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Solid-State Metal Additive Manufacturing for Structural Repair

Accounts of Materials Research 2021年第9期2卷 780-792页

作者： Ryan B.Gottwald R.joey Griffiths Dylan T.Petersen mackenzie e.j.perry Hang Z.Yu Department of Materials Science and engineering Virginia TechBlacksburgVirginia 24061United States

CONSPeCTUS:Structural metal components play a vital role in a broad range of industries,from aerospace and automotive to infrastructure and *** service,these components can experience substantial wear,thermal fatigue,erosion,corrosion,or chemical reactions,resulting in significant surface or even volumetric *** of these components is often energy-intensive and economically *** repair,which aims to restore the original geometry while enabling good mechanical performance postrepair,can offset the costs *** on the additive capabilities and bonding mechanisms,structural repair technologies can be divided into four categories:nonadditive,nonmelting-based;nonadditive,melting-based;additive,nonmelting-based;additive,*** melting-based approaches can be applied to various repair geometries with good precision,the underlying melting and solidification processes inevitably lead to crucial problems impacting the mechanical performance,such as solidification porosity,high residual stresses,dendritic microstructure formation,elemental segregation,hot cracking,and stress corrosion *** fundamentally solve or minimize these problems,one may employ solid-state technologies that leverage ultrasonic vibration,friction stirring,or particle impact to facilitate metallurgical bond *** robust geometry restoration,an additive capability needs to be incorporated for continuous material feeding and precise deposition path ***,two solid-state technologies satisfy the requirement,cold spray and additive friction stir *** this Account,we discuss the structural repair enabled by solid-state metal additive manufacturing,focusing on(i)cold spray,which is a relatively established process,and(ii)additive friction stir deposition,which is an emerging process recently triggering significant research effortsthe authors are particularly invested in this process and are pioneering th

关键词： friction solidification corrosion

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A review of geometry-confined perovskite morphologies:From synthesis to efficient optoelectronic applications

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Nano Research 2022年第8期15卷 7402-7431页

作者： jinshuai Zhang perry Ping Shum Lei Su School of engineering and Materials Science Queen Mary University of LondonLondon E14NSUK College of engineering Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China

With the continuous study of metal halide perovskite,geometry-confined technologies have been widely applied to reduce the material dimensionality and to produce pre-designed structures,which can tune optical reflectance,scattering,and absorption,thereby optimizing the performance of perovskite-based optoelectronic devices and improving their commercial *** morphologies of perovskite active layer play a pivotal role in optoelectronic properties and the resulting device *** this review,we systematically summarized recent progress in the preparation and manufacture of various perovskite geometry-confined morphologies,as well as their promising advances in different optoelectronic applications,including photodetectors,solar cells(SCs),lasers,and light-emitting diodes(LeDs).In addition,the remaining challenges and further improvements of preparation unique geometry-confined perovskite morphologies for next-generation high quality optoelectronic devices are discussed.

关键词： geometry confinement metal halide perovskite controllable morphology optoelectronics

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Vector textures derived from higher order derivative domains for classification of colorectal polyps

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 187-200页

作者： Weiguo Cao Marc j.Pomeroy Zhengrong Liang Almas FAbbasi perry j.Pickhardt Hongbing Lu Department of Radiology State University of New York at Stony BrookStony Brook NY 11794USA Department of Biomedical engineering State University of New York at Stony BrookStony Brook NY 11794USA Department of Radiology University of Wisconsin Medical SchoolMadison WI 53705USA Department of Biomedical engineering the Fourth Medical UniversityXi’an 710032ShaanxiChina

Textures have become widely adopted as an essential tool for lesion detection and classification through analysis of the lesion *** this study,higher order derivative images are being employed to combat the challenge of the poor contrast across similar tissue types among certain imaging *** make good use of the derivative information,a novel concept of vector texture is firstly introduced to construct and extract several types of polyp *** widely used differential operators,i.e.,the gradient operator and Hessian operator,are utilized to generate the first and second order derivative *** derivative volumetric images are used to produce two angle-based and two vectorbased(including both angle and magnitude)***,a vector-based co-occurrence matrix is proposed to extract texture features which are fed to a random forest classifier to perform polyp *** evaluate the performance of our method,experiments are implemented over a private colorectal polyp dataset obtained from computed tomographic *** compare our method with four existing state-of-the-art methods and find that our method can outperform those competing methods over 4%-13%evaluated by the area under the receiver operating characteristics curves.

