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e.vironme.tal landscape.de.e.minants of maximum fore.t canopy he.ght of bore.l fore.ts

Journal of Plant e.ology 2019年第1期12卷 96-102页

作者： Lingfe.g Mao Christophe. W.Bate. John JStadt Barry White.Piotr Tompalski Nicholas C.Coops Scott e.nielsen De.artme.t of Re.e.able.Re.ource. University of AlbertaEdmontonAlberta T6G 2H1Canada Fore.t Manage.e.t Branch Forestry DivisionAlberta Agriculture and ForestryEdmontonAlberta T5K 2M4Canada De.artme.t of Fore.t Re.ource.Manage.e.t University of British ColumbiaVancouverBritish Columbia V6T 1Z4Canada

Aims Canopy he.ght is a ke. drive. of fore.t biodive.sity and carbon *** e.timate. of canopy he.ght are.ne.de. for asse.s-ing me.hanisms re.ating to e.ological patte.ns and proce.se. of tre. he.ght *** global scale. fore.t canopy he.ght patte.ns are.large.y controlle. by climate.while.local variation at fine.scale. is due.to diffe.e.ce. in disturbance.history and local patte.ns in e.vir-onme.tal *** re.ative.e.fe.t of local e.vironme.tal driv-e.s on canopy he.ght is poorly unde.stood partly due.to gaps in data on canopy he.ght and me.hods for e.amining limiting ***,we.use. airborne.lase. scanning(ALS)data on ve.e.ation structure.of bore.l fore.ts to e.amine.the.e.fe.ts of e.vironme.tal factors on pote.tial maximum fore.t canopy *** Re.ationships be.we.n maximum canopy he.ght from ALS me.s-ure. and e.vironme.tal variable. we.e.e.amine. to asse.s factors limiting tre. ***,we.use. quantile.re.re.sion at the.0.90 quantile.to re.ate.maximum canopy he.ght with e.vironme.tal characte.istics of climate.*** annual te.pe.ature.MAT]and me.n annual pre.ipitation),te.rain(***)and de.th-to-wate.(DTW)across a 33000 km2 multiple.use.bore.l fore.t landscape.in northe.st Albe.ta,*** Findings Maximum canopy he.ght was positive.y associate. with MAT,te.-rain slope.and te.rain-de.ive. DTW,colle.tive.y e.plaining 33.2%of the.variation in *** stronge.t e.planatory variable.was DTW e.plaining 26%of canopy he.ght variation with pe.tland fore.ts having naturally shorte. maximum canopy he.ghts,but also more.site. curre.tly at the.r maximum pote.tial *** con-trast,the.most productive.fore.ts(*** to xe.ic upland fore.ts)had the.fe.e.t site. at the.r pote.tial maximum he.ght,illustrating the.e.fe.ts of long-te.m fore.t manage.e.t,wildfire. and ge.e.al anthropoge.ic footprints on re.ucing the.e.te.t and abundance.of olde.,talle. fore.t habitat in Albe.ta’s bore.l fore.t.

关键词： fore.t succe.sion ve.e.ation structure quantile.re.re.sion re.ote.se.sing airborne.lase. scanning(ALS)

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盐梯度太阳池内部稳定性的实用判据和监测方法

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太阳能学报 1990年第1期11卷 79-88页

作者：徐河 C.e.nielsen 北京师范学院物理系美国俄亥俄州立大学物理系

本文从太阳池中梯度区内部的动力学稳定性条件出发,引入局部相对安全数的概念,提出一个梯度区内部稳定性的实用判据和监测方法,并用几个不同太阳池中的数据对这种方法的实际应用做了示范。

关键词：盐梯度太阳池稳定性监测法

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Loss of mismatch re.air signaling impairs the.WNT–bone.morphoge.e.ic prote.n crosstalk and the.colonic home.stasis

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Journal of Mole.ular Ce.l Biology 2020年第6期12卷 410-423页

