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Advancing orthopaedic trauma care through WhatsApp:An analysis of clinical and non-clinical applications,challenges,and future directions

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World Journal of Orthopedics 2024年第6期15卷 529-538页

作者： Ravi Saini madhan jeyaraman Naveen jeyaraman Vijay Kumar Jain Swaminathan Ramasubramanian Karthikeyan P Iyengar Department of Orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalNew Delhi 110001India Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Trauma and Orthopaedics Southport and Ormskirk HospitalsMersey and West Lancashire Teaching NHS TrustSouthport PR86PNUnited Kingdom

The integration of WhatsApp,a widely-used instant messaging application(IMA),into the realm of orthopaedics and trauma surgery has emerged as a significant development in recent *** paper explores the multifaceted role of WhatsApp in orthopaedics,focusing on its clinical and non-clinical applications,advantages,disadvantages,and future *** study synthesizes findings from various research papers,emphasizing the growing reliance on mobile technology in ***’s role in orthopaedics is notable for its ease of use,real-time communication,and ***,it facilitates triage,teleconsultation,diagnosis,treatment,patient advice,and post-operative ***-clinically,it supports telemedicine,teleradiology,virtual frac-ture clinics,research,and education in orthopaedic *** application has proven beneficial in enhancing communication among healthcare teams,providing quick responses,and motivating junior *** use in educational settings has been shown to improve learner’s understanding and patient ***,the use of WhatsApp in orthopaedics is not without *** include the potential spread of misleading information,privacy concerns,and issues with image quality affecting diagnosis and treatment *** paper acknowledges the importance of maintaining professional boundaries and the need for oversight measures to ensure content *** forward,the potential of WhatsApp and similar IMAs in orthopaedics lies in their ability to streamline data collection and retrieval,improve doctor-patient communication,and address challenges like bureaucratic red tape and limited *** paper suggests that future orthopaedic practice,particularly in emergency departments,will increasingly rely on such technologies for efficient patient *** shift,however,must be approached with an understanding of the ethical,legal,and practical implications of integrating social media and mobile

关键词： Social media WhatsApp Orthopaedics Trauma Research

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Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： madhan jeyaraman Naveen jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh Kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

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Optimizing outcomes:Implementing enhanced recovery after surgery in orthopedic surgery

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World Journal of Methodology 2024年第4期14卷 6-12页

作者： Sathish Muthu madhan jeyaraman Naveen jeyaraman Swaminathan Ramasubramanian Department of Orthopedics Orthopedic Research GroupTamil NaduCoimbatore 641045India Department of Orthopedics Government Medical CollegeTamil NaduKarur 639003India Department of Biotechnology Karpagam Academy of Higher EducationTamil NaduCoimbatore 641021India Department of Orthopedics ACS Medical College and HospitalDr MGR Educational and Research InstituteTamil NaduChennai 600077India Department of Orthopedics Government Medical CollegeOmandurar Government EstateTamil NaduChennai 600002India

In the realm of orthopedics,the adoption of enhanced recovery after surgery(ERAS)protocols marks a significant stride towards enhancing patient *** embracing a holistic approach that encompasses preoperative counseling,dietary optimization,minimally invasive procedures,and early postoperative mobilization,these protocols have ushered in a new era of surgical *** encountering hurdles like resistance to change and resource allocation challenges,the efficacy of ERAS protocols in improving clinical outcomes is *** benefits include shortened hospital stays and bolstered improved patient-safety *** ahead,the horizon for ERAS in orthopedics appears bright,with an emphasis on tailoring care to individual needs,integrating cutting-edge technologies,and perpetuating research *** shift towards a more personalized,streamlined,and cost-efficient model of care underscores the transformative potential of ERAS in reshaping not only orthopedic surgery but also the journey to patient *** editorial details the scope and future of ERAS in the orthopedic specialty.

