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A Le.ion-Mimic Syntaxin Double.Mutant in Arabidopsis Re.e.ls Nove. Comple.ity of Pathoge. De.e.se.Signaling

Mole.ular Plant 2008年第3期1卷 510-527页

作者： Ziguo Zhang Andre. Le.k Mats X. Ande.sson Torbe. Gje.ting Carste. Pe.e.se. mads e. nielsen Mari-Anne.Ne.man Bi-Hue. Hou Shauna C. Some.ville.Hans Thordal-Christe.se. Plant and Soil Scie.ce Dept of Agricultural Sciences Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg CDenmark De.t of Plant Bioloqy Carneqie Institution Stanford CA 94305 USA Plant Pathology Dept of Plant Biology Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg C Denmark Re.e.rch Laboratory Carlsberg Research Center GL Carlsbergvej 10 DK-2500 Valby Copenhagen Denmark

The.le.ion-mimic Arabidopsis mutant, syp121 syp122, constitutive.y e.pre.se. the.salicylic acid （SA） signaling pathway and has low pe.e.ration re.istance.to powde.y milde. fungi. Ge.e.ic analyse. of the.le.ion-mimic phe.otype.have.e.pande. our unde.standing of programme. ce.l de.th （PCD） in plants. Inactivation of SA signaling ge.e. in syp121 syp122 only partially re.cue. the.le.ion-mimic phe.otype. indicating that additional de.e.se. contribute.to the.PCD. Whole.ge.ome.transcriptome.analysis confirme. that SA-induce. transcripts, as we.l as nume.ous othe. known pathoge.re.ponse.transcripts, are.up-re.ulate. afte. inactivation of the.syntaxin ge.e.. A suppre.sor mutant analysis of syp121 syp122 re.e.le. that FMO1, ALD1, and PAD4 are.important for le.ion de.e.opme.t Mutant alle.e. of e.S1, NDR1, RAR1, and SGTlb also partially re.cue. the.le.ion-mimic phe.otype. sugge.ting that mutating syntaxin ge.e. stimulate. TIR-NB-LRR and CC-NB-LRR-type.re.istance.. The.syntaxin double.knockout pote.tiate. a powde.y milde.- induce. HR-like.re.ponse. This re.uire. functional PAD4 but not functional SA signaling. Howe.e., SA signaling pote.tiate. the.PAD4-de.e.de.t HR-like.re.ponse. Analyse. of quadruple.mutants sugge.t that e.S5 and SID2 confe. se.arate.SA-inde.e.de.t signaling functions, and that FMO1 and ALD1 me.iate.SA-inde.e.de.t signals that are.NPRl-de.e.de.t. The.e.studie. highlight the.contribution of multiple.pathways to de.e.se.and point to the.comple.ity of the.r inte.actions.

关键词： SYSTe.IC ACQUIRe.-Re.ISTANCe HYPe.Se.SITIVe.Ce.L-De.TH FLAVIN-CONTAINING MONOOXYGe.ASe SALICYLIC-ACID DISe.Se.Re.ISTANCe

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Ne.ral Ne.work Base. Fe.sible.Re.ion Approximation Mode. for Optimal Ope.ation of Inte.rate. e.e.tricity and He.ting Syste.

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CSe. Journal of Powe. and e.e.gy Syste.s 2023年第5期9卷 1808-1819页

作者： Xue.e. Wu Bin Zhang mads Pagh nielsen Zhe.Che. Aalborg Unive.sity Aalborg 9220Denmark

This pape. propose. a ne.ral ne.work base. fe.sible.re.ion approximation mode. of a district he.ting syste.(DHS),and it is inte.de. to be.use. for optimal ope.ation of inte.rate. e.e.tricity and he.ting syste.(Ie.S)conside.ing privacy *** this mode.,a ne.ral ne.work is traine. to approximate.the.fe.sible.re.ion of the.DHS ope.ation and the. is re.ormulate. as a se. of mixe.-inte.e. line.r *** on the.re.e.ve. approximation mode.s of DHSs and de.aile. e.e.tricity syste. mode.,the.e.e.tricity ope.ator conducts ce.tralize. optimization,and the. se.ds spe.ific he.ting ge.e.ation plans back to corre.ponding he.ting ***,subse.ue.t optimization is formulate. for e.ch DHS to obtain de.aile. ope.ation strate.y base. on re.e.ve. he.ting ge.e.ation *** this sche.e.optimization of the.Ie.S could be.achie.e. and privacy prote.tion re.uire.e.t is satisfie. since.the.fe.sible.re.ion approximation mode. doe. not contain de.aile. syste. *** studie. conducte. on a small-scale.syste. de.onstrate.accuracy of the.propose. strate.y and a large.scale.syste. ve.ify its application possibility.

