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Mouse models in liver cancer research:A review of current literature

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world Journal of Gastroenterology 2008年第45期14卷 6915-6923页

作者： Martijn wH Leenders maarten w Nijkamp Inne HM Borel Rinkes Department of Surgery University Medical Center Utrecht

Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver can-cer varies among the world, with a peak in East-Asia. As this disease is still lethal in most of the cases, research has to be done to improve our understanding of the disease, offering insights for possible treatment options. For this purpose, animal models are widely used, especially mouse models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field. we focus on hepatocellular carcinoma (HCC), as this is by far the most common type of primary liver cancer, accounting for 70%-85% of cases.

关键词： Primary liver cancer Hepatocellular carcinoma Mouse model Genetically engineered mice

Yes indeed,most Americans do eat GMOs every day!

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Journal of Integrative Plant Biology 2014年第1期56卷 4-6页

作者： maarten J.Chrispeels University of California

while teaching a course on Crop Biotechnology at Huazhong Agricultural University （wuhan, Hubei Province, China） this past October, I was asked by one of my students if it is true that American farmers grow genetically modified crops （GMOs） only for export, and that GMO-foods are not sold in the USA. The student implied that Americans thought that such crops were ＂good enough＂ for developing countries but not good enough for themselves.

关键词： GMOs very Yes indeed,most Americans do eat GMOs every day

Theorems of Erds-Ko-Rado type in geometrical settings

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Science China Mathematics 2013年第7期56卷 1333-1348页

作者： DE BOECK maarten STORME Leo Department of Mathematics Krijgslaan 281-Building S22 9000 GentFlanders Belgium

The original Erdos-Ko-Rado problem has inspired much research. It started as a study on sets of pairwise intersecting k-subsets in an n-set, then it gave rise to research on sets of pairwise non-trivially intersecting k-dimensional vector spaces in the vector space V（n, q） of dimension n over the finite field of order q, and then research on sets of pairwise non-trivially intersecting generators and planes in finite classical polar spaces. we summarize the main results on the Erdos-Ko-Rado problem in these three settings, mention the ErdSs-Ko-Rado problem in other related settings, and mention open problems for future research.

关键词： Erdos-Ko-Rado theorem finite sets finite vector spaces finite classical polar spaces

Personalized query suggestion diversification in information retrieval

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Frontiers of Computer Science 2020年第3期14卷 129-141页

作者： wanyu CHEN Fei CAI Honghui CHEN maarten DE RIJKE Science and Technology on Information Systems Engineering Laboratory National University of Defense TechnologyChangsha 410073China Informatics Institute University of AmsterdamAmsterdam1098XHThe Netherlands

Query suggestions help users refine their queries after they input an initial *** work on query suggestion has mainly concentrated on approaches that are similarity-based or context-based,developing models that either focus on adapting to a specific user(personalization)or on diversifying query aspects in order to maximize the probability of the user being satisfied(diversification).we consider the task of generating query suggestions that are both personalized and *** propose a personalized query suggestion diversification(PQSD)model,where a user's long-term search behavior is injected into a basic greedy query suggestion diversification model that considers a user's search context in their current *** aspects are identified through clicked documents based on the open directory project(ODP)with a latent dirichlet allocation(LDA)topic *** quantify the improvement of our proposed PQSD model against a state-of-the-art baseline using the public america online(AOL)query log and show that it beats the baseline in terms of metrics used in query suggestion ranking and *** experimental results show that PQSD achieves its best performance when only queries with clicked documents are taken as search context rather than all queries,especially when more query suggestions are returned in the list.

