检索结果-南通市图书馆

Comparison of neonatal tolerance to thoracoscopic and open repair of esophageal atresia with tracheoesophageal fistula

引用

Chinese Medical journal 2012年第19期125卷 3492-3495页

作者： ma Li LIU Yong-zhe ma Ya-qun ZHANG Sheng-suo PAN Ning-ling Department of Anesthesiology Beijing Military General Hospital of Chinese People's Liberation ArmyBeijing 100700China

Background Advances in minimally invasive surgical techniques and neonatal intensive care for neonates have allowed for repair of the neonatal esophageal atresia with tracheoesophageal fistula （EA/TEF） to be approached endoscopically. However, thoracoscopic surgery in children is still performed in only a few centers throughout the world. The aim of this study was to compare the neonatal tolerance to the thoracoscopic repair （TR） and the open repair （OR） and also to discuss anesthetic management in thoracoscopic procedure. Methods We performed a prospective study enrolling newborns diagnosed with EA with distal TEF （type C） receiving the repair surgery between june 2009 and january 2012 in our institution. Data collected included the newborns＇ gestational age and weight at the time of the operation, operative time, parameters of intraoperative mechanical ventilation, oxygenation, end-tidal carbon dioxide （ETCO2）, and analysis of blood gases. Time to extubation and length of stay were also recorded. Results Intravenous induction with muscle paralysis followed by pressure-control ventilation and tracheal intubation regardless of the position of the fistula can be performed uneventfully in EA/TEF newborns with no additional airway anomalies and large, pericarinal fistulas in our experiences. The thoracoscopic approach appeared to take longer than the open approach. During the procedure of repair, hypercarbia and acidosis developed immediately 1 hour after pneumothorax in both groups. CO2 insufflation did have additional influence on the respiratory function of the newborns in the TR group; values of PaCO2 and ETCO2 were higher in the TR group but the difference did not reach statistical significance. By the end of the procedure, values of PaCO2 and ETCO2 returned to the baseline levels while pH did not, but all parameters made no difference in the two groups. Besides, time to extubation was shorter in the TR group. Conclusions Thoracoscopic repair of EA/TEF is comparab

关键词： esophageal atresia," tracheoesophageal fistula thoracoscopy," neonate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice

引用

journal of Traditional Chinese Medicine 2018年第4期38卷 570-578页

作者： Zhang Yi Mo Fangfang Zhang Dongwei Gao Sihua Zhao Dandan Yu Na Mu Qianqian Zuo jiacheng ma Yue Diabetes Research Center Beijing University of Chinese Medicine Beijing 100029 China Institute of Traditional Chinese Medicine Health management Beijing Open University Beijing 100081 China

OBjECTIVE:To observe the effect of jiangtang Xiaoke(jTXK) granule on endoplasmic reticulum(ER)stress in high fat diet(HFD)-induced type 2 diabetes mellitus(T2 DM) KK-Ay ***:KK-Ay mice were fed with HFD to induce the T2 DM model,while normal control C57 BL/6 j mice were given standard *** blood glucose(FBG) in all mice was measured weekly and oral glucose tolerance tests(OGTTs) were performed at 4 and 10 weeks after start of treatment to determine glucose *** fasting insulin(FINS) and insulin sensitivity index(ISI) were measured to determine insulin sensitivity.m RNA expressions of eukaryotic initiation factor-2 alpha(e IF2α),glucose regulated protein 78(GRP78),activating transcription factor 4(ATF4),and C/EBP homology protein(CHOP) were assessed by reverse transcription polymerase chain reaction and the protein expressions of p-e IF2α,GRP78,and CHOP were assessed by Western ***:jTXK granule significantly reduced FBG and free fatty acid levels and improved OGTT at the120 min of the 10-week treatment in T2 DM KK-Ay *** and Hb Alc levels were reduced and insulin sensitivities were increased in KK-Ay diabetic mice,which were improved with the treatment of jTXK granule,especially at the 7 and 3.5 g/kg *** granule at the 3.5 g/kg dose was most effective in reducing both gene and protein expressions of e IF2α,GRP78,and ***:ER stress response is increased in T2 DM KK-Ay *** with jTXK granule attenuates glucose disorders,improves insulin sensitivity,and reduces serum FFA in T2 DM KK-Ay *** mechanisms may be attributed to regulation of the signaling ER stress pathway via decreasing e IF2α phosphorylation and suppressing e IF2α-ATF4-CHOP activation.

