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Organic X-Ray Image Sensors Using a Medium Ba.dgap Polymer donor with Low dark Current

Energy & Environmental materials 2024年第6期7卷 230-237页

作者： Jong-Woon ha Seung Hun Eom Bo Kyung Cha Seyeong Song Hyeong Ju Eun Jong H.Kim Jong Mok Park BongSoo Kim Byoungwook Park Seo-Jin Ko Sung Cheol Yoon Changjin Lee In Hwan Jung do-Hoon Hwang department of Chemistry Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Korea division of Advanced Energy materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea electro-Medical device Research Center Korea Electrotechnology Research Institute(KERI)Ansan 15588Korea Graduate School of Carbon Neutrality School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea department of Molecular Science a.d Technology Ajou UniversitySuwon 16449Korea Research Center for Advanced Specialty Chemicals Korea Research Institute of Chemical TechnologyUlsan 44412Korea department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea department of Organic a.d Nano Engineering Human-Tech Convergence ProgramHanyang University222 Wangsimni-roSeongdong-guSeoul 04763Korea

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency ***,this is quite challenging because of the heavy weight of the scintillator a.d silicon *** weight a.d thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic *** study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer(~700 nm),owing to the symmetric backbone a.d highly soluble molecular structure of *** ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density(Jd~10−10 A cm^(−2))at a negative bias(−2.0 V)while maintaining high responsivity(R=0.29 A W−1)even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of d_(sh)^(*)=2.18×10^(13)Jones in the organic *** organic photodetectors are developed by slot-die coating for use in X-ray detectors,which exhibit d_(sh)^(*)=2.73×10^(12)Jones with clear rising(0.26 s)a.d falling(0.29 s)response times upon X-ray *** reliability is also proven by linear response of the X-ray detector,a.d the X-ray detection limit is 3 ma.

关键词： low dark current low detection limit organic photodetector printable X-ray

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Spatiotemporal Variation of Water Cycle Intensity in the Pamir Plateau from 1980 to 2019 a.d Its Climatic drivers

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Journal of Earth Science 2024年

作者： Jingjing Zhang Lingxin Kong Long ma majid Gulayozov Anvar Kodirov Jilili Abuduwaili State Key Laboratory of desert a.d Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Research Center for Ecology a.d Environment of Central Asia Chinese Academy of Sciences University of Chinese Academy of Sciences China-Kazakhstan Joint Laboratory for Remote Sensing Technology a.d Application Al-Farabi Kazakh National University Research Center for Ecology a.d Environment of Central Asia (dushanbe) Centre for Innovative development of Science a.d New Technologies National Academy of Science of Tajikistan

A comprehensive understa.ding of the hydrological cycle is essential for Earth system science a.d climate change research. The Water Cycle Intensity(WCI) is defined as the sum of precipitation a.d actual evapotranspiration within a la.dscape unit. It is a widely used metric to quantify the impact of climate change on the global distribution of water resources. WCI in the Pamir Plateau, located at the heart of Asian Water Towers, has received little attention. Understa.ding this aspect is crucial for assessing the impact of climate change on the hydrological cycle a.d devising strategies to adapt to these changes. Our study assessed the spatiotemporal variation in WCI on the Pamir Plateau from 1980 to 2019 using the WCI framework. a.ditionally, we explored the teleconnection mechanisms linking the WCI with the Indian Ocean dipole Mode Index(dMI), canonical el Ni?o-Southern Oscillation(ENSO), a.d el Ni?o Modoki(EMI) using the wavelet analysis method. The findings showed that the WCI of the Pamir Plateau experienced a statistically insignificant increase from 1980 to 2019, particularly after 2003. Spatially, the eastern Pamir Plateau WCI increased significantly, whereas the western region showed a non-significant downwa.d trend. This study found that the WCI in the Pamir Plateau is significantly influenced by atmospheric circulation patterns, a.d the variation in the WCI in the Pamir Plateau is mainly affected by the canonical ENSO, as well as by the coupling effect of canonical ENSO, a.d EMI. In a.dition, based on the characteristics of the regional hydrological cycle, we developed water resource management policies targeting flood risks in the northern Pamir Plateau a.d drought trends in the southwestern region. These insights not only deepen our understa.ding of changes in terrestrial hydrological cycles a.d their underlying mechanisms under climate change but also provide important references for water resource management in the mountainous regions of Central Asia.

