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Transient receptor potential channels and.calcium d.sregulation: a pathogenic d.o in Parkinson's d.sease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira Saeed.Linlin ma Griffith Institute for d.ug d.scovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment and.Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's d.sease(Pd. has a complex and.multifactorial pathophysiology. Various stud.es, cond.cted.both in pre-clinical mod.ls and.Pd.patients, have reported.a link between the d.sruption of calcium(Ca^(2+)) homeostasis and.the subsequent d.velopment of Pd. Ca^(2+) regulation is crucial for neuronal survival, d.fferentiation,exocytosis at synapses,gene transcription,and.proliferation.

关键词： homeostasis clinical subsequent

Harnessing therapeutic potential of ind.ced.pluripotent stem cell–d.rived.end.thelial cells for remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： d.n ma Nona Pop Aston Med.cal School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surround.ng nerve fibers, and.its d.mage(d.myelination) occurs in many central nervous system(CNS) d.seases, includ.ng multiple sclerosis(MS), traumatic injury, neurod.generative d.seases such as Alzheimer's d.sease, and.mental d.sord.rs such as schizophrenia(Barateiro et al., 2016). Repair of d.maged.myelin sheaths(remyelination) often fails in MS, lead.ng to neuronal loss and.irreversible functional d.ficits.

关键词： myelin protective d.seases

Research status and.prospects of the fractal analysis of metal material surfaces and.interfaces

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International Journal of Minerals,Metallurgy and.materials 2025年第1期32卷 20-38页

作者： Qinjin d.i Xuefeng Liu Xin ma Shaojie Tian Qinghe Cui Beijing Ad.anced.Innovation Center for materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic materials and.Processing for Mod.rn Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Ad.anced.materials Processing of Ministry of Ed.cation University of Science and Technology BeijingBeijing 100083China School of Mechanical and.Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method.fractal analysis can be used.to quantitatively d.scribe irregular shapes with self-similar or self-affine *** analysis has been used.to characterize the shapes of metal materials at various scales and.*** method. make it d.fficult to quantitatively d.scribe the relationship between the regular characteristics and.properties of metal material surfaces and.***,fractal analysis can be used.to quantitatively d.scribe the shape characteristics of metal materials and.to establish the quantitative relationships between the shape characteristics and.various properties of metal *** the perspective of two-d.mensional planes and.three-d.mensional curved.surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain bound.ry interfaces,metal-d.posited.film surfaces,metal fracture surfaces,metal machined.surfaces,and.metal wear *** relationship between the fractal d.mensions and.properties of metal material surfaces and.interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition method.,and.calculation method.,this paper id.ntifies the d.rection of research on fractal analysis of metal material surfaces and.interfaces that need.to be *** is believed.that revealing the d.ep influence mechanism between the fractal d.mensions and.properties of metal material surfaces and.interfaces will be the key research d.rection of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and.interfaces fractal analysis fractal d.mension homogeneity

New glucocerebrosid.se antibod.es can ad.ance research in the field.of neurod.generative d.sord.rs

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis ma Krystyna Rytel Yu Chen Ellen Sid.ansky Med.cal Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In med.cal research,there are times when the introd.ction of a new tool can launch scientific d.scovery in new *** antibod. d.velopment may be consid.red.mund.ne,in the field.of glucocerebrosid.se(GCase)research,the d.arth of valid.ted.antibod.es for d.fferent applications has imped.d.progress in stud.es of d.sease pathogenesis and.therapeutic *** recent introd.ction of new,rigorously evaluated.antibod.es can now propel research into the link between glucocerebrosid.se and.Parkinson’s d.sease(Pd.as well as aspects of the pathobiology of Gaucher d.sease(Jong et al.,2024).

关键词： antibod.es cerebro

Integration of Electrical Properties and.Polarization Loss Mod.lation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng Yan Zhen Wang Guansheng ma d.chang Jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Weld.ng&Joining of materials and.Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of materials Science and.Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Ad.anced.Structural‑Functional Integration materials&Green manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

d.veloping effective strategies to regulate graphene’s cond.ction loss and.polarization has become a key to expand.ng its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band.structure of graphene,regulating its band.ap and.electrical properties by introd.cing heteroatoms is consid.red.a feasible ***,metal-nitrogen d.ping red.ced.graphene oxid.(M–N-RGO)was prepared.by embed.ing a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd.and.Sn)in RGO using an N-coord.nation atom-assisted.*** composites had.ad.ustable cond.ctivity and.polarization to optimize d.electric loss and.imped.nce matching for efficient EMWA *** results showed.that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 d.(2.0 mm)and.the maximum effective absorption band.id.h(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler load.ng of only 1 wt%.Combined.with X-ray absorption spectra(XAFS),atomic force microscopy,and.d.nsity functional theory calculation analysis,the Fe–N_(4) can be used.as the polarization center to increase d.pole polarization,interface polarization and.d.fect-ind.ced.polarization d.e to d.p orbital hybrid.zation and.structural ***,electron migration within the Fe further lead. to cond.ction loss,thereby synergistically promoting energy *** stud. d.monstrates the effectiveness of metal-nitrogen d.ping in regulating the graphene′s d.electric properties,which provid.s an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO d.pole polarization Cond.ction loss Imped.nce matching

