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世界核心医学期刊文摘（眼科学分册） 2006年第4期2卷 2-3页

作者： van leeuwen R. Boekhoorn s. Vingerling J.R. P.T.V.M. De Jong 张磊 Dr. Netherlands Ophthalmic Research Institute KNAW Meibergdreef 47 1105 BA Amsterdam Netherlands

Context: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness in developed countries. Recently, high-dose supplementation with beta carotene, vitamins C and E, and zinc was shown to slow the progression of AMD. Objective: To investigate whether regular dietary intake of antioxidants is associated with a lower risk of incident AMD. Design: Dietary intake was assessed at baseline in the Rotterdam study (1990-1993) using a semiquantitative food frequency questionnaire. Incident AMD until final follow-up in 2004 was determined by grading fundus color transparencies in a masked way according to the International Classification and Grading system. setting: Population-based cohort of all inhabitants aged 55 years or older in a middle-class suburb of Rotterdam, the Netherlands. Participants: Of 5836 persons at risk of AMD at baseline, 4765 had reliable dietary data and 4170 participated in the follow-up. Main Outcome Measure: Incident AMD, defined as soft distinct drusen with pigment alterations, indistinct or reticular drusen, geographic atrophy, or choroidal neovascularization. Results: Incident AMD occurred in 560 participants after a mean follow-up of 8.0 years (range, 0.3-13.9 years). Dietary intake of both vitamin E and zinc was inversely associated with incident AMD. The hazard ratio (HR) per standard deviation increase of intake for vitamin E was 0.92 (95%confidence interval [CI], 0.84-1.00) and for zinc was 0.91 (95%CI, 0.83-0.98). An above-median intake of all 4 nutrients, beta carotene, vitamin C, vitamin E, and zinc, was associated with a 35%reduced risk (HR, 0.65; 95%CI, 0.46-0.92) of AMD. Exclusion of supplement users did not affect the results. Conclusion: In this study, a high dietary intake of beta carotene, vitamins C and E, and zinc was associated with a substantially reduced risk of AMD in elderly persons.

关键词：年龄相关性黄斑变性患病风险抗氧化剂脉络膜新生血管饮食 β-胡萝卜素玻璃膜疣受试者

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Calculating China's Historical Economic Aggregate: A GDP-centered Overview

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social sciences in China 2016年第4期37卷 56-75页

作者：倪玉平徐毅范鲁文.巴斯 Wang Wene school of Humanities Tsinghua University College of Historical Culture and Tourism Guangxi Normal University International Institute of social History the Netherlands

since the 1990s, thanks to the concerted efforts of domestic and international scholars, the research on China＇s historical GDP that began in the 1930s has received widespread attention, and is becoming a widely discussed issue at the forefront of research on world economic history. At the same time, several scholars at home and abroad have also voiced a call for more theoretical and empirical reflection within this line of research. Diversification of methods, systematic reconstruction of historical data, and international comparisons represent three emerging trends in future research on this subject. By encouraging and leading these trends, Chinese scholars can assume a greater role in international research on economic history.

关键词： China historical GDP economic aggregate calculation

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Approaches for Evaluating the Groundwater suitability for Domestic and Agricultural Uses in Guenniche Plain, Northern Tunisia

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Journal of Hydraulic Engineering 2016年第1期2卷 38-51页

作者： Jamila Hammami Lamia Kouzana Boutheina Farhat Abdallah Ben Mammou maarten Waterloo Dhafer Ghabri Faculty of sciences of Tunis University of Tunis El Manar 2092 Tunis Tunisia Acacia Water van Hoogendorpplein 4 2805 BM Gouda The Netherlands Regional Commission for Agricultural Development Av. Hassen Nouri Bizerte 7000 Tunisia

In add and semi-add regions groundwater is often the only natural resource for water supply. suitability of groundwater for domestic and irrigation purposes as well as its hydrochemical characteristics was estimated in the aquifer of Guenniche plain in Northern Tunisia. samples, collected in March and July 2007, were analysed for a range of chemical parameters （pH, conductivity, TDs, calcium, magnesium, sodium, potassium, sulphate, chloride, carbonate and bicarbonate）. The mean concentration of cations （mg.L-~） indicated that Na＋〉 Ca2＋〉 Mg2＋〉 K＋. similarly, the mean concentration of anions （mg.L-1） displayed the following decreasing trend： Cl-〉 sO42〉 HCO3〉 CO32-. A comparison of groundwater quality parameters in relation to specified limits for drinking water showed that the concentrations of EC, TDs, Ca2＋, Na＋, Cl-, sO42 and total hardness exceeded the desirable limits in many water samples. Majority of the samples were not suitable for drinking purposes. Furthermore, suitability of groundwater for irrigation was evaluated based on sodium absorption ratio, sodium percent, permeability index, residual sodium carbonate, magnesium hazard and Kelly＇s ratio. All these quality parameters revealed that the groundwater is of good to suitable category for irrigation.