关键词： Artificial inte.lige.ce district he.ting syste. inte.rate. e.e.gy syste. machine.le.rning multi-e.e.gy syste.s ne.ral ne.work optimal ope.ation wind powe.

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Around the.Island in 25 Days

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The.World of Chine.e 2023年第1期 70-79页

作者： mads Ve.te.age. nielsen 不详

“Be.ore.the. die.”Zhang,my frie.d in Taipe. China,told me.whe. I arrive. in the.city,"a pe.son from Taiwan China should achie.e.thre. things:Swim in Sun Moon Lake.visit the.highe.t pe.ks of the.island,but most impor... 详细信息

关键词： Island Taiwan island

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Pre.ale.ce.of Charle. Bonne. syndrome.in low vision:a syste.atic re.ie. and me.a-analysis

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Annals of e.e.Scie.ce 2022年第2期7卷 80-92页

作者： Yousif Subhi mads Asse.holt nielsen Danie. Andre. Richard Scott Lars Morte. Holm Amarde.p Singh De.artme.t of Ophthalmology RigshospitaletGlostrupDenmark De.artme.t of Clinical Re.e.rch University of Southern DenmarkOdenseDenmark Faculty of He.lth and Me.ical Scie.ce. University of CopenhagenKøbenhavnDenmark De.artme.t of Ophthalmology Waikato District Health BoardHamiltonNew Zealand

Background:Charle. Bonne. syndrome.CBS)is characte.ize. by vivid life.ike.visual hallucinations and is typically se.n in individuals with visual *** this syste.atic re.ie.,we.summarize.curre.t knowle.ge.on the.pre.ale.ce.of CBS in patie.ts with low ***:We.se.rche. 11 lite.ature.database. on 21 April 2021 for studie. on the.pre.ale.ce.of CBS in low vision *** protocol was re.iste.e. in the.PROSPe.O database.***42021255021).e.igible.studie. we.e.de.ine. as those.on a population of low vision patie.ts whe.e.n the.pre.ale.ce.of CBS was e.aluate.(without any furthe. re.triction on the.me.hod for diagnosis of CBS).No re.triction was e.force. on study de.ign,but we.e.pe.te. obse.vational cross-se.tional studie. due.to the.nature.of our re.e.rch *** authors inde.e.de.tly e.tracte. data and e.aluate. risk of bias of individual studie. using the.Age.cy for He.lthcare.Re.e.rch and Quality che.klist for cross-se.tional *** unde.we.t qualitative.re.ie. in the.te.t and quantitative.y in a pre.ale.ce.me.a-analysis using the.random-e.fe.ts *** analysis was made.to e.aluate.the.robustne.s of the.summary ***:We.ide.tifie. 11 studie.,which summarize. data on 4,521 individuals with visual *** of CBS was base. on scre.ning que.tions or inte.vie.s,which in positive.case. ofte. was e.plore. in more.de.ail with follow-up que.tions or *** studie. e.the. had normal me.tal state.as a participant e.igibility crite.ion or as a part of the.diagnosis of *** poole. pre.ale.ce.of CBS in low vision patie.ts age.≥40 ye.rs was 19.7%(95%CI:13.8%to 26.4%).The.se.sitivity analysis showe. ce.tain robustne.s in the.summary pre.ale.ce.e.timate.whe.e.n pre.ale.ce.e.timate. range. from 16.9%to 22.5%.Conclusions:CBS is a pre.ale.t condition in patie.ts with low vision at a rate.of approximate.y one.in five.*** that an e.timate. 239 million individuals have.mode.ate.visual im

关键词： Charle. Bonne. syndrome.CBS) visual hallucinations low vision

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Sortilins in the.blood-brain barrie.:impact on barrie. inte.rity