关键词： query suggestion personalization query suggestion diversification

Circle of willis variants are not associated with thrombectomy outcomes

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Stroke & Vascular Neurology 2021年第2期6卷 310-313页

作者： Thomas Seifert-Held Katharina Eberhard Soren Christensen Edith Hofer Christian Enzinger Gregory w Albers maarten Lansberg Department of Neurology Medical University of GrazGrazAustria Core Facility Computational Bioanalytics Center for Medical ResearchMedical University of GrazGrazAustria Department of Neurology&Neurological Sciences Stanford UniversityStanfordCaliforniaUSA

Background The circle of willis(COw)is part of the brain collateral *** absence of COw segments may affect functional outcome in patients with ischaemic stroke undergoing endovascular *** In 182 patients in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Study and the CT Perfusion to Predict Response to Recanalisation in Ischaemic Stroke Project,COw anatomy was evaluated on postinterventional magnetic resonance *** absence of the posterior communicating artery or the first segments of posterior or anterior cerebral arteries ipsilateral to the ischaemic infarction was rated as an incomplete *** regression was applied to evaluate an association with the patients’modified Rankin scale(mRS)at 90 days after stroke Results An incomplete ipsilateral COw was not predictive of the patients’mRS at 90 days after *** associations were shown for the patients’baseline National Institutes of Health Stroke Scale(NIHSS),age and reperfusion *** effect size suggests that a significant association of an incomplete COw with the mRS at 90 days may be obtained in cohorts of more than 3000 *** Compared with the established predictors NIHSS,age and reperfusion status,an incomplete COw is not associated with functional outcome after endovascular therapy.

关键词： willis anatomy incomplete

C-NOT gate based on ultracold Rydberg atom interactions

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Science China(Physics,Mechanics & Astronomy) 2013年第11期56卷 2134-2137页

作者： RASHID Muhammad maarten Hoogerland YASIR Jamil Department of Physics University of Auckland Private Bag 92019 Auckland New Zealand Education Department Government of the Punjab Pakistan Laser Spectroscopy Lab. Department of Physics University of Agriculture Faisalabad-38040 Pakistan

The Rydberg states of neutral atoms are strongly polarisable and possess long lifetimes because of high energies which can lead to strong and long range dipole-dipole *** energy levels corresponding to these states are shifted because of dipole-dipole interactions and can be used to block transitions of more than one excitation in the Rydberg *** reputed Rydberg blockade is obtained when the excitation is shifted out of resonance by these *** induced transparency(EIT)is sensitive to a small *** large distances,up to several micrometers,the interactions can interrupt the EIT *** we investigate a novel scheme based on EIT and Rydberg blockade and performed a simulation of a controlled-NOT(C-NOT)quantum gate which is critical for quantum computation by using neutral atoms.

关键词： Rydberg atoms dipole-dipole interactions fidelity quantum gates

Four billion years of ophiolites reveal secular trends in oceanic crust formation

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Geoscience Frontiers 2014年第4期5卷 571-603页

作者： Harald Furnes maarten de wit Yildirim Dilek Department of Earth Science and Centre for Geobiology University of BergenAllegt.415007 BergenNorway AEON and Earth Stewardship Science Research Institute Nelson Mandela Metropolitan University 7701Port Elizabeth 6031South Africa Department of Geology and Environmental Earth Science Miami University State Key Laboratory of Geological Processes and Mineral Resources and School of Earth Science and Mineral ResourcesChina University of Geosciences

