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Effects of B[a]P-UVA Co-Exposure on Epigenetic Marks of Isolated Skin Cells and Impact of an Arundo donax L. Extract of These Changes

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 253-269页

作者： Marie M. Dorr magali favre-mercuret Katell Vié Richard Fitoussi Laboratoires Clarins Pontoise France

Background: Extrinsic aging results from environmental stressors such as UVR or pollutants. While the effects of single pollutants are better understood, those of their combination remain poorly scrutinized. Objective: Building on a study showing downregulation of several processes upon co-exposure to B[a]P and UVA, we investigated changes induced by epigenetic marks. Materials and Methods: Human primary fibroblasts and HaCaT cells were exposed to B[a]P and UVA. After 24 hours, exposed and unexposed cells were compared to assess DNA methylation. Focusing on HaCaT, multiplex assays enabled quantifying histone H3 modifications and evaluating four splicing factors (SRSF1, SRSF3, SFPQ, and SF3B1) by immunohistochemical labeling. The expression of keratinocyte-/fibroblast-relevant genes was assessed by RT-qPCR. Finally, the impact of an Arundo donax L. extract added 24 hours before B[a]P-UVA co-exposure was analyzed. Results: Exposure to B[a]P-UVA raised DNA methylation (HaCaT: ×3.6, fibroblasts: ×1.9), an increase prevented by the extract. In HaCaT cells, B[a]P-UVA increases the frequency of S10P (+38%). When exposure was preceded by extract treatment, the frequency of several methylations was impacted. B[a]P-UVA only induced the expression of SRSF1 and SFPQ in HaCaT (+46% and +34%). Treatment with the extract abolished this effect. Co-exposure increases the expression of inflammation-related genes (IL-1α, IL-1β) in HaCaT cells and decreases those of AQP3, KRT15, and SOD2. The extract has little effect on these changes. In primary fibroblasts, exposure to B[a]P-UVA lowered the expression of LOXL2, LUM, and TGFBR2 (−38%, −59%, and −51%, respectively), and the extract did not affect these modifications. Conclusion: Within 24 hours, a single B[a]P-UVA co-exposure changes epigenetic marks of skin cells but has only mild effects on gene expression. An Arundo donax L. extract can prevent part of the epigenetic marks’ changes and could stimulate the expression of some genes in

关键词： Extrinsic Aging DNA Methylation Histone H3 Splicing Factors Arundo donax L.

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Effect of Red <i>Panax ginseng</i>on Mitochondrial Dynamics and Bioenergetics in HaCaT Cells Exposed to Urban Pollutants

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第2期11卷 84-95页

作者： Gallic Beauchef magali favre-mercuret Beatrice Blanc Richard Fitoussi Katell Vié Nathalie Compagnone Clarins Research laboratory Pontoise France ICDD-sas Gemenos France Bliive Consulting Auriol France

Background: Urban air pollution contributes to lung and cardiovascular system dysfunction, making it a major concern for human health. Its impact on skin integrity, associated with increased occurrence of atopic dermatitis, is now recognized, but its cellular mechanisms remain poorly understood. Objective: In the present study we aimed at establishing the impact of urban pollutant on mitochondrial dynamics and bioenergetics using the HaCaT cell model. We also sought to establish the protective effect of ECH-5195 (red Panax ginseng extract), standardized in ginsenosides, in reversing pollution-induced mitochondrial defects. Methods: Urban pollution exposure was mimicked by 1 h exposure of HaCaT cells with standardized atmospheric particulate matter containing PAHs, nitro-PAHs, PCB congeners, and chlorinated pesticides with a mean particulate diameter of 5.85 μm (SRM1648). Results: The presence of urban pollutant in the cultures increased the prevalence of hyperfission by 1.41-fold (p = 0.023) and fission by 1.35 fold (p = 0.006) in the reticular mitochondrial network. ECH-5195 reduced both pollution-induced hyperfission by 0.54-fold (p = 0.004) and fission by 0.68-fold (p = 0.0006) normalizing the mitochondrial reticular network. Pollution exposure was associated with a significant reduction of basal OCR and increased lactate production, pushing the cell to rely on glycolysis for ATP production. When ECH-5195 was used, OCR was significantly increased, and the glycolytic contribution to ATP production was reduced while both oxidative phosphorylation and mitochondrial respiration were increased demonstrating mitochondrial re-engagement in ATP production. Conclusions: Pollution exposure was disruptive for both the mitochondrial network dynamics and mitochondrial respiration. Ginsenosides in ECH-5195 efficiently protected both from pollution-induced defects.