关键词： Endoplasmic reticulum stress Fatty liver Lipid metabolism Diabetes mellitus type 2 jiangtang Xiaoke granule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microarray gene expression analysis of chemosensitivity for docetaxel,cisplatin and 5-fluorouracil(TPF)combined chemotherapeutic regimen in hypopharyngeal squamous cell carcinoma

引用

Chinese journal of Cancer Research 2017年第3期29卷 204-212页

作者： Meng Lian Haizhou Wang jugao Fang jie Zhai Ru Wang Xixi Shen Yifan Yang Zhihong ma Honggang Liu Department of Otorhinolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology Beijing 100730China

Objective: To screen out a set of candidate genes which could help to determine whether patients with hypopharyngeal squamous cell carcinoma (HSCC) could benefit from docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy. Methods: Gene-expression profiles in 12 TPF-sensitive patients were compared to 9 resistant controls by microarray analysis. Subsequently, expression levels of potential biomarkers in chemosensitive cell line FaDu after TPF treatment were observed by quantitative real-time polymerase chain reaction (qRT-PCR). Results: Through microarray analysis, 1,579 differentially expressed genes were identified, of which 815 were up-regulated in TPF chemotherapy-responsive tissues whereas 764 were down-regulated. Gene ontology (GO) analysis suggested these genes participating in physiological processes including transcription and its regulation, cellular signal transduction and metabolic process. Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) database revealed that maPK and jat/STAT signaling pathways occupied important roles in TPF chemotherapeutic sensitivity. Moreover, in vitro cell culture experiments revealed the expression alternations of IL-6, maPK14, jUN, CDK5 and CAMK2A exposed to TPF treatment by qRT-PCR, whilst providing an insight into the mechanism underlying TPF chemotherapeutic response in HSCC. Conclusions: These results provided a battery of genes related to TPF chemotherapeutic sensitivity and might act as molecular targets in HSCC treatment. Moreover, these candidate biomarkers could contribute to HSCC individualized treatment.

关键词： Microarray HSCC induction chemotherapy maPK

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical applications of free medial tibial flap with posterior tibial artery for head and neck reconstruction after tumor resection

引用

Chinese journal of Cancer Research 2017年第3期29卷 231-236页

作者： Qi Zhong jugao Fang Zhigang Huang Xiaohong Chen Lizhen Hou Yang Zhang Pingdong Li Hongzhi ma Hongbo Xu Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing Institute of Otolaryngology Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University) Ministry of Education

Tumor resection causes damage in the head and neck which creates problems in swallowing, chewing, articulation, and vision, all of which seriously affect patients' quality of life. In this work, we evaluated the application of a free medial tibial flap in reconstruction of head and neck defects after tumor resection. We discussed the anatomy, surgical technique, and the advantages and disadvantages of the flap. We found several benefits for the flap, such as, it is especially effective for the defects that require thin-layer epithelium to cover or the separated soft tissue defect; a two-team approach can be used because the donor site is far away from the head and neck; and the flap is easy to integrate because of the subcutaneous fat layer of the free medial tibial flap is thin and the flap is soft. Thus, the medial tibial flap could replace the forearm flap for certain applications.

关键词： Head and neck free flap posterior tibial artery reconstruction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The “Hyperreality” Utopia: Analysis of the Landscape Architecture of Disneyland from a Semiotic Perspective

引用

journal of Landscape Research 2017年第3期9卷 1-2,8页

作者： ma Fangnan School of Art and Design Wuhan University of Technology

Modern society has become a society of the spectacle that centers on production and consumption of visual signs. The sign is no longer in its natural state but gets involved in the society of the spectacle with massive reproduction and representation. Literature review and semiotic principles were applied to summarize the landscape architecture of Disneyland. This study proposed the following three arguments by correlating Baudrillard's concept "hyperreality" with the landscape architecture of Disneyland: the disappearance of history in landscape architecture, simulacra reproduction in landscape architecture and the consumerism tendency in landscape architecture. The analysis of Disneyland's landscape architecture from a semiotic perspective will be a more profound examination of landscape architecture.