作者： Katrine.Nørgaard Carolin Mülle. Nadja Christe.se. María L.Chiloe.he. Ce.ilie.L.madse. Sabine.S.nielsen Tine.e.Thingholm Antoane.a Be.che.a De.artme.t of Bioche.istry and Mole.ular Biology University of Southern DenmarkCampusvej 555230 Odense MDenmark De.artme.t of Mole.ular Me.icine University of Southern DenmarkJ.B.Winsløws Vej 255230 Odense MDenmark

The.fine.balance.be.we.n prolife.ation,diffe.e.tiation,and apoptosis in the.colonic e.ithe.ium is tightly controlle. by the.inte.play be.we.n WNT,Notch,and bone.morphoge.e.ic prote.n(BMP)*** the.e.comple. ne.works coordinate.the.colonic home.stasis,e.pe.ially if cance. pre.isposing mutations such as mutations in the.DNA mismatch re.air(MMR)are.pre.e.t,is *** of the.MMR syste. has long be.n linke. to colore.tal cance.;howe.e.,little.is known about its role.in the.re.ulation of the.colonic *** has be.n shown that loss of MMR promote. the.prolife.ation of colon e.ithe.ial ce.ls that re.de.s the. highly susce.tible.to *** me.hanism through which MMR me.iate. this e.fe.t,ye.,re.ains to be.*** an MMR-de.icie.t mouse.mode.,we.show that incre.se. me.hylation of Dickkopf1 impacts its e.pre.sion,and conse.ue.tly,the.ability to ne.ative.y re.ulate.WNT *** a re.ult,e.ce.sive.le.e.s of active.-cate.in promote.strong crypt proge.itor-like.phe.otype.and abnormal *** the.e.se.tings,the.de.e.opme.t and function of the.goble. ce.ls are.***-de.icie.t mice.have.fe.e. goble. ce.ls with e.large. mucin-loade. *** furthe. show that MMR inactivation impacts the.WNT–BMP signaling crosstalk.

关键词： MMR colonic e.ithe.ium WNT BMP crypt home.stasis

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Se.sory te.ting of the.human gastrointe.tinal tract

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World Journal of Gastroe.te.ology 2009年第2期15卷 151-159页

作者： Christina Brock Lars Are.dt-nielsen Olive. Wilde.-Smith Asbjφrn Mohr Dre.e. Me.h-Se.se Department of Gastroenterology Aalborg Hospital DK-9000 Aalborg Denmark Ce.te. for Se.sory-Motor Inte.actions Department of Health Science and Technology Aalborg University DK-9000 Aalborg Denmark Pain and Nocice.tion Re.e.rch Group Department of Anaesthesiology Radboud University Nijmegen Medical Centrethe Netherlands Me.h-Se.se Department of Gastro-enterology Aalborg Hospital DK-9000 Aalborg Denmark Author

The.obje.tive.of this appraisal is to she. light on the.various approache. to scre.n se.sory information in the.human gut. Unde.standing and characte.ization of se.sory symptoms in gastrointe.tinal disorde.s is poor. e.pe.ime.tal me.hods allowing the.inve.tigator to control stimulus inte.sity and modality, as we.l as using validate. me.hods for asse.sing se.sory re.ponse.have.contribute. to the.unde.standing of pain me.hanisms. Me.hanical stimulation base. on impe.ance.planime.ry allows dire.t re.ordings of luminal cross-se.tional are.s, and combine. with ultrasound and magne.ic re.onance.imaging, the.contribution of diffe.e.t gut laye.s can be.e.timate.. e.e.trical stimulation de.olarize. fre. ne.ve.e.dings non-se.e.tive.y. Conse.ue.tly, the.stimulation paradigm (single. train, te.anic) influe.ce. the.involve. se.sory ne.ve.. Visual controlle. e.e.trical stimulation combine. the.probe. with an e.doscopic approach, which allows the.inve.tigator to inspe.t and obtain small biopsie. from the.stimulation site. The.mal stimulation (cold or warm) activate. se.e.tive.y mucosal re.e.tors, and che.ical substance. such as acid and capsaicin (e.the. alone.or in combination) are.use. to e.oke.pain and se.sitization. The.possibility of multimodal (e.g. me.hanical, e.e.trical, the.mal and che.ical) stimulation in diffe.e.t gut se.me.ts has de.e.ope. visce.al pain re.e.rch. The.major advantage.is involve.e.t of distinctive.re.e.tors, various se.sory ne.ve. and diffe.e.t pain pathways mimicking clinical pain that favors inve.tigation of ce.tral pain me.hanisms involve. in allodynia, hype.alge.ia and re.e.re. pain. As impairme.t of de.ce.ding control me.hanisms partly unde.lie. the.pathoge.e.is in chronic pain, a cold pre.sor te.t that indire.tly stimulate. such control me.hanisms can be.adde.. He.ce. the.me.hods undoubte.ly re.re.e.t a major ste. forward in the.future.characte.ization and tre.tme.t of patie.ts with various dise.se. of the.gut, which provide. knowle.ge.to clinician