关键词： Enhanced recovery after surgery Orthopedic surgery Perioperative care Personalized care Patient reported outcome measure Complications

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Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells:A systematic review

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World Journal of Methodology 2024年第2期14卷 134-144页

作者： Vamsi Krishna Mundluru MJ Naidu Ravi Teja Mundluru Naveen jeyaraman Sathish Muthu Swaminathan Ramasubramanian madhan jeyaraman Department of Orthopaedics MJ Naidu Super Speciality HospitalVijayawada 520002Andhra PradeshIndia Department of Regenerative Medicine StemC ClinicsVijayawada 520002Andhra PradeshIndia Department of Orthopaedics ACS Medical College and HospitalDr.MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

BACKGROUND Adipose-derived stem cells(ADSCs)and the stromal vascular fraction(SVF)have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of *** enzymatic methods for isolating these cells face challenges such as high costs,lengthy processing time,and regulatory *** This systematic review aimed to assess the efficacy and practicality of nonenzymatic,mechanical methods for isolating SVF and ADSCs,comparing these to conventional enzymatic *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a comprehensive literature search was conducted across multiple *** were selected based on inclusion criteria focused on non-enzymatic isolation methods for SVF and ADSCs from adipose *** risk of bias was assessed,and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included *** Nineteen studies met the inclusion criteria,highlighting various mechanical techniques such as centrifugation,vortexing,and ultrasonic *** review identified significant variability in cell yield and viability,and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic *** some advantages of mechanical methods,including reduced processing time and avoidance of enzymatic reagents,the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic *** Non-enzymatic,mechanical methods offer a promising alternative to enzymatic isolation of SVF and ADSCs,potentially simplifying the isolation process and reducing regulatory ***,further research is necessary to standardize these techniques and ensure consistent,high-quality cell yields for clinical *** development of efficient,safe,and reproducible non-enzymatic isolation methods could signi

关键词： Adipose-derived stem cells Stromal vascular fraction Regenerative medicine Non-enzymatic isolation Mechanical separation techniques

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Comparative evaluation of artificial intelligence systems'accuracy in providing medical drug dosages:A methodological study

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World Journal of Methodology 2024年第4期14卷 121-130页

作者： Swaminathan Ramasubramanian Sangeetha Balaji Tejashri Kannan Naveen jeyaraman Shilpa Sharma Filippo Migliorini Suhasini Balasubramaniam madhan jeyaraman Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Paediatric Surgery All India Institute of Medical SciencesNew Delhi 110029India Department of Life Sciences HealthLink Campus UniversityRome 00165Italy Department of Orthopaedic and Trauma Surgery Academic Hospital of Bolzano(SABES-ASDAA)Teaching Hospital of the Paracelsus Medical UniversityBolzano 39100Italy Department of Radio-Diagnosis Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia

BACKGROUND Medication errors,especially in dosage calculation,pose risks in *** intelligence(AI)systems like ChatGPT and Google Bard may help reduce errors,but their accuracy in providing medication information remains to be *** To evaluate the accuracy of AI systems(ChatGPT 3.5,ChatGPT 4,Google Bard)in providing drug dosage information per Harrison's Principles of Internal *** A set of natural language queries mimicking real-world medical dosage inquiries was presented to the AI *** were analyzed using a 3-point Likert *** analysis,conducted with Python and its libraries,focused on basic statistics,overall system accuracy,and disease-specific and organ system *** ChatGPT 4 outperformed the other systems,showing the highest rate of correct responses(83.77%)and the best overall weighted accuracy(0.6775).Disease-specific accuracy varied notably across systems,with some diseases being accurately recognized,while others demonstrated significant *** system accuracy also showed variable results,underscoring system-specific strengths and *** ChatGPT 4 demonstrates superior reliability in medical dosage information,yet variations across diseases emphasize the need for ongoing *** results highlight AI's potential in aiding healthcare professionals,urging continuous development for dependable accuracy in critical medical situations.

关键词： Dosage calculation Artificial intelligence ChatGPT Drug dosage Healthcare Large language models

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Evolution of evidence in spinal surgery–past,present and future Scientometric analysis of randomized controlled trials in spinal surgery

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World Journal of Orthopedics 2022年第9期13卷 853-869页

作者： Sathish Muthu madhan jeyaraman Naveen jeyaraman Department of Orthopaedics Government Medical College and HospitalDindigul 624304Tamil NaduIndia Department of Orthopaedics Faculty of Medicine–Sri Lalithambigai Medical College and HospitalDr MGR Educational and Research InstituteChennai 600095Tamil NaduIndia Department of Orthopaedics Atlas HospitalsTiruchirappalli 620002Tamil NaduIndia

