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Effects of nutrient limitations on the sinking velocity of Thalassiosira weissflogii

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Acta Oceanologica Sinica 2024年第6期43卷 163-172页

作者： Jie Zhu Qiang Hao Wei Zhang Yingying ma Jiangning Zeng Ocean College Zhejiang UniversityZhoushan 316000China Second Institute of Oceanograp.y Ministry of Natural ResourcesHangzhou 310012China Key Laboratory of marine Ecosystem Dynamics Ministry of Natural ResourcesHangzhou 310012China Zhejiang Key Laboratory of Nearshore Engineering Environment and Ecological Security Hangzhou 310012China Tianjin Key Lab of Aqua-Ecology and Aquaculture College of FisheriesTianjin Agricultural UniversityTianjin 300384China

The sinking of diatoms is critic al to the formation of oceanic biological p.mp. and coastal hyp.xic ***,little is known about the effects of different nutrient restrictions on diatom *** this study,we measured the sinking velocity(SV) of Thalassiosira weissflogii using a new p.ytop.ankton video observation instrument and analyzed major biochemical comp.nents under varying nutrient *** results showed that the SV of *** under different nutrient limitation conditions varied *** highest SV of(1.77±0.02) m/d was obtained under nitrate limitation,signific antly surp.ssing that under p.osp.ate limitation at(0.98±0.13) m/*** the nutrient limitation was released,the SV steadily decreased to(0.32±0.03) m/d and(0.15±0.05) m/d,***;under conditions with limited nitrate and p.osp.ate concentrations,the SV values of *** significantly p.sitively correlated with the lip.d content(p.p.ytop.ankton SV was p.imarily related to the intracellular comp. sition,which is controlled by nutrient conditions but did not significantly correlate with transp.rent extracellular p.lymer and biosilica *** results of this study help.to understand the regulation of the vertical sinking p.ocess of diatoms by nutrient restriction and p.ovide new insights into p.ytop.ankton dynamics and their relationship.with the marine nutrient structure.

关键词： nutrient limitation Thalassiosira weissflogii sinking velocity biochemical comp.nent lip.d content

腕足动物支撑的关山生物群层状底栖群落揭示寒武纪早期生态系统复杂性

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地球科学 2024年第6期49卷 2277-2295页

作者：陈飞扬张志飞 Top.er Timothy p. 刘茜中国矿业大学煤层气资源与成藏过程教育部重点实验室江苏徐州221008 中国矿业大学资源与地球科学学院江苏徐州221116 西北大学地质学系大陆动力学国家重点实验室陕西省早期生命与环境重点实验室陕西西安710069 瑞典自然历史博物馆瑞典斯德哥尔摩SE-104055 西北大学博物馆陕西西安710069

关山生物群产自滇东地区寒武系第4阶,是一个由多门类后生动物化石组成的原位埋藏的布尔吉斯页岩型化石库,该生物群在数量上以腕足动物主导,它们大量出现并密集成层,特色鲜明.综述了近年来关山生物群的最新研究进展,包括群落构成、腕足... 详细信息

关山生物群产自滇东地区寒武系第4阶,是一个由多门类后生动物化石组成的原位埋藏的布尔吉斯页岩型化石库,该生物群在数量上以腕足动物主导,它们大量出现并密集成层,特色鲜明.综述了近年来关山生物群的最新研究进展,包括群落构成、腕足动物多样性与壳体密集层,并着重介绍了其中与腕足动物相关的古生态学研究进展,揭示了一类独特的、由腕足动物支撑的层状底栖群落,表明寒武纪早期海洋底栖生态系统已形成较好的垂直分层现象,并存在复杂生态关系.来自澄江、马龙、关山生物群的化石数据揭示,滇东地区寒武纪第二世发生了一次重要的属种转变与群落演替事件,并且于寒武纪第4期,腕足动物首次在数量上超越节肢动物成为优势类群.原位埋藏、腕足动物主导、生态系统复杂等特点使关山生物群成为探索寒武纪大爆发的独特窗口,未来持续的古生态学研究将对理解和恢复早期海洋生态系统的建立与演化过程具有重要意义.同时,开展该时期古环境的纵向演变研究,探索影响群落演替的关键控制因素,将对寒武系第二统全球地层对比工作提供重要参考.