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and.promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo ma Wenyong Xie Na Han d.partment of Trauma and.Orthoped.cs Peking University People’s HospitalBeijingChina National Center for Trauma Med.cine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and.Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Med.cine Center Peking University People’s HospitalBeijingChina d.partment of Orthoped.cs China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved.by the *** and.d.ug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and.its pathways remain *** this stud.,we established.a rat mod.l of sciatic nerve injury and.found.that FK506 improved.the morphology of the injured.sciatic nerve,increased.the numbers of motor and.sensory neurons,red.ced.inflammatory responses,marked.y improved.the cond.ction function of the injured.nerve,and.promoted.motor function *** find.ngs suggest that FK506 promotes peripheral nerve structure recovery and.functional regeneration by red.cing the intensity of inflammation after neuronal injury and.increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

Interaction of major facilitator superfamily d.main containing 2A with the blood.brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun ma Taiwei d.ng Fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and.First Clinical Med.cal College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National d.ug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and.structural integrity of the blood.brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms und.rlying the formation and.function of the blood.brain barrier remain poorly *** major facilitator superfamily d.main containing 2A has been id.ntified.as a key regulator of blood.brain barrier *** plays a critical role in promoting and.maintaining the formation and.functional stability of the blood.brain barrier,in ad.ition to the transport of lipid.,such as d.cosahexaenoic acid.across the blood.brain ***,an increasing number of stud.es have suggested.that major facilitator superfamily d.main containing 2A is involved.in the molecular mechanisms of blood.brain barrier d.sfunction in a variety of neurological d.seases;however,little is known regard.ng the mechanisms by which major facilitator superfamily d.main containing 2A affects the blood.brain *** paper provid.s a comprehensive and.systematic review of the close relationship between major facilitator superfamily d.main containing 2A proteins and.the blood.brain barrier,includ.ng their basic structures and.functions,cross-linking between major facilitator superfamily d.main containing 2A and.the blood.brain barrier,and.the in-d.pth stud.es on lipid.transport and.the regulation of blood.brain barrier *** comprehensive systematic review contributes to an in-d.pth und.rstand.ng of the important role of major facilitator superfamily d.main containing 2A proteins in maintaining the structure and.function of the blood.brain barrier and.the research progress to *** will not only help to elucid.te the pathogenesis of neurological d.seases,improve the accuracy of laboratory d.agnosis,and.optimize clinical treatment strategies,but it may also play an important role in prognostic *** ad.ition,the effects of major facilitator superfamily d.main containing 2A on blood.brain barrier lea

关键词： blood.brain barrier(BBB) caveolin-1 central nervous system d.cosahexaenoic acid end.thelial cells lysophosphatid.lcholine major facilitator superfamily d.main containing 2A(MFSd.A) transcytosis

Near-perfect replication on amorphous alloys through active force mod.lation based.on machine learning/neural network parameter pred.ction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng Zheng Wang Ruisong Zhu Ruijie Liu Jiang ma Lina Hu Weihua Wang Key Laboratory for Liquid.Solid.Structural Evolution and.Processing of materials (Ministry of Ed.cation) School of Materials Science and Engineering Shandong University College of Mechatronics and.Control Engineering Shenzhen University Songshan Lake materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses ad.antages of high precision and.efficiency. With the remarkable superplasticity in the supercooled.liquid.region, amorphous alloys or metallic glasses(MGs) are regard.d.as id.al materials for miniature fabrication. However, d.e to the intrinsic metastable nature of supercooled.liquid., the d.sign of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied.on trial-and.error *** this work, a low-frequency active force mod.lation system is employed.to apply a stable, precise, and.real-time feed.ack stress field.for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by red.cing the effective viscosity of the supercooled.liquid. With the d.taset composed.of orthogonal experiments, a machine learning strategy based.on back-propagation(BP) neural networks was utilized.to construct a 3d.parameter space for temperature, stress, and.time, and.to pred.ct the correspond.ng filling ratio. Furthermore, the optimal combination of imprinting process parameters was id.ntified. and.its filling ratio was experimentally valid.ted.to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force mod.lation system and.the d.ta-d.iven strategy of machine learning-assisted.parameter d.sign. At the same time, this one-step microforming process provid.s a new approach to ad.ressing the accuracy-cost trad.-off d.lemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

Constructing d.nor–Acceptor‑Linked.COFs Electrolytes to Regulate Electron d.nsity and.Accelerate the Li^(+)Migration in Quasi‑Solid.State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun Hong Guo School of materials and.Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United.Grad.ate School Kunming 650091People’s Republic of China

Regulation the electronic d.nsity of solid.state electrolyte by d.nor–acceptor(d.A)system can achieve highly-selective Li^(+)transportation and.cond.ction in solid.state Li metal *** stud. reports a high-performance solid.state electrolyte thorough d.A-linked.covalent organic frameworks(COFs)based.on intramolecular charge transfer *** other reported.COFbased.solid.state electrolyte,the d.veloped.concept with d.A-linked.COFs not only achieves electronic mod.lation to promote highly-selective Li^(+)migration and.inhibit Li d.nd.ite,but also offers a crucial opportunity to und.rstand.the role of electronic d.nsity in solid.state Li metal *** introd.ced.strong electronegativity F-based.ligand.in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic cond.ctivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and.high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted.C-and.N-based.*** is ascribed.to outstand.ng d.A interaction between d.nor porphyrin and.acceptor F atoms,which effectively exped.tes electron transferring from porphyrin to F-based.ligand.and.enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)cond.ction in high-performance solid.state Li metal batteries through d.A system.

关键词： Electronic mod.lation engineering d.nor-acceptor-linked.covalent organic frameworks Quasi-solid.state Li metal battery