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Predictive Prefetching for Parallel Hybrid Storage Systems

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International Journal of Communications, Network and System Sciences 2015年第5期8卷 161-180页

作者： maen m. Al Assaf King Abdullah II School for Information Technology The University of Jordan Amman Jordan

In this paper, we present a predictive prefetching mechanism that is based on probability graph approach to perform prefetching between different levels in a parallel hybrid storage system. The fundamental concept of our approach is to invoke parallel hybrid storage system’s parallelism and prefetch data among multiple storage levels (e.g. solid state disks, and hard disk drives) in parallel with the application’s on-demand I/O reading requests. In this study, we show that a predictive prefetching across multiple storage levels is an efficient technique for placing near future needed data blocks in the uppermost levels near the application. Our PPHSS approach extends previous ideas of predictive prefetching in two ways: (1) our approach reduces applications’ execution elapsed time by keeping data blocks that are predicted to be accessed in the near future cached in the uppermost level;(2) we propose a parallel data fetching scheme in which multiple fetching mechanisms (i.e. predictive prefetching and application’s on-demand data requests) can work in parallel;where the first one fetches data blocks among the different levels of the hybrid storage systems (i.e. low-level (slow) to high-level (fast) storage devices) and the other one fetches the data from the storage system to the application. Our PPHSS strategy integrated with the predictive prefetching mechanism significantly reduces overall I/O access time in a hybrid storage system. Finally, we developed a simulator to evaluate the performance of the proposed predictive prefetching scheme in the context of hybrid storage systems. Our results show that our PPHSS can improve system performance by 4% across real-world I/O traces without the need of using large size caches.

关键词： Predictive Prefetching Probability Graph Parallel Storage Systems Hybrid Storage System

Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer

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World Journal of Gastroenterology 2021年第38期27卷 6387-6398页

作者： Stephen Safe Rupesh Shrestha Kumaravel mohankumar marcell Howard Erik Hedrick maen Abdelrahim Department of Veterinary Physiology and Pharmacology Texas A&M UniversityCollege StationTX 77845United States Department of Biochemistry and Biophysics Texas A&M UniversityCollege StationTX 77845United States Cancer Institute Cleveland ClinicClevelandOH 44195United States Department of medical Oncology Houston Methodist Hospital Cancer CenterHoustonTX 77030United States

Specificity protein(Sp)transcription factors(TFs)Sp1,Sp3 and Sp4,and the orphan nuclear receptor 4A1(NR4A1)are highly expressed in pancreatic tumors and Sp1 is a negative prognostic factor for pancreatic cancer patient *** of knockdown and overexpression of Sp1,Sp3 and Sp4 in pancreatic and other cancer lines show that these TFs are individually pro-oncogenic factors and loss of one Sp TF is not compensated by other ***4A1 is also a prooncogenic factor and both NR4A1 and Sp TFs exhibit similar functions in pancreatic cancer cells and regulate cell growth,survival,migration and *** is also evidence that Sp TFs and NR4A1 regulate some of the same genes including survivin,epidermal growth factor receptor,PAX3-FOXO1,α5-andα6-integrins,β1-,β3-andβ4-integrins;this is due to NR4A1 acting as a cofactor and mediating NR4A1/Sp1/4-regulated gene expression through GC-rich gene promoter *** studies show that drugs targeting Sp downregulation or NR4A1 antagonists are highly effective inhibitors of Sp/NR4A1-regulated pathways and genes in pancreatic and other cancer cells,and the triterpenoid celastrol is a novel dual-acting agent that targets both Sp TFs and NR4A1.

关键词： Specificity protein Nuclear receptor 4A1 Pancreatic cancer Transcription factors Ligand inhibitors Nuclear receptor 4A antagonists

A Comparison Study between Informed and Predictive Prefetching mechanisms for I/O Storage Systems

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International Journal of Communications, Network and System Sciences 2015年第5期8卷 181-186页

作者： maen m. Al Assaf Ali Rodan mohammad Qatawneh mohamed Riduan Abid King Abdullah II School for Information Technology The University of Jordan Amman Jordan Al Akhawayn University Ifrane Morocco

In this paper, we present a comparative study between informed and predictive prefetching mechanisms that were presented to leverage the performance gap between I/O storage systems and CPU. In particular, we will focus on transparent informed prefetching (TIP) and predictive prefetching using probability graph approach (PG). Our main objective is to show the main features, motivations, and implementation overview of each mechanism. We also conducted a performance evaluation discussion that shows a comparison between both mechanisms performance when using different cache size values.

