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Design Improvements and Validation of a Novel Fully 3D Printed Analogue Lumbar Spine Motion Segment

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Journal of Bionic Engineering 2024年第3期21卷 1388-1396页

作者： Siril teja Dukkipati Mark Driscoll Musculoskeletal Biomechanics Research Lab Department of Mechanical EngineeringMcGill University845 Sherbrooke St.W(163)MontréalQCH3A 0C3Canada Orthopaedic Research Lab Montreal General Hospital1650 Cedar Ave(LS1.409)MontréalQCH3G 1A4Canada

Spine biomechanical testing methods in the past few decades have not evolved beyond employing either cadaveric studies or finite element modeling ***,both these approaches may have inherent cost and time *** studies are the present gold standard for spinal implant design and regulatory approval,but they introduce significant variability in measurements across patients,often requiring large sample *** element modeling demands considerable expertise and can be computationally expensive when complex geometry and material nonlinearity are *** analogue spine models could complement these traditional methods as a low-cost and high-fidelity alternative.A fully 3D printable L-S1 analogue spine model with ligaments is developed and validated in this *** stiffness of the model under pure bending loading in flexion-extension,Lateral Bending(LB)and Axial Rotation(AR)is evaluated and compared against historical ex vivo and in silico ***,the effect of interspinous,intertransverse ligaments and the Thoracolumbar Fascia(TLF)on spinal stiffness is evaluated by systematic construction of the *** flexion,model Range of Motion(ROM)was 12.92±0.11°(ex vivo:16.58°,in silico:12.96°)at *** LB,average ROM was 13.67±0.12°at 7.5 Nm(ex vivo:15.21±1.89°,in silico:15.49±0.23°).Similarly,in AR,average ROM was 17.69±2.12°at 7.5Nm(ex vivo:14.12±0.31°,in silico:15.91±0.28°).The addition of interspinous and intertransverse ligaments increased both flexion and LB stiffnesses by approximately 5%.Addition of TLF showed increase in flexion and AR stiffnesses by 29%and 24%,*** novel model can reproduce physiological ROMs with high repeatability and could be a useful open-source tool in spine biomechanics.

关键词： Lumbar spine 3D printing Intervertebral disc Biomechanical testing Spine mechanics

Identification and Transcriptional Regulation of CAMTA Genes in Liriodendron chinense

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 413-425页

作者： Kaiyue Hong Yasmina Radani teja Manda Jinhui Chen Liming Yang State Key Laboratory of Tree Genetics and Breeding College of Life SciencesNanjing Forestry UniversityNanjing210037China

This study explores CAMTA genes in the rare and endangered Chinese plant species,Liriodendron *** the completion of whole-genome sequencing,the roles of CAMTA genes in calcium regulation and stress responses in this species remain largely *** the *** genome,we identiﬁed two CAMTA genes,Lchi09764 and Lchi222536,characterized by four functional domains:CG-1,TIG,ANK repeats,and IQ *** analyses,including phylogenetic investigations,cis-regulatory element analyses,and chromosomal location studies,aim to elucidate the deﬁning features of CAMTA genes in *** Weighted Gene Co-Expression Network Analysis(WGCNA),we explored the impact of CAMTA genes on different organs and their regulation under abiotic stress *** identiﬁcation of signiﬁcant gene modules and the prediction of promoter binding sites revealed co-expressed genes associated with CAMTA transcription *** summary,this study provides initial insights into CAMTA genes in ***,laying the groundwork for future research on their evolution and biological *** knowledge enhancement contributes to a better understanding of plant responses to environmental stress—an essential aspect of plant biology.

