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American Journal of Analytical Chemistry 2023年第9期14卷 378-389页

作者： Waleed Alhussaini Ezzeldeen Ghanem magd alsahly Amani Kurdi Eman Alharbi Imadul Islam Majed Aljeraisy Department of Pharmaceutical Analysis King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Ministry of the National Guard—Health Affairs Riyadh Saudi Arabia Research Office King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Ministry of the National Guard—Health Affairs Riyadh Saudi Arabia

A sensitive, accurate and robust Liquid Chromatography Tandem Mass Spectrometry method has been developed and validated to measure voriconazole trough levels in human plasma. The plasma samples were mixed with fluconazole as an Internal Standard and directed to protein precipitation and drug extraction. An aliquot of 1 μl was injected into the chromatographic system and separated by the Acquity BEH C18 column at a flow rate of 0.30 ml/min in a gradient mobile phase consisting of acetonitrile, Ultrapure water (UPW), methanol and formic acid. Voriconazole was detected by a Triple Quadrupole Detector (TQD) operating on Multiple Reaction Monitoring (MRM) and a positive ion mode Electrospray ionization (ESI) Q1 mass: 350.1 m/z, Q3 mass: 281.1 m/z. Method linearity of the calibration curve (0.10 - 8.00 μg/ml) indicated a correlation coefficient r ≥ 0.99. The intra and inter-assay accuracy was within 85% - 115% and the intra and inter-assay precision was ≤5.76%. Voriconazole recovery percentage was between 97.69 - 119.62%. The method was successively applied in routine voriconazole TDM.

关键词： Voriconazole Human Plasma Liquid Chromatography Tandem Mass Spectrometry Therapeutic Drug Monitoring

Effect of fatigue load on the bending tribo-corrosion-fatigue behaviors between the main cable wires

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Friction 2024年第7期12卷 1512-1531页

作者： Bo WANG Dagang WANG Jihong YE Liang TANG Hailang CHONG Wei XU Xinxin ZHANG Jianhao CHEN Haiyan DENG Jie ZHANG Guowen YAO magd Abdel WAHAB School of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China Xuzhou Key Laboratory for Fire Safety of Engineering Structures China University of Mining and TechnologyXuzhou 221116China National Wire Rope Quality Inspection Center Nantong Product Quality Supervision and Inspection InstituteNantong 226011China Jiangsu Langshan Wire Rope Co. Ltd.Nantong 226003China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China School of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityZwijnaarde B-9052Belgium

The main cable bent around the saddle of the suspension bridge is subjected to the wind,the vehicle,the bridge’s own weight and the corrosive *** coupling of the three loads and the environments causes the friction,the corrosion,and the fatigue(tribo-corrosion-fatigue)among the wires inside the main *** this paper,a wire bending tribo-corrosion-fatigue test rig was designed and *** effect of fatigue load on the bending friction behaviors between the cable wires in ultrapure water and 3.5%NaCl solution was *** tribological properties and electrochemical corrosion behaviors under different fatigue loading ranges were *** tribo-corrosion-fatigue interaction between the cable wires was quantitatively characterized,and the mechanism of the interaction was *** results demonstrate that the increasing fatigue load exacerbates the coupling damage of the cable wires attributed to the enhanced *** findings carry theoretical importance when assessing the main cable’s deterioration and the load-bearing safety of a suspension bridge.

关键词： bending tribo-corrosion-fatigue interaction parallel steel wires fatigue load

Determination of Voriconazole in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry: Application in Therapeutic Drug Monitoring

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Multi-Scale Analysis of Fretting Fatigue in Heterogeneous Materials Using Computational Homogenization

American Journal of Analytical Chemistry（美国分析化学） 2023年第9期

作者： Waleed Alhussaini Ezzeldeen Ghanem magd alsahly Amani Kurdi Eman Alharbi Imadul Islam Majed Aljeraisy

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Computers, Materials & Continua 2020年第1期62卷 79-97页

作者： Dimitra Papagianni magd Abdel Wahab Department of Materials Science and Engineering University of IoanninaIoanninaGreece Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903Zwijnaarde B-9052Belgium Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

This paper deals with modeling of the phenomenon of fretting fatigue in heterogeneous materials using the multi-scale computational homogenization technique and finite element analysis(FEA).The heterogeneous material for the specimens consists of a single hole model(25% void/cell,16% void/cell and 10% void/cell)and a four-hole model(25%void/cell).Using a representative volume element(RVE),we try to produce the equivalent homogenized properties and work on a homogeneous specimen for the study of fretting ***,the fretting fatigue contact problem is performed for 3 new cases of models that consist of a homogeneous and a heterogeneous part(single hole cell)in the contact *** aim is to analyze the normal and shear stresses of these models and compare them with the results of the corresponding heterogeneous models based on the Direct Numerical Simulation(DNS)***,by comparing the computational time and%deviations,we draw conclusions about the reliability and effectiveness of the proposed method.