关键词：内窥镜检查胃肠疾病神经生理学疼痛

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Inve.tigation on balcony plume.e.trainme.t

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Journal of Ce.tral South Unive.sity 2009年第S1期16卷 105-110页

作者：刘方 nielsen P V He.LSe.Be.G P BROHUS H Faculty of Urban Construction and e.vironme.t e.gine.ring Chongqing University De.artme.t of Civil e.gine.ring Aalborg University

An inve.tigation on the.sce.arios of the.spill plume.and its e.uation was pre.e.te.,including two aspe.ts,i.e.,the.small-scale.e.pe.ime.t and the.nume.ical simulation. Two balcony spill plume.mode.s are.asse.se. by comparing with the.fire.dynamic simulation (FDS) and small scale.mode. e.pe.ime.t re.ults. Be.ide. validating the.spill mode. by e.pe.ime.ts,the.e.fe.t of diffe.e.t fire.locations on balcony plume.is also discusse.. The.re.ults show that the.balcony e.uation in NFPA give. good pre.ictions on the.mass flow rate. And the.balcony plume.e.trainme.t coe.ficie.t is inde.e.de.t of the.fire.location. This inve.tigation is use.ul for the.fire.e.gine.rs in de.igning smoke.control syste.s.

关键词： fire plume e.trainme.t atrium

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8-甲氧补骨脂素诱导的四膜虫DNA损伤修复

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中国药理学与毒理学杂志 1992年第2期6卷 88-91页

作者：夏凤琴赵武 Pe.e. e.nielsen 白求恩医科大学放射医学研究所长春130021 长春市第二医院 130061 De.artme.t of Bioche.istry B The Panum Institute University of Copenhagen Copenhagen N2200 Denmark

用0.6 μg·ml^(-1)8-甲氧补骨脂素(8-me.hoxypsorale.,8-MOP)与365 nm UVA(紫外线)联合处理后,四膜虫DNA的修复反应,表现为细胞增殖反应受抑;DNA,RNA合成率在0 h受抑,(DNA为对照的5％,RNA为对照的20％),但经过一段修复后,DNA,RNA合成... 详细信息

用0.6 μg·ml^(-1)8-甲氧补骨脂素(8-me.hoxypsorale.,8-MOP)与365 nm UVA(紫外线)联合处理后,四膜虫DNA的修复反应,表现为细胞增殖反应受抑;DNA,RNA合成率在0 h受抑,(DNA为对照的5％,RNA为对照的20％),但经过一段修复后,DNA,RNA合成率均回升,在24h,DNA达70％,而RNA则几乎100％,同样条什下,用分子杂交等技术,观察到在0 h产生了分子交联(DNA双链在受热100℃时仍不能解链),经过24h培养后,有部分分子交联被去除(受热后DNA解链且被S1酶降解)。

关键词： DNA损伤甲氧补骨脂素细胞增殖

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Do ne.works of social inte.actions re.le.t patte.ns of kinship？

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Curre.t Zoology 2012年第2期58卷 319-328页

作者： Joah R. MADDe. Johanna F. nielsen Tim H. CLUTTON-BROCK Ce.tre.for Re.e.rch in Animal Be.aviour College of Life and Environmental Sciences University of Exeter Exeter EX4 4QG UK. Institute.of e.olutionary Biology School of Biological Sciences University of Edinburgh West Mains Road Edinburgh EH9 3JT UK. Institute.of Zoology Zoological Society of London Regent＇s Park London NW1 4RY UK Large.Animal Re.e.rch Group Department of Zoology University of Cambridge Cambridge CB2 3E J UK.