关键词： Ginsenosides Arylhydrocarbon Receptor Particulate Matter HaCaT Cells Mitochondria Dynamics Cell Bioenergetics

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天然护发产品蕴含新一代活性成分

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中国化妆品 2014年第7期 38-39页

作者： Petra Schlege magali-mercuret favre 艾琳绿科公司德国施塔恩贝格绿科公司法国圣比兹不详

今年欧睿信息咨询公司已经确认趋势,认为消费者寻求的产品让他们看起来尽可能好,但同时消费者也想省钱推迟拜访美发师.为此,护发产品为人们提供更好的护理和发型表现,甚至比以前有着更大需求.这一趋势的结果意味着专业护理和大众护理的... 详细信息

今年欧睿信息咨询公司已经确认趋势,认为消费者寻求的产品让他们看起来尽可能好,但同时消费者也想省钱推迟拜访美发师.为此,护发产品为人们提供更好的护理和发型表现,甚至比以前有着更大需求.这一趋势的结果意味着专业护理和大众护理的边界变得更加模糊.

关键词：护发产品活性成分天然专业护理咨询公司消费者

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极干旱胁迫对雀麦、多年生黑麦草生长和体内水分的影响

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草地学报 2024年

作者：张咏梅胡海英白小明 Matthew Cory García-favre Javier Ordó?ez Iván P 甘肃农业大学干旱生境作物学国家重点实验室宁夏大学林业与草业学院甘肃农业大学草业学院农业与环境学院梅西大学坎佩奈克农艺研究所

为研究极端干旱对牧草生长的影响，选择多年生黑麦草（Lolium Perenne）(Lp)和雀麦（Bromus Valdivianus）(Bv)给予80%?85%植物有效水（Plant available water， PAW）和20%?25% PAW 2种水分处理，分析2牧草生长及体内水分状况对干旱胁... 详细信息

为研究极端干旱对牧草生长的影响，选择多年生黑麦草（Lolium Perenne）(Lp)和雀麦（Bromus Valdivianus）(Bv)给予80%?85%植物有效水（Plant available water， PAW）和20%?25% PAW 2种水分处理，分析2牧草生长及体内水分状况对干旱胁迫的响应。研究表明：1)80%?85% PAW充足水分下，2牧草生物量积累、水势（Water potential， WP）、相对含水量（Relative water content， RWC）和净光合速率（Net photosynthetic rate， Pn）无明显种间差异。Bv叶片宽而重、蒸腾速率（Transpiration rate， Tr）、CO2总导度(Total conductance to CO2， CndCO2)和气孔导度(Conductance to H2O， Gs)显著高于Lp。而Lp分蘗多、叶多汁；瞬时水分利用效率是Bv的1.63倍。2)20%?25% PAW对2牧草生长影响不完全一致，叶饱和重、干重和叶面积有相反变化趋势，但与充足水分相比差异不显著；Pn，Tr，CndCO2，Gs和RWC则极显著降低，WP极显著降低了1.60 MPa，致使枯叶占比和叶温差的显著升高。总之，雀麦和多年生黑麦草生长相近，水分利用模式不同；遭受极端干旱，不同种的2牧草耐旱机制具有一定的共性，通过增强叶片持水力、降低水分循环、减少蒸腾失水以提高牧草抗旱性。

关键词：干旱胁迫光合作用蒸腾作用生物量积累瞬时水分利用效率水势

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Secretory IgA in complex with Lactobacillus rhamnosus potentiates mucosal dendritic cell-mediated Treg cell differentiation via TLR regulatory proteins, RALDH2 and secretion of IL-IO and TGF-β

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Cellular & Molecular Immunology 2017年第6期14卷 546-556页

