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Excess properties and spectroscopic studies for binary system polyethylene glycol 600 + dimethyl sulfoxide at T =(298.15, 303.15,308.15, 313.15, and 318.15) k

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Chinese Journal of Chemical Engineering 2017年第9期25卷 1249-1255页

作者： Liang ma Feng sha Xianshu Qiao Qiang Li Jianbin Zhang College of Chemical Engineering Inner Mongolia University of Technology

The work presents density(ρ) and viscosity(η) data of binary system polyethylene glycol 600(PEG) + dimethyl sulfoxide(DMSO) over the entire concentration range at T =(298.15, 303.15, 308.15, 313.15 and 318.15) k and atmospheric pressure. On the basis of density and viscosity values, the excess properties of PEG(1) + DMSO(2) mixtures, including excess molar volume(V_m^E), viscosity deviation(Δη), excess free energies of activation(ΔG^(*E)), and isobaric thermal expansion coefficient(αp), were calculated. At the same time, in order to conjecture the density viscosity under different conditions, the density and viscosity data were fitted with the corresponding formula. The calculated results of V_m^E, Δη, and ΔG^(*E) were fitted with the Redlich–kister equation to derive coefficients and estimate the standard deviations(σ) between the experimental and calculated values. Moreover, the intermolecular interaction of PEG with DMSO was discussed on the basis of FTIR and UV–Vis spectral results of PEG(1) + DMSO(2) mixtures. The results indicated that there were the hydrogen bonding and interactions of hydroxyl hydrogen atoms in PEG with oxygen atoms in DMSO.

关键词： Density Viscosity Excess property PEG600 Dimethyl sulfoxide

High performance strain sensor based on leather activated by micro-cracking conductive layer

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Collagen and Leather 2023年第4期5卷 76-87页

作者： Jianzhong ma Zhijie Cheng sha Tan Tian Zheng Yan Zong College of Bioresources Chemical and materials Engineering Shaanxi University of Science and TechnologyXi'an 710021China Xi'an key Laboratory of Green Chemicals and Functional materials Xi'an 710021China materials Characterization and Fabrication Platform Department of Chemical EngineeringUniversity of MelbourneParkvilleMelbourne 3010Australia

Flexible strain sensors are capable to detect external force induced strain change owing to their unique ability to convert deformation into electrical ***,micro/nano patterning of conductive layer in strain sensor is an effective method to improve its sensitivity,however the sophisticated manipulation process is limited only in laboratory *** this report,a simple and scalable fabrication strategy was used to create micro-cracking conductive layer as an alternative patterning method to achieve high performance of strain *** details,the sensor was fabricated using leather as the substrate to filtrated acidified multi-walled carbon nanotubes(a-MWCNTs)/layered double hydroxides(LDHs)*** stretching process,micro-cracking structure emerged on the percolated a-MWCNTs/LDHs layer,causing a rise up of resistance according to increasing strain and generated a detectable electrical *** prepared sensor had a large detecting range(60%),high sensitivity(GF of 7238.92 at strain 30-60%),fast response(tensile response time of 270 ms),good stability and *** sensor also inherited the advantages of leather,such as biodegradability and good air permeability,and the introduction of a-MWCNTs/LDHs further enhanced its fire retardancy *** features ensured the sensor as an eco-friendly,comfortable and safe electronic device for human motion detection.

关键词： a-MWCNTs LDHs Leather Flexible strain sensor

Foliar application of strigolactones improves the desiccation tolerance,grain yield and water use efficiency in dryland wheat through modulation of non-hydraulic root signals and antioxidant defense

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Stress Biology 2023年第1期3卷 583-597页

作者： sha Guo Xiaofei Wei Baoluo ma Yongqing ma Zihan Yu Pufang Li College of Forestry Northwest A&F UniversityShaanxi 712000YanglingChina College of Soil and Water Conservation Science and Engineering Northwest A&F UniversityShaanxi 712000YanglingChina Ottawa Research and Development Centre(ORDC) Agriculture and Agri-Food CanadaOttawaON K1A0C6Canada College of Natural Resources and Environment Northwest A&F UniversityShaanxi 712000YanglingChina

