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Aqueous Extract of Ceiba pentandra Stimulates the Production of Fetal Hemoglobin in Sickle Cell Patients

Journal of Biosciences and Medicines 2024年第8期12卷 295-306页

作者： Marie Miezi Nsimba magain Barihuta mihatano Blaise Maya Mbamu Aline Diza Lubongo Thoms Nzaji Kolombo Josué Matadi Mukengeshaie José Nzunzu Lami Laboratoire de Recherche Bio-Organique Dpartement de Chimie Mdicinale et Pharmacognosie Facult des Sciences Pharmaceutiques Universit de Kinshasa Kinshasa Democratic Republic of the Congo Laboratoire dAnalyse Biologique Hpital Biamba Marie Mutombo Kinshasa Democratic Republic of the Congo Centre de Phytothrapie Moderne NIECA Commune de Ngaba Kinshasa Democratic Republic of the Congo Traumatology Service Department of Surgery Kinshasa University Hospital University of Kinshasa Kinshasa Democratic Republic of the Congo

Subsequent studies have demonstrated the reversed activity of the aqueous extract of Ceiba pentandra on the deformity of sickled red blood cells in hypoxia conditions. The observation which related to an in vitro study had given rise to hopes as to the management of sickle cell disease (SCD) by the use of this plant species. In this paper, the authors aimed to investigate the effect of the aqueous extract of C. pentandra on the production of fetal hemoglobin in SCD patients. The work carried out hemoglobin electrophoresis, for a period of six months, on blood samples from SCD patients who voluntarily undergone routine treatment, based on the medicinal recipe prepared from the bark of the trunk and branches of C. pentandra, in a hospital center of herbal medicines located in Kinshasa. The medicinal recipe called BEAT-SS is a patented product of the hospital center named Centre de Phytothérapie Moderne NIECA. Blood samples from patients under treatment were taken to evaluate the behavior of different forms of hemoglobin (hemoglobin S, hemoglobin F and hemoglobin A2). Agarose gel electrophoresis with integrated reading was used for the separation of the different forms of hemoglobin, as well as their dosage on each sample of sickle blood. A reduction in the proportion of hemoglobin S and an increase in the proportion of fetal hemoglobin were found in all sickle cell patients during the treatment period. This observation could affirm that the management of sickle cell patients using the recipe prepared from the aqueous extract of C. pentandra could increase the level of fetal hemoglobin in these patients.

关键词： Sickle Cell Disease Hemoglobin S Fetal Hemoglobin Ceiba pentandra

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Determination of the Mineral Composition of the Pulp and Evaluation of the Acute Toxicity of the Seeds of Carica papaya L. Consumed in Lubumbashi and Kinshasa in the Democratic Republic of the Congo

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Journal of Biosciences and Medicines 2024年第9期12卷 266-279页

作者： Guelord Inkalaba Janvier Arnauld Kiza magain mihatano Mathilde Bushiri Furaha Arthur Duki Olivier Nzingula Armelle Naniwambote Maguy Luvandu Nicole Misengabu Désiré Musuyu Fridolin Kodondi Kule-Koto Laboratory of Biochemistry Nutrition and Hematology Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo Faculty of Pharmaceutical Sciences University of Lubumbashi Lubumbashi Democratic Republic of the Congo Food Technology and Food Analysis Laboratory Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo Higher Institute of Medical Techniques Nutrition and Dietetics Section Kinshasa Democratic Republic of the Congo Laboratory of the National Institute of Biomedical Research (NIBR) Kinshasa Democratic Republic of the Congo

This work aimed, on the one hand, to determine the mineral and phytochemical composition of Carica papaya in order to guarantee the food safety of consumers and on the other hand, to evaluate the acute toxicity of papaya seeds. The papayas were bought at the Mzée market in Lubumbashi and Selembao in Kinshasa. Fruit sampling was done according to the ISO 7002 standard on agricultural and food products;the papayas were firm, mature, and without stains or physical damage. The analysis results of the papaya pulp showed both for the samples from the city of Lubumbashi and for the city province of Kinshasa that it contains respectively 85.87% and 84.46% water, 0.59% and 0.53% ash content. The mineral evaluation of our two samples presented a potassium content of 200 ± 8 mg, magnesium 13.12 ± 3 mg, calcium 22.15 ± 2 mg, sodium 3 mg ± 0.5 for the sample from Lubumbashi and 192.32 ± 8 mg of potassium, 14.458 ± 3 mg of magnesium, 20.58 ± 2 mg of calcium and 3.58 ± 0.5 mg of sodium for the sample from Kinshasa in macroelements. Concerning the trace elements, after analysis, we found zinc content (0.29 ± 0.1 mg and 0.12 ± 0.1 mg), copper (0.02 ± 0.01 mg and 0.14 ± 0.01 mg), and iron (2.22 ± 0.5 mg and 2.04 ± 0.5 mg) respectively for Lubumbashi and Kinshasa. The chemical screening indicates the presence of alkaloids, saponosides, tannins catechics, flavonoids and anthocyanins in the palm wine and ethanolic extract of the seeds of Carica papaya and an absence of cyanogenic glycosides and gallic tannins. With mild toxicity, the seeds of the fruit of Carica papaya L. can be used with moderate risk by the population.

关键词： Carica papaya Mineral Composition Acute Toxicity

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