关键词： Machine learning Gradient Hessian matrix Haralick feature Random forest Image texture

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Female Carriers of the Met Allele of the BDNF Val66Met Polymorphism Develop Weaker Fear Memories in a Fear-Potentiated Startle Paradigm

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journal of Behavioral and Brain Science 2022年第5期12卷 211-235页

作者： Phillip R. Zoladz mackenzie R. Riggenbach jordan N. Weiser jennifer j. Hipskind Leighton e. Wireman Kelsey L. Hess Tessa j. Duffy julie K. Handel mackenzie G. Kaschalk Kassidy e. Reneau Brianne e. Mosley Psychology Program The School of Health and Behavioral Sciences Ohio Northern University Ada USA

The val66met polymorphism of the bdnf gene, which is associated with compromised brain-derived neurotrophic factor (BDNF) signaling, impaired synaptic plasticity, and impaired learning, may increase one’s susceptibility to stress- and anxiety-related disorders. Indeed, previous work has reported greater anxiety-related behaviors and impairments of fear conditioning and extinction in individuals who carry the met allele that results from this polymorphism. Nevertheless, findings in this area of research have been equivocal. Thus, we examined the influence of the val66met polymorphism on fear conditioning, extinction, and extinction memory testing. One hundred and twenty healthy participants completed differential fear conditioning in a fear-potentiated startle paradigm, followed by extinction and extinction memory testing 24 and 48 hr later, respectively. Participants were genotyped for the val66met polymorphism and divided into met allele carriers and non-carriers. Results revealed that, although both met-carriers and non-carriers developed conditioned fear, met-carriers exhibited significantly weaker fear acquisition than non-carriers. This difference persisted throughout extinction and extinction memory testing and, during these last two days of testing, was primarily evident in females. These results are consistent with previous work demonstrating that this polymorphism is associated with impaired amygdala-dependent fear learning and extend such findings by demonstrating that females may be more sensitive to such effects.

关键词： Fear Conditioning extinction Polymorphism BDNF Val66Met Startle

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Developing one-dimensional implosions for inertial confinement fusion science

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High Power Laser Science and engineering 2016年第4期4卷 1-7页

作者： j.L.Kline S.A.Yi A.N.Simakov R.e.Olson D.C.Wilson G.A.Kyrala T.S.perry S.H.Batha e.L.Dewald j.e.Ralph D.j.Strozzi A.G.MacPhee D.A.Callahan D.Hinkel O.A.Hurricane R.j.Leeper A.B.Zylstra R.R.Peterson B.M.Haines L.Yin P.A.Bradley R.C.Shah T.Braun j.Biener B.j.Kozioziemski j.D.Sater M.M.Biener A.V.Hamza A.Nikroo L.F.Berzak Hopkins D.Ho S.LePape N.B.Meezan D.S.Montgomery W.S.Daughton e.C.Merritt T.Cardenas e.S.Dodd Los Alamos National Laboratory Lawrence Livermore National Laboratory

experiments on the National Ignition Facility show that multi-dimensional effects currently dominate the implosion performance. Low mode implosion symmetry and hydrodynamic instabilities seeded by capsule mounting features appear to be two key limiting factors for implosion performance. One reason these factors have a large impact on the performance of inertial confinement fusion implosions is the high convergence required to achieve high fusion *** tackle these problems, a predictable implosion platform is needed meaning experiments must trade-off high gain for performance. LANL has adopted three main approaches to develop a one-dimensional(1D) implosion platform where 1D means measured yield over the 1D clean calculation. A high adiabat, low convergence platform is being developed using beryllium capsules enabling larger case-to-capsule ratios to improve symmetry. The second approach is liquid fuel layers using wetted foam targets. With liquid fuel layers, the implosion convergence can be controlled via the initial vapor pressure set by the target fielding temperature. The last method is double shell targets. For double shells, the smaller inner shell houses the DT fuel and the convergence of this cavity is relatively small compared to hot spot ignition. However,double shell targets have a different set of trade-off versus advantages. Details for each of these approaches are described.

关键词： beryllium capsules double shells inertial confinement fusion liquid layers

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The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration

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Sports Medicine and Health Science 2021年第4期3卷 212-217页

作者： j.William Deaver eleanor R.Schrems Lemuel A.Brown Wesley A.Haynie Richard A.perry jr. Megan e.Rosa-Caldwell Michelle A.Tedrowe Nicholas P.Greene Tyrone A.Washington exercise Muscle Biology Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA Cachexia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA

Diet-induced obesity has previously been shown to occur with the concomitant rise in the expression of proin-flammatory cytokines and increases in collagen *** it has been known that the regenerative process of skeletal muscle is altered in obese mice following an acute muscle injury,we sought to examine differences in the expression of various markers of extracellular matrix remodeling and *** laboratory has previously reported an impaired inflammatory and protein synthetic signaling in these mice that may contribute negatively to the muscle regenerative *** expand upon this previous investigation,tissues from these animals un-derwent further analysis to determine the extent of changes to the regenerative response within the extracellular matrix,including transcriptional changes in CollagenⅠ,CollagenⅢ,and ***,we show that the expression of CollagenⅢ:Ⅰis significantly increased at 3-days post-injury in obese injured animals compared to lean injured animals(p=0.0338),and by 28-days the obese injured animals exhibit a significantly lower CollagenⅢ:Ⅰthan their lean injured counterparts(p=0.0035).We demonstrate an impaired response to an acute muscle injury in obese mice when compared with lean ***,further studies are required to elucidate translational consequences of these changes,as well as to determine any causative mechanisms that may be driving this effect.

关键词： Diet induced obesity extracellular matrix remodeling Skeletal muscle

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Multimedia developer''s guide 1st ed.

Multimedia developer''s guide

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1994年

作者： perry Paul j.