关键词： Liriodendron chinense CAMTA genes abiotic stress WGCNA different organs

Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) prefer shells for nesting:A field experiment

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Avian Research 2024年第1期15卷 55-59页

作者： macarena Castro Andrés De la Cruz Nuria Martin-Sanjuan Alejandro Pérez-Hurtado Instituto Universitario de Investigacion Marina(INMAR) Campus de Excelencia Internacional del Mar(CEIMAR)Departamento de BiologíaUniversidad de CadizPuerto RealSpain Servicios centrales de Investigacion Salinas de la Esperanza Universidad de CadizPuerto RealSpain

Shorebird populations are declining worldwide,mainly due to human disturbances and loss of coastal ***,supratidal habitats as saltpans could play a role in buffering human *** have shown to be important as feeding or breeding sites of some shorebird species.A potential conservation strategy to increase shorebird populations in saltpans is to manipulate the cues that birds use to select optimal breeding *** it is hypothesized that shorebirds are attracted to bivalve shells due to the advantages they *** this hypothesis,we supplemented a restored saltpan in 2019 and 2021 with bivalve shells,expecting an increase in the number of breeding birds’ *** than 75% of Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) nests were found in patches with shells in both *** best model for both species indicates that the presence of shells is the factor that most correlates with the location of *** probability of choosing one place over another to settle their nest increases in areas with an abundance of shells,double in the case of the Kentish Plover and triple in the case of the Little *** result of this study may constitute a valuable tool for attracting birds to restored saltpans and could contribute to the success of expensive restoration projects where time is usually a constraint.

关键词： Habitat management Nest site selection Saltpan restoration Shell supplementation Shorebirds

Dengue hemorrhagic fever with rectus sheath hematoma:A case report

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 136-138页

作者： Boudhayan Bhattacharjee Hardik Patel Rucha Karad Vasireddy teja Agnibho Mondal Soumendra Nath Haldar Bibhuti Saha Department of Infectious Diseases and Advanced Microbiology School of Tropical MedicineKolkataIndia

Rationale:Acute pain is a medical emergency that requires prompt abdominal evaluation and ***,a mosquito-borne arboviral infection,can lead to complications such as acute abdominal *** concerns:A 72-year-old hypertensive female presented with high-grade intermittent fever with chills and rigors for four *** was diagnosed with dengue fever(NS1Ag-reactive)the day before admission.A contrast-enhanced computed tomography of the abdomen showed a hematoma along the rectus sheath which was managed conservatively as per surgical ***:Dengue hemorrhagic fever with rectus sheath ***:Blood transfusion and fluid ***:Ten days after discharge,the patient reproted no pain in the right iliac fossa and the size of the hematoma was significantly ***:Although it is rarely seen as a cause of acute abdomen,complaints of adnominal pain should never be ignored in critical or convalescent phase of dengue *** investigations should be promptly conducted as hematoma is often difficult to be diagnosed *** in diagnosis of rectus sheath hematoma can be fatal.

关键词： Dengue fever Rectus sheath hematoma Surgical emergency Acute appendicitis

Impact of depression on in-hospital outcomes for adults with type 2 myocardial infarction:A United States population-based analysis

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World Journal of Cardiology 2024年第7期16卷 412-421页

作者： Sivaram Neppala Himaja Dutt Chigurupati Shaylika Chauhan Mrunal teja Chinthapalli Rupak Desai Department of Internal Medicine University of Texas at San AntonioSan AntonioTX 78249United States Department of Internal Medicine New York Medical College at Saint Michael’s Medical CenterNewarkNJ 07102United States Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States Department of Internal Medicine Mayo ClinicRochesterMN 55905United States Independent Researcher AtlantaGA 30079United States

BACKGROUND Type 2 myocardial infarction(T2MI)is an ischemic myocardial injury in the context of oxygen supply/demand mismatch in the absence of a primary coronary ***,though there is a rising prevalence of depression and its potential association with type 1 myocardial infarction(T1MI),data remains nonexistent to evaluate the asso-ciation with *** To identify the prevalence and risk of T2MI in adults with depression and its impact on the in-hospital *** We queried the National Inpatient Sample(2019)to identify T2MI hospitalizations using Internal Classification of Diseases-10 codes in hospitalized adults(≥18 years).In addition,we compared sociodemographic and comorbidities in the T2MI cohort with vs without comorbid ***,we used multivariate regression analysis to study the odds of T2MI hospitalizations with vs without depression and in-hospital outcomes(all-cause mortality,cardiogenic shock,cardiac arrest,and stroke),adjusting for *** significance was RESULTS There were 331145 adult T2MI hospitalizations after excluding T1MI(median age:73 years,52.8%male,69.9%white);41405(12.5%)had depression,the remainder;289740 did not have *** analysis revealed lower odds of T2MI in patients with depression vs without[adjusted odds ratio(aOR)=0.88,95%confidence interval(CI):0.86-0.90,P=0.001].There was the equal prevalence of prior MI with any revascularization and a similar prevalence of peripheral vascular disease in the cohorts with depression vs without *** is a greater prevalence of stroke in patients with depression(10.1%)vs those without(8.6%).There was a slightly higher prevalence of hyperlipidemia in patients with depression vs without depression(56.5%vs 48.9%),as well as obesity(21.3%vs 17.9%).There was generally equal prevalence of hypertension and type 2 diabetes mellitus in both *** was no significant difference in elective and non-elective admissions frequency b

