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Effect of Red <i>Panax ginseng</i>on Mitochondrial Dynamics and Bioenergetics in HaCaT Cells Exposed to Urban Pollutants

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第2期11卷 84-95页

作者： Gallic Beauchef magali favre-mercuret Beatrice Blanc Richard Fitoussi Katell Vié Nathalie Compagnone Clarins Research laboratory Pontoise France ICDD-sas Gemenos France Bliive Consulting Auriol France

Background: Urban air pollution contributes to lung and cardiovascular system dysfunction, making it a major concern for human health. Its impact on skin integrity, associated with increased occurrence of atopic dermatitis, is now recognized, but its cellular mechanisms remain poorly understood. Objective: In the present study we aimed at establishing the impact of urban pollutant on mitochondrial dynamics and bioenergetics using the HaCaT cell model. We also sought to establish the protective effect of ECH-5195 (red Panax ginseng extract), standardized in ginsenosides, in reversing pollution-induced mitochondrial defects. Methods: Urban pollution exposure was mimicked by 1 h exposure of HaCaT cells with standardized atmospheric particulate matter containing PAHs, nitro-PAHs, PCB congeners, and chlorinated pesticides with a mean particulate diameter of 5.85 μm (SRM1648). Results: The presence of urban pollutant in the cultures increased the prevalence of hyperfission by 1.41-fold (p = 0.023) and fission by 1.35 fold (p = 0.006) in the reticular mitochondrial network. ECH-5195 reduced both pollution-induced hyperfission by 0.54-fold (p = 0.004) and fission by 0.68-fold (p = 0.0006) normalizing the mitochondrial reticular network. Pollution exposure was associated with a significant reduction of basal OCR and increased lactate production, pushing the cell to rely on glycolysis for ATP production. When ECH-5195 was used, OCR was significantly increased, and the glycolytic contribution to ATP production was reduced while both oxidative phosphorylation and mitochondrial respiration were increased demonstrating mitochondrial re-engagement in ATP production. Conclusions: Pollution exposure was disruptive for both the mitochondrial network dynamics and mitochondrial respiration. Ginsenosides in ECH-5195 efficiently protected both from pollution-induced defects.

关键词： Ginsenosides Arylhydrocarbon Receptor Particulate Matter HaCaT Cells Mitochondria Dynamics Cell Bioenergetics

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天然护发产品蕴含新一代活性成分

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中国化妆品 2014年第7期 38-39页

作者： Petra Schlege magali-mercuret favre 艾琳绿科公司德国施塔恩贝格绿科公司法国圣比兹不详

今年欧睿信息咨询公司已经确认趋势,认为消费者寻求的产品让他们看起来尽可能好,但同时消费者也想省钱推迟拜访美发师.为此,护发产品为人们提供更好的护理和发型表现,甚至比以前有着更大需求.这一趋势的结果意味着专业护理和大众护理的... 详细信息

今年欧睿信息咨询公司已经确认趋势,认为消费者寻求的产品让他们看起来尽可能好,但同时消费者也想省钱推迟拜访美发师.为此,护发产品为人们提供更好的护理和发型表现,甚至比以前有着更大需求.这一趋势的结果意味着专业护理和大众护理的边界变得更加模糊.

关键词：护发产品活性成分天然专业护理咨询公司消费者

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Umbilical Cord Prolapse Managed by Assisted Vacuum Delivery

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Case Reports in Clinical Medicine 2024年第7期13卷 234-240页

作者： Katherine magali Michael Haule Musa Faraay Eltruda Tesha Obstetrics and Gynecology Department Manyara Regional Referral Hospital Babati Tanzania Theatre and Anaesthesia Unit Manyara Regional Referral Hospital Babati Tanzania

G4P3L3 was at 40 weeks of gestation who was admitted in active stage of labor with normal fetal heart rate. At 8 cm cervical dilatation she experienced spontaneous rupture of membrane with clear liquor. Cord prolapse was detected and was prepared for caesarian section meanwhile she was kept in knee chest position and bladder was filled with normal saline 0.9%. 30 min before operation she was fully dilated with signs of Non reassuring fetal status, vacuum extraction was done to assist delivery as soon as possible. The APGAR score was 6 and 10 in the first and fifth minutes respectively. Mother and the baby were discharged the next day in good condition.