关键词： Guenniche plain Tunisia suitability drinking use irrigation.

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Upper Gastrointestinal Cancers in Rwanda: Epidemiological, Clinical and Histopathological Features in Patients Presenting to a Tertiary Referral Hospital

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Open Journal of Gastroenterology 2022年第10期12卷 286-298页

作者： Felicien shikama steve P. Bensen Robert Giraneza Prosper Ndayisaba Elisée Hategekimana Eric Rutaganda Aloys Tuyizere Tindoho Nkakyekorera Benoit seminega Francois Ngabonziza Placide Kamali Vincent Dusabejambo Dirk J. van leeuwen Martin Munyaneza Frederick L. Makrauer Audrey H. Calderwood Centre Hospitalier Universitaire de Butare (CHUB) Department of Gastroenterology Kigali Rwanda Dartmouth Hitchcock Medical Center (DHMC) Section of Gastroenterology and Hepatology New Hampshire USA Department of Internal Medicine Ruhango District Hospital Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of Pathology Kigali Rwanda Centre Hospitalier Universitaire de Kigali (CHUK) Department of Gastroenterology Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of Internal Medicine Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of Radiology Kigali Rwanda Centre Hospitalier Universitaire de Butare (CHUB) Department of General Surgery Kigali Rwanda section of Gastroenterology and Hepatology Brigham and Women’s Hospital Boston USA

Background: scant data on upper gastrointestinal cancers in Rwanda exist to guide potential prevention efforts. We evaluated the epidemiological, clinical and histopathological data among patients with gastric and esophageal tumors at a tertiary Referral Hospital in Rwanda. Methodology: We performed a retrospective review of histologically-confirmed esophageal and gastric cancers in adults age ≥ 18 yrs. old presenting to a university teaching hospital (Centre Hospitalier Universitaire de Butare) from 2014-2019. Variables included age at diagnosis, sex, clinical presentation, tumor location and histopathological type. Results: There were 149 upper gastrointestinal cancers, of which 137 (92%) were gastric and 12 (8%) were esophageal. Gastric cancer patients had a mean age at presentation of 56.9 ± 12.3 years (range 21 - 87). Presenting symptoms were epigastric pain (78.8%), weight loss (53.3%), post-prandial vomiting (52.6%), early satiety (29.9%), epigastric mass (24.8%), hematemesis (19.7%) and melena (16.8%). The location was antrum 50.3%, corpus 21.8%, fundus 8%, and cardia 8%. Tumor type was adenocarcinoma in 94.1%. Helicobacter pylori infection was present in 108 (78.8%). Esophageal cancer patients had a mean age of 54.4 ± 9.5 years (range 35 - 72). Presenting symptoms were dysphagia (100%) and weight loss (83%). The most common site was lower third esophagus (9/12), and adenocarcinoma cancer subtype accounted for 5/12 (41.6%) cases. Conclusion: Gastric adenocarcinoma was the most commonly diagnosed upper gastrointestinal cancers and was associated with a high prevalence of H. pylori infection. This study lays the foundation for future work to improve cancer outcomes in Rwanda.

关键词： Epidemiology Upper Gastrointestinal Cancer H. pylori Rwanda

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以热机械浆和旧报纸/旧杂志纸为原料的新闻纸厂活性污泥菌胶团的黏性膨胀

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中国造纸 2015年第4期 76-76页

作者： sTEVEN NOTHROP DEs RICHARDsON JOHN van leeuwen MICHAEL MACHIN KOBUs THEUNIssEN TROY WATKINs BEN van DEN AKKER

在这项研究中,我们发现发生在一家新闻纸厂活性污泥废水处理厂的污泥膨胀是由菌胶团黏性膨胀(或水合膨胀)所导致的。在挪威诺斯克公司Albury工厂的活性污泥厂(AsP),菌胶团黏性膨胀表现为显微镜下的无定形团块,它在二次澄清过程中在曝气... 详细信息