关键词： Informed Prefetching Predictive Prefetching Probability Graph Parallel Storage Systems

Pancreatic adenocarcinoma with early esophageal metastasis: A case report and review of literature

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World Journal of Clinical Oncology 2020年第2期11卷 83-90页

作者： Ethan Alexander Burns Saro Kasparian Usman Khan maen Abdelrahim Department of Internal medicine Houston Methodist HospitalHoustonTX 77030United States Department of Oncology Houston Methodist Cancer CenterHoustonTX 77030United States

BACKGROUND Pancreatic adenocarcinoma is an aggressive malignancy with a high propensity to *** metastasis manifesting as dysphagia is rarely reported in the literature and has not to our knowledge been reported prior to the appearance of the primary *** SUmmARY A patient presented with progressive dysphagia to solids and a persistent *** tomography of the neck and chest revealed a 3.0 cm×1.8 cm heterogeneous mass originating from the upper third of the esophagus,necrotic cervical and supraclavicular lymphadenopathy,and bilateral pulmonary *** underwent a core needle biopsy of a right cervical node,which suggested a well-differentiated adenocarcinoma of unknown *** had an upper endoscopy with biopsy of the esophageal mass suggestive of a welldifferentiated *** emission tomography imaging revealed increased uptake in the esophageal mass,cervical,and mediastinal lymph *** was started on folinic acid,fluorouracil,and *** to initiation of cycle 8,the patient was found to have a pancreatic body mass that was not present on prior radiographic imaging,confirmed by endoscopic ultrasonography and biopsy to be pancreatic ***19-9 was>10000 U/m L,suggesting a primary pancreaticobiliary *** Esophageal metastasis diagnosed before primary pancreatic adenocarcinoma is *** case highlights the profound metastatic potential of pancreatic adenocarcinoma.

关键词： Pancreatic body neoplasm Adenocarcinoma Esophagus metastasis Dysphagia Earache Carcinogenesis Case report

Chemotherapy rechallenge in metastatic colon cancer:A case report and literature review

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World Journal of Clinical Oncology 2020年第11期11卷 959-967页

作者： Tejaswini Parlapalle Reddy Usman Khan Ethan Alexander Burns maen Abdelrahim College of medicine Texas A&M University Health Science CenterBryanTX 77807United States Department of medical Oncology Houston Methodist Hospital Cancer CenterHoustonTX 77030United States Section of GI Oncology Department of Medical OncologyHouston Methodist Cancer Center.Cockrell Center of Advanced Therapeutics Phase I ProgramHouston Methodist Research Institute and Weill Cornell Medical CollegeHoustonTX 77030United States

BACKGROUND Colorectal cancer(CRC)is the third leading cause of cancer-related death in males and females in the United ***,20%-22%of patients have metastatic disease at the time of presentation,and 50%-60%will develop metastasis over the course of their *** advances in systemic therapies,there remains a paucity of effective third-and later-line therapies for patients with ongoing disease ***,rechallenging chemoresistant CRC tumors with previously administered therapies is an emerging concept that may be a life-prolonging option for heavily treated metastatic colorectal cancer(mCRC).CASE SUmmARY A 41-year-old man with no previous medical history initially presented with worsening diffuse abdominal *** tomography was significant for a splenic flexure mass and hepatic lesions concerning for metastatic *** underwent a colectomy with *** pathology was diagnostic for moderately to well-differentiated adenocarcinoma(T4bN1bm1a).He received adjuvant 5-fluorouracil,leucovorin,and oxaliplatin(FOLFOX),but therapy was discontinued due to the development of atrial *** workup indicated a carcinoembryonic antigen level of 508.2 ng/mL,and mutational analysis found that the tumor was microsatellite instability-high and KRAS/BRAF *** was started on irinotecan with oxaliplatin(IROX),and bevacizumab(14 cycles),developed disease progression,was transitioned to FOLFOX and cetuximab,and then eventually three cycles of *** disease progression,he was rechallenged with IROX therapy,as he previously responded well to oxaliplatin-based *** IROX rechallenge provided this patient with a ten-month survival benefit,decreased metastatic burden,and marked improvement in his clinical *** Rechallenge of previous lines of well-tolerated systemic chemotherapy regimens may be a valuable therapeutic strategy in patients with heavily-treated mCRC

关键词： metastatic colorectal cancer Rechallenge therapy Treatment holiday Oxaliplatin Irinotecan Case report Chemoresistance Palliative option