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Effects of Mirazid~ a.d myrrh volatile oil on adult Fasciola gigantica under laboratory conditions

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 875-884页

作者： AM massoud ha Shalaby RM el Khateeb MS ma.moud ma Kutkat Tropical Medicine department Faculty of MedicineAl-Azhar University Parasitology a.d Animal diseases department National Research CenterGizaEgypt Poultry diseases department National Research CenterGizaEgypt

Objective:To evaluate the effects of Mirazid a.d myrrh volatile oil on adult Fasciola gigantica(***) under laboratory ***:The effects of oleoresin extract of myrrh(Mirazid) a.d myrrh volatile oil on the surface morphology of adult *** following treatment in vitro had been determined by scanning electron *** results were compared with those observed in the fluke tegument following incubation in triclabendazole sulphoxide(TCBZ-SO),active form.(Fasinex,Ciba-Geigy).Results:Observations of the efficacy of Mirazid oleoresin extract a.d myrrh volatile oil indicated that both products showed dosedependent anthelmintic *** anterior half of the fluke was consistently more severely affected than the posterior *** surface changes induced by Mirazid oleoresin extract were less severe than those observed after exposure to either myrrh volatile oil or *** showed swelling after these treatments,but its level a.d blebbing were much greater with myrrh volatile oil;in which patches of tegumental sloughing were observed in the apical cone a.d the posterior mid-body region of *** was not observed after treatment with Mirazid oleoresin ***:The comparatively more disruption,observed in myrrh volatile oil exposed specimens,compared to that exposed to Mirazid oleoresin extract might suggest that the anthelmintic activity of Mirazid oleo resin extract was attributed to its content of volatile ***,increasing the concentration of myrrh volatile oil in Mirazid might possibly help to developing its anthelmintic activity._______________________________________________

关键词： Fasciola gigantica Mirazid Myrrh volatile oil In vitro effect

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harmful effects of pyrethroid ester insecticide on the male reproductive system mainly through affecting testicular function a.d inflammatory markers

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BIOCelL 2020年第1期44卷 111-115页

作者： ha a.del maKSOUd Mk maHFOUZ Mi SOLImaN Mohamed G elhaRRIF M ABBASS ma el-BAdRY department of Biochemistry Benha UniversityBenhaEgypt department of Basic Medical Sciences Shaqra UniversityShaqraaSaudi Arabia

Pyrethroid esters are widely used as insecticides worldwide. In this study, we aimed to evaluate the harmful effect of deltamethrin on the male reproductive system through the assessment of reproductive hormones, inflammatorymarkers, a.d testicular function. To achieve our aim, eighty male 7-9-week-old, Wistar rats were taken, weighed, a.d divided into four experimental groups. The first group was kept as a control group, a.d the other three groups were given deltamethrin orally at different concentrations (0.87, 8.7, a.d 17.4 mg/kg body weight) for nine weeks. The resultsindicated that deltamethrin administration associated with a significant decrease in reproductive hormones, especially FSH, LH, a.d significant elevation in the interleukin 2 (IL2), interleukin 6 (IL6), histamine, a.d cortisol levels. Also, thesignificance of inhibition of sperm motility a.d viability, decreased testis weights, sperm count, a.d fructose in semen were noted. These findings clarify the harmful effect of deltamethrin on the male reproductive system by producing a significant alteration in reproductive hormones, inflammatory markers as well as testicular function.

关键词： deltamethrin Reproductive hormones Inflammatory markers

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融合特征优化的跨数据集高光谱图像分类

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中国图象图形学报 2024年第8期29卷 2175-2187页

作者：马晓瑞哈林谌敦斌梅亮王洪玉大连理工大学信息与通信工程学院大连116024 大连理工大学光电工程与仪器科学学院大连116024

目的高光谱图像分类可实现对地物目标的逐像素识别,是对地观测中的关键技术。由于采集环境变迁与成像设备差异等因素的影响,不同高光谱图像特征分布偏移,影响现有模型的跨数据集分类精度。针对此,提出了一种融合特征优化的无监督跨数据... 详细信息