在这项研究中,我们发现发生在一家新闻纸厂活性污泥废水处理厂的污泥膨胀是由菌胶团黏性膨胀(或水合膨胀)所导致的。在挪威诺斯克公司Albury工厂的活性污泥厂(AsP),菌胶团黏性膨胀表现为显微镜下的无定形团块,它在二次澄清过程中在曝气池的废水表面形成硬壳,同时在曝气池生成大量泡沫。使用亚甲蓝染色法确认了能引起发泡的多糖/胞外聚合物类物质(EPs)产生,另外(污泥)絮状物比较分散并且呈淡蓝色。这一条件导致大量的白色泡沫,对活性污泥的沉降性能和脱水性能产生了不利影响。菌胶团黏性膨胀可以通过以下方面进行控制:减少营养物/微生物(F/M)的比例;维持宏观养分(正磷酸盐和氨;磷和氮)的残余浓度;通过在好氧选择器后添加厌氧选择器和/或在好氧选择器前减少缺氧程度来控制微生物增长率等。在活性污泥厂,当进入选择器1的化学耗氧度的F/M比例为20∶1时,菌胶团膨胀非常严重。通过使用缺氧选择器2并在两个曝气池中保持适当的铵和正磷酸盐的浓度来控制菌胶团的生长速率成功地控制EPs的产生。在此情况下,使用亚甲蓝染色法观测到的絮状物呈现紧实特性(深蓝色和低多糖)。消泡剂的用量也减少了90%。

关键词：菌胶团黏性膨胀增长速度缺氧选择器生物可利用的营养物质胞外聚合物

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OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

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signal Transduction and Targeted Therapy 2022年第5期7卷 1842-1859页

作者： Chuannan Fan Qian Wang Gerard van der Zon Jiang Ren Cedrick Agaser Roderick C.slieker Prasanna Vasudevan Iyengar Hailiang Mei Peter ten Dijke Department of Cell and Chemical Biology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Oncode Institute Leiden University Medical CenterLeiden 2300 RCThe Netherlands Department of Biomedical Data sciences Sequencing Analysis Support CoreLeiden University Medical CenterLeiden 2300 RCThe Netherlands Department of Epidemiology and Data science Amsterdam Public Health InstituteAmsterdam Cardiovascular Sciences InstituteAmsterdam UMClocation VUmcAmsterdam 1081 HVThe Netherlands

Ovo-like transcriptional repressor 1(OVOL1)is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition(MET).The cytokines transforming growth factor-β(TGF-β)and bone morphogenetic proteins(BMP)control the epithelial–mesenchymal plasticity(EMP)of cancer cells,but whether this occurs through interplay with OVOL1 is not ***,we show that OVOL1 is inversely correlated with the epithelial–mesenchymal transition(EMT)signature,and is an indicator of a favorable prognosis for breast cancer ***1 suppresses EMT.

关键词： invasion breast cancer

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手术期间输注血小板和红细胞对肝移植手术后生存率的影响

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麻醉与镇痛 2009年第1期5卷 32-46页

作者： Marieke T. de Boer Michael C. Christensen Mikael Asmussen Christian s. van der Hilst Herman G. D. Hendriks maarten J. H. slooff Robert J. Porte 侯磊(译) 陈卫民(校) Department of surgery Section of Hepatobiliary Surgery and Liver Transplantation University Medical Center Groningen University of Groningen Groningen The Netherlands Global Development Novo Nordisk A/S Bagsvaerd Denmark Office for Medical Technology Assessment University Medical Center Groningen University of Groningen Groningen The Netherlands Department of Anesthesiology University Medical Center Groningen University of Groningen Groningen The Netherlands 不详

背景手术期间输入红细胞与原位肝移植患者的不良预后有关。实验性研究已经证实血小板可导致肝脏再灌注损伤，但是输注同种异体血小板对患者预后的影响尚未见详细的研究。本研究中，我们评估了不同血液制品对原位肝移植患者预后的影响。... 详细信息

