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Functional analysis and screening small molecules to RpfF protein in Xanthomonas oryzae involved in rice bacterial blight disease

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Journal of Integrative Agriculture 2020年第3期19卷 735-747页

作者： Mundla Srilatha Naina Patyal madhu Sudhana Saddala Department of Biotechnology Sri Venkateswara UniversityTirupati 517502India Department of Bioinformatics and Computational Biology Central University of Himachal PradeshKangra 176206India Mason Eye Institute University of Missouri School of MedicineColumbia 65202USA

Xanthomonas oryzae ***(Xoo) is an important rice *** is a vascular pathogen entering the plant via the hydathodes causing rice bacterial *** has been known that most regulation of pathogenicity factor F(RpfF) genes in Xanthomonas regulates virulence in response to the diffusible signal factor(DSF).The RpfF recognized as an attractive drug target in bacterial rice blight *** this study,we performed the gene-gene interaction of RpfF and pathway functional analysis.3 D structure of RpfF protein was predicted using a homology modelling tool Swiss-Model and refined by molecular dynamics(MD) *** refined model protein was predicted structural assessment using various tools such as PROCHECK,ERRAT,and VERIFY-3 *** have collected 2 500 rifampicin analogues from Zinc Database by virtual *** screened compounds were docked into the active site of the RpfF protein using AutoDock Vina in PyRx Virtual Screening ***,docking result and in silico ADMET analysis described that the compounds ZINC03056414,ZINC03205310,ZINC08673779,ZINC09100848,ZINC09729566,ZINC11415953,ZINC12810788,ZINC24989313,ZINC27441787 and ZINC32739565 have best binding energies and less toxicity than reference *** study revealed that the active site residues such as HIS-118,HIS-147,THR-148,ARG-179,ASP-207,ARG-240 and THR-244 are key roles in the *** could be beneficial in the design of small molecule therapeutics or the treatment of rice bacterial blight disease.

关键词： RpfF virtual screening molecular dynamics docking Zinc Database

Deep Stacked Ensemble Learning Model for COVID-19 Classification

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Computers, Materials & Continua 2022年第3期70卷 5467-5486页

作者： G.madhu B.Lalith Bharadwaj Rohit Boddeda Sai Vardhan K.Sandeep Kautish Khalid Alnowibet Adel F.Alrasheedi Ali Wagdy Mohamed Department of Information Technology VNRVJIETHyderabad500090India Department of Computer Science and Engineering VNRVJIETHyderabad500090India LBEF Campus Kathmandu44600Nepal Statistics and Operations Research Department College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Wireless Intelligent Networks Center(WINC) School of Engineering and Applied SciencesNile UniversityGiza12588Egypt

COVID-19 is a growing problem worldwide with a high mortality *** a result,the World Health Organization(WHO)declared it a *** order to limit the spread of the disease,a fast and accurate diagnosis is required.A reverse transcript polymerase chain reaction(RT-PCR)test is often used to detect the ***,since this test is time-consuming,a chest computed tomography(CT)or plain chest X-ray(CXR)is sometimes *** value of automated diagnosis is that it saves time and money by minimizing human *** significant contributions are made by our *** initial purpose is to use the essential finetuning methodology to test the action and efficiency of a variety of vision models,ranging from Inception to Neural Architecture Search(NAS)***,by plotting class activationmaps(CAMs)for individual networks and assessing classification efficiency with AUC-ROC curves,the behavior of these models is visually ***,stacked ensembles techniques were used to provide greater generalization by combining finetuned models with six ensemble neural *** stacked ensembles,the generalization of the models ***,the ensemble model created by combining all of the finetuned networks obtained a state-of-the-art COVID-19 accuracy detection score of 99.17%.The precision and recall rates were 99.99%and 89.79%,respectively,highlighting the robustness of stacked *** proposed ensemble approach performed well in the classification of the COVID-19 lesions on CXR according to the experimental results.

关键词： COVID-19 classification class activation maps(CAMs)visualization finetuning stacked ensembles automated diagnosis deep learning

Mechanical and electronic approaches to improve the sensitivity of microcantilever sensors

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Acta Mechanica Sinica 2009年第1期25卷 1-12页

作者： madhu Santosh Ku Mutyala Deepika Bandhanadham Vijaya Rohini Pendyala Institute for Micromanufacturing Louisiana Tech University

Advances in the field of micro electro mechanical systems and their uses now offer unique opportunities in the design of ultrasensitive analytical tools. The analytical community continues to search for cost-effective, reliable, and even portable analytical techniques that can give reliable and fast response results for a variety of chemicals and biomolecules. Microcantilevers （MCLs） have emerged as a unique platform for label-free chem-sensor or bioassay. Several electronic designs, including piezoresistive, piezoelectric, and capacitive approaches, have been applied to measure the bending or frequency change of the MCLs upon exposure to chemicals. This review summarizes mechanical, fabrication, and electronics approaches to increase the sensitivity of MCL sensors.

