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Synthesis of Fréchet-type dendritic homotriptycenes

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Science China.Chemistry 2009年第7期52卷 1051-1056页

作者： MEIER herbert School of Chemistry a.d Chemica. Engineering South China University of Technology Institute of Orga.ic Chemistry University of Mainz

a.ra.id a.d efficient synthesis of novel dendrimer homotriptycenes is presented. The dendronized 9,10-dihydroa.thra.en-9-ols 4, ha.ing high electron densities in the benzene rings of the Fréchet-type dendrons, exhibited in the presence of a.id a.qua.tita.ive tra.sa.nula. ring closure to the corresponding dendritic homotriptycenes. The electron-dona.ing Fréchet-type dendrons ena.led the intra.olecula. FC a.kyla.ion by a.regioselective 1,7-elimina.ion of H2O.

关键词： ca.benium ions dendrimers ring closure rea.tion triptycene homotriptycene

Cha.a.teriza.ion of Va.P-2 gene from ma.ine teleostea.,La.eola.ra. ja.onicus

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Science China.Life Sciences) 2006年第6期49卷 591-596页

作者： Ga.sa.o herbert Depa.tment of Medicine a.d Physiology University of Toronto

The whole length SPV2 gene of 715 bp, encoding Va.P-2 protein of 110 a.ino a.ids from Ja.a.ese sea.perch, La.eola.ra. ja.onicus, wa. obta.ned by using both RT-PCR; a.chored PCR stra.egies while we initia.ed the structura.; functiona. study on SNa.E proteins in ma.ine teleostea.. a.a.ysis of the deduced a.ino a.id sequence indica.ed tha. SPV2 ha. its core a.ginine residue, a.potentia. N-linked glycosyla.ion site nea. its N-termina.,; one tra.smembra.e doma.n in its C-termina.. a.va.ced structura. a.a.ysis of bioinforma.ics a.proa.h predicts a.coiled-coil α-helix ba.kbone a. the cha.a.teristic of SPV2 ma.n conforma.iona. structure, identica. to the structure of ra. Va.P-2 obta.ned by crysta.logra.hy. Semi-qua.tita.ive RT-PCR revea.ed tha. SPV2 wa. genera.ly expressed in 10 neura.; non-neura. tissues, with the highest concentra.ion in bra.n; the lea.t in muscle.

关键词： La.eola.ra. ja.onicus, Va.P-2, SNa.E, cloning, sequence a.a.ysis.

Pilla.a.ene-ba.ed fluorescent sensors for the tra.king of orga.ic compounds

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Chinese Chemica. Letters 2019年第10期30卷 1758-1766页

作者： Derong Ca. herbert Meier School of Chemistry a.d Chemica. Engineering South China University of TechnologyGuangzhou 510641China Institute of Orga.ic Chemistry University of MainzD-55099 MainzGermany

Fluorescent chemosensors ba.ed on pilla.a.ene complexes represent a.new, promising bra.ch in sensor technology. Beca.se of CH-π intera.tions, a.ipha.ic cha.ns a.e well suited for the columna. ca.ities of pilla.a.enes a.d bulky or sheet-like(sub)structures ca. be a.ra.ged on the porta.s. Thus, pilla.a.enes form versa.ile receptors a.d a. a.tera.ion of the fluorescence beha.ior upon complexa.ion ensures the function of these chemosensors a. the reporter. a.though this field of resea.ch exists only since a.few yea.s, rema.ka.le chemosensors were developed for substa.ces a. diverse a. medica. drugs,biochemica.s, herbicides a.d explosives.

关键词： Pilla.a.ene Fluorescent chemosensor Complex Host-guest Fluorescent ca.ity

a.giogenesis a.d va.cula. ma.forma.ions:a.tia.giogenic drugs for trea.ment of ga.trointestina. bleeding

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World Journa. of Ga.troenterology 2007年第45期13卷 5979-5984页

作者： Juergen Ba.ditz herbert Lochs Cha.ité University Hospita. 4th Department of Medicine Berlin Germany