关键词： Type 2 myocardial infarction Depression Major adverse cardiovascular events Mortality Stroke Cardiac arrest Outcomes

Remimazolam in intensive care unit:Potential applications and considerations

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World Journal of Critical Care Medicine 2024年第3期13卷 25-31页

作者： Praveen Reddy Elmati teja Nagaradona Gowthami Sai Kogilathota Jagirdhar Salim Surani Department of Anesthesiology Saint Clair HospitalDoverNJ 07801United States School of Medicine St George UniversityGranada SW170BDWest Indies Department of Medicine Saint Michaels Medical CenterNewarkNJ 07107United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

This manuscript explores the potential use of Remimazolam in the intensive care unit(ICU)and critical care units,considering its pharmacological characteristics,clinical applications,advantages,and comparative effectiveness over current sedatives and *** reviewed existing PubMed and Google Scholar literature to find relevant studies on Remimazolam in *** created search criteria using a combination of free text words,including Remimazolam,critical care,intensive care,sedation,anesthesia,pharmacokinetics,and *** articles published in the English language were analyzed and *** is an ultra-short-acting benzodiazepine derivative promising for sedation and *** is a safer option for hemodynamically unstable,elderly,or liver or kidney *** also has comparable deep sedation properties to propofol in the ***,it reduces post-procedural delirium and patient comfort and reduces the need for additional sedatives in pediatric *** conclusion,Remimazolam is an excellent alternative to current sedatives and anesthetics in the *** cost is comparable to that of current *** research on its long-term safety in the ICU and its broader application and incorporation into routine use is necessary.

关键词： Remimazolam Intensive care Critical care Anesthesia Sedation Mechanical ventilation Benzodiazepine

Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells:A systematic review

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World Journal of Methodology 2024年第2期14卷 134-144页

作者： Vamsi Krishna Mundluru MJ Naidu Ravi teja Mundluru Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Madhan Jeyaraman Department of Orthopaedics MJ Naidu Super Speciality HospitalVijayawada 520002Andhra PradeshIndia Department of Regenerative Medicine StemC ClinicsVijayawada 520002Andhra PradeshIndia Department of Orthopaedics ACS Medical College and HospitalDr.MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

BACKGROUND Adipose-derived stem cells(ADSCs)and the stromal vascular fraction(SVF)have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of *** enzymatic methods for isolating these cells face challenges such as high costs,lengthy processing time,and regulatory *** This systematic review aimed to assess the efficacy and practicality of nonenzymatic,mechanical methods for isolating SVF and ADSCs,comparing these to conventional enzymatic *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a comprehensive literature search was conducted across multiple *** were selected based on inclusion criteria focused on non-enzymatic isolation methods for SVF and ADSCs from adipose *** risk of bias was assessed,and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included *** Nineteen studies met the inclusion criteria,highlighting various mechanical techniques such as centrifugation,vortexing,and ultrasonic *** review identified significant variability in cell yield and viability,and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic *** some advantages of mechanical methods,including reduced processing time and avoidance of enzymatic reagents,the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic *** Non-enzymatic,mechanical methods offer a promising alternative to enzymatic isolation of SVF and ADSCs,potentially simplifying the isolation process and reducing regulatory ***,further research is necessary to standardize these techniques and ensure consistent,high-quality cell yields for clinical *** development of efficient,safe,and reproducible non-enzymatic isolation methods could signi