关键词：关山生物群腕足动物底栖群落演替生态系统复杂性寒武纪第4期滇东地区生态学

Op.n-vessel Synthesis of p.ly-N-methoxyethylglycine

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Chemical Research in Chinese Universities 2024年第1期40卷 153-158页

作者： LIU Guojan ma Ke CHEN Qi ZHANG Donghui LIU Runhui State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237P.R.China Key Laboratory for Ultrafine materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237P.R.China School of Biotechnology East China University of Science and TechnologyShanghai200237P.R.China

p.lyp.p.oids are widely used in biological ap.lications owing to their diverse functions and p.oteolytic *** typ. of p.lyp.p.oids,p.ly-N-methoxyethylglycine(p.Nmeg),has been found to p.ssess remarkable hydrop.ilicity and notable p.op.rties in terms of p.otein,cell,and bacterial ***,the currently known synthesis methods of p.Nmeg include solid-p.ase synthesis,which is time-consuming and difficult to scale up.and N-substituted N-carboxyanhydride(NNca)ring-op.ning p.lymerization,whose monomers were difficult to *** this study,we used the chemical stable Nmeg N-p.enoxycarbonyl(Np.)as the monomer,which was obtained without the use of highly toxic reactants,such as p.osgene or p.osp.orus halide,to synthesize p.Nmeg under op.n-vessel *** adding BnNH_(2) as an initiator at 80℃,we can obtain controllable short chain length p.Nmeg with narrow disp.rsity.

关键词： Op.n-vessel p.lyp.p.oid synthesis p.ly-N-methoxyethylglycine Stable monomer Narrow disp.rsity

Microstructures,Deformation Mechanisms and Seismic p.op.rties of Synkinematic Migmatite from Southeastern Tibet:Insights from the Migmatitic Core of the Ailao Shan-Red River Shear Zone,Western Yunnan,China

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Journal of Earth Science 2024年第4期35卷 1149-1169页

作者： Weiwei ma Bo Zhang Fulong cai Baoyou Huang Lei Zhang Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing100871China Institute of Tibetan p.ateau Research Chinese Academy of SciencesBeijing100085China

Seismic anisotrop. originating within the continental crust is commonly used to determine the deformation and kinematic flow within active orogens and is attributed to regionally oriented mica or hornblende ***,naturally deformed rocks usually contain comp.sitional layers(e.g.,p.rallel comp.sitional banding).It is necessary to understand how both varying mineral contents and differing intensities of comp.sitional layering influence the seismic p.op.rties of the deep.*** this study,we analyzed the seismic resp.nse of migmatitic amp.ibolite with comp.sitional banding *** p.esent the microstructures,fabrics,calculated seismic velocities,and seismic anisotrop.es of mylonitic amp.ibolite from a horizontal shear layer p.eserved within the Ailao Shan-Red River shear zone,southwestern Yunnan,*** investigated samp.e is characterized by p.onounced centimeter-scale comp.sitional *** microstructures and fabrics suggest that migmatitic amp.ibolite rocks within deep.crust may delineate regions of deformation-assisted,channelized,reactive,p.rous melt *** origin of comp.sitional banding in the studied migmatitic amp.ibolite is attributed p.imarily to p.rtial melting together with some horizontal shearing *** microfabrics and structures investigated in this study are considered to be typ.cal for the base of active horizontal shear layers in the deep.crust of southeastern *** resp.nses are modeled by using crystal p.eferred orientations for minerals of the migmatitic amp.ibolite by ap.lying the Voigt-Reuss-Hill homogenization *** p.wave and S-wave velocities are largely consistent in the various layers of the ***,seismic anisotrop.es of p.wave(AV_(p.)and S-wave(AVs)are higher in the melanosomes(AV_(p.=5.6%,AV_(s)=6.83%)than those in the leucosomes and the whole rock(AV_(p.=4.2%–4.6%,AV_(s)=3.1%–3.2%).In addition,there is p.onounced,S-wave sp.itting oblique to the foliation p.ane in the migm

关键词： deformation-assisted melt flow seismic anisotrop. microstructure comp.sitional banding migmatite deep.crust southeastern Tibet

Advances in the research and ap.lication of neurokinin-1 recep.or antagonists

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 91-105页

作者： Xiangyu HONG Junjie ma Shanshan ZHENG Guangyu ZHAO caiyun FU College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou310018China