Non-hydraulic root signals(nHRS)are affirmed as a unique positive response to soil drying,and play a crucial role in regulating water use efficiency and yield formation in dryland wheat ***(SLs)can enhance plant drought ***,the question of whether strigolactones enhance grain yield and water use efficiency by regulating nHRS and antioxidant defense systems in dryland wheat remains *** this study,pot experiments were conducted to investigate the effects of strigolactones on nHRS,antioxidant defense system,and grain yield and water use efficiency in dryland *** results showed that external application of SLs increased drought-induced abscisic acid(ABA)accumulation and activated an earlier trigger of nHRS at 73.4% field capacity(FC),compared to 68.5%FC in the control group(Ck).This phenomenon was mechanically associated with the physiological mediation of *** application of SLs significantly enhanced the activities of leaf antioxidant enzymes,reduced ROS production,and mitigated oxidative damage to lipid ***,root biomass,root length density,and root to shoot ratio were increased under strigolactone ***,exogenous application of SLs significantly increased grain yield by 34.9%under moderate drought *** use efficiency was also increased by 21.5% and 33.3% under moderate and severe drought conditions respectively,compared to the control group(Ck).The results suggested that the application of strigolactones triggered earlier drought-sensing mechanism and improved the antioxidant defense ability,thus enhancing grain yield and water use efficiency in dryland wheat production.

关键词： Strigolactones Non-hydraulic root signals Antioxidant defense system Grain yield Water use efficiency

云南省昭通市50岁及以上HIV感染者/AIDS患者抗病毒治疗失败病例耐药和分子网络分析

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中国热带医学 2024年第5期24卷 542-549页

作者：吴智星刘家法张米李健健程鹏邓雪媚马莎王佳丽董兴齐昆明医科大学公共卫生学院云南昆明650000 云南省传染病医院检验科云南昆明650301

目的了解云南省昭通市2020—2022年50岁及以上抗病毒治疗失败[血浆病毒载量(viral load,VL)≥1000拷贝/mL]人类免疫缺陷病毒感染者/艾滋病患者(human immunodeficiency virus/acquired immunodeficiency syndrome,HIV/AIDS)的耐药及分子网络特征。方法通过云南省抗病毒治疗数据库收集2020—2022年昭通市50岁及以上抗病毒治疗失败的HIV/AIDS患者人口学资料,采集患者血浆,通过逆转录聚合酶链反应扩增HIV pol基因蛋白酶和逆转录酶区,采用ContigExpress软件拼接并进行序列测定,运用美国斯坦福大学HIVdb数据库进行耐药突变分析,利用HyPhy 2.2.4以TN93模型计算序列间的两两基因距离,以1.7%作为阈值构建HIV分子网络,使用Cytoscape 3.7.0将网络可视化。结果共纳入HIV/AIDS病例480例,血浆样本扩增阳性417例,耐药196例,总耐药率为47.0%;非核苷类反转录酶抑制剂(non-nucleoside reverse transcriptase inhibitors,NNRTIs)的耐药率最高为45.6%(190/417),反转录酶抑制剂(nucleoside reverse transcriptase inhibitors,NRTIs)耐药率为14.4%(60/417),蛋白酶抑制剂(protease inhibitors,PIs)的耐药率较低,为0.2%(1/417)。NNRTIs耐药突变位点中,以k103N/E/S突变位点为主,突变率为33.3%(139/417);NRTIs耐药突变位点中,以M184V/I突变位点为主,突变率为13.9%(58/417);PIs耐药位点突变率相对较低,突变率为0.2%(1/417)。通过构建分子网络,88例患者进入分子网络,入网率为21.1%,参与构成21个传播簇,其中CRF01_AE构成了一个包含37例的大簇。结论相较于云南省其他地区研究,本研究昭通市抗病毒治疗失败的老年人群耐药率有所下降,URFs成为主要亚型,提示昭通市老年人传播关系逐渐复杂化,应加强监测检测;通过构建分子网络,提示CRF01_AE、已婚或有配偶男性入网率最高,应加强重点人群干预,多元化开展老年人艾滋病防治工作。