BACKGROUND Spine surgery is evolving and in the due course of its evolution,it is useful to have a comprehensive summary of the process to have a greater understanding to refine our future *** the multiple domains of research in the spine,it has become difficult for a surgeon to find the potential hotspots in research or identify the emerging research *** To analyze RCTs(1990–2019)for potential research domains along with their research networks and identify the hot topics for future *** A comprehensive and systematic analysis of all the RCTs published on spinal surgery from 1990 to 2019 retrieved from the Web of Science Core Collection *** and visual analysis of their characteristics,cooperation networks,keywords,and citations were made using CiteSpace *** and article impact index were retrieved from Reference Citation Analysis(RCA)*** A total of 696 RCTs were published on spinal surgery from 1990 to 2019;of which,the United States(n=263)and China(n=71)made a significant *** Jefferson University(n=16)was the leading contributor to RCTs on spinal *** JN was the most cited author in the field followed by Deyo ***(n=559)remained the top-cited journal for RCTs on spinal *** literature co-citation analysis,spinal stenosis,anterior cervical discectomy and fusion,degenerative disc disease,and minimally invasive decompression were identified as the hotspots and potential research *** The identified hotspots that extending the frontiers in the management of degenerative disorders of the spine through further research holds the potential for advancement in spinal care.

关键词： Randomized controlled trials Scientometrics Spine surgery

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Revitalizing case reports: Standardized guidelines and mentorship

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World Journal of Clinical Cases 2023年第19期11卷 4729-4733页

作者： madhan jeyaraman Swaminathan Ramasubramanian Naveen jeyaraman Arulkumar Nallakumarasamy Shilpa Sharma Department of Orthopaedics ACS Medical College and HospitalChennai 600056Tamil NaduIndia Department of General Medicine Government Medical CollegeOmandurar Government EstateChennai 600018Tamil NaduIndia Department of Orthopaedics Shri Sathya Sai Medical College and Research InstituteSri Balaji VidyapeethChengalpet 603108Tamil NaduIndia Department of Orthopaedics All Indian Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Paediatric Surgery All India Institute of Medical SciencesNew Delhi 110029India

Despite a decrease in publication,case reports remain essential in medical literature as they offer detailed descriptions of individual patient cases and valuable insights for future *** reports adhere to a standardized structure comprising sections such as abstract,introduction,case report,discussion,and *** informed consent and adhering to guidelines is *** reports contribute to evidence-based medicine by detecting new therapies and adverse *** also facilitate clear reporting,guideline adherence,and mentorship *** reports are vital for documenting rare occurrences,assisting clinicians in timely management,and communicating novel information to busy medical *** case report guidelines ensures comprehensive and standardized reporting,enhancing the acceptance and quality of case reports,and advancing medical knowledge.

关键词： Case report Case report guidelines Literature Research

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Silver nanoparticle technology in orthopaedic infections

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世界骨科杂志:英文版 2023年第9期14卷 662-668页

作者： madhan jeyaraman Naveen jeyaraman Arulkumar Nallakumarasamy Karthikeyan P Iyengar Vijay Kumar Jain Anish G Potty Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Trauma and Orthopaedics Southport&Ormskirk Hosp NHS Trust SouthportRichmond PR86PNSouthportUnited Kingdom Department of Orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalDelhi 110001New DelhiIndia Department of Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Regenerative Medicine BioIntegarteLawrencevilleGA 30043United States

The irrational and prolonged use of antibiotics in orthopaedic infections poses a major threat to the development of antimicrobial *** combat antimi-crobial resistance,researchers have implemented various novel and innovative modalities to curb *** involves doping ions/metals onto the scaffolds to reach the target site to eradicate the infective *** this conno-tation,we reviewed silver nanoparticle technology in terms of mechanism of action,clinical applications,toxicity,and regulatory guidelines to treat ortho-paedic infections.

