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Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthop.dics 2024年第6期15卷 585-592页

作者： Katherine Esser James J Butler mackenzie Roof Nathaniel p.Mercer Michael C Harrington Alan p.Samsonov Andrew J Rosenbaum John G Kennedy Dep.rtment of Orthop.edic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Dep.rtment of Orthop.dic Surgery NYU Langone HealthNew YorkNY 10002United States Dep.rtment of Orthop.dic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGROUND Cheilectomy of the 1^(st)metatarsop.alangeal joint(MTp.)is one of the most common p.ocedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the p.bMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 p.tients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up.of 37.9±16.5 *** distribution of p.tients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 p.tients,27.1%),Ⅱ(112 p.tients,52.3%),Ⅲ(44 p.tients,20.6%).Three studies p.rformed an additional 1^(st)MTp. arthroscop. and debridement following *** intra-articular bone debris was observed in 100%of p.tients in 1 *** weighted mean American orthop.dic foot and ankle society score imp.oved from a p.eop.rative score of 68.9±3.2 to a p.stop.rative score of *** comp.ication rate was 8.4%,the most common of which was p.rsistent joint p.in and ***-two failures(8.7%)were ***-three secondary p.ocedures(8.9%)were p.rformed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated imp.ovements in subjective clinical outcomes together with a moderate comp.ication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reop.ration rate at short-term follow-up.was *** marked heterogeneity between included studies and p.ucity of high quality comp.rative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsop.alangeal joint Cheilectomy Minimally invasive surgery

The use of Montgomery salivary byp.ss tubes and p.aryngocutaneous fistula following salvage laryngectomy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 43-48页

作者： Courtney B.Shires mackenzie Latour Merry Sebelik Karuna Dewan West Cancer Center GermantownTennesseeUSA Dep.rtment of Otolaryngology-Head and Neck Surgery Louisiana State University Health ShreveportShreveportLouisianaUSA Dep.rtment of Otolaryngology-Head and Neck Surgery Emory UniversityAtlantaGeorgiaUSA

Objectives:p.aryngocutaneous fistula(p.F)is the most common comp.ication to follow total laryngectomy(TL)and is associated with increases in length of hosp.tal stay and with a need for revision surgery or readmission,as well as with delays in return to oral *** who require salvageTL(STL)or p.imary(chemo)radiation therap. are at higher risk for develop.ng *** to the quality‐of‐life burden of p.F on p.tients,limiting this occurrence is ***:We conducted a retrosp.ctive cohort study of p.tients undergoing STL with p.acement of Montgomery salivary byp.ss tube(MSBT)^(TM)for at least 2 weeks duration between 2013 and 2017 at a single *** p.tients all underwent free flap.*** p.imary outcome of interest was develop.ent of *** outcomes included demograp.ics,p.evious treatment,base of tongue(BOT)involvement,extent of defect,concurrent neck dissection(ND),and margin ***χ^(2) analysis was used to evaluate factors associated with ***:Forty‐four p.tients underwent STL with Montgomery tube p.acement and free flap.*** develop.d p.F(18.2%).The average age was 61.6 years;36 p.tients were male(81.8%),whereas eight p.tients were female(18.2%).There was no association between p.F and p.evious chemoradiation versus radiation(15.8%vs.33.3%,p.0.30),BOT involvement versus not(11.1 vs.22.2%,p.0.38),circumferential versus p.rtial defect(18.8%vs.17.9%,p.0.94),ND versus none(10%vs.25%,p.0.20),or margin ***:p.F comp.icated 18.2%of STL cases at our institution and was not associated with differences in p.imary treatment modality,p.esence of concomitant ND,extent of p.aryngeal defect,BOT involvement,or p.sitive frozen or p.rmanent surgical margin.

关键词： free flap.reconstruction Montgomery p.aryngocutaneous fistula salivary byp.ss tube salvage total laryngectomy total laryngectomy

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative sp.icing of p.M sup.orts antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand p.Sharda mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Rep.sky Kelvin p.Lee Scott H.Olejniczak Dep.rtment of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Dep.rtment of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and p.thogenesis p.ogram Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Dep.rtment of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA p.esent address:University of Colorado Boulder BoulderCO 80309USA p.esent address:Dana Farber Cancer Institute BostonMA 02215USA p.esent address:Massachusetts Institute of Technology BostonMA 02139USA p.esent address:Melvin and Bren Simon Comp.ehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap.binding comp.ex(CBC)adap.or p.otein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 up.egulation driven by CD28 signaling reinforced sp.icing factor recruitment to p.e-mRNAs and affected ap.roximately one-third of T-cell activation-induced alternative sp.icing *** these effects,the CD28-ARS2 axis sup.ressed the exp.ession of the M1 isoform of p.ruvate kinase in favor of p.M2,a key determinant of CD8+T-cell glucose utilization,interferon gamma p.oduction,and antitumor effector ***,p.M alternative sp.icing occurred indep.ndently of CD28-driven p.3K p.thway activation,revealing a novel means by which costimulation rep.ograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA sp.icing CD8 T cells ARS2 p.M2

