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Women's health in exercise and aging:What do we know?

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Journal of Sport and Health Science 2014年第3期3卷 153-154,248页

作者： rena Li Center for Hormone Advanced Science and Education Roskamp Institute

Recent articles published in Nature point out how sex bias,primarily concerning male-exclusivity,in biological research result in misleading and ambiguous science.1-4 For example,the majority of animal studies published in academic journals used only males,while only very limited studies were investigated in females or both *** consequences of such male-favored sex bias in biomedical studies had lead to a huge cost in the biomedical industry including drug *** 1997and 2001,eight out of 10 prescription drugs were withdrawn from the market by the US FDA because they showed more side

关键词：公共健康女性老龄化生物医药产业科学基础运动美国FDA 学术刊物

Troubleshooting of reinterventions after stent-by-stent placement for malignant hilar biliary obstruction(with videos)

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 500-502页

作者： Tadahisa Inoue rena Kitano Masashi Yoneda Department of Gastroenterology Aichi Medical University1-1 YazakokarimataNagakuteAichi 480-1195Japan

To the Editor:Biliary drainage is essential for controlling cholangitis and/or jaundice in patients with malignant hilar biliary obstruction,and endoscopy is the first choice of approach due to its less *** unresectable cases,placement of self-expandable metal stents(SEMSs)has been recommended over that of plastic stents due to their longer patency,and bilateral placement is also recommended to achieve higher clinical success and patency rates[1].

关键词： obstruction malignant stent

Development of a portable reference aerosol generator （PRAG） for calibration of particle mass concentration measurements

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Particuology 2018年第2期16卷 134-142页

作者： Francois Gaie-Levrel Soleiman Bourrous Tatiana macé Laboratoire national de metrologie et d'essais (LNE) Chemistry and Biology Division Gas and Aerosol Metrology Department I Rue Caston Boissier 75724 Paris Cedex 15 France Institut de Radioprotection et de SUreté Nucleaire (LRSN) PSNRES SCA Gif-sur-Yvette 91192 France

The tapered element oscillating microbalance with filter dynamics measurement system （TEOM-FDMS） is an instrument commonly employed by the French air quality monitoring network. This instrument is currently calibrated with calibration weights traceable to SI but having value and mass differences between each of them that are not representative of real atmospheric particle mass measurements. Moreover, these calibration weights do not allow detection of any technical problems associated with either the TEOM-FDMS sampling system upstream of the mass measurement or the intrinsic TEOM-FDMS filtration system. Therefore, a calibration method was developed using a portable reference aerosol generator （PRAG） that produces known and stable particle mass concentrations over time. Here, we present the characterization of the PRAG system in terms of a reference range of particle masses between 30 - 10 and 3456 ± 83 μg at three sampling times. Its coupling with the TEOM-FDMS and a global comparison between the defined reference range of particle masses and the measured masses obtained with each TEOM-FDMS implicated in this study are also presented.

关键词： Aerosol Generator Mass concentration Particulate mass Calibration TEOM-FDMS

Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease

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World Journal of Clinical Cases 2022年第7期10卷 2095-2105页

作者： Lian Qin rena Rehemuding Aikeliyaer Ainiwaer Xiang Ma Department of Cardiology First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous regionChina

BACKGROUND The results of previous animal experiments and clinical studies have shown that there is a correlation between expression of betatrophin and blood lipid ***,there are still differences studies on the correlation and interaction mechanism between betatrophin,angiogenin-likeprotein3(ANGPTL3)and lipoprotein lipase(LPL).In our previous studies,we found an increase in serum ANGPTL3 Levels in Chinese patients with coronary heart disease(CHD).Therefore,we retrospectively studied Kazakh CHD *** To explore the correlation between the betatrophin/ANGPTL3/LPL pathway and severity of coronary artery disease(CAD)in patients with *** Nondiabetic patients diagnosed with CHD were selected as the case group;79 were of Kazakh descent and 72 were of Han *** control groups comprised of 61 Kazakh and 65 Han *** serum levels of betatrophin and LPL were detected by enzyme-linked immunosorbent assay(ELISA),and the double antibody sandwich ELISA was used to detect serum level of *** levels of triglycerides,total cholesterol,and fasting blood glucose in each group were determined by an automatic biochemical *** the same time,the clinical baseline data of patients in each group were *** Betatrophin,ANGPTL3 and LPL levels of Kazakh patients were significantly higher than those of Han patients(P=0.031,0.038,0.021 respectively).There was a positive correlation between the Gensini score and total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),betatrophin,and LPL in Kazakh patients(r=0.204,0.453,0.352,0.471,and 0.382 respectively),(P=0.043,0.009,0.048,0.001,and P<0.001 respectively).A positive correlation was found between the Gensini score and body mass index(BMI),TC,TG,LDL-C,LPL,betatrophin in Han patients(r=0.438,0.195,0.296,0.357,0.328,and 0.446 respectively),(P=0.044,0.026,0.003,0.20,0.004,and P<0.001).TG and betatrophin were the risk factors of coronary artery disease in Kaza