作者： Josip Mikulic Stephanie Longet Laurent favre Jalil Benyacoub Blaise Corthesy R&D Laboratory Division of Immunology and Allergy CHUV Centre des Laboratoires d'Epalinges 1066 Epalinges Switzerl Nutrition and Health Nestle Research Center 1000 Lausanne 26 Switzerland

The importance of secretory IgA in controlling the microbiota is well known, yet how the antibody affects the perception of the commensals by the local immune system is still poorly defined. We have previously shown that the transport of secretory IgA in complex with bacteria across intestinal micmfold cells results in an association with dendritic cells in Peyer＇s patches. However, the consequences of such an interaction on dendritic cell conditioning have not been elucidated. In this study, we analyzed the impact of the commensal Lactobacillus rhamnosus, alone or associated with secretory IgA, on the responsiveness of dendritic cells freshly recovered from mouse Peyer＇s patches, mesenteric lymph nodes, and spleen. Lactobacillus rhamnosus-conditioned mucosal dendritic cells are characterized by increased expression of Toll-like receptor regulatory proteins lincluding single immunoglobulin interleukin-1 receptor-related molecule, suppressor of cytokine signaling 1, and Toll-interacting moleculel and retinaldehyde dehydrogenase 2, low surface expression of co-stimulatory markers, high anti- versus pro-inflammatory cytokine production ratios, and induction of T regulatory cells with suppressive function. Association with secretory IgA enhanced the anti-inflammatory/regulatory Lactobacillus rhamnosus-induced conditioning of mucosal dendritic cells, particularly in Peyer＇s patches. At the systemic level, activation of splenic dendritic cells exposed to Lactobacillus rhamnosus was partially dampened upon association with secretory IgA. These data suggest that secretory IgA, through coating of commensal bacteria, contributes to the conditioning of mucosal dendritic cells toward tolerogenic profiles essential for the maintenance of intestinal homeostasis.

关键词： commensal bacteria dendritic cells secretory IgA TLR regulatory proteins T regulatory cells

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Spatio-temporal evolution of Allium L. in the Qinghaie-Tibet-Plateau region: Immigration and in situ radiation

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Plant Diversity 2017年第4期39卷 167-179页

作者： Frank Hauenschild Adrien favre Jan Schnitzler Ingo Michalak Martin Freiberg Alexandra N. Muellner-Riehl Leipzig University Department of Molecular Evolution and Plant Systematics & Herbarium (LZ) Johannisallee 21-23 04103 Leipzig Germany Leipzig University Department of Systematic Botany and Functional Biodiversity Research Johannisallee 21-23 04103 Leipzig Germany German Centre for Integrative Biodiversity Research (iDly) Halle-lena-Leipzig Deutscher Platz 5e 04103 Leipzig Germany

A plethora of studies investigating the origin and evolution of diverse mountain taxa has assumed a causal link between geological processes （orogenesis） and a biological response （diversification）. Yet, a substantial delay （up to 30 Myr） between the start of orogenesis and diversification is often observed. Evolutionary biologists should therefore identify alternative drivers of diversification and maintenance of biodiversity in mountain systems. Using phylogenetic, biogeographic, and diversification rate analyses, we could identify two independent processes that most likely explain the diversity of the widespread genus Allium in the Qinghai-Tibet Plateau （QTP） region：（1） While the QTP-related taxa of the subgenus Melanocrommyum diversified in situ, （2） QTP-related taxa of other subgenera migrated into the QTP from multiple source areas. Furthermore, shifts in diversification rates within Allium could not be attributed spatially and temporally to the uplift history of the QTP region. Instead, global cooling and climate oscillations in the Quaternary were major contributors to increased speciation rates in three clades of AUium. Our study therefore adds to the growing evidence supporting the ＂mountain-geo-biodiversity hypothesis＂, which highlights the role of climate oscillations for the diversification of mountain organisms.