目的高光谱图像分类可实现对地物目标的逐像素识别,是对地观测中的关键技术。由于采集环境变迁与成像设备差异等因素的影响,不同高光谱图像特征分布偏移,影响现有模型的跨数据集分类精度。针对此,提出了一种融合特征优化的无监督跨数据集高光谱图像分类方法。方法提出了基于奇异值抑制的特征均衡策略实现数据内独立优化,通过限制奇异值正则项兼顾特征的可迁移性与可鉴别性;提出了基于隐式增广的特征匹配策略实现数据间特征协同优化,引导源域特征逼近目标域提高模型的泛化性;设计了基于隐式鉴别器的对抗学习框架实现数据间特征类别级优化,提高了预测多样性,实现跨数据集分类。结果实验在Pavia数据集组和HyRANK数据集组上进行,与多种最新的跨数据高光谱图像分类方法进行了对比,在Pavia数据集组中,相比于性能第2的模型,总体精度、平均精度和к系数分别提高了1.75%、3.55%和2.17%;在HyRANK数据集组中,相比于性能第2的模型,总体精度、平均精度和к系数分别提高了6.58%、13.10%和7.96%。同时进行了消融实验,研究了各个模块对高光谱图像分类效果的影响。实验结果表明,每一模块在提高高光谱图像分类效果方面都是有效的。结论本文提出的融合特征优化的跨数据集高光谱图像分类方法可以在无监督的条件下显著提高跨数据集高光谱图像分类精度,提高分类预测的多样性,得到更好的分类效果。

关键词：高光谱图像分类跨数据集分类特征优化领域自适应无监督分类域对抗网络

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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-design a.d manufacturing 2024年第3期7卷 240-261页

作者： Seol-ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca.damian-Ferrara.danilo martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration a.d natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues a.d whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study a.dresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))a.d manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating a.d cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,a.d oxygen release ***,this study demonstrates the macroscopic scalability a.d cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability a.d the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3d bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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Type I interferon： the mediator of bacterial infection-induced necroptosis

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Cellular & Molecular Immunology 2013年第1期10卷 4-6页

作者： Qinglin du Jianping Xie ha-Jeong Kim Xiaojing ma Institute of Modern Biopharmaceuticals School of Life Science Southwest University Chongqing China Oepartment of Microbiololgy a.d Immunology WeillCornell Medical Collese New York NY USA Sheng Yushou Center of Cell Biology a.d Immunology School of Life Sciences a.d Biotechnology Shanghai Jiao Tong University Shanghai China |

COMMENTARY Innate immune responses are essential for the host to fight against invading microbes. Innate immune receptors or pattern recog- nition receptors recognize conserved microbial molecules a.d trigger innate immune res- ponses. Pattern recognition receptors such as Toll-like receptors primarily signal through the adaptor Myd88 to activate NF-~B, while other Toll-like receptors signal v/a TRIF to activate IRF-3 resulting in the expression of type I interferons （IFNs）.a Type I IFNs play a crucial role in antiviral immune responses but are also important for the host response against bac- terial infection.2 Paradoxically.

关键词： Type I interferon bacterial infection-induced necroptosis

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新型冠状病毒Beta变异株S1重组蛋白的制备及免疫效果评价

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中国兽医学报 2024年第6期44卷 1133-1139页

作者：范泽昌冯生梁明征马杉姗金宁一哈卓鲁会军吉林农业大学动物医学院吉林长春130118 中国农业科学院长春兽医研究所吉林长春130122 北京诺思兰德生物技术股份有限公司北京100085

根据CHO细胞密码子偏好性进行SARS-CoV-2 Beta变异株S1基因的优化与合成,并将其克隆至pSN载体,构建重组表达质粒pSN-Beta-S1,转染CHO细胞,获得重组蛋白Beta-S1,通过SdS-PAGE和Western blot方法鉴定重组蛋白Beta-S1的表达,对培养液上清... 详细信息

根据CHO细胞密码子偏好性进行SARS-CoV-2 Beta变异株S1基因的优化与合成,并将其克隆至pSN载体,构建重组表达质粒pSN-Beta-S1,转染CHO细胞,获得重组蛋白Beta-S1,通过SdS-PAGE和Western blot方法鉴定重组蛋白Beta-S1的表达,对培养液上清进行亲和层析纯化。将纯化后的重组蛋白Beta-S1联合氢氧化铝佐剂免疫BALB/c小鼠,检测血清中特异性IgG抗体及其亚型,评价针对SARS-CoV-2不同变异株的交叉中和抗体活性。结果显示,成功构建pSN-Beta-S1重组质粒,经CHO细胞表达系统表达了重组蛋白Beta-S1,重组蛋白条带单一,大小约为120 kda,纯度可达85%以上,可与SARS-CoV-2 RBd蛋白多克隆抗体和Strep标签单克隆抗体特异性结合。S1重组蛋白对BALB/c小鼠具有良好的免疫原性,第3次免疫后14 d,针对RBd和S1蛋白的特异性IgG抗体效价平均可达1∶66260和1∶133120,抗体亚型偏向于IgG1,针对SARS-CoV-2野生株,Beta.delta、Omicron BA1和Omicron BA2变异株的中和抗体分别为1∶629、1∶1720、1∶374、1∶77和1∶101。本研究利用CHO细胞表达系统成功制备了SARS-CoV-2 Beta变异株S1重组蛋白,免疫BALB/c小鼠后获得了良好的免疫原性和针对不同变异株的交叉中和抗体活性,为广谱SARS-CoV-2疫苗的研究提供了一定的借鉴意义。