关键词： Umbilical Cord Prolapse Operative Vaginal Delivery Vacuum Extraction

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Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells

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Genes & Diseases 2023年第6期10卷 2210-2214页

作者： Mathieu Adjemout Bruno Pouvelle Fatou Thiam Alassane Thiam magali Torres Samia Nisar Babacar Mbengue Alioune Dieye Pascal Rihet Sandrine Marquet Institut National de la SantéEt de la Recherche Médicale(INSERM) UnitéMixte de Recherche(UMR)U1090Aix Marseille UniversitéTAGC Theories and Approaches of Genomic ComplexityInstitut MarMaRaMarseilleFrance Groupe de Recherche Biotechnologie Appliquée et Bioprocédés Environnementaux(GRBA-BE) Ecole Supérieure PolytechniqueUniversitéCheikh Anta Diop de DakarDakar BP5005Senegal Pole D’Immunophysiopathologie&Maladies Infectieuses(IMI) Institut Pasteur de DakarDakar BP 220Senegal Service D’Immunologie UniversitéCheikh Anta Diop de DakarDakar BP5005Senegal Aix Marseille University CNRSMarseille 13009France

Malaria caused by the Plasmodium falciparum parasite is responsible for more than 240 million cases per year and killed 627,000 people in 2020,mostly African *** malaria parasite is transmitted by mosquitos belonging to the genus *** an asymptomatic liver stage,the parasite is released into the bloodstream to invade red blood cells(RBCs)and replicate *** erythrocytic phase is associated with a variety of clinical manifestations,including mild and severe *** malaria(CM)is one of the most severe forms,characterized by the sequestration of parasitized RBCs in the small capillaries of the brain and the local development of cytokine-mediated *** variants in genes encoding proteins involved in red blood cell physiology are protective factors against severe malaria,as clearly demonstrated for the sickle cell variant of hemoglobin(HbS).

关键词： malaria falciparum Plasmodium

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NONLOCAL CROWD DYNAMICS MODELS FOR SEVERAL POPULATIONS

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Acta Mathematica Scientia 2012年第1期32卷 177-196页

作者： Rinaldo M.Colombo magali Lcureux-Mercier Department of Mathematics Brescia University Department of Mathematics TechnionIsrael Institute of Technology

This paper develops the basic analytical theory related to some recently intro- duced crowd dynamics models. Where well posedness was known only locally in time, it is here extended to all of R＋. The results on the stability with respect to the equations are improved. Moreover, here the case of several populations is considered, obtaining the well posedness of systems of multi-D non-local conservation laws. The basic analytical tools are provided by the classical Kruzkov theory of scalar conservation laws in several space dimensions.

关键词： hyperbolic conservation laws nonlocal flow pedestrian traffic

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Electrochemical reactivity of In-Pb solid solution as a negative electrode for rechargeable Mg-ion batteries

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Journal of Energy Chemistry 2021年第4期30卷 124-128页

作者： Lucie Blondeau Suzy Surble Eddy Foy Hicham Khodja magali Gauthier UniversitéParis-Saclay CEACNRSNIMBELEEL91191Gif-sur-YvetteFrance UniversitéParis-Saclay CEACNRSNIMBELAPA-IRAMAT91191Gif-sur-YvetteFrance

A composite In-Pb:carbon was successfully synthetized by a two-step mechanochemical synthesis in order to obtain an adequate particles size and structure to investigate the electrochemical reactivity of the In-Pb solid solution towards Mg.A potential synergetic coupling of electroactive elements In and Pb was examined using electrochemical and ex situ X-ray diffraction *** potential profile of the solid solution indicates the formation of Mg_(2)Pb and Mg ***,the diffraction study suggests a peculiar electrochemically-driven amorphization of Mg In during the magnesiation,in strong contrast to Mg In crystallization in In-based and In Bi-based electrodes reported in the *** In and Pb favors the amorphization of Mg In and a high first magnesiation capacity of about 550 m Ah g^(-1),but is thereafter detrimental to the material’s *** results emphasize the possible influence of electrochemically-driven amorphization and crystallization processes on electrochemical performance of battery materials.

关键词： Magnesium battery Negative electrode Alloy Amorphization

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An optimized use of limited ground based topographic data for river applications

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International Journal of Sediment Research 2019年第3期34卷 216-225页

作者： Mohamed Jaballah Benoit Camenen ANDré Paquier magali Jodeau Irstea UR River Ly centre de Lyon-Villeurbanne EDF R&D

A prime requirement for hydrological applications, such as sediment budgeting or numerical modelling,is that produced Digital Terrain Models(DTMs) accurately represent the shape of landforms, especially for river reaches where data are not homogeneous. DTM error is a function of data point measurement accuracy and density and also of the field survey strategy when limited amounts of data will be *** paper aims to advance the importance of the field survey strategy for the specific, but common cases, where only limited topographic data will be available. This methodology is based on the idea that any feature can be properly described by a set of cross sections and breaklines describing both main and secondary directions of the flow. Then, a longitudinal linear interpolation can be applied to the defined homogeneous zones. This morphologically oriented(MO) method that includes data acquisition strategy and interpolation, was validated using a reference DTM derived from Li DAR measurements. An estimation of the uncertainties also is suggested based on the distance of the nearest point and the local slope using a geographically weighted regression. The proposed MO method is typically applicable to Alpine river reaches characterized by multiple channels that may always be underwater and not navigable such as an alternate bar system with secondary and transverse channels.