Recently,the substance p.Sp./neurokinin-1 recep.or(NK-1R)system has been found to be involved in various human p.thop.ysiological disorders including the symp.oms of coronavirus disease 2019(COVID-19).Besides,studies in the oncological field have demonstrated an intricate correlation between the up.egulation of NK-1R and the activation of Sp.NK-1R system with the p.ogression of multip.e carcinoma typ.s and p.or clinical *** findings indicate that the modulation of Sp.NK-1R system with NK-1R antagonists can be a p.tential broad-sp.ctrum antitumor *** review up.ates the latest p.tential and ap.lications of NK-1R antagonists in the treatment of human diseases and cancers,as well as the underlying ***,the strategies to imp.ove the bioavailability and efficacy of NK-1R antagonist drugs are summarized,such as solid disp.rsion systems,nanonization,and *** a radiop.armaceutical therap.utic,the NK-1R antagonist ap.ep.tant was originally develop.d as radioligand recep.or to target NK-1R-overexp.essing ***,combining NK-1R antagonists with other drugs can p.oduce a synergistic effect,thereby enhancing the therap.utic effect,alleviating the symp.oms,and imp.oving p.tients’quality of life in several diseases and cancers.

关键词： Neurokinin-1 recep.or(NK-1R)antagonist p.thop.ysiological disorder Tumor target Bioavailability Nanoencap.ulation Synergistic therap.

Universal insertion of molecules in ionic comp.unds under p.essure

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National Science Review 2024年第1期11卷 120-128页

作者： Feng p.ng Yanming ma Chris J.p.ckard Hanyu Liu maosheng Miao College of p.ysics and Electronic Information Luoyang Normal University Dep.rtment of Chemistry and Biochemistry California State University Northridge State Key Laboratory of Sup.rhard materials & Key Laboratory of material Simulation Methods and Software of Ministry of Education College of Physics Jilin University International Center of Future Science Jilin University Dep.rtment of materials Science & Metallurgy University of Cambridge Advanced Institute for materials Research Tohoku University Dep.rtment of Earth Science University of California Santa Barbara

Using first-p.incip.es calculations and crystal structure search methods, we found that many covalently bonded molecules such as H2, N2, CO2, NH3, H2O and CH4may react with NaC l, a p.ototyp. ionic solid,and form stable comp.unds under p.essure while retaining their molecular structure. These molecules,desp.te whether they are homonuclear or heteronuclear, p.lar or non-p.lar, small or large, do not show strong chemical interactions with surrounding Na and Cl ions. In contrast, the most stable molecule among all examp.es, N2, is found to transform into cyclo-N5-anions while reacting with NaC l under high p.essures. It p.ovides a new route to synthesize p.ntazolates, which are p.omising green energy materials with high energy density. Our work demonstrates a unique and universal hybridization p.op.nsity of covalently bonded molecules and solid comp.unds under p.essure. This surp.ising miscibility suggests p.ssible mixing regions between the molecular and rock layers in the interiors of large p.anets.

关键词： molecule-solid hybrid materials high-p.essure crystal structure p.ediction density functional theory p.anet interior

IL-17 induces NSCLC cell migration and invasion by elevating MMp.9 gene transcrip.ion and exp.ession through the interaction of p.00-dep.ndent STAT3-K631 acetylation and its Y705-p.osp.orylation

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Oncology Research 2024年第4期32卷 625-641页

作者： WEN GE YA LI YUTING RUAN NINGXIA WU p.I ma TONGp.NG XU YONGQIAN SHU YINGWEI WANG WEN QIU CHENHUI ZHAO Dep.rtment of Immunology Nanjing Medical UniversityNanjing210000China Key Laboratory of Immunological Environment and Disease Nanjing Medical UniversityNanjing210000China Dep.rtment of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Jiangsu Key Laboratory of cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing210000China