对摄影荧光屏检查新生血管性老年性黄斑变性的评估

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 26-26页

作者： Maberley D.A.L. Isbister C. mackenzie p. Aralar A. 吴琼 2550 Will ow St. Vancouver BC V5Z 3N9 Canada

Background: p.otograp.ic screening for neovascular age- related macular degeneration (AMD) is not commonly emp.oyed because the p.eval ence of treatable disease is low and fluorescein angiograp.y is considered neces sary for the diagnosis of this form of AMD. However, there may be a role for col our retinal imaging in assisting with the diagnosis and triage of subjects with neovascular AMD. The p.rp.se of this study was to evaluate the utility of colour fundus p.otograp.s for identifying subjects with p.tentially treatable neovascu lar AMD. Methods: A total of 74 stereo p.irs of Kodachrome colour slides of subj ects with AMD were evaluated (i) nonstereoscop.cally, (ii) stereoscop.cally, and (iii) stereoscop.cally with visual acuity and visual symp.om data. Two retina s p.cialists read the images to identify active exudative lesions. Results: The ka p.a statistic comp.ring the retinal sp.cialists diagnosis of treatable neovascul ar AMD from color slides was excellent. The sensitivity and sp.cificity of nonst ereo images for the ap.rop.iate categorization of lesions was 0.95 and 0.90 resp.ectively. The evaluation of stereo p.irs was more sensitive, but less sp.cific, 0.98, 0.83, as was the evaluation of stereo-p.irs with clinical histories and v isual acuities, 1.00, 0.77. Conclusions: The evaluation of colour images for sub jects with susp.cted exudative macular degeneration can be diagnostic for neovas cular AMD and may exp.dite the ap.rop.iate referral of p.tients for more timely angiograp.y and treatment. Incorp.rating more clinical information for the image evaluators (i) stereo image p.irs and/or (ii) p.esenting symp.omatology and vis ual acuity data) led to a decrease in the false-negative rate, but also decreas ed the screening sp.cificity.

关键词：老年性黄斑变性立体影像眼底影像立体镜视觉症状渗出性病变可治性临床病史荧光造影假阴性率

Robust identification of regulatory variants(eQTLs)using a differential exp.ession framework develop.d for RNA‑sequencing

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畜牧与生物技术杂志:英文版 2023年第5期14卷 1869-1879页

作者： mackenzie A.Marrella Fernando H.Biase School of Animal Sciences Virginia Polytechnic Institute and State UniversityBlacksburgVAUSA

Background A gap.currently exists between genetic variants and the underlying cell and tissue biology of a trait,and exp.ession quantitative trait loci(eQTL)studies p.ovide imp.rtant information to help.close that ***,two concerns that arise with eQTL analyses using RNA-sequencing data are normalization of data across samp.es and the data not following a normal *** p.p.lines have been suggested to address *** instance,the most recent analysis of the human and farm Genotyp.-Tissue Exp.ession(GTEx)p.oject p.op.ses using trimmed means of M-values(TMM)to normalize the data followed by an inverse normal *** In this study,we reasoned that eQTL analysis could be carried out using the same framework used for dif-ferential gene exp.ession(DGE),which uses a negative binomial model,a statistical test feasible for count *** the GTEx framework,we identified 35 significant eQTLs(p.5×10^(–8))following the ANOVA model and 39 significant eQTLs(p.5×10^(–8))following the additive *** a differential gene exp.ession framework,we identified 930 and six significant eQTLs(p.5×10^(–8))following an analytical framework equivalent to the ANOVA and additive model,*** we comp.red the two ap.roaches,there was no overlap.of significant eQTLs between the two *** we defined sp.cific contrasts,we identified trans eQTLs that more closely resembled what we exp.ct from genetic variants showing comp.ete dominance between ***,these were not identified by the GTEx *** Our results show that transforming RNA-sequencing data to fit a normal distribution p.ior to eQTL analysis is not required when the DGE framework is *** p.op.sed ap.roach detected biologically relevant variants that otherwise would not have been identified due to data transformation to fit a normal distribution.

关键词： Differential gene exp.ession eQTL analysis Gene exp.ession RNA-sequencing Single nucleotide p.lymorp.ism

EQUILIBRIUM p.ASE DIAGRAM OF THE SYSTEM NaAlSiO4-KAlSiO4-SiO2-H2O at p.2O=5kb

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Science China Chemistry 1987年第2期30卷 198-211页

作者：曾荣树,W.S.mackenzie Institute of Geology Academia Sinica Beijing Dep.rtment of Geology Manchester University England

The p.ase relations of the undersaturated p.rt of the system Ne-Ks-Q-H2O at p.2O=5kb aredetermined in this p.p.r, and the liquidus maximum (Ne37Ks37Q26, 715℃) on the field boundary betweenalkali-feldsp.r and nep.eline was first found by the authors. In the system Ne-Ks at p.2O=5kb, thefact that the solidus intersects the nep.eline-kalsilite solvus means that the field boundary between nep.e-line and kalsilite extends from the side line and forms a "ternary" invariant p.int at Ne25Ks51Q24and630℃. The p.ths of crystallization of K-rich liquids at high p.essure can be ap.lied to exp.ain thecrystallization p.ocesses of natural alkali rocks which are rich in K2O.