关键词： Fretting fatigue multi-scale analysis computational homogenization heterogeneous materials stress analysis finite element analysis

A Review on Fretting Wear Mechanisms,Models and Numerical Analyses

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Computers, Materials & Continua 2019年第5期59卷 405-432页

作者： Tongyan Yue magd Abdel Wahab State Grid Xinyuan Maintenance Branch BeijingChina Department of Electrical Energy MetalsMechanical Constructions&SystemsSoete LaboratoryFaculty of Engineering and ArchitectureGhent UniversityGhentBelgium Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

Fretting wear is a material damage in contact surfaces due to micro relative displacement between *** causes some general problems in industrial applications,such as loosening of fasteners or sticking in components supposed to move relative to each *** wear is a complicated problem involving material properties of tribosystem and working conditions of *** to these various factors,researchers have studied the process of fretting wear by experiments and numerical modelling *** paper reviews recent literature on the numerical modelling method of fretting *** a briefly introduction on the mechanism of fretting wear,numerical models,which are critical issues for fretting wear modelling,are *** paper is concluded by highlighting possible research topics for future work.

关键词： Fretting wear wear models wear mechanisms numerical modelling

Effect of wear debris on fretting fatigue crack initiation

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Friction 2022年第6期10卷 927-943页

作者： Shengjie WANG Tongyan YUE Dagang WANG magd ABDEL WAHAB Soete Laboratory Department of Electrical EnergyMetalsMechanical Construction&SystemsFaculty of Engineering and ArchitectureGhent UniversityGhent 9052Belgium State Grid Xinyuan Maintenance Branch Beijing 100000China School of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China Faculty of Engineering Van Lang UniversityHo Chi Minh City 700000Vietnam Soete Laboratory Ghent UniversityGhent 9052Belgium

Both wear and fatigue occur in fretting condition,and they interact with one another during the whole *** fatigue is commonly analysed without considering the effect of wear in partial slip regime,although wear affects the lifetime of crack *** paper investigates,for the first time,the effect of wear debris on fretting fatigue crack *** investigate the effect of debris,first fretting wear characteristics in partial slip regime are analysed for loading ***,the effect of wear on fretting fatigue crack initiation is investigated using Ruiz parameters and critical plane methods without considering the debris *** the results,we can see that loading conditions affect the wear profiles in different ***,wear has a significant effect on the fatigue in partial slip regime without considering debris especially on the crack initiation ***,considering wear debris in the analysis,its effect on critical plane parameters is *** is found that by considering the wear debris effect,the frtting fatigue crack initiation location is shifted towards the trailing *** predictions of both crack initiation location and lifetime show a good agreement with the experimental data.

关键词： fretting wear fretting fatigue critical plane Ruiz parameter debris

Review on the Prediction of Residual Stress in Welded Steel Components

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Computers, Materials & Continua 2020年第2期62卷 495-523页

作者： Junyan Ni Xincun Zhuang magd Abdel Wahab Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityGhentBelgium Institute of Forming Technology and Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina National Engineering Research Center of Die&Mold CAD Shanghai Jiao Tong UniversityShanghaiChina Division of Computational Mechanics Ton Duc Thang UniversityHo Chi MinhVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi MinhVietnam

Residual stress after welding has negative effects on the service life of welded steel components or *** work reviews three most commonly used methods for predicting residual stress,namely,empirical,semi-empirical and process simulation *** principles adopted by these methods are *** features and limitations of each method are discussed as *** empirical method is the most practical but its accuracy relies heavily on *** theories are employed in the semi-empirical method,while other aspects,such as temperature variation and phase transformation,are simply *** process simulation method has been widely used due to its capability of handling with large and complex *** improve its accuracy and efficiency,several improvements need to be done for each simulation aspect of this method.