The.unde.lying kin structure.of groups of animals may be.glimpse. from patte.ns of spatial position or te.poral association be.we.n individuals, and is pre.ume. to facilitate.inclusive.fitne.s be.e.its. Such structure.may be.e.ide.t at a fine., be.avioural, scale.with individuals pre.e.e.tially inte.acting with kin. We.te.te. whe.he. kin structure.within groups of me.rkatsSuricata suricattamatche. thre. forms of social inte.action ne.works: grooming, dominance.or foraging compe.itions. Ne.works of dominance.inte.actions we.e.positive.y re.ate. to ne.works of kinship, with close.re.ative. e.gaging in dominance.inte.actions with e.ch othe.. This re.ationship pe.siste. e.e. afte. e.cluding the.bre.ding dominant pair and whe. we.re.tricte. the.kinship ne.work to only include.links be.we.n first orde. kin, which are.most like.y to be.able.to disce.n kin through simple.rule. of thumb. Conve.se.y, we.found no re.ationship be.we.n kinship ne.works and e.the. grooming ne.works or ne.works of foraging compe.itions. This is surprising be.ause.a positive.association be.we.n kin in a grooming ne.work, or a ne.ative.association be.we.n kin in a ne.work of foraging compe.itions offe.s opportunitie. for inclusive.fitne.s be.e.its. Inde.d, the.positive.association be.we.n kin in a ne.work of dominance.inte.actions that we.did de.e.t doe. not offe. cle.r inclusive.fitne.s be.e.its to group me.be.s. We.conclude.that kin structure.in be.avioural inte.actions in me.rkats may be.drive. by factors othe. than indire.t fitne.s be.e.its, and that ne.works of coope.ative.be.aviours such as grooming may be.drive. by dire.t be.e.its accruing to individuals pe.haps through mutualism or manipulation [Curre.t Zoology58 (2): 319–328, 2012].

关键词：关系网络亲属关系社会交往相互作用群体结构网络优势时空模式空间位置

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Inflammatory pathways of importance.for manage.e.t of inflammatory bowe. dise.se

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World Journal of Gastroe.te.ology 2014年第1期20卷 64-77页

作者： Jannie.Pe.e.se. Me.me. Coskun Christoffe. Soe.de.gaard Mohammad Sale. Ole.Haage. nielsen De.artme.t of Gastroe.te.ology Medical SectionUniversity of CopenhagenHerlev HospitalDK-2730 HerlevDenmark De.artme.t of Ce.lular and Mole.ular Me.icine the Panum InstituteUniversity of CopenhagenDK-2200 CopenhagenDenmark

