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Chinese Journal Of Geochemistry 2015年第4期34卷 620-633页

作者： Rajkumar Herojeet madhuri s.rishi Naval Kishore Department of Environment studies Panjab University Department of Geology (CAs) Panjab University

Chemometric techniques and pollution assessment indices were applied to determine the source and intensity of pollution in the sirsa River, Himachal Pradesh,India. Results show EC, Cr, Fe, Mn, and Ni were above the permissible limit as per the Bureau of Indian *** heavy metal pollution index(HPI) and contamination index(Cd) provided contrasting outcome and poor correlation was observed. A heavy metal evaluation index(HEI)method was developed using a multiple of the mean and correlation coefficient values to provide an alternative pollution classification. The criteria of HEI adopted for reclassification of HPI and Cdproduced comparable results; 40 % samples were labeled as low contamination,50 % as medium contamination, and 10 % as high contamination for all indices. Principal component analysis along with cluster analysis was used to identify the main factors responsible for degradation of water quality,namely discharge of industrial effluent, river bed mining,agricultural runoff, and minor natural or geogenic *** methods and chemometric study proposed here can be used as effective tools to gather information about water quality and water resource management.

关键词：化学计量学污染指数评价指标重金属印度盆地模型锡

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Probing and understanding interaction of Eu(Ⅲ)withγ-alumina in presenceof malonic acid

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Journal of Environmental sciences 2021年第2期33卷 181-192页

作者： madhuri A Patel Aishwarya soumitra Kar Vaibhavi V Raut B.s.Tomar Radioanalytical Chemistry Division Bhabha Atomic Research CentreMuambai 400085India Homi Bhabha National institute AnushaktinagarMumbai 400094India

Radionuclide migration in aquatic environment is influenced by its sorption onto colloids/mineral oxides and the presence of organic complexing *** a view to understand the sorption of trivalent actinides by mineral oxides in presence of organic acid,in the present study,Eu(Ⅲ),malonic acid(MA)andγ-alumina are considered as representatives of trivalent actinides,low molecular weight natural occurring organic acid and aluminol sites,*** influence of MA on sorption of Eu(Ⅲ)byγ-alumina was elucidated by batch sorption,spectroscopic techniques and surface complexation modeling,for the first *** Total Reflection-Fourier Transform Infrared spectroscopic studies of MA sorbed onγ-alumina revealed the presence of two inner-sphere surface *** sorption for binary(alumina-Eu(Ⅲ))and ternary(alumina-Eu(Ⅲ)-MA)systems were investigated as a function of p H,Eu(Ⅲ)concentration and sequential addition of Eu(Ⅲ)/*** p H edge for Eu(Ⅲ)sorption shifts to higher p H with increasing Eu(Ⅲ)*** ternary systems,Eu(Ⅲ)sorption is significantly enhanced at p Hspeciation onγ-alumina is independent of addition sequence of Eu(Ⅲ)/*** resolved fluorescence spectroscopy of Eu(Ⅲ)sorbed onγ-alumina exhibited two surface species,≡XOEu^2+and(≡YO)2 Eu^(+).The enhancement in I 616/I 592 and lifetime for ternary systems,as compared to binary system,at low p H,indicates the participation of Eu-MA complexes in the formation of surface species in ternary *** diffuse layer model has been employed to successfully model the experimental sorption profiles of binary and ternary systems,using code FITEQL 4.0,by considering the surface species identified by spectroscopic techniques.

关键词： Malonic acid Eu(Ⅲ) γ-alumina sorption ATR-FTIR TRFs surface complexation modeling

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

Robertson-Walker cosmological models with perfect fluid in general relativity

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Research in Astronomy and Astrophysics 2011年第7期11卷 767-775页

作者： rishi Kumar Tiwari Department of Mathematics Govt.Model Science College Rewa(M.P.) 486001India

Einstein＇s field equations with variable gravitational and cosmological constants are considered in the presence of perfect fluid for a Robertson-Walker universe by assuming the cosmological term to be proportional to R-m（R is a scale factor and m is a constant）.A variety of solutions is *** physical significance of the cosmological models has also been discussed.

关键词： cosmological parameters—cosmology:variable cosmological term

Enhanced Deep Learning for Detecting suspicious Fall Event in Video Data

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Intelligent Automation & soft Computing 2023年第6期36卷 2653-2667页

作者： madhuri Agrawal shikha Agrawal Department of CsE University Institute of TechnologyRajiv Gandhi Proudyogiki VishwavidyalayaBhopalIndia

suspicious fall events are particularly significant hazards for the safety of patients and ***,suspicious fall event detection has become a robust research case in real-time *** paper aims to detect suspicious fall events during video monitoring of multiple people in different moving back-grounds in an indoor environment;it is further proposed to use a deep learning method known as Long short Term Memory(LsTM)by introducing visual atten-tion-guided mechanism along with a bi-directional LsTM *** method contributes essential information on the temporal and spatial locations of‘suspi-cious fall’events in learning the video frame in both forward and backward *** effective“You only look once V4”(YOLO V4)–a real-time people detection system illustrates the detection of people in videos,followed by a track-ing module to get their *** Neural Network(CNN)fea-tures are extracted for each person tracked through bounding ***,a visual attention-guided Bi-directional LsTM model is proposed for the final suspicious fall event *** proposed method is demonstrated using two different datasets to illustrate the *** proposed method is evaluated by comparing it with other state-of-the-art methods,showing that it achieves 96.9%accuracy,good performance,and ***,it is accep-table to monitor and detect suspicious fall events.

关键词： Convolutional neural network(CNN) Bi-directional long short term memory(Bi-directional LsTM) you only look once v4(YOLO-V4) fall detection computer vision