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Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis

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World Journal of Hepatology 2013年第2期5卷 74-81页

作者： Tarek E korah Sawsan El-Sayed maathir k elshafie Ghada E Hammoda Manal A Safan Department of Internal Medicine Faculty of MedicineMenoufiya University32511 MenoufiyaEgypt Department of Tropical Medicine Faculty of MedicineMenoufiya University32511 MenoufiyaEgypt Department of Medical Biochemistry Faculty of MedicineMenoufiya University32511 MenoufiyaEgypt

AIM:To study serum levels of leptin and adiponectin in patients with chronic hepatitis C virus infection genotype-4(HCV-4) related steatosis and ***:We prospectively studied 45 untreated men with chronic HCV-4,with proven steatosis(group Ⅰ,30 patients),and fibrosis(group Ⅱ,15 patients),on liver *** addition,15 healthy men(group Ⅲ),matched for age,and body mass index were ***,we excluded another five patients with steatohepatitis,and six patients with *** measured total serum leptin and adiponectin levels,as potential predictors for liver steatosis and ***,a correlation between these adipokines and various clinical and laboratory data were *** subjects were selected from Tropical and Internal medicine departments,Menoufiya University Hospital,Menoufiya,Egypt,during the period from February 2010 to August ***:In group Ⅰ,severity of hepatic steatosis was mild,moderate,and severe,in 19 patients(63.5%),8 patients(26.5%),and 3 patients(10%),*** contrast,in group Ⅱ,hepatic fibrosis was found to be in stage 1,2,and 3,in 6 patients(40%),in 6 patients(40%),and in 3 patients(20%),*** comparing group Ⅰ with group Ⅱ,there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 436 ± 9.75 pg/mL,P 0.05).However,in the same group,when compared with group Ⅲ,there was a significant increase in serum leptin levels(34.69 ± 7.69 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001),while there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 342.4 ± 44.48 pg/mL,P < 0.001).In contrast,in group Ⅱ,when compared with group Ⅲ,there was a significant increase in serum leptin and adiponectin levels(35.17 ± 1.06 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001,and 436 ± 9.75 pg /mL vs 342.4 ± 44.48 pg/mL,P < 0.05,respectively),while the

关键词： Leptin Adiponectin Hepatitis C virus Hepatic steatosis Hepatic fibrosis

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