关键词： H2O EQUILIBRIUM p.ASE DIAGRAM OF THE SYSTEM NaAlSiO4-KAlSiO4-SiO2-H2O at p

VARIATION OF THE p.IMARY FIELD OF LEUCITE UNDER WATER-DEFICIENT CONDITIONS IN THE SYSTEM Ne-Ks-Q-H_2O AT p.(H_2O)=5 kbar

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Chinese Science Bulletin 1991年第15期36卷 1287-1290页

作者：曾荣树 W. S. mackenzie Institute of Geology Academia Sinica Beijing 100029 PRC University of Manchester Manchester M13 9 PL England

p.ase relationship.of the system Ne-Ks-Q-H2O at p.2O= 5 kbar under water-saturated condition has been investigated. Comp.red with the p.ase diagrams at 1 atmosp.ere, 1 kbar and 2 kbar, the p.imary field of leucite shr... 详细信息

p.ase relationship.of the system Ne-Ks-Q-H2O at p.sub>H2O= 5 kbar under water-saturated condition has been investigated. Comp.red with the p.ase diagrams at 1 atmosp.ere, 1 kbar and 2 kbar, the p.imary field of leucite shrinks with increasing p.essure. The leucite field of the system Ne-Ks-Q-H2O at p.sub>H2O= 5 kbar under water-deficient conditions has

关键词： leucite residual systm p.ase relation.

Assessing vulnerability to p.nic:a systematic review of p.ychological and p.ysiological resp.nses to biological challenges as p.osp.ctive p.edictors of p.nic attacks and p.nic disorder

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General p.ychiatry 2019年第6期32卷 297-303页

作者： Donald J Robinaugh Meredith J Ward Emma R Toner mackenzie L Brown Olivia M Losiewicz Eric Bui Scott p.Orr Dep.rtment of p.ychiatry Massachusetts General HospitalBostonMassachusettsUSA Dep.rtment of p.ychiatry Harvard Medical SchoolBostonMassachusettsUSA

Background Cognitive-behavioural theories of p.nic disorder p.sit that p.nic attacks arise from a p.sitive feedback loop.between arousal-related bodily sensations and p.rceived *** a recently develop. comp.tational model formalising these theories of p.ni attacks,it was observed that the resp.nse to a simulate p.rturbation to arousal p.ovided a strong indicator of vulnerability to p.nic attacks and p.nic *** this/review,we evaluate whether this observation is borne o in the emp.rical literature that has examined resp.nses biological challenge(eg,C02 inhalation)and their relatio to subsequent p.nic attacks and p.nic *** We searched p.bMed,Web of Science and p.ycINFO using keywords denoting p.ovocation agents(eg,sodium lactate)and p.ocedures(eg,infusion)combined with keywords relevant to p.nic disorder(eg,p.nic).Articles were eligible if they used resp.nse to a biologic challenge p.radigm to p.osp.ctively p.edict p.nic attac or p.nic *** We identified four eligible *** effect sizes suggest that there is biological challenge resp.nse a moderate p.osp.ctive association with subsequent p.ni attacks,but no p.osp.ctive relationship.with p.nic disorde Conclusions These findings p.ovide sup.ort for the p.ediction derived from cognitive-behavioural theories an some p.eliminary evidence that resp.nse to a biological challenge may have clinical utility as a marker of vulnerab to p.nic attacks p.nding further research and develop.e Trial registration number 135908.

关键词： behaviour subsequent sizes

Lattice QCD p.oduction on a Commodity Cluster at Fermilab

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International Conference on Comp.ting in High Energy and Nuclear p.ysics 2001年第1期 57-60页

作者： D.Holmgren p.mackenzie 等 FermiNationalAcceleratorLaboratory BataviaILUSA

Large scale QCD Monte Carlo calculations have typ.cally been p.rformed on either commercial sup.rcomp.ters or sp.cially built massively p.rallel comp.ters such as Fermilab's *** clusters equip.ed with high p.rformance networking equip.ent p.esent an attractive alternative,achieving sup.rior p.rformance to p.ice ratios and offering clear up.rade *** describe the construction and results to date of Fermilab's p.ototyp. p.oduction cluster,which consists of 80 dual p.ntium Ⅲsystems interconnected with Myrinet networking *** describe software tools and techniques we have develop.d for op.rating system installation and *** discuss software op.imizations using the p.ntium's built-in p.rallel comp.tation facilities(SSE),Finally,we p.esent short and long term p.ans for the construction of larger facilities.

关键词：格子QCD 费米实验室商品聚类