关键词： Microcantilever Sensor MEMS Sensitivity

Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients

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World Journal of Diabetes 2017年第3期8卷 112-119页

作者： Neerja Aggarwal Pawan kumar Kare Parul Varshney Om Prakash Kalra Sri Venkata madhu Basu Dev Banerjee Anil Yadav Alpana Raizada Ashok kumar Tripathi Department of Medicine University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital Department of Biochemistry University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital Pt. B. D. Sharma University of Health Sciences

AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) *** In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and < 300 mg/g creatinine) or macro-albuminuric(≥ 300 mg/g creatinine) at the time of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms.

关键词：糖尿病的 nephropathy 变换酶禁止者治疗的血管收缩素 Renin-angiotensin-aldosterone 系统基因多型性应答者尿 albumin/creatinine 比率蛋白尿

Approaches for Optimal Planning of Energy Storage Units in Distribution Network and Their Impacts on System Resiliency

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CSEE Journal of Power and Energy Systems 2020年第4期6卷 816-833页

作者： Balaji Venkateswaran V Devender K.Saini madhu Sharma Department of Electrical and Electronics Engineering University of Petroleum and Energy StudiesDehradun 248007India

In the recent decade,a significant increase in the penetration level of renewable energy sources(RESs)into the distribution grid is evident due to the world’s shift towards clean energy and to increase the reliability or inboard manner resiliency of electrical distribution *** based microgrids are the most favorable option available,especially to enhance ***,the integration of RES over the distribution grid would hamper the grid stability due to its stochastic nature under normal *** extreme weather conditions,RES behavior is completely *** there is a need to eliminate the adverse effects caused by the RES and make the distribution grid more reliable and stable under normal and resilient *** address these issues,many researchers proposed several methods to place energy storage units(ESUs)and microgrids(RES integrated),which can support critical loads at an optimal location in the distribution system during normal and extreme conditions,*** aim of this article is to consolidate and review the research towards various approaches to formulate the problem(optimal location,allocation,and operation of ESU and microgrids to face regular and extreme weather condition)and tools to solve it for enhanced system flexibility and *** on the review,a generalized methodology has been designed to adapt the inputs and address both *** the end of the review,future aspects for ESU to strengthen resistance and resiliency of its own are presented,which can be helpful to further improve the reliability and resiliency of the distribution system.

关键词： Energy storage units(ESUs) electrical distribution grid resiliency renewable energy sources(RES)

Influence of welding consumables on tensile and impact properties of multi-pass SMAW Armox 500T steel joints vis-a-vis base metal

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Defence Technology（防务技术） 2018年第3期14卷 188-195页

作者： Ambuj Saxena A.kumaraswamy G.madhusudhan Reddy Vemuri madhu Defence Institute of Advanced Technology(DU) Pune 411025India Defence Metallurgical Research Laboratory KanchanbaghHyderabad 500048India

In this investigation, comparative study of tensile and impact properties of multi-pass SMAW Armox500 T steel joints fabricated by austenitic stainless steel(ASS) and low hydrogen ferritic steel(LHF)consumables vis-a-vis base metal was carried out. The tensile tests were conducted on computer controlled Walter t Bai Ag UTM at a nominal strain rate of 10à3 sà1. Subsequently, charpy impact tests were carried out on an instrumented Zwick-Roell test setup to obtain load vs. displacement and maximum energy absorbed vs. displacement of the specimen. It was observed that, the joint efficiency of weldment processed by LHF consumable was 41.7% and weldment processed by ASS was 30.6% of its base metal indicating the influence of electrode consumable on tensile properties of the joints. On the contrary, impact toughness of weldment processed by ASS was 20% more and weldment processed by LHF was 12% less than that of base metal. Microstructural studies also revealed that, ASS can be considered as a candidate welding consumable for good strain hardening and toughness of the welding joint in impact applications. However, LHF steel consumable is recommended for welding joints that requires higher joint efficiency under tensile loading conditions.