关键词：人类免疫缺陷病毒老年人耐药分子网络

不同豆禾混播组合在帕米尔高原牧区产草量和营养品质的比较

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饲料研究 2024年第4期47卷 110-115页

作者：马小龙赛里克·都曼艾比布拉·伊马木李陆斌白丽莎新疆农业大学草业学院新疆乌鲁木齐830052 新疆畜牧科学院草业研究所新疆乌鲁木齐830000

试验旨在探究豆禾牧草混播组合在帕米尔高原牧区的产草量和营养品质,开展了以箭筈豌豆(Vicia sativa)分别和燕麦(Avena sativa)、小黑麦(Triticale)及黑麦(Secale)的混播组合研究。试验设置单播边锋255 kg/hm^(2)(B-D)、凯速255 kg/hm^(... 详细信息

试验旨在探究豆禾牧草混播组合在帕米尔高原牧区的产草量和营养品质,开展了以箭筈豌豆(Vicia sativa)分别和燕麦(Avena sativa)、小黑麦(Triticale)及黑麦(Secale)的混播组合研究。试验设置单播边锋255 kg/hm^(2)(B-D)、凯速255 kg/hm^(2)(k-D)、速捷255 kg/hm^(2)(S-D)、捷达冬牧70 255 kg/hm^(2)(J-D)、陇箭2号150 kg/hm^(2)(L-D)为对照,混播边锋210 kg/hm^(2)+陇箭2号120 kg/hm^(2)(BL-H)、凯速210 kg/hm^(2)+陇箭2号120 kg/hm^(2)(kL-H)、速捷210 kg/hm^(2)+陇箭2号120 kg/hm^(2)(SL-H)、捷达冬牧70 210 kg/hm^(2)+陇箭2号120 kg/hm^(2)(JL-H)为处理组,试验共9个处理,测定生产性能和营养指标,并运用灰色关联度进行综合评价。结果显示,混播组合中,JL-H总干草产量最高(15.58 t/hm^(2)),极显著高于其他混播组合(Pkg/hm^(2)+陇箭2号120 kg/hm^(2))适合在帕米尔高原牧区种植应用。

关键词：混播组合产草量营养品质综合评价

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Melatonin alleviates heat stress‑induced testicular damage in dairy goats by inhibiting the PI3k/AkT signaling pathway

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Stress Biology 2022年第1期2卷 120-135页

作者： Yundie Liu Hui Cai Xinrui Guo Aili Aierken Jinlian Hua Baohua ma sha Peng College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest Agriculture and Forestry University of Science and TechnologyYangling 712100ShaanxiChina

Current measures mainly focus on how melatonin reduces physiological heat stress in animals,but its effects on reproductive damage to male dairy goats have been *** study aimed to determine the protective effect of melatonin on male reproduction during heat stress in dairy goats and to further explore its mechanisms.A natural heat stress model of Saanen dairy goats was used to assess testicular tissue damage 7days after heat stress and to examine semen quality changes during a spermatogenic ***-seq,Western blot,RT–qPCR,and immunofluo-rescence staining were used to explore the mechanism by which melatonin protects against heat stress-induced reproductive damage and to validate the *** data suggested that melatonin significantly alleviated the heat stress-induced decrease in sperm quality,protected varicose tubule structure,reduced the levels of heat shock proteins and apoptotic proteins and protected the spermatocytes and round spermatozoa,which are mainly affected by heat ***-seq results suggest that melatonin inhibits the PI3k/AkT signaling pathway,reduces the level of p-AkT,and promotes elevated *** addition,melatonin treatment could upregulate the gene expression of MT2 which was downregulated by heat stress and improve the change in extracellular matrix components and restore serum testosterone *** results suggest that melatonin can protect against testicular and spermatogenic cell damage and improve semen quality in male dairy goats under heat *** study provides an important reference for subsequent studies on the molecular mechanisms of melatonin in protecting male reproductive processes under heat stress and using exogenous melatonin to prevent heat stress.