Inflammatory bowe. dise.se.IBD)is a group of chronic disorde.s of the.gastrointe.tinal tract comprising Crohn’s dise.se.CD)and ulce.ative.colitis(UC).The.r e.iologie. are.unknown,but the. are.characte.ise. by an imbalance. production of pro-inflammatory me.iators,e.g.,tumor ne.rosis factor(TNF)-α,as we.l as incre.se. re.ruitme.t of le.kocyte. to the.site.of *** in unde.standing the.role.of the.inflammatory pathways in IBD and an inade.uate.re.ponse.to conve.tional the.apy in a large.portion of patie.ts,has ove. the.last two de.ade. le.d to ne. the.apie. which include. the.TNF inhibitors(TNFi),de.igne. to targe. and ne.tralise.the.e.fe.t of TNF-α.TNFi have.shown to be.e.ficie.t in tre.ting mode.ate.to se.e.e.CD and ***,conve.ie.t alte.native.the.ape.tics targe.ing othe. immune.pathways are.ne.de. for patie.ts with IBD re.ractory to conve.tional the.apy including ***,se.e.al the.ape.tics are.curre.tly unde. de.e.opme.t,and have.shown succe.s in clinical *** include.antibodie. targe.ing and ne.tralising inte.le.kin-12/23,small pharmacologic Janus kinase.inhibitors de.igne. to block intrace.lular signaling of se.e.al pro-inflammatory cytokine.,antibodie. targe.ing inte.rins,and small anti-adhe.ion mole.ule. that block adhe.ion be.we.n le.kocyte. and the.inte.tinal vascular e.dothe.ium,re.ucing the.r infiltration into the.inflame. *** this re.ie. we.have.e.ucidate. the.major signaling pathways of clinical importance.for IBD the.apy and highlighte. the.ne. promising the.apie. *** state. in this pape. se.e.al ne. tre.tme.t options are.unde. de.e.opme.t for the.tre.tme.t of CD and UC,howe.e.,no drug fits all ***,optimisations of tre.tme.t re.ime.s are.warrante. for the.be.e.it of the.patie.ts e.the. through biomarke. e.tablishme.t or othe. rationale. to maximise.the.e.fe.t of the.broad range.of mode.of-actions of the.pre.e.t and future.drugs in IBD.

关键词： Anti-tumor ne.rosis factor Biologics Crohn’s dise.

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In-vivo validation of fast spe.tral ve.ocity e.timation te.hnique.pre.iminary re.ults

In-vivo validation of fast spectral velocity estimation tech...

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2008 Ie.e.Inte.national Ultrasonics Symposium

作者： Kristoffe. L.Hanse. Fre.rik Gran mads M.Pe.e.se. Jφrge. A.Je.se. Michae. B.nielsen Unive.sity Hospital of Cope.hage.

＜正＞Background,Motivation and Obje.tive.A common way of displaying blood ve.ocity is to e.timate.the.powe. spe.tral de.sity（PSD）as a function of time.yie.ding a *** usual me.hod to e.timate.PSD is by using the.ave...

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Pre.pe.ative.Pain Manage.e.t of Patie.ts with Hip Fracture.: Blind Fascia Iliaca Compartme.t Block Compare. to Ultrasound Guide. Fe.oral Ne.ve.Block—A Randomize. Controlle. Trial

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Ope. Journal of Ane.the.iology 2020年第11期10卷 371-380页

作者： Johanne.Bangshoe. Thomas Thougaard Hans Fje.dsøe.nielsen Sandra Vigge.s De.artme.t of Ane.the.iology Nykoebing Falster Hospital Nykoebing Falster Denmark

Introduction: Blind fascia iliaca compartme.t block (FICB) and ultrasound guide. fe.oral ne.ve.block (FNB) are.two type. of pe.iphe.al ne.ve.blocks, commonly use. in pre.pe.ative.pain manage.e.t in patie.ts with hip f... 详细信息

Introduction: Blind fascia iliaca compartment block (FICB) and ultrasound guided femoral nerve block (FNB) are two types of peripheral nerve blocks, commonly used in preoperative pain management in patients with hip fractures in Danish emergency departments. The aim of this study was to compare the efficacy in pain management of these two types of peripheral nerve blocks in the preoperative period in patients with hip fractures. Method: We performed a randomized controlled study. The primary outcome was the proportion of patients with a numeric rating scale (NRS) pain score equal to three or less at rest and after passive leg raise test three hours after block administration. Results: A total of 88 patients were included in the study and 67 patients in the statistical analysis with 33 in the FICB group and 34 in the FNB group. The results showed a significant reduction in the proportion of patients with an NRS score higher than three, three hours after administration of either FICB or FNB compared to at inclusion. There was no significant difference in pain scores between patients receiving FICB versus patients receiving FNB at rest or after passive leg raise (p = 0.25 and p = 0.86, respectively). Conclusion: Blind FICB and ultrasound guided FNB were effective in preoperative pain management in patients with hip fractures. The results showed that the two types of peripheral nerve blocks were equally efficient in providing pain management in the preoperative period.

关键词： Local Analge.ia Pe.iphe.al Ne.ve.Block Pain Control Pre.pe.ative.Optimization

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