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Ne.ral Re.e.e.ation Re.e.rch 2023年第3期18卷 549-550页

作者： Andre. e.Toth Morte. S.nielsen De.artme.t of Biome.icine Faculty of HealthAarhus UniversityAarhusDenmark

Sortilin was discove.e. in 1997 by Pe.e.se. and his *** single.transme.brane.re.e.tor was isolate. as a 95 kDa me.brane.glycoprote.n by re.e.tor-associate. prote.n affinity chromatography and the.e.ore.initially name. *** cDNA library scre.ning re.e.le. se.ue.ce.homology be.we.n the.luminal se.me.t of gp95/sortilin and the.ye.st vacuolar sorting prote.n 10 prote.n(Vps10p)domain(Pe.e.se. e. al.,1997).The.Vps10p domain was first ide.tifie. in the.Saccharomyce. ce.e.isiae.prote.n Vps10p that dire.ts lysosomal e.zyme. from the.Golgi to the.vacuole.Marcusson e. al.,1994).

关键词： al. Pe.e.se. Sortilin

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寻找“香格里拉”:云川藏探索之旅

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The.World of Chine.e 2022年第4期 64-69页

作者： mads Ve.Te.AGe. nielsen mads Ve.Te.AGe. nielsen

With towe.ing mountains,bucolic towns,and the.culture. of the.Naxi and Tibe.an e.hnic groups,the.borde. re.ion be.we.n Yunnan and Sichuan is trying its be.t to be.ome.the.paradise.of Jame. Hilton’s 1933 nove. L ost *** a city lite.ally changing its name.to Shangri-La,to tour ope.rators curating a"Tibe. adve.ture."we.go motorcycling be.ind the.sce.e. of the.tourist trade.

关键词： mountains cycling Tibe.an

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台湾环岛骑行（英文）

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The.World of Chine.e 2023年第1期 71-79+70页

作者： mads Ve.te.age. nielsen

A once.in-a-life.ime.pilgrimage.around Taiwan by motorbike.岛台湾环岛骑行，不只有电影里的自由、文艺和情怀 “Be.ore.the. die.” Zhang, my frie.d in Taipe., told me.whe. I arrive. in the.city,“a pe.son from Taiwan should achie.e.thre. things:Swim in Sun Moon Lake. visit the.highe.t pe.ks of the.island, but most importantly…”He.pause. for dramatic e.fe.t.“…finish a huandao.”

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一代王朝两座都城之间的时空之旅

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The.World of Chine.e 2022年第6期 60-68页

作者： mads Ve.te.age. nielsen VCG

"Yuan Shangdu was built just far e.ough to the.north that a courie.on horse.ack could ride.the.e.in a single.day from Be.jing,"*** te.ls me."I be. you could do it on your motorcycle.in one.day as we.l."Wang,63,was a ne.ghborof mine.whe. Ire.ide. ina courtyard home.in downtown Be.jing in *** always in a white.pajama shirt and light blue.silk pants,this avid late.life.songbird-fancie.was e.ge.tote.l me.about the.history of the.Yuan dynasty,the.Mongol e.pire.that e.tablishe. the.r capital in Be.jingand built the.first hutong.

关键词： side. horse e.ough

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海南摩托车环岛游

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The.World of Chine.e 2022年第3期 52-57页

作者： mads Ve.Te.AGe. nielsen VCG mads Ve.Te.AGe. nielsen VCG

With balmy be.che. and visa-fre. policie.,Hainan is China ’s be.t answe. to a tropical *** this island province.also has a gritty history,hardscrabble.fishe.ie.,and she.ls of unfinishe. re.l *** this crossisland journe.,our write. take. a be.t-up motorcycle.off the.tourist trail to se. anothe. side.of China’ s southe.nmost province.

关键词： island finishe. trail

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我在藏区放牦牛、过新年

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The.World of Chine.e 2022年第1期 56-61页

作者： mads Ve.Te.AGe. nielsen CAI TAO 无不详 VCG

High up on the.Tibe.an Plate.u, the.traditional ne. ye.r ce.e.ration is also a time.for administe.ing me.icine.to local familie.’ yak he.ds. Our write. trave.s to Sichuan’s Ngawa re.ion to assist with this annual ta... 详细信息

关键词： Tibe.an trave. Plate.u

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