关键词： Natural heat stress Melatonin PI3k/AkT signaling pathway Spermatocytes Apoptosis

TRPV1介导H4组蛋白乳酸化调控AD炎症激活小胶质细胞

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现代生物医学进展 2024年第3期24卷 401-404,474页

作者：沙旭栋鲁佳林佳源黄立栋马小莉虞志华上海交通大学医学院药理学与化学生物学系上海200025

目的:阿尔茨海默病(AD)中小胶质细胞的免疫监测和吞噬功能逐渐减弱并发生炎症激活。以往研究报道瞬时受体电位香草素1型(TRPV1)通道的激活可以缓解3xTg小鼠脑内小胶质细胞的炎症激活和吞噬功能障碍,作用机制尚不清楚。方法:首先,通过蛋... 详细信息

目的:阿尔茨海默病(AD)中小胶质细胞的免疫监测和吞噬功能逐渐减弱并发生炎症激活。以往研究报道瞬时受体电位香草素1型(TRPV1)通道的激活可以缓解3xTg小鼠脑内小胶质细胞的炎症激活和吞噬功能障碍,作用机制尚不清楚。方法:首先,通过蛋白印迹法和免疫荧光实验测量3xTg小鼠大脑细胞核内组蛋白H4的12位赖氨酸乳酸化(H4k12la)的表达水平和细胞定位情况。其次,验证TRPV1的激活是否可以调控3xTg小鼠大脑细胞核内H4k12la的表达水平。最后,使用Imaris软件和流式细胞术分析TRPV1的激活对小胶质细胞炎症激活形态和生物标志物的影响。结果:蛋白印迹法显示3xTg小鼠大脑细胞核内H4k12la的表达水平上升,免疫荧光实验证明H4k12la与小胶质细胞共定位。TRPV1的激活可以减少3xTg小鼠脑内小胶质细胞中H4k12la的表达水平,缓解3xTg小鼠脑内小胶质细胞炎症激活。结论:TRPV1可以通过抑制组蛋白H4k12la表达缓解AD小胶质细胞炎症激活。

关键词：阿尔茨海默病瞬时受体电位香草素1型小胶质细胞 H4k12la

山东省作物秸秆和畜禽粪尿有机肥资源现状及替代化肥潜力分析

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中国农业科学 2024年第4期57卷 721-739页

作者：马荣辉杨武杰于蕾杨泽龙王健郭跃升山东省农业技术推广中心山东师范大学地理与环境学院

【目的】计算作物秸秆、畜禽粪尿资源数量及养分总量，分析其替代化肥潜力，为统筹与合理利用全省有机肥资源提供数据支撑。【方法】对不同作物(小麦、玉米、水稻/稻谷、大豆、马铃薯、花生和棉花)和畜禽(牛、猪、羊、家禽和兔)，利用... 详细信息

【目的】计算作物秸秆、畜禽粪尿资源数量及养分总量，分析其替代化肥潜力，为统筹与合理利用全省有机肥资源提供数据支撑。【方法】对不同作物(小麦、玉米、水稻/稻谷、大豆、马铃薯、花生和棉花)和畜禽(牛、猪、羊、家禽和兔)，利用草谷比和排泄系数法，估算山东省2016—2020年作物秸秆和畜禽粪尿资源总量及养分总量，分析变化趋势，计算不同区域和种类有机肥替代化肥潜力。【结果】(1)2020年全省作物秸秆资源总量为7 616.8×104t，养分总量为163.2×104t,N、P2O5、k2O养分量分别为63.6×104、9.2×104和90.5×104t。秸秆养分资源理论替代化肥潜力为42.9%，实际替代化肥潜力为20.9%；秸秆中N、P2O5、k2O资源理论替代化肥潜力分别为35.3%、9.0%和92.2%，实际替代化肥潜力分别为12.5%、4.2%和53.7%;2016—2020年作物秸秆资源总量增加了16.8%。(2)2020年全省畜禽粪尿资源总量为9 131.2×104t，养分总量为82.7×104t,N、P2O5、k2O养分量分别为35.2×104、11.7×104和35.7×104t。畜禽粪尿养分资源理论替代化肥潜力为21.7%，实际替代化肥潜力为19.5%；畜禽粪尿中N、P2O5、k2O资源理论替代化肥潜力分别为19.6%、11.4%和36.4%，实际替代化肥潜力分别为17.7%、10.3%和32.9%;2016—2020年畜禽粪尿资源总量减少了25.4%。(3)不同区域作物秸秆和畜禽粪尿养分资源理论替代化肥潜力大小为鲁西和鲁北>鲁南>鲁中南>鲁中>鲁东地区。鲁西和鲁北、鲁南地区最高，分别为77.0%和75.6%；鲁东地区最低，为46.5%。其中德州潜力最大，为95.3%，其次是东营、滨州，分别为92.6%和91.2%；烟台和威海最小，分别为35.5%和40.6%。(4)不同作物秸秆和畜禽粪尿养分资源理论替代化肥潜力分别为玉米秸秆(16.7%)>小麦秸秆(16.2%)>马铃薯秸秆(4.9%)>花生秸秆(3.6%)>水稻秸秆(0.7%)>棉花秸秆(0.4%)、大豆秸秆(0.4%)，牛粪尿(8.7%)>猪粪尿(6.5%)>羊粪尿(3.2%)、家禽粪(3.2%)>兔粪(0.1%)。【结论】2020年全省作物秸秆和畜禽粪尿资源总量为16 748.0×104t，养分总量为245.9×104t。作物秸秆和畜禽粪尿养分资源理论替代化肥潜力为64.6%，实际替代化肥潜力为40.4%。作物秸秆和畜禽粪尿中氮(N)、磷(P2O5)和钾(k2O)资源理论替代化肥潜力分别为54.8%、20.4%和128.6%，实际替代化肥潜力分别为30.2%、14.5%和86.6%。鲁西、鲁北以及鲁南地区作物秸秆和畜禽粪尿有机肥资源非常丰富，鲁中、鲁东地区相对较少；玉米和小麦等作物秸秆有机肥资源较多，牛和猪等畜禽粪尿有机肥资源较多，高效合理利用作物秸秆和畜禽粪尿等有机肥资源，是实现化肥减施增效的重要保障。