关键词： Allium Evolution Hengduan mountains Historical biogeography Molecular dating Qinghai-Tibet plateau

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ART ET DELIRE DANS ILLUMINATIONS

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法国研究 1989年第2期 32-39页

作者： yves-Alain favre

Eblouissante et irritante énigme, Illuminations apparait d’emblée comme une oeuvre paradoxale. On y apercoit d’abord une explosion d’images incontrolées qui naissent au cours de la reverie et qui surgissent, s’enchainent et s’effacent selon des processus qui échappent à toute logique. Mais on y décèle aussi toute une organisatiou et toute une concertation qui président à ces tableaux visionnaires. Le poète manifeste une volonté d’art, en intervenant dans la mise en scène du speeta-

关键词：切落主任

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Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis

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World Journal of Gastroenterology 2011年第4期17卷 459-469页

作者： David Philippe Laurent favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum Department of Nutrition and Health Nestlé Research Centre Department of Pathology University of Bern

AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.

关键词： Probiotics Bifidobacterium Colitis Adoptive transfer model Regulatory T cells Inflammation Mice

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Reverse Engineering Activity Diagrams from Object Oriented Code： An MDA-Based Approach

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Computer Technology and Application 2011年第12期2卷 969-978页

作者： Liliana Martinez Claudia Pereira Liliana favre Universidad Nacional del Centro de la Provincia de Buenos Aires Paraje Arroyo Seco （B7000） Tandil Argentina Comisien de Investigaciones Cientificas de la Provincia de Buenos Aires Argentina

The success of system modernization depends on the existence of technical frameworks for information integration and tool interoperation like the Model Driven Architecture （MDA）. Reverse engineering techniques play a crucial role in system modernization. This paper describes how to reverse engineering activity diagrams from object oriented code in the MDA context focusing on transformations at model and metamodel levels. A framework to reverse engineering MDA models from object oriented code that distinguishes three different abstraction levels linked to models, metamodels and formal specifications, is described. At model level, transformations are based on static and dynamic analysis. At metamodel level, transformations are specified as 0CL （Object Constraint Language） contracts between M0F （Meta Object Facility） metamodels which control the consistency of these transformations. The level of formal specification includes algebraic specifications of MOF metamodels and metamodel-based transformations. This paper analyzes a recovery process of activity diagrams from Java code by applying static and dynamic analysis and shows a formalization of this process in terms of MOF metamodels. The authors validate their approach by using Eclipse Modeling Framework, Ecore metamodels and ATL （Atlas Transformation Language）.

关键词： Metamodeling meta model facility reverse engineering model driven architecture transformation.

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Feasibility study of cosmic-ray componentsmeasurement by using a scintillating fiber tracker in space

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Radiation Detection Technology and Methods 2021年第3期5卷 389-403页

作者： Jun-jing Wang Xin Wu Ming Xu Chiara Perrina Philipp Azzarello Franck Cadoux Yannick favre Daniel La Marra Bo-bing Wu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Nuclear and Particle Physics University of Geneva1211 Geneva 4Switzerland University of Chinese Academy of Sciences Beijing 100049China Institute of Physics École Polytechnique Fédérale de Lausanne(EPFL)1015LausanneSwitzerland

Purpose The application of traditional silicon strip detectors in space experiments often suffers from heat and power consumption limitations when a large area has to be ***,a scintillating fiber detector with SiPM readout was proposed and adopted by ground high-energy *** excellent performance in track measurement and mechanical flexibility makes it a prospective candidate for large-area tracking detectors in the next-generation space *** paper mainly focuses on its performance in cosmic-ray charge *** A fast Geant4 simulation for a single tracker module was developed and compared with the beam test *** non-uniformity of the detector response was ***,a full tracker simulation using a variety of typical cosmic ray nuclei was *** performance of a fiber tracker with multiple layers was *** and conclusion The comparison between the simulation results and the beam test data of protons and helium nuclei shows a good *** non-uniformity study reveals the strong dependence of the detector signal on the position and inclination angle of the incident ***,a corresponding correction algorithm was developed and applied in the following data *** preliminary result shows that the charge measurement capability of the fiber tracker composed of 9 XY superlayers is comparable to that of the AMS-02 inner tracker,which consists of 7 layers of double-sided silicon micro-strip *** paper discusses the feasibility of using fiber trackers to measure cosmic ray charges and provide a guide for the optimization of detector design.

关键词： Fiber tracker SiPM Charge measurement Cosmic-ray Simulation

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