关键词： Digital Terrain Model Survey strategy Interpolation DTM error Gravel bar

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Insights into the Social Determinants of Health in Older Adults

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Journal of Biomedical Science and Engineering 2022年第11期15卷 261-268页

作者： Felipe P. Perez Carmen A. Perez magali N. Chumbiauca Department of Medicine Division of General Internal Medicine and Geriatrics Indiana University School of Medicine Indianapolis IN USA School of Social Work Indiana University Indianapolis IN USA Richard L. Roudebush Veterans Affairs Medical Center Home Based Primary Care Indianapolis IN USA

In this paper, we review the social determinants of health in older adults and their complex interrelationship with medical diseases. Also, we provide recommendations to address these determinants in the integrated healthcare plan. The social determinants in older adults and its influence in health outcomes have been studied for decades. There is solid evidence for the interrelationship between social factors and the health of individuals and populations;however, these studies are unable to define their complex interrelatedness. Health is quite variable and depends on multiple biological and social factors such as genetics, country of origin, migrant status, etc. On the other hand, health status can affect social factors such as job or education. Addressing social determinants of health in the integrated healthcare plan is important for improving health outcomes and decreasing existing disparities in older adult health. We recommend a person-centered approach in which individualized interventions should be adopted by organizations to improve the health status of older adults at the national and global level. Some of our practical recommendations to better address the social determinants of health in clinical practice are EHR documentation strategies, screening tools, and the development of linkages to the world outside of the clinic and health system, including social services, community activities, collaborative work, and roles for insurance companies.

关键词： Social Determinants Integrated Plan Older Adult Health Personalized Social Services

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The Sulfate Transporter Family in Wheat： Tissue-Specific Gene Expression in Relation to Nutrition

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Molecular Plant 2010年第2期3卷 374-389页

作者： Peter Buchner Saroj Parmar Anne Kriegel magali Carpentier Malcolm J. Hawkesford Rothamsted Research Plant Science Department West Common Harpenden Hertfordshire AL5 2JQ UK Molecular Plant Nutrition University of Hohenheim Stuttgart Germany

Sulfate uptake and distribution in plants are managed by the differential expression of a family of transporters, developmentally, spatially, and in response to sulfur nutrition. Elucidation of the signaling pathways involved requires a knowledge of the component parts and their interactions. Here, the expression patterns of the full complement of sulfate transporters in wheat, as influenced by development and sulfur nutrition, are described. The 10 wheat sulfate transporters characterized here are compared to the gene families for both rice and Brachypodium, for whom full genome information is available. Expression is reported in young seedlings with a focus on roles in uptake from nutrient solution and differential expression in relation to sulfate deprivation. In addition, patterns of expression in all organs at the grain filling stage are reported and indicate differential responses to nutritional signals of the individual transporters in specific tissues and an overall coordination of uptake, storage, and remobilization to deliver sulfur to the developing grain.

关键词： Sulfate transporter wheat transcriptional regulation sulfur nutrition grain filling.

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Experimental manipulation of reproductive tactics in Seba’s short-tailed bats:consequences on sperm quality and oxidative status

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Current Zoology 2019年第6期65卷 609-616页

作者： magali MENIRI Florence GOHON Ophelie GNING Gaetan GLAUSER Armelle VALLAT Nicolas JFASEL Fabrice HELFENSTEIN Laboratory of Evolutionary Ecophysiology Institute of BiologyUniversity of NeuchatelSwitzerland Neuchatel Platform of Analytical Chemistry University of NeuchatelSwitzerland Leibniz Institute for Zoo and Wildlife Research Germany

To reproduce,males have to fertilize the female’s eggs,sometimes in competition with ejaculates of other *** species where males display alternative reproductive tactics,whereby territorial males secure mating and non-territorial males have to sneak copulations,the latter might be expected to invest relatively more resources towards sperm quality compared with the territorial *** cells are especially vulnerable to oxidative stress,which reduces male ***,antioxidant resources are expected to modulate sperm quality,and might be allocated differently between reproductive *** test the link between reproductive tactics,redox profile and sperm quality,we experimentally induced changes in the reproductive tactics of 39 captive males Seba's short-tailed bats Carollia *** monitored the blood and ejaculate oxidative balance,and the sperm quality before,7 days and 21 days after the manipulation of reproductive *** ejaculates'oxidative damage was negatively related to sperm velocity,males exhibited similar blood and ejaculates redox profiles and similar sperm quality,regardless of their reproductive ***,these results arise as a consequence of some constraints having been lifted during the *** results also suggest that,in Seba's short-tailed bats,the expression of alternative reproductive tactics is not subjected to strong oxidative ***,our results could reflect an absence of trade-off between pre-and post-copulatory traits in harem males,as they could be selected to invest both in female attraction and sperm quality,as a consequence of their inability to fully monopolize females.

关键词： oxidative stress sperm competition alternative reproductive tactics Carollia perspicillata

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