指南的执行和落实情况,重点介绍ICH指南执行和落实情况评估结果、主要监管机构成员和ICH观察员的自我评估,以及跨国制药公司对各监管机构执行情况的反馈。研究结果表明,各参与研究的监管机构对ICH指南的执行和落实程度非常高,制药企业看法与监管机构自我评估结果一致。

关键词： ICH 监管指南执行

Protective role of Juniperus phoenicea and Cupressus sempervirens against CCl_4

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第6期1卷 123-131页

作者： Sanaa Ahmed Ali Maha Zaki Rizk Nabawia Ali Ibrahim Mohga Shafik Abdallah Hayat Mohamed Sharara magda Mohamed Moustafa Department of Theraputical Chemistry National Research Centre Department of Pharmacognosy National Research Centre Department of Chemistry Faculty of Science Helwan University

AIM: To investigate the role of Cupressus sempervirens (C. sempervirens) and Juniperus phoenicea (J. phoe-nicea) extracts as therapeutic effect against CCl4 with biochemical, histopathological evaluations. METHODS: A single intraperitoneal dose of 10% CCl4 in olive oil (1 mL/kg body weight) was administered to a group of female Wister rats, sacrificed after 24 h (as the injury group). The other groups were given CCl4 as de-scribed above and divided as follows: two groups of ten rats each were orally administered either J. phoenicea extract or C. sempervirens extract three times per week for six weeks and a further group administered CCl4 was left for six weeks to allow self-recovery. At the end of experiment, the rats from all groups were sacrificed for sampling and for biochemical and histological analysis. RESULTS: Remarkable disturbances were observed in the levels of all tested parameters. On the other hand,rats injected with the toxic agent and left for one and a half month to self recover showed moderate improve-ments in the studied parameters while, treatment with both medicinal herbal extracts ameliorated the levels of the disturbed biochemical parameters. The group treated with J. phoenicea extract showed a remarkable improvement in comparison to the CCl4 treated group. The C. sempervirens group revealing an even more re-markable effect showing histopathological liver& kidney profiles close to those of the control ***: C. sempervirens and J. phoenicea leaf extracts show a remarkable effect in enhancing liver and kidney functions and may thus be of therapeutic potential in treatment hepatotoxicity and nephrotoxicity.

关键词： Cupressus sempervirens Juniperus phoeni-cea Carbon tetrachloride Hepatotoxicity Nephrotoxicity

Occult hepatitis B virus infection among Egyptian blood donors

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World Journal of Hepatology 2013年第2期5卷 64-73页

作者： Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat Microbiology and Immunology Department Faculty of Medicine(for Girls)AlAzhar University11511 CairoEgypt Pediatric Department Hematology/Oncology DivisionFaculty of MedicineAin Shams University11511 CairoEgypt Community Medicine Department National Research Center12411 GizaEgypt Ain-Shams Maternity and Women's University Hospital 11511 CairoEgypt Community Enviromental and Occupational Medicine DepartmentFaculty of MedicineAin Shams University11511 CairoEgypt National Blood Transfusion Center 11511 CairoEgypt TB Surveillance officer STB/WHO/EMRO.Focal pointTropical Disease Research11511 CairoEgypt Tropical Medicine Department Faculty of Medicine-Cairo University11511 CairoEgypt

AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood ***:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus *** were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered *** HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/***,265 recipients were included,34 of whom were followed up for 3-6 *** were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and ***:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs *** by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed *** for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total *** DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of *** and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity a

关键词： Hepatitis B virus Total anti-HBc Occult hepatitis B virus infection Hepatitis B surface antigen Hepatitis B virus-DNA