关键词： Antimicrobial resistance Biofilms Silver Nanoparticles Orthopaedics

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Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis:A meta-analysis

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World Journal of Orthopedics 2023年第1期14卷 23-41页

作者： Sathish Muthu Sandesh C Patil Naveen jeyaraman madhan jeyaraman Prakash Gangadaran Ramya Lakshmi Rajendran Eun Jung Oh Manish Khanna Ho Yun Chung Byeong-Cheol Ahn Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater Noida 201310Uttar PradeshIndia jeyaraman Research AssociateOrthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Indian Stem Cell Study Group Association Lucknow 226001Uttar PradeshIndia Department of Orthopaedic Rheumatology Dr.RML National Law UniversityLucknow 226012Uttar PradeshIndia ACS Medical College&Hospital Dr MGR Educational and Research InstituteChennai 600056Tamil NaduIndia BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents Department of Biomedical SciencesSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Plastic and Reconstructive Surgery CMRIKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Plastic and Reconstructive Surgery School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 41944South Korea

BACKGROUND Osteoarthritis(OA)is the most common joint disorder,is associated with an increasing socioeconomic impact owing to the ageing *** To analyze and compare the efficacy and safety of bone-marrow-derived mesenchymal stromal cells(BM-MSCs)and adipose tissue-derived MSCs(AD-MSCs)in knee OA management from published randomized controlled trials(RCTs).METHODS Independent and duplicate electronic database searches were performed,including PubMed,EMBASE,Web of Science,and Cochrane Library,until August 2021 for RCTs that analyzed the efficacy and safety of AD-MSCs and BM-MSCs in the management of knee *** visual analog scale(VAS)score for pain,Western Ontario McMaster Universities Osteoarthritis Index(WOMAC),Lysholm score,Tegner score,magnetic resonance observation of cartilage repair tissue score,knee osteoarthritis outcome score(KOOS),and adverse events were *** was performed on the R-platform using OpenMeta(Analyst)***-one studies,involving 936 patients,were *** one study compared the two MSC sources without patient randomization;hence,the results of all included studies from both sources were pooled,and a comparative critical analysis was *** At six months,both AD-MSCs and BM-MSCs showed significant VAS improvement(P=0.015,P=0.012);this was inconsistent at 1 year for BM-MSCs(P<0.001,P=0.539),and AD-MSCs outperformed BM-MSCs compared to controls in measures such as WOMAC(P<0.001,P=0.541),Lysholm scores(P=0.006;P=0.933),and KOOS(P=0.002;P=0.012).BM-MSC-related procedures caused significant adverse events(P=0.003)compared to AD-MSCs(P=0.673).CONCLUSION Adipose tissue is superior to bone marrow because of its safety and consistent efficacy in improving pain and functional *** trials are urgently warranted to validate our findings and reach a consensus on the ideal source of MSCs for managing knee OA.

关键词： Mesenchymal stromal cell Adipose tissue-derived mesenchymal stromal cell Bone-marrow derived mesenchymal stromal cell Cartilage regeneration Knee osteoarthritis Meta-analysis Efficacy Safety

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ChatGPT in action:Harnessing artificial intelligence potential and addressing ethical challenges in medicine,education,and scientific research

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World Journal of Methodology 2023年第4期13卷 170-178页

作者： madhan jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Naveen jeyaraman Arulkumar Nallakumarasamy Shilpa Sharma Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of General Medicine Government Medical CollegeOmandurar Government EstateChennai 600018Tamil NaduIndia Department of Paediatric Surgery All India Institute of Medical SciencesDelhi 110029New DelhiIndia

Artificial intelligence(AI)tools,like OpenAI's Chat Generative Pre-trained Transformer(ChatGPT),hold considerable potential in healthcare,academia,and diverse *** demonstrates its capability at a medical student level in standardized tests,suggesting utility in medical education,radiology reporting,genetics research,data optimization,and drafting repetitive texts such as discharge ***,these tools should augment,not supplant,human *** promising applications,ChatGPT confronts limitations,including critical thinking tasks and generating false references,necessitating stringent *** concerns,such as potential misuse,bias,blind trust,and privacy,underscore the need for transparency,accountability,and clear *** of AI-generated content and preservation of academic integrity are *** responsible use,AI can significantly improve healthcare,academia,and industry without compromising integrity and research *** effective and ethical AI deployment,collaboration amongst AI developers,researchers,educators,and policymakers is *** development of domain-specific tools,guidelines,regulations,and the facilitation of public dialogue must underpin these endeavors to responsibly harness AI's potential.

关键词： Artificial intelligence ChatGPT Open artificial intelligence Education Research

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