关键词： Adipose-derived stem cells Stromal vascular fraction Regenerative medicine Non-enzymatic isolation Mechanical separation techniques

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天文爱好者 2024年第8期 92-93页

作者： [印]teja Begari 崔洁(译) 不详

在读小学三年级的时候,我从科学课本的太阳系插图里,辨认出了地球。我问科学老师:“图片里的这些是什么?”她告诉我,这些被称作“行星”。那是我第一次听到“行星”这个词语。后来,当我父亲向我和我的姐姐介绍网络浏览器时,我请他搜索... 详细信息

在读小学三年级的时候,我从科学课本的太阳系插图里,辨认出了地球。我问科学老师:“图片里的这些是什么?”她告诉我,这些被称作“行星”。那是我第一次听到“行星”这个词语。后来,当我父亲向我和我的姐姐介绍网络浏览器时,我请他搜索了关于行星的内容。尽管我并未读懂维基百科上的文章,但就在那一天,我决定成为一名天体物理学家。

关键词：天体物理学家网络浏览器维基百科小学三年级插图太阳系行星

In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity:Insights from national inpatient sample 2020

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World Journal of Hepatology 2024年第6期16卷 912-919页

作者： Sashwath Srikanth Vibhor Garg Lakshmi Subramanian Jyoti Verma Hansika Sharma Harroop Singh Klair Shrenil A Kavathia Jithin Kolli teja Nikhil Sai Vasireddy Kumar Anmol Dhanush Kolli Shruti Sanjay Bodhankar Sobya Hashmi Shaylika Chauhan Rupak Desai Department of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Medicine North Alabama Medical CentreFlorenceAL 35630United States Department of General Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Government Medical CollegePatiala 147001PunjabIndia Department of Medicine B.J.Medical CollegeAhmedabad 380016GujaratIndia Department of Medicine JSS Medical CollegeMysore 570015KarnatakaIndia Department of Internal Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Kasturba Medical CollegeManipal 575001KarnatakaIndia Clinical Extern Department of Internal MedicineBeaumont HospitalDearbornMI 48124United States Department of Internal Medicine Geisinger Health SystemWilkes-BarrePA 18702United States Independent Researcher AtlantaGA 30079United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular diseases independently of other risk ***,data on its effect on cardiovascular outcomes in coronavirus disease 2019(COVID-19)hospitalizations with varied obesity levels is *** management and patient care depend on understanding COVID-19 admission results in NAFLD patients with varying obesity *** To study the in-hospital outcomes in COVID-19 patients with NAFLD by severity of *** COVID-19 hospitalizations with NAFLD were identified using International Classification of Disease-10 CM codes in the 2020 National Inpatient Sample *** and Obesity Classes Ⅰ,Ⅱ,and Ⅲ(body mass index 30-40)were *** adverse cardiac and cerebrovascular events(MACCE)(all-cause mortality,acute myocardial infarction,cardiac arrest,and stroke)were compared between *** regression analyses adjusted for sociodemographic,hospitalization features,and *** Our analysis comprised 13260 hospitalizations,7.3% of which were overweight,24.3% Class Ⅰ,24.1% Class Ⅱ,and 44.3% Class Ⅲ.Class Ⅲ obesity includes younger patients,blacks,females,diabetics,and hypertensive *** multivariable logistic analysis,Class Ⅲ obese patients had higher risks of MACCE,inpatient mortality,and respiratory failure than Class Ⅰ obese *** Ⅱ obesity showed increased risks of MACCE,inpatient mortality,and respiratory failure than Class I,but not *** obesity classes had non-significant risks of MACCE,inpatient mortality,and respiratory failure compared to the overweight *** Class Ⅲ obese NAFLD COVID-19 patients had a greater risk of adverse outcomes than class Ⅰ.Using the overweight group as the reference,unfavorable outcomes were not significantly *** obesity had a greater risk of MACCE regardless of the referent group(overweight or Class Ⅰ obese)compared to overweight NAFLD patients admitte

关键词： Non-alcoholic fatty liver disease Obesity Obese Body mass index Major adverse cardiac and cerebrovascular events Mortality Acute myocardial infarction Cardiac arrest Stroke