关键词： Hyperreality Landscape design Semiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on intestinal transport of Veratrum alkaloids compatible with Panax ginseng across the Caco-2 cell monolayer model by UPLC-ESI-MS method

引用

Chinese Chemical Letters 2016年第2期27卷 215-220页

作者： Ying-Hui ma Meng-Ying Wei Yuan-Yuan Liu Feng-Rui Song Zhong-Ying Liu Zi-Feng Pi College of Pharmacy Jilin University Changchun Institute of Applied Chemistry Chinese Academy of Sciences

The Caco-2 cells have been recognized as effective tools to be applied to imitate the drug absorption in human intestine for the transport of drug. In this study, Caco-2 cell monolayer model was used to study compatibility of the transport of the Veratrum alkaloids in different proportions with Panax ginseng. A specific ultra-high performance liquid chromatographic-electrospray ionization-mass spectrometric（UPLC-ESI-MS） method is developed for the semi-quantitative determination of Veratrum alkaloids on intestinal transport with berberine as internal standard（IS）. In the Caco-2 model constructed, three influencing factors are investigated, including time, concentration and recovery rates of the Veratrum alkaloids during the uptake from AP（apical side） to BL（basolateral side）. The results suggest that the flux of Veratrum alkaloids is time dependent and concentration dependent. And the absorption of all eight Veratrum alkaloids increase after compatibility with Panax ginseng compared to the single Veratrum nigrum extraction. This research was studied from the perspective of intestinal absorption by the UPLCESI-MS method. This method was successfully applied to transport studies of the Veratrum alkaloids and the interaction mechanism between Veratrum nigrum and Panax ginseng.

关键词： UPLC-ESI-MS Veratrum nigrum Alkaloids Panax ginseng Transport Caco-2 cell monolayer model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An advanced low-cost cathode composed of graphene-coated Na_(2.4)Fe_(1.8)(SO_(4))_(3) nanograins in a 3D graphene network for ultra-stable sodium storage

引用

journal of Energy Chemistry 2021年第3期30卷 564-570页

作者： Yongjin Fang Qi Liu Xiangming Feng Weihua Chen Xinping Ai Liguang Wang Liang Wang Zhiyuan ma Yang Ren Hanxi YangYuliang Cao College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds&Materials of Ministry of EducationWuhan UniversityWuhan 430072HubeiChina Department of Physics City University of Hong KongTat Chee AvenueKowloonHong KongChina College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001HenanChina X-ray Science Division Advanced Photon SourceArgonne National Laboratory9700 South Cass AvenueLemontIL 60439USA

Iron-based electrodes have attracted great attention for sodium storage because of the distinct cost ***,exploring suitable iron-based electrodes with high power density and long duration remains a big ***,a spray-drying strategy is adopted to construct graphene-coated Na_(2.4)Fe_(1.8)(SO_(4))_(3) nanograins in a 3D graphene microsphere *** unique structural and compositional advantages endow these electrodes to exhibit outstanding electrochemical properties with remarkable rate performance and long cycle *** analyses further explain the outstanding electrochemical properties from the structural aspect.

关键词： Na_(2.4)Fe_(1.8)(SO_(4))_(3) Polyanions Spray-drying Cathode Sodium-ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of cold rolling process on microstructure and mechanical properties of high strength β titanium alloy thin sheets

引用

Progress in Natural Science:materials International 2018年第6期28卷 711-717页

作者： Yan ma Zhaoxin Du Xiaoming Cui jun Cheng Guolong Liu Tianhao Gong Huimin Liu Xiaopeng Wang Yuyong Chen School of materials Science and Engineering Inner Mongolia University of Technology Northwest Institute for Nonferrous Metal Research National Key Laboratory for Precision Hot Forming of Metals Harbin Institute of Technology

The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short *** to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching.