关键词： Betatrophin/angiogenin-likeprotein3/Lipoprotein lipase pathway Coronary heart disease Gensini integral Coronary artery disease

Parametric study of turbine NGV blade lean and vortex design

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Chinese Journal of Aeronautics 2016年第1期29卷 104-116页

作者： Zhang Shaowen David G.mac Manus Luo Jianqiao Department of Turbine Design China Aviation Powerplant Research Institute AVIC School of Aerospace Transport and Manufacturing Cranfield University

The effects of blade lean and vortex design on the aerodynamics of a turbine entry nozzle guide vane （NGV） are considered using computational fluid dynamics. The aim of the work is to address some of the uncertainties which have arisen from previous studies where conflicting results have been reported for the effect on the NGV. The configuration was initially based on the energy efficient engine turbine which also served as the validation case for the computational method. A total of 17 NGV configurations were evaluated to study the effects of lean and vortex design on row efficiency and secondary kinetic energy. The distribution of mass flow ratio is introduced as an additional factor in the assessment of blade lean effects. The results show that in the turbine entry NGV, the secondary flow strength is not a dominant factor that determines NGV losses and therefore the changes of loading distribution due to blade lean and the associated loss mecha- nisms should be regarded as a key factor. Radial mass flow redistribution under different NGV lean and twist is demonstrated as an addition key factor influencin~ row efficiency.

关键词： Blade lean Losses Mass flow radial distribu-tion Parametric study Secondary kinetic energy Turbine Vortex design

Phytochemistry, anti-asthmatic and antioxidant activities of Anchomanes difformis(Blume) Engl. leaf extract

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 225-231页

作者： Ovuakporie-Uvo Oghale mac Donald Idu Department of Plant Biology and Biotechnology University of Benin

Objective: To study the phytochemistry, anti-asthmatic and antioxidant activities of the aqueous leaf extract of Anchomanes difformis(Blume) Engl.(A. difformis) and to verify claims of use in folk ***: For anti-asthmatic activity, male and female guinea pigs with average body weight of(451.4 ± 118.1) g were divided into six groups of six animals each. Group 1served as control(distilled water); Group 2 was administered with salbutamol(reference drug) only; Group 3 served as ovalbumin sensitized group, Group 4, 5 and 6 were treated with A. difformis extract at doses of 100, 200 and 400 mg/kg, respectively. Described methods were used to test fluid viscosity, fluid volume and quantitative phytochemistry analysis. Absorbance was read using a UV–Vis spectrophotometer and results computed in percentage. Total antioxidant assays [2, 2-diphenyl-1-picrylhydrazyl(DPPH) and lipid peroxidation assay], were carried out using reported ***: The anti-asthmatic evaluation showed that protection from asthma of the animals in Group 6(400 mg/kg, 32.7%) were similar to that in Group 2(salbutamol, 33.0%).Excised trachea was free of mucus secretion in Group 5(200 mg/kg) as was observed in the control group. Fluid volume increase in Groups 3 and 6 indicated mucus *** radical scavenging activity of extract was effective as ascorbic acid which served as standard at 20 mg/m L. But, the extract elicited low lipid peroxidation activity compared with the reference(tocopherol) at concentrations ***: A. difformis aqueous leaf extract is safe and possesses positive antiasthmatic and antioxidant activities as claimed by traditional herbal practitioners in Delta State.