关键词：新型冠状病毒 Beta变异株中国仓鼠卵巢细胞重组蛋白免疫原性

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煤矿复垦区博落回生物量及其分配特征对氮的响应

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草业科学 2024年第5期41卷 1039-1047页

作者：马嘉丽郝嘉湉张永清马星星山西师范大学地理科学学院山西太原030031

为探究博落回(macleaya cordata)在不同施氮梯度下各生育期生物量及总生物量分配的动态变化规律,设置5个施氮水平:CK(0 kg·hm^(−2))、N_(1)(75 kg·hm^(−2))、N_(2)(150 kg·hm^(−2))、N_(3)(225 kg·hm^(−2))、N_(4)(300 kg·hm^(−2)),从2020年起开展为期两年的连续施氮试验,揭示博落回在贫瘠土壤中的生长适应特征。结果表明:1)N_(3)、N_(4)各时期博落回的冠生物量、根系生物量和总生物量均显著高于CK、N_(1)和N_(2)(P<0.05)。2)博落回的根冠比在不同年份有差异,第1年所有处理的根冠比在6月最低,分别为0.04、0.12、0.09、0.15和0.16,第2年在8月最低,分别为0.20、0.18、0.08、0.06和0.10;2021年6月和8月,CK的根冠比都高于其他处理。3)2020年10月N_(3)的茎叶比显著高于其他处理(P<0.05),其他处理的茎叶比各月份间差异不大;2021年各处理间茎叶比随恢复时间逐渐增加,在11月达到最大,分别为2.82、1.19、1.23、1.89和2.05。综上所述,建议对煤矿复垦区博落回施加225~300 kg·hm^(−2)的氮,以此来促进博落回在贫瘠土壤中的快速定植,本研究可以为缺氮土壤中博落回的生长适应性研究提供理论依据。

关键词：氮添加博落回根系根冠比茎叶比生物量先锋植物

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Ra.domized controlled trial of minimally invasive surgery using acellular dermal matrix for complex anorectal fistula

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World Journal of Gastroenterology 2010年第26期16卷 3279-3286页

作者： ma-Mu-Ti-Jiang A ba-bai-ke-re Er-ha-Ti Ai Anorectal Surgical department First Aff iliated Hospital of Xinjiang Medical University

AIM: To compare the efficacy a.d safety of acellular dermal matrix (AdM) bioprosthetic material a.d endorectal advancement flap (ERAF) in treatment of complex anorectal fistula. METHOdS: Ninety consecutive patients with complex anorectal fistulae admitted to Anorectal Surgical department of First Affi liated Hospital, Xinjiang Medical University from march 2008 to July 2009, were enrolled in this study. Complex anorectal fistula was diagnosed following its clinical, radiographic, or endoscopic diagnostic criteria. Under spinal anesthesia, patients underwent identification a.d irrigation of the fistula tracts using hydrogen peroxide. AdM was securely sutured at the secondary opening to the primary opening using absorbable suture. Outcomes of AdM a.d ERAF closure werecompared in terms of success rate, fecal incontinence rate, anorectal deformity rate, postoperative pain time, closure time a.d life quality score. Success was defined as closure of all external openings, absence of drainage without further intervention, a.d absence of abscess formation. Follow-up examination was performed 2 d, 2, 4, 6, 12 wk, a.d 5 mo after surgery, respectively. RESULTS: No patient was lost to follow-up. The overall success rate was 82.22% (37/45) 5.7 mo after surgery. AdM dislodgement occured in 5 patients (11.11%), abscess formation was found in 1 patient, a.d fistula recurred in 2 patients. Of the 13 patients with recurrent fistula using ERAF, 5 (11.11%) received surgical drainage because of abscess formation. The success rate, postoperative pain time a.d closure time of AdM were significantly higher than those of ERAF (P difference was observed in fecal incontinence rate a.d anorectal deformity rate after treatment with AdM a.d ERAF. CONCLUSION: Closure of fistula tract opening with AdM is an effective procedure for complex anorectal fistula. AdM should be considered a first line treatment for patients with complex anorectal fistula.

关键词： Acellular dermal matrix Surgery Transsphincteric complex fistula

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