关键词： Cold rolling process High strength β titanium alloy Microstructure Mechanical properties

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The ferroxidases LPR1 and LPR2 control iron translocation in the xylem of Arabidopsis plants

引用

Molecular Plant 2022年第12期15卷 1962-1975页

作者： Zhong-Rui Xu Mei-Ling Cai Ying Yang ting-ting You jian Feng ma Peng Wang Fang-jie Zhao State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China Institute of Plant Science and Resources Okayama UniversityChuo 2-20-1Kurashiki 710-0046Japan Academy for Advanced Interdisciplinary Studies Nanjing Agricultural UniversityNanjing 210095China

Iron(Fe)deficiency is common in agricultural crops and affects millions of people *** of Fe in the xylem is a key step for Fe distribution in *** mechanism controlling this process remains largely ***,we report that two Arabidopsis ferroxidases,LPR1 and LPR2,play a crucial and redundant role in controlling Fe translocation in the ***1 and LPR2 are mainly localized in the cell walls of xylem vessels and the surrounding cells in roots,leaves,and *** of both LPR1 and LPR2 increased the proportion of Fe(II)in the xylem sap,and caused Fe deposition along the vascular bundles especially in the petioles and main veins of leaves,which was alleviated by blocking blue *** lpr1 lpr2 double mutant displayed constitutive expression of Fe deficiency response genes and overaccumulation of Fe in the roots and mature leaves under Fe-sufficient supply,but Fe deficiency chlorosis in the new leaves and inflorescences under low Fe ***,the lpr1 lpr2 double mutant showed lower Fe concentrations in the xylem and phloem saps,and impaired 57Fe translocation along the *** vitro assays showed that Fe(III)-citrate,the main form of Fe in xylem sap,is easily photoreduced to Fe(II)-citrate,which is unstable and prone to adsorption by cell *** together,these results indicate that LPR1 and LPR2 are required to oxidize Fe(II)and maintain Fe(III)-citrate stability and mobility during xylem translocation against *** study not only uncovers an essential physiological role of LPR1 and LPR2 but also reveals a new mechanism by which plants maintain Fe mobility during long-distance translocation in the xylem.

关键词： iron xylem translocation ferroxidases LPR1 LPR2 iron redox

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In vitro and in vivo evaluation of improved EGFR targeting peptide-conjugated phthalocyanine photosensitizers for tumor photodynamic therapy

引用

Chinese Chemical Letters 2018年第7期29卷 1171-1178页

作者： Qingle Chen Yanhong ma jisi Zhao Mei Zhao Wenjing Li Qian Liu Li Xiong Wenjie Wu Zhangyong Hong College of materials Science and Chemical Engineering Tianjin University of Science and Technology Tianjin 300457 China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein Sciences College of Life Sciences Nankai University Tianjin 300071China Department of General Surgery Second Xiangya Hospital Central South University Changsha 410011 China

Phthalocyanine（Pc） is one of the most promising photosensitizer candidates because of its strong absorption（extinction coefficient ε > 10;LmoI;cm;） at long wavelengths and strong singlet oxygen generation abilities（a singlet oxygen quantum yield of approximately 50%）. However, low tumor targeting, low water solubility and a high tendency to aggregate appear to significantly restrict the compound’s application in tumor treatment. Conjugating Pc with peptide ligands could be a useful strategy for alleviating these problems. Here, to further optimize the structures of peptide-conjugated zinc Pcs for PDT therapy, we finely tuned the hydrophilicity of the modified Pc aromatic macrocycle with varied length of polyethylene glycol（PEG） and added an extra PEG linker and an extra glutamic acid between the Pc ring and the peptide ligand to reduce the influence of the ligand on the Pc aromatic *** the synthesized conjugates, Pc-3 showed greatly improved targeting towards tumors and abolished inoculated tumors with only a single PDT treatment in a subcutaneous xenograft tumor model,making this approach a promising therapeutic agent for the treatment of cancer.

关键词： Photodynamic therapy Potosensitizer Phthalocyanine Peptide conjugate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：