关键词： Computational simulation steel welding residual stress

Improvement of Flat Surfaces Quality of Aluminum Alloy 6061-O By A Proposed Trajectory of Ball Burnishing Tool

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Computers, Materials & Continua 2019年第8期61卷 555-568页

作者： Ruba Alghazoul Almohanad Makki magd Abdel Wahab Faculty of Mechanical and Electrical Engineering Al Baath UniversityHomsSyria Institute of Research and Development Duy Tan University03 Quang TrungDa NangVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityGentBelgium

Burnishing is a profitable process of surface finishing due to its ability to be automated,which makes burnishing method more desirable than other finishing *** obtain high surface finish,non-stop operation is required for CNC machine and we can attain that by choosing a suitable trajectory of the finishing *** other words,burnishing paths should be multidirectional rather than monotonic,in order to cover uniformly the ***,the burnishing force is also a key parameter of the burnishing process because it determines the degree of plastic deformation,and that makes determining the optimum burnishing force an essential step of the burnishing process a ***,we consider the strategy of ball burnishing path and the burnishing force as variable parameters in this *** this paper,we propose a new strategy of burnishing tool path with trochoid cycles that achieves a multidirectional burnishing of the surface according to various *** into consideration the optimum burnishing force,to improve flat surface finish of AL6061-O samples by reducing the surface roughness parameter(Rz).Experiments carried out on 3-axis milling machine show that the proposed trochoidal path is more effective than the conventional one.

关键词： Ball burnishing surface quality trajectories roughness

Fatigue crack propagation across grain boundary of Al-Cu-Mg bicrystal based on crystal plasticity XFEM and cohesive zone model

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Journal of Materials Science & Technology 2022年第31期126卷 275-287页

作者： Qi Zhao magd Abdel Wahab Yong Ling Zhiyi Liu School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China Faculty of Mechanical-Electrical and Computer Engineering School of Engineering and TechnologyVan Lang UniversityHo Chi Minh CityVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903B-9052 ZwijnaardeBelgium School of Materials Science and Engineering Central South UniversityChangsha 410083China

In this paper,a methodology integrating crystal plasticity(CP),the eXtended finite element method(XFEM)and the cohesive zone model(CZM)is developed for an Al-Cu-Mg alloy to predict fatigue crack propagation(FCP)across grain boundary(GB)of Al-Cu-Mg alloy during stageІІ.One GB model is incor-porated into FCP constitutive law to describe grain interaction at GB.A bicrystal containing GB is built up to simulate FCP behavior through L participated *** features including GB characteristic,cumulative plastic strain(CPS)distribution and crystal slipping evidence can be *** numer-ical results are compared with published experimental data to check the accuracy of *** work demonstrates that the combination of CP containing GB constitutive laws,XFEM and CZM is a promising methodology in predicting twist angle-controlled crack deflection through GBs.

关键词： Grain boundary Twist angle Crystal plasticity Extended finite element method Fatigue crack propagation Cumulative plastic strain

The Effect of Surface Pit Treatment on Fretting Fatigue Crack Initiation

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Computers, Materials & Continua 2021年第1期66卷 659-673页

作者： Qingming Deng Xiaochun Yin magd Abdel Wahab Department of Mechanics and Engineering Science Nanjing University of Science and TechnologyNanjing210094China Soete Laboratory Department of Electrical EnergyMetalsMechanical Constructions and SystemsFaculty of Engineering and ArchitectureGhent UniversityZwijnaarde9052Belgium Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

This paper analyses the effect of surface treatment on fretting fatigue specimen by numerical simulations using Finite Element *** processed specimen refers to artificially adding a cylindrical pit to its contact ***,the contact radius between the pad and the specimen is controlled by adjusting the radius of the *** stress distribution and slip amplitude of the contact surface under different contact geometries are *** critical plane approach is used to predict the crack initiation life and to evaluate the effect of processed specimen on its fretting fatigue *** crack initiation life and angle can be predicted by the critical plane *** parameter is used to consider the effect of contact *** is shown that the crack initial position is dependent on the tensile *** same type of model,three kinds of critical plane parameters and Ruiz method provide very similar position of crack ***,the improved sample is much safer than the flat-specimen.

关键词： Finite element analysis surface pit stress distribution fretting fatigue critical plane approach