背景手术期间输入红细胞与原位肝移植患者的不良预后有关。实验性研究已经证实血小板可导致肝脏再灌注损伤，但是输注同种异体血小板对患者预后的影响尚未见详细的研究。本研究中，我们评估了不同血液制品对原位肝移植患者预后的影响。方法对1989年到2004年之间行第1次原位肝移植的433例患者与预后有关的29个变量，包括血液制品输注等进行了研究。各项数据采用单因素和多因素逐步Cox比例风险模型法进行了统计分析，并对血小板输注采用校正倾向评分分析法以控制使用血液制品中的选择性偏差。结果输注血液制品的移植患者比例从1989～1996年的100％下降到1997～2004年的74％。在单因素和多因素分析中，移植的指征、输注血小板和红细胞是预测移植患者1年生存率最重要的因素。这些危险因素与终末肝病分型评分和garnofsky评分等已被公认的肝脏疾病指数无关。输注血小板和红细胞呈剂量依赖性影响1年生存率，输注每单位血小板的危险比为1．377（P=0．01），输注每单位红细胞的危险比为1．057（P=0．001）。经校正倾向性评分分析证实，血小板输注对生存率有负面影响。结论本项回顾性研究表明，除红细胞外，血小板输注也是影响原位肝移植术后存活的独立危险因素。这些研究结果对肝移植受体的临床液体输注具有重要意义。

关键词：输注血小板术后生存率肝移植患者手术期间红细胞移植手独立危险因素血小板输注

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应用Gd-EOB-DTPA行肝脏MR扫描延时10min为显示病变特征的最佳延时时间

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国际医学放射学杂志 2012年第6期 608-608页

作者： C.s.van Kessel W.B.Veldhuis M.A.A.J.van den Bosch M.s.van leeuwen 陈莉 Department of Radiology University Medical Centre UtrechtHeidelberglaan 1003584CX UtrechtThe Netherlands

目的采用Gd-EOB-DTPA对肝功能正常的病人行增强MRI检查,评价延时10min是否是显示病变特征的最佳延时时间。方法 42例疑似肝脏局灶性病变病人,经静脉注射Gd-EOB-DTPA后分别在5、10和20min进行肝胆期动态MRI扫描。在检查各期分别针对低信... 详细信息

目的采用Gd-EOB-DTPA对肝功能正常的病人行增强MRI检查,评价延时10min是否是显示病变特征的最佳延时时间。方法 42例疑似肝脏局灶性病变病人,经静脉注射Gd-EOB-DTPA后分别在5、10和20min进行肝胆期动态MRI扫描。在检查各期分别针对低信号和高信号病灶就以下参数进行评估:实质增强程度、胆管对比剂排泄情况、病变的强化特征(低信号、等信号或高信号,边缘强化、非中央强化),以及对比度和信噪比。结果肝实质病变增强信号程度至10min时显著增加(86.3%,PsNR)在增强后10min达到峰值(P<0.05),20min时没有进一步增加。结论在肝功能正常的病人行Gd-EOB-DTPA增强MRI检查,可在延时10min时得到显示病变特征的最佳延时时间。

关键词： Gd-EOB-DTPA 检查时间动态对比增强MRI 肝胆管成像病变特征

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供应胃管动脉的钙化:食管术后吻合口漏的一项新危险因素

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国际医学放射学杂志 2015年第2期 167-167页

作者： P.s.N.van Rossum L.Haverkamp H.M.Verkooijen M.s.van leeuwen R.van Hillegersberg J.P.Ruurda 庞国栋 Department of surgery University Medical Centre UtrechtHeidelberglaan 1003584CX Utrecht the Netherlands

摘要目的本研究旨在应用血管钙化评分系统并根据食管癌病人食管切除与胃管重建术后的吻合口漏的发生来评估胃管的供血动脉钙化的数量和位置的关系。材料与方法

关键词：吻合口漏动脉钙化病人胃管动脉

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CT评分系统对食管切除术后吻合口瘘的诊断效能:与经验性CT评估相比较

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国际医学放射学杂志 2017年第6期 747-747页

作者： L.Goense P.M.stassen F.J.Wessels P.s.van Rossum J.P.Ruurda M.s.van leeuwen 刘瑶 Department of surgery University Medical Center Utrecht

摘要目的建立评估食管切除术后吻合口瘘的CT预测评分系统,并将其与经验性CT评估进行比较。方法分析2003年—2014年间食管切除颈部吻合术后,临床怀疑吻合

关键词：吻合口瘘食管切除术诊断效能经验性 CT

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