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Assessing the welfare of genetically altered mice

中国比较医学杂志 2007年第3期17卷 146-146页

作者： Wells D J Playle L C Enser W E j Flecknell P A Gardiner m A Holland j Howard B RT Hubrecht R Humphreys K R Jackson IJ Lane N maconochie m mason G morton D B Raymond R Robinson V Smith J A Watt N Department of Cellular and molecular Neuroscience Imperial College Faculty of Medicine UK National Centre for the Replacement Refinement and Reduction of Animals in Research UK Harlan UK Ltd UK Comparative Biology Centre University of Newcastle UK mRC mary Lyon Centre UK mRC National Institute formedical Research UK medical School University of Sheffield UK Universities Federation for Animal Welfare UK GlaxoSmithKline UK mRC Human Genetics Unit UK Royal Society for the Prevention of Cruelty toAnimals UK Department of Biology and Environmental Science University of Sussex UK University ofGuelph Canada medical School University of Birmingham UK Cancer Research UK UK Boyd Group UK Home Office Dundee UK

In 2003, under the auspices of the main UK funders of biological and biomedical research, a working group was established with a remit to review potential welfare issues for genetically altered (GA) mice, to summarize current practice, and to recommend contemporary best practi。ce for welfare assessments。The working group has produced a report which makes practical recommendations for GA mouse welfare assessment and dissemination of welfare information between establishments using a 'mouse passport'。The report can be found at www。nc3rs, org。uk/GAmice and www。lal。org。uk/gaa and includes templates for the recommended welfare assessment scheme and the mouse passport。An overview is provided below。

关键词：鼠动物福利评价实验动物遗传

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就地取材——安娜堡图书馆

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中国建筑装饰装修 2011年第12期 78-83页

作者： michael Guthrie Cory Lavigne Jame Haefner Justin maconochie inFORm studio

精选理由Ann Arbor市是密歇根大学Ann Arbor校区的所在地。密歇根大学是美国中西部BigTen十大联盟之一,无论校地大小、校园建筑、学术地位、教学资源、师资或学生素质都是美国州立大学的翘楚。Ann Arbor District Library是该市的公共... 详细信息

精选理由Ann Arbor市是密歇根大学Ann Arbor校区的所在地。密歇根大学是美国中西部BigTen十大联盟之一,无论校地大小、校园建筑、学术地位、教学资源、师资或学生素质都是美国州立大学的翘楚。Ann Arbor District Library是该市的公共图书馆。而此图书馆采用当地已死的树木作为建筑材料。窗户的造型设计成竖条状,仿佛是木材的机理。透过灯光,整个图书馆散发着木头的暖色调,仿佛置身于一棵巨大的树干中。

关键词：公共图书馆就地取材州立大学 Ann 校园建筑教学资源学生素质建筑材料

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对1990～1991年间参加过海湾战争的英国男性退役军人中不孕症患者的研究——生殖队列医学研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 3-3页

作者： maconochie N. Doyle P. Carson C. 石磊 Dept. of Epidemiol. and Pop. Health London Sch. of Hyg. and Trop. Med. University of London LondonWC1E 7HT United Kingdom

Objectives: To examine the hypothesis that, theoretically at least, exposure to toxicants of the type present in the Gulf war could affect spermatogenesis, which might be observed as increased levels of infertility. Design: Retrospective reproductive cohort analysis. Setting: male UK Gulf war veterans and matched comparison group of non deployed servicemen, surveyed by postal ***: 42 818 completed questionnaires were returned, representing response rates of 53%for Gulf veterans and 42%for non Gulf veterans; 10 465 Gulf veterans and 7376 non Gulf veterans reported fathering or trying to father pregnancies after the Gulf war. main outcome measures: Failure to achieve conceptions (type Iinfertility) or live births (type II infertility) after the Gulf war,having tried for at least a year and consulted a doctor;time to conception among pregnancies fathered by men not reporting fertility problems. Results: Risk of reported infertility was higher among Gulf war veterans than among non Gulf veterans (odds ratio for type I infertility 1.41,95%confidence interval 1.05 to 1.89; type II 1.50,1.18 to1.89). This small effect was constant over time since the war and was observed whether or not the men had fathered pregnancies before the war. Results were similar when analyses were restricted to clinically confirmed diagnoses. Pregnancies fathered by Gulf veterans not reporting fertility problems also took longer to conceive (odds ratio for > 1 year 1.18,1.04 to 1.34). Conclusions:We found some evidence of an association between Gulf war service and reported infertility. Pregnancies fathered by Gulf veterans with no fertility problems also reportedly took longer to conceive.

关键词：退役军人医学研究现役军人精子发生能力问题生育问题应答率发病风险于非

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