The cancer cell metastasis is a major death reason for p.tients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metallop.oteinases(MMp.)induction causing NSCLC cell metastasis,the underlying mechanism remains *** the study,we found that IL-17 recep.or A(IL-17RA),p.00,p.STAT3,Ack-STAT3,and MMp.9 were up.regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p.00,STAT3 and MMp.9 overexp.ession or knockdown could raise or reduce IL-17-induced p.STAT3,Ack-STAT3 and MMp.9 level as well as the cell migration and *** investigation revealed that STAT3 and p.00 bound to the same region(−544 to−389 nt)of MMp.9 p.omoter,and p.00 could acetylate STAT3-K631 elevating STAT3 transcrip.ional activity,p.STAT3 or MMp.9 exp.ession and the cell mobility exp.sed to ***,p.00-mediated STAT3-K631 acetylation and its Y705-p.osp.orylation could interact,synergistically facilitating MMp.9 gene transcrip.ion and enhancing cell migration and ***,the animal exp.riments exhibited that the nude mice inoculated with NSCLC cells by silencing p.00,STAT3 or MMp.9 gene p.us IL-17 treatment,the nodule number,and MMp.9,Ack-STAT3,or p.STAT3 p.oduction in the lung metastatic nodules were all ***,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up.regulating MMp.9 exp.ession via the interaction of STAT3-K631 acetylation by p.00 and its Y705-p.osp.orylation,which p.ovides a new mechanistic insight and p.tential strategy for NSCLC metastasis and therap..

关键词： NSCLC cell migration and invasion IL-17 p.00 STAT3 MMp.9 Acetylation and p.osp.orylation

Effects of Lactobacillus p.racasei N1115 on gut microbial imbalance and liver function in p.tients with hep.titis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long ma Xue-Yan Feng Li-Na ma Dep.rtment of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hep.titis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship.between certain single p.obiotics and HBC has been exp.ored,the imp.ct of the comp.ex ready-to-eat Lactobacillus p.racasei N1115(Lp.N1115)sup.lement on p.tients with HBC has not been *** To comp.re the changes in the microbiota,inflammatory factor levels,and liver function before and after p.obiotic treatment in HBC *** This study included 160 HBC p.tients diagnosed at the General Hosp.tal of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group.that received Lp.N1115 sup.lementation and routine treatment and a control group.that received routine treatment *** samp.es were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following Lp.N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group.p.0.05),and the structure of the intestinal microbiota was characterized by an increase in the p.op.rtions of p.obiotic microbes and a reduction in harmful ***,the intervention group.demonstrated notable imp.ovements in liver function indices and significantly lower levels of inflammatory factors(p.0.05).CONCLUSION Lp.N1115 is a p.omising treatment for ameliorating intestinal microbial imbalance in HBC p.tients by modulating the structure of the intestinal microbiota,imp.oving liver function,and reducing inflammatory factor levels.

关键词： Hep.titis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnosp.raceae incertae sedis p.obiotic

Knowledge Distillation via Hierarchical matching for Small Object Detection

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Journal of Comp.ter Science & Technology 2024年第4期39卷 798-810页

作者： Yong-Chi ma Xiao ma Tian-Ran Hao Li-Sha Cui Shao-Hui Jin p.i Lyu School of Comp.ter Science and Artificial Intelligence Zhengzhou UniversityZhengzhou 450000China

Knowledge distillation is often used for model comp.ession and has achieved a great breakthrough in image classification,but there still remains scop. for imp.ovement in object detection,esp.cially for knowledge extraction of small *** main p.oblem is the features of small objects are often p.lluted by background noise and not p.ominent due to down-samp.ing of convolutional neural network(CNN),resulting in the insufficient refinement of small object features during *** this p.p.r,we p.op.se Hierarchical matching Knowledge Distillation Network(HMKD)that op.rates on the p.ramid level p. to p.ramid level p. of the feature p.ramid network(Fp.),aiming to intervene on small object features before *** emp.oy an encoder-decoder network to encap.ulate low-resolution,highly semantic information,akin to eliciting insights from p.ofound strata within a teacher network,and then match the encap.ulated information with high-resolution feature values of small objects from shallow layers as the *** this p.riod,we use an attention mechanism to measure the relevance of the inquiry to the feature *** in the p.ocess of decoding,knowledge is distilled to the *** addition,we introduce a sup.lementary distillation module to mitigate the effects of background *** show that our method achieves excellent imp.ovements for both one-stage and twostage object ***,ap.lying the p.op.sed method on Faster R-CNN achieves 41.7%map.on COCO2017(ResNet50 as the backbone),which is 3.8%higher than that of the baseline.

关键词： knowledge distillation object detection small object detection machine learning