关键词： Anti-asthmatic Anti-oxidant Phytochemistry Anchomanes difformis

A comprehensive approach for assessing the economic contribution of forage and livestock improvement options to smallholder farming enterprises

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Journal of Integrative Agriculture 2015年第8期14卷 1573-1580页

作者： Neil mac Leod Scott Waldron WEN Shi-lin Agriculture Flagship Commonwealth Scientific and Industrial Research Organisation (CSIRO) University of Queensland Red Soils Experimental Station Chinese Academy of Agricultural Sciences

The importance of livestock production activities to improving the livelihoods of smallholder farming households and the efficiency of their underlying farming systems is increasingly recognized.A rapid increase in livestock numbers, especially beef cattle, and special purpose forages is being promoted for smallholder farms which have traditionally undertaken subsistence cropping activities or simple livestock rearing activities using low quality *** limited plantings of specialized forages combined with a poor knowledge of animal nutrition are a challenge to establishing sustainable livestock enterprises, much public policy and research is now being focused on the use of new forages and improved feeding practices.A number of economic studies have suggested that specialized forage growing and livestock feeding activities can make a positive contribution to smallholder *** studies have typically compared the total level of farm or household income with and without livestock *** attention is given to how much the new forage or livestock activities actually contribute to or draw resources from other farm activities to assess their real economic contribution to the enterprise, and the availability of simple tools to assist in making such assessments are *** paper describes a simple modelling approach that was developed for an Australian Centre for International Agricultural Research（ACIAR）-supported project to explore the real as opposed to apparent economic impact of integrating improved forages and livestock within smallholder farming systems in the Red Soils region of south-central *** of the model is demonstrated using a simple case study of a smallholder enterprise that plans to introduce a new beef cattle rearing activity to its existing farm activity *** case study highlights the importance of explicitly valuing transfers of resources between different farm activities to gauge the real contribution o

关键词： smallholder farming systems economics resource transfers opportunity costs economic profit

What does complement do in Alzheimer’s disease? Old molecules with new insights

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Translational Neurodegeneration 2013年第1期2卷 143-153页

作者： Yong Shen Libang Yang rena Li Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute2040 Whitfield AvenueSarasotaUSA Department of Pediatrics School of MedicineUniversity of MinnesotaMinneapolisMN 55455USA Department of Neurology College of MedicineUniversity of FloridaGainesvilleFL 32610USA Center for Hormones Advanced Science and Education Roskamp Institute2040 Whitfield AvenueSarasotaFloridaUSA

Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease(AD)and anti-inflammatory and immunotherapeutic approaches may be amenable to AD *** is known that complement activation occurs in the brain of patients with AD,and contributes to a local inflammatory state development which is correlated with cognitive *** addition to the complement’s critical role in the innate immune system recognizing and killing,or targeting for destruction,complement proteins can also interact with cell surface receptors to promote a local inflammatory response and contributes to the protection and healing of the *** the other hand,complement activation also causes inflammation and cell damage as an essential immune function to eliminate cell debris and potentially toxic protein *** is the balance of these seemingly competing events that influences the ultimate state of neuronal *** mini review will be focusing on the unique molecular interactions happening in the AD development,the functional outcomes of those interactions,as well as the contribution of each element to AD.

关键词： Alzheimer healing inflammation

Design of face-hobbed spiral bevel gears with reduced maximum tooth contact pressure and transmission errors

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Chinese Journal of Aeronautics 2013年第3期26卷 777-790页

作者： Vilmos simon Budapest University of Technology and Economics Faculty of Mechanical Engineering Department for Machine Design

The aim of this study is to define optimal tooth modifications, introduced by appropriately chosen head-cutter geometry and machine tool setting, to simultaneously minimize tooth contact pressure and angular displacement error of the driven gear （transmission error） of face-hobbed spiral bevel gears. As a result of these modifications, the gear pair becomes mismatched, and a point contact replaces the theoretical line contact. In the applied loaded tooth contact analysis it is assumed that the point contact under load is spreading over a surface along the whole or part of the ‘‘potential’’ contact line. A computer program was developed to implement the formulation provided above. By using this program the influence of tooth modifications introduced by the variation in machine tool settings and in head cutter data on load and pressure distributions, transmission errors, and fillet stresses is investigated and discussed. The correlation between the ease-off obtained by pinion tooth modifications and the corresponding tooth contact pressure distribution is investigated and the obtained results are presented.

关键词： Ease-off Face-hobbed spiral bevel gears Load distribution Transmission errors Gear teeth