we combine a geological, geochemical and tectonic dataset from 118 ophiolite complexes of the major global Phanerozoic orogenic belts with similar datasets of ophiolites from 111 Precambrian greenstone belts to construct an overview of oceanic crust generation over 4 billion years. Geochemical discrimi- nation systematics built on immobile trace elements reveal that the basaltic units of the Phanerozoic ophiolites are dominantly subduction-related （75%）, linked to backarc processes and characterized by a strong MORB component, similar to ophiolites in Precambrian greenstone sequences （85%）. The remaining 25% Phanerozoic subduction-unrelated ophiolites are mainly （74%） of Mid-Ocean-Ridge type （MORB type）, in contrast to the equal proportion of RiftlContinental Margin, Plume, and MORB type ophiolites in the Precambrian greenstone belts. Throughout the Phanerozoic there are large geochemical variations in major and trace elements, but for average element values calculated in 5 bins of 100 million year intervals there are no obvious secular trends. By contrast, basaltic units in the ophiolites of the Precambrian greenstones （calculated in 12 bins of 250 million years intervals）, starting in late Paleo- to early Mesoproterozoic （ca. 2.0-1.8 Ga）, exhibit an apparent decrease in the average values of incom- patible elements such as Ti, P, Zr, Y and Nb, and an increase in the compatible elements Ni and Cr with deeper time to the end of the Archean and into the Hadean. These changes can be attributed to decreasing degrees of partial melting of the upper mantle from HadeanJArchean to Present. The onset of geochemical changes coincide with the timing of detectible changes in the structural architecture of the ophiolites such as greater volumes of gabbro and more common sheeted dyke complexes, and lesser occurrences of ocelli （varioles） in the pillow lavas in ophiolites younger than 2 Ga. The global data from the Precambrian ophiolites, representative of nearly 50% of all known

关键词： Phanerozoic and Precambrian greenstonebeltsOphiolite classificationSubduction-related ophiolitesSubduction-unrelated ophiolitesPrecambrian plate tectonics

Stem cells： novel players in the treatment of erectile dysfunction

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Asian Journal of Andrology 2012年第1期14卷 145-155,179页

作者： Haiyang Zhang maarten Albersen Xunbo Jin Guiting Lin Minimally Invasive Urology Center Provincial Hospital Affiliated to Shandong University Jinan 250021 China Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA 94143 USA Laboratory of Experimental Urology Department of Urology University Hospitals Leuven Leuven 3000 Belgium

Stem cells are defined by their capacity for both self-renewal and directed differentiation; thus, they represent great promise for regenerative medicine. Historically, stem cells have been categorized as either embryonic stem cells （ESCs） or adult stem cells （ASCs）. It was previously believed that only ESCs hold the ability to differentiate into any cell type, whereas ASCs have the capacity to give rise only to cells of a given germ layer. More recently, however, numerous studies demonstrated the ability of ASCs to differentiate into cell types beyond their tissue origin. The aim of this review was to summarize contemporary evidence regarding stem cell availability, differentiation, and more specifically, the potential of these cells in the diagnosis and treatment of erectile dysfunction （ED） in both animal models and human research. we performed a search on PubMed for articles related to definition, iocalisation and circulation of stem cells as well as the application of stem cells in both diagnosis and treatment of ED. Strong evidence supports the concept that stem cell therapy is potentially the next therapeutic approach for ED. To date, a large spectrum of stem cells, including bone marrow mesenchymal stem cells, adipose tissue-derived stem cells and muscle-derived stem cells, have been investigated for neural, vascular, endothelial or smooth muscle regeneration in animal models for ED. In addition, several subtypes of ASCs are localized in the penis, and circulating endogenous stem cells can be employed to predict the outcome of ED and ED-related cardiovascular diseases.

关键词： adipose tissue-derived stem cells bone marrow stem cells erectile dysfunction mesenchymal stem cells stem cells

Frequency Extrapolation through Sparse Sums of Lorentzians

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Journal of Earth Science 2014年第1期25卷 117-125页

作者： Fredrik Andersson Marcus Carlsson maarten V de Hoop Centre for Mathematical Sciences Lund University Department of Mathematics Purdue University

Sparse sums of Lorentzians can give good approximations to functions consisting of linear combination of piecewise continuous functions. To each Lorentzian, two parameters are as- signed： translation and scale. These parameters can be found by using a method for complex fre- quency detection in the frequency domain. This method is based on an alternating projection scheme between Hankel matrices and finite rank operators, and have the advantage that it can be done in weighted spaces. The weighted spaces can be used to partially revoke the effect of finite band-width filters. Apart from frequency extrapolation the method provides a way of estimating discontinuity locations.

关键词： sparse sum Lorentzians Hankel matrices finite rank operator discontinuity location.