关键词：作物秸秆畜禽粪尿有机肥资源替代化肥潜力山东省

益气续骨方调节PI3k/Akt信号通路对激素性股骨头坏死大鼠骨代谢的影响

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现代中西医结合杂志 2024年第9期33卷 1181-1187,1196页

作者：李皎许康周志能马桃红石小东戚琬若王琪沙正才董玮昆明市中医医院云南昆明650500 云南中医药大学云南昆明650500

目的探究益气续骨方调节磷脂酰肌醇3-激酶(PI3k)/蛋白激酶B(Akt)信号通路对激素性股骨头坏死大鼠骨代谢的影响。方法将50只SD雄性大鼠随机分为正常组、模型组、益气续骨方低剂量组、益气续骨方高剂量组、益气续骨方+LY294002组,每组10... 详细信息

目的探究益气续骨方调节磷脂酰肌醇3-激酶(PI3k)/蛋白激酶B(Akt)信号通路对激素性股骨头坏死大鼠骨代谢的影响。方法将50只SD雄性大鼠随机分为正常组、模型组、益气续骨方低剂量组、益气续骨方高剂量组、益气续骨方+LY294002组,每组10只。除正常组外,其余组大鼠右臀肌肉注射醋酸泼尼松龙注射液4周建立激素性股骨头坏死模型。造模结束后,益气续骨方低、高剂量组大鼠分别给予益气续骨方0.5 mL(含生药0.285 g/mL)和1 mL(含生药0.57 g/mL)灌胃,益气续骨方+LY294002组大鼠给予益气续骨方1 mL灌胃并腹腔注射6 mg/kg的LY294002,正常组和模型组给予等体积生理盐水灌胃,均1次/d,连续干预8周。ELISA检测大鼠血清白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血钙、血磷、骨保护素(OPG)、骨钙素(OCN)、碱性磷酸酶(ALP)水平,Micro-CT检测观察股骨头形态,HE染色观察股骨头组织病理形态,TRAP染色观察破骨细胞生成情况,Western blot法检测股骨头组织中骨特异性转录因子2(Runx2)、骨形态发生蛋白2(BMP-2)、裂解半胱天冬酶-3(Cleaved-Caspase-3)、PI3k、Akt蛋白表达情况。结果与正常组比较,模型组大鼠血清IL-4、IL-6、TNF-α、OPG、ALP水平和骨小梁分离度(***)、空骨陷窝率及股骨头组织中Cleaved-Caspase-3蛋白相对表达量均明显升高(P均k/PI3k、p-Akt/Akt蛋白相对表达量均明显降低(P均k/PI3k、p-Akt/Akt蛋白相对表达量均明显升高(P均k/Akt信号通路有关。

关键词：激素性股骨头坏死益气续骨方磷脂酰肌醇3-激酶蛋白激酶B 骨代谢

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