关键词： SMAW 不锈钢金属相焊接张力关节性质传递

THE EFFECT OF MAGNETIC FIELDS ON LOW FREQUENCY OSCILLATING NATURAL CONVECTION WITH PRESSURE GRADIENT

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Applied Mathematics and Mechanics(English Edition) 2003年第3期24卷 274-283页

作者： G.C.Sharma madhu Jain Mahesh Chandra School of Mathematical Sciences Institute of Basic ScienceSchool of Mathematical SciencesInstitute of Basic ScienceSchool of Mathematical SciencesInstitute of Basic Science KhandariAgra-282002IndiaKhandariAgra-282002IndiaKhandariAgra-282002India

The oscillating natural convection in the presence of transverse magnetic field with time depending pressure gradient is studied. The analysis of the problem is carried out by assuming that the fluid is flowing in a parallel plate configuration. The emphasis is on low frequency oscillating convective flows induced by g-jitter associated with micro gravity because of their importance to the space processing materials. A general solution for an oscillating flow in the presence of transverse magnetic field is carried out. Some special cases of the oscillating flow and its response to an applied magnetic field are performed. It was observed that the behavior of oscillating free convective flows depends on frequency, amplitude of the driving buoyancy forces, temperature gradient,magnetic field and the electric conditions of the channel walls. In the absence of magnetic field, buoyancy force plays a predominant role in driving the oscillatory flow pattern, and velocity magnitude is also affected by temperature gradients. To suppress the oscillating flow external magnetic field can be used. It is also found that the reduction of the velocity is inversely proportional to the square of the applied magnetic field with conducting wall but directly proportional to the inverse of the magnetic field with insulating wall. Detailed calculations and computational results are also carried out to depict the real situation.

关键词： convection g- jitter acceleration buoyancy force magnetic field pressure gradient

Multi-objective optimization of feature selection using hybrid cat swarm optimization

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Science China(Technological Sciences) 2021年第3期64卷 508-520页

作者： GAO Xiao-Zhi NALLURI madhu Sudana Rao KANNAN K SINHAROY Diptendu School of Computing University of Eastern FinlandKuopio 70210Finland School of Engineering Department of MathematicsAmrita Vishwa VidyapeethamCoimbator 641112India School of Humanities and Sciences SASTRA UniversityThanjavur 612001India Department of Computer Science and Engineering National Institute of TechnologyMeghalayaShillong 793003India

With the pervasive generation of information from a wide range of sensors and devices,there always exist a large number of input features in databases,thus complicating machine learning problem ***,certain features are relatively impertinent to specific problems,which may degrade the performances of classifiers in terms of prediction accuracy,sensitivity,specificity,and recall *** main goal of a multi-objective optimization problem is to identify the subsets of the given *** this end,a hybrid cat swarm optimization(HCSO)algorithm is proposed in our paper for performance improvement of the basic cat swarm optimization(CSO)that incorporates guided and competitive&inherent characteristics into the original *** performance of HCSO has been tested by finding the optimal feature subset for 15 benchmark *** number of class labels for these datasets varies between 2 and *** time complexity analysis of both CSO and HCSO has also been ***,the performance of the proposed algorithm has been compared with that of simple CSO and other state-ofthe-art *** performances obtained by HCSO have an average 2.68%improvement with a standard deviation of *** maximum performance improvement is up to 10.09%in prediction *** on the same datasets,CSO has yielded improvements within the range of-7.27%to 8.51%with an average improvement 0.9%and standard deviation *** statistical tests carried out in the experiments prove that HCSO manifests a moderately better feature selection capacity than that of its counterparts.

关键词： feature selection competition cat swarm optimization guided search parameter evolution

Camelina sativa,a short gestation oilseed crop with biofuel potential:Opportunities for Indian scenario

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Oil Crop Science 2021年第3期6卷 114-121页

作者： Ankur Agarwal Om Prakash madhu Bala Defence Institute of Bio-Energy Research Defence R&D OrganizationGoraparaoP.O.ArjunpurHaldwaniUttarakhand263139India

Camelina is an oilseed crop which is being commercially produced globally as feedstock for *** a non-edible oil bearing low input crop owing to its low fertilizer and water requirement,fits well for biofuel *** India,targets for biofuel blending has been set by New Biofuel Policy-2018 and to meet these targets efforts are being made to harness the potential of available feedstock in the *** these feedstock,contribution of short gestation oilseed bearing crop has been very *** has been introduced in India during 2009–10 as experimental crop by DIBER,*** then various efforts have made to standardize the production technology of this crop under various agro-climatic regions of the country,crop improvement,oil quality analysis and development of high energy *** has various advantages to offer for Indian biofuel *** paper reviews the potential of this crop for Indian Biofuel scenario.

关键词： Camelina False flax Production Agro-technology Crop improvement Economics