来源：畅想之星图书光盘版（南... 评论

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effects of PGC-1αoverexpression on the myogenic response during skeletal muscle regeneration

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Sports Medicine and Health Science 2022年第3期4卷 198-208页

作者： Tyrone A.Washington Wesley S.Haynie eleanor R.Schrems Richard A.perry jr. Lemuel A.Brown Breanna M.Williams Megan e.Rosa-Caldwell David e.Lee jacob L.Brown exercise Muscle Biology Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA Cachexia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA

The ability of skeletal muscle to regenerate from injury is crucial for locomotion,metabolic health,and quality of *** proliferator-activated receptor-γcoactivator-1α(PGC1A)is a transcriptional coactivator required for mitochondrial *** mitochondrial biogenesis is associated with improved muscle cell differentiation,however PGC1A's role in skeletal muscle regeneration following damage requires further *** purpose of this study was to investigate the role of skeletal muscle-specific PGC1A overexpression during regeneration following damage.22 C57BL/6j(WT)and 26 PGC1A muscle transgenic(A1)mice were injected with either phosphate-buffered saline(PBS,uninjured control)or Bupivacaine(MAR,injured)into their tibialis anterior(TA)muscle to induce skeletal muscle *** muscles were extracted 3-or 28-days postinjury and analyzed for markers of regenerative myogenesis and protein ***1a mRNA was~10–20 fold greater in A1 *** of protein synthesis,AKT and 4eBP1,displayed decreases in A1 mice compared to WT at both timepoints indicating a decreased protein synthetic *** mRNA was~75%lower compared to WT 3 days *** mice exhibited decreased cross-sectional area of the TA muscle at 28 days post-injection with bupivacaine compared to all other ***1A overexpression modifies the myogenic response during regeneration.

关键词： PGC-1α Skeletal muscle Muscle regeneration Satellite cells Protein turnover p38 MAPK

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Sol-Gel工艺制备铁电KTN和KN陶瓷中络合反应的研究

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湖北大学学报(自然科学版) 1988年第1期 13-19页

作者：邝安祥,e.T.Wu,A.Nazeri—eshghi,j.D.mackenzie 中国湖北大学美国加里福尼亚大学美国加里福尼亚大学美国加里福尼亚大学

在Sol—Gel（溶胶—凝胶）工艺制备铁电KTa1-xNbxO3（KTN）和KNbO3（KN）陶瓷中,我们用电导滴定法和红外吸收谱测定法研究[M2（OC2H5）10+CH3OH+K（OC2H6）)和[M2（OC2H5）10+C2H5OH+K（OC2H5）]（M=Nb,Ta）系统的溶液,发现这些系统的... 详细信息

关键词：金属醇盐 KTN 络合反应 Sol-Gel KN 工艺制备铁电

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Uncovering genetic and metabolite markers associated with resistance against anthracnose fruit rot in northern highbush blueberry

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Horticulture Research 2023年第10期10卷 25-36页

作者： mackenzie jacobs Samantha Thompson Adrian e.Platts Melanie j.A.Body Alexys Kelsey Amanda Saad Patrick Abeli Scott j.Teresi Anthony Schilmiller Randolph Beaudry Mitchell j.Feldmann Steven j.Knapp Guo-qing Song Timothy Miles Patrick P.edger Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Molecular Plant Science Program Michigan State UniversityEast LansingMI 48824USA Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Department of Horticulture and Natural Resources Kansas State UniversityOlatheKS 66061USA Genetics and Genome Sciences Program Michigan State UniversityEast LansingMI 48824USA Mass Spectrometry&Metabolomics Core Michigan State UniversityEast LansingMI 48824USA Department of Plant Sciences University of CaliforniaDavisCA 95616USA

Anthracnose fruit rot(AFR),caused by the fungal pathogen Colletotrichum fioriniae,is among the most destructive and widespread fruit disease of blueberry,impacting both yield and overall fruit *** cultivars have highly variable resistance against *** date,this pathogen is largely controlled by applying various fungicides;thus,a more cost-effective and environmentally conscious solution for AFR is *** we report three quantitative trait loci associated with AFR resistance in northern highbush blueberry(Vaccinium corymbosum).Candidate genes within these genomic regions are associated with the biosynthesis of flavonoids(***)and resistance against ***,we examined gene expression changes in fruits following inoculation with Colletotrichum in a resistant cultivar,which revealed an enrichment of significantly differentially expressed genes associated with certain specialized metabolic pathways(*** biosynthesis)and pathogen *** non-targeted metabolite profiling,we identified a flavonol glycoside with properties consistent with a quercetin rhamnoside as a compound exhibiting significant abundance differences among the most resistant and susceptible individuals from the genetic mapping *** analysis revealed that this compound exhibits significant abundance differences among the most resistant and susceptible individuals when analyzed as two ***,individuals within each group displayed considerable overlapping variation in this compound,suggesting that its abundance may only be partially associated with resistance against *** findings should serve as a powerful resource that will enable breeding programs to more easily develop new cultivars with superior resistance to AFR and as the basis of future research studies.

关键词： applying resistance specialized

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