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Functional Characterization of Porcine (<i>Sus scrofa</i>) BCL10

Open Journal of Immunology 2015年第2期5卷 64-71页

作者： Pellegrino Mazzone Ivan Scudiero Angela Ferravante Marina Paolucci Luca E. D’Andrea Ettore Varricchio Gianluca Telesio maddalena pizzulo Tiziana Zotti Carla Reale Pasquale Vito Romania Stilo Laboratory of Immunogenetics Biogem Via Camporeale Ariano Irpino Italy Dipartimento di Scienze e Tecnologie Università del Sannio Benevento Italy Dipartimento di Medicina molecolare Biotecnologie mediche Università di Napoli “Federico II” Napoli Italy

Human BCL10 (hBCL10) protein is a signal transduction molecule originally identified because of its direct involvement in a subset of mucosa-associated lymphoid tissue (MALT) lymphomas, and later recognized as a crucial factor in regulating activation of NF-kB transcription factor following antigen receptor stimulation on lymphocytes. In this study, we characterized the NF-kB inducing activity of porcine BCL10 (pBCL10). pBCL10 oligimerizes, binds to components of the CARMA/ BCL10/MALT1 complex and forms cytoplasmic filaments. Functionally, in human cells pBCL10 is more effective in activating NF-kB compared to hBCL10, possibly due to the lack of carboxy-terminal inhibitory serine residues present in the human protein. Also, depletion experiments carried out through expression of short hairpin RNAs targeting hBCL10 indicate that pBcl10 can functionally replace the human protein and retains its higher NF-kB-inducing property in the absence of hBCL10. Our results contribute useful information on BCL10 protein in pigs, and may help the development of strategies based on the control of the immune response in pigs.

关键词： BCL10 CARMA NF-kB CARD

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Uterine Artery Embolization for a Safe Surgical Abortion in Human Very High-Order Multifetal Pregnancy: A Case Report

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Open Journal of Obstetrics and Gynecology 2015年第13期5卷 735-739页

作者： Federica Brosio Mizar Paragona Sabrina pizzulo Pascale Riu Daniela Valeriani Giovanna Scassellati Sforzolini Patrizia Logoteta Vittorio Unfer Department of Obstetrics and Gynecology San Camillo Forlanini Hospital Rome Italy Department of Cardiological Science San Camillo Forlanini Hospital Rome Italy AGUNCO Obstetrics and Gynecology Centre Rome Italy

In the last few decades, the use of ovarian stimulation with follicle stimulating hormone (FSH) or clomiphene citrate (CC) increases the percentage of multiple pregnancies. The presence of many follicles can lead to the risk of higher-order multiple pregnancy and ovarian high stimulation syndrome (OHSS). This is correlated to a significant increase in morbidity and mortality maternal and/or fetal rate. For this reason, sometime therapeutic measures are necessary to preserve woman’s health. We describe the case of a surgical abortion using a transcatheter arterial embolization (TAE), a minimally invasive, safe and effective procedure to preserve the patients.

关键词： Multiple Pregnancies Transcatheter Arterial Embolization Abortion Pelvic Hemorrhage

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