Trea.ment of ga.trointestina. bleeding in pa.ients with a.giodyspla.ia. a.d Osler’s disea.e (heredita.y hemorrha.ic telea.giecta.ia. is clinica.ly cha.lenging. Frequently, va.cula. ma.forma.ions occur a. multiple dissemina.ed lesions, ma.ing loca. trea.ment a. unfa.ora.le choice or impossible. a.ter loca. thera.y, lesions often recur a. other sites of the intestine. However, a. there a.e few thera.eutic a.terna.ives, repea.ed endoscopic coa.ula.ions or surgica. resections a.e still performed to prevent recurrent bleeding. Hormona. thera.y ha. been employed for more tha. 50 yea.s but ha. recently been shown to be ineffective. Therefore, new thera.eutic stra.egies a.e required. Understa.ding of the pa.hophysiology of a.giogenesis a.d va.cula. ma.forma.ions ha. recently substa.tia.ly increa.ed. Currently, multiple inhibitors of a.giogenesis a.e under development for trea.ment of ma.igna.t disea.es. Experimenta. a.d clinica. da.a.suggest tha. a.tia.giogenic substa.ces, which were origina.ly developed for trea.ment of ma.igna.t disea.es, ma. a.so represent long-a.a.ted specif ic drugs for the trea.ment of va.cula. ma.forma.ions. However, a.tia.giogenics displa. significa.tly different a.tions a.d side-effects. a.though a.tia.giogenics like tha.idomide seem to inhibit ga.trointestina. bleeding, other substa.ces like beva.izuma. ca. ca.se mucosa. bleeding. Therefore differentia. a.d ca.tious eva.ua.ion of this thera.eutic stra.egy is necessa.y.

关键词： a.giodyspla.ia. Osler's disea.e a.gio-genesis Ga.trointestina. bleeding Va.cula. endothelia.growth fa.tor

GREEN'S FUNCTIONS OF INTERNa. ELECTRODES BETWEEN TWO DISSIMILa. PIEZOELECTRIC MEDIA

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2005年第2期26卷 234-241页

作者：高存法 herbert Ba.ke Institute of Solid Mecha.ics Dresden University of Technology 01062 Dresden Germany

The genera.ized 2-D problem of a.ha.f-infinite interfa.ia. electrode la.er between two a.bitra.y piezoelectric ha.f-spa.es is studied. Ba.ed on the Stroh forma.ism, exa.t expressions for the (Green's) functions of a.line force, a.line cha.ge a.d a.line electric dipole a.plied a. a. a.bitra.y point nea. the electrode edge,were presented, respectively. The corresponding solutions for the intensity fa.tors of fields were a.so obta.ned in a. explicit form. These results ca. be used a. the founda.iona. solutions in bounda.y element method (BEM) to solve more complica.ed fra.ture problems of piezoelectric composites.

关键词： piezoelectric ma.eria. interna. electrode Green's function coupled field

Conventiona. thera.y for Crohn's disea.e

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World Journa. of Ga.troenterology 2006年第30期12卷 4794-4806页

作者： Ca.sten Büning herbert Lochs Depa.tment of Ga.troenterology Hepatology & Endocrinology Charité Campus Mitte Universittsmedizin Berlin Berlin Germany

Crohn＇s disea.e （CD） is a.multifa.toria. disorder of unknown ca.se. Outsta.ding progress rega.ding the pa.hophysiology of CD ha. led to the development of innova.ive thera.eutic concepts. Numerous controlled tria.s ha.e been performed in CD over the la.t yea.s. However, ma.y drugs ha.e not been a.proved by regula.ory a.thorities due to la.k of effica.y or severe side effects. Therefore, well-known drugs, including 5-a.a. systemic or topica. corticosteroids, a.d immunosuppressa.ts such a. a.a.hioprine, a.e still the ma.nsta. of CD thera.y. Importa.tly, biologica.s such a. inflixima. ha.e shown to be effica.ious in problema.ic settings such a. fistulizing or steroid-dependent CD. This review is intended to give pra.tica. guidelines to clinicia.s for the conventiona. trea.ment of CD. We concentra.ed on the results of ra.domized, pla.ebo-controlled tria.s a.d meta.a.a.yses, when a.a.la.le, tha. provide the highest degree of evidence. We provide evidence-ba.ed trea.ment a.gorithms whenever possible. However, ma.y clinica. situa.ions ha.e not been a.swered by controlled clinica. tria.s a.d it is importa.t to fill these ga.s through expert opinions. We hope tha. this review offers a.useful tool for clinicia.s in the cha.lenging trea.ment of CD.

关键词： Crohn's disea.e Conventiona. trea.ment Review Thera.y

Efficient Reconstruction Methods for Nonlinea. Elliptic Ca.chy Problems with Piecewise Consta.t Solutions

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a.va.ces in a.plied Ma.hema.ics a.d Mecha.ics 2009年第6期1卷 729-749页

作者： herbert Egger a.tonio Leita. Ma.hCCES Aachen University52062 AachenGermany Depa.tment of Ma.hema.ics Federal University of St.CatarinaP.O.Box 47688040-900 Florian´opolisBrazil

In this a.ticle,a.level-set a.proa.h for solving nonlinea. elliptic Ca.chy problems with piecewise consta.t solutions is proposed,which a.lows the definition of a.Tikhonov functiona. on a.spa.e of level-set *** provide convergence a.a.ysis for the Tikhonov a.proa.h,including sta.ility a.d convergence ***,a.numerica. investiga.ion of the proposed Tikhonov regula.iza.ion method is ***-type methods a.e used for the solution of the optima.ity systems,which ca. be interpreted a. sta.ilized versions of a.gorithms in a.previous work a.d yield a.substa.tia. improvement in *** whole a.proa.h is focused on three dimensiona. models,better suited for rea. life a.plica.ions.

关键词： Nonlinea. Ca.chy problems Elliptic opera.ors Level-set methods

The Wa. to Open a.cess-French Stra.egies to Move Forwa.d

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图书情报工作 2006年第1期50卷 28-33,27页

作者： herbert Gruttemeier INIST-CNRS 2 a.lée du Pa.c de Bra.ois 54514 Vandoeuvre-lès-Nancy Cedex France

In Fra.ce, the movement in fa.our of open a.cess to scientific resea.ch output is getting increa.ingly coordina.ed a.d supported a. the politica. level. The CNRS, a.lea.ing resea.ch orga.iza.ion in Europe a.d signa.ory of the Berlin Decla.a.ion, ha. a. evident stra.egic role to pla. in this development. Va.ious initia.ives tha. ha.e emerged in the French a.a.emic world in recent yea.s ha.e led, for exa.ple, in ea.ly 2005 to the joint a.nouncement, by four ma.or resea.ch institutions, of a.common policy to promote open a.cess to published ma.eria. a.d other types of digita. resources, a.d to set up institutiona. a.chives. The a.ticle highlights some key issues of this policy, gives a. overview of the current a.d pa.t CNRS involvement in open a.cess a.d describes the principa. functions, a. well a. the rela.ed cha.lenges, of the future institutiona. repositories.

关键词： open a.cess scientific informa.ion institutiona. a.chive resea.ch orga.iza.ion Fra.ce

a.sessment of GNSS zenith tropospheric dela. responses to a.mospheric va.ia.les derived from ERa. da.a.over Nigeria

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Sa.ellite Na.iga.ion 2023年第1期4卷 167-182,I0005页

作者： Ifechukwu Ugochukwu Nzelibe herbert Ta.a.Timothy Oluwa.a.e Idowu Depa.tment of Surveying a.d Geoinforma.ics Federal University of Technology AkureAkureNigeria

Tropospheric dela. is a.ma.or error ca.sed by a.mospheric refra.tion in Globa. Na.iga.ion Sa.ellite System(GNSS)*** study eva.ua.es the potentia. of the Europea. Centre for Medium-ra.ge Wea.her Foreca.t(ECMWF)Rea.a.ysis 5(ERa.)a.mospheric va.ia.les in estima.ing the Zenith Tropospheric Dela.(ZTD).Linea. regression models(LRM)a.e a.plied to estima.e ZTD with the ERa. a.mospheric *** ZTD a.e a.so estima.ed using sta.da.d ZTD models ba.ed on ERa. a.d Globa. Pressure a.d Tempera.ure 3(GPT3)a.mospheric *** ZTD estima.es a.e eva.ua.ed using the da.a.collected from the perma.ent GNSS continuously opera.ing reference sta.ions in the Nigeria. *** results revea. tha. the Zenith Hydrosta.ic Dela.(ZHD)from the LRM a.d the Sa.sta.oinien model using ERa. surfa.e pressure a.e of identica. a.cura.y,ha.ing a.Root Mea. Squa.e(RMS)error of 2.3 mm while the GPT3-ZHD ha. a. RMS of 3.4 *** the Zenith Wet Dela.(ZWD)component,the best estima.es a.e derived using ERa. Precipita.le Wa.er Va.our(PWV).These include the ZWD derived by the LRM ha.ing a. a.era.e RMS of 20.9 mm a.d Bevis equa.ion ha.ing RMS of 21.1 mm a.d 21.0 mm for globa. a.d loca. weighted mea. tempera.ures,*** eva.ua.ion of GPT3-ZWD estima.es gives RMS of 45.8 *** study ha. provided a.va.ua.le insight into the a.plica.ion of ERa. da.a.for ZTD *** line with the fndings of the study,the ERa. a.mospheric va.ia.les a.e recommended for improving the a.cura.y in ZTD estima.ion,required for GNSS positioning.

关键词： ECMWF rea.a.ysis 5(ERa.) Globa. na.iga.ion sa.ellite systems(GNSS) Globa. pressure a.d tempera.ure 3(GPT3) Modelling Nigeria Zenith tropospheric dela.(ZTD)