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Effects of Duhuojisheng Tang and combined therapies on prolapse of lumbar intervertebral disc:a systematic review of randomized control trails

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Journal of Traditional Chinese Medicine 2013年第2期33卷 145-155页

作者： Yanxu ma Minghua Huang Jingyan Cui Kai Meng Yuhao Zhao Department of Orthopedics Beijing Traditional Chinese Medicine HospitalCapital Medical University editorial Board(Chinese edition) Journal of Traditional Chinese Medicine College of Health Administration and education under Capital Medical University Capital Base for Research into Health Administration and Policy School of Traditional Chinese Medicine Capital Medical University

OBJECTIVE： A systematic review of the literature was conducted to evaluate the curative effect and safety of Duhuojisheng Tang on prolapse of the lumbar intervertebral disc. METHODS： The databases of PubMed, China Na- tional Knowledge Infrastructure （CNKI）, Chinese Sci- entific Journals Database （VlP）, Chinese Biomedical Literature Database （CBM） and Chinese Medical Ci- tation Index （CMCl） were searched up to January 30, 2012. Randomized controlled trials were select- ed to compare Duhuojisheng Tang with one ormore of the following treatments： traction, acu- puncture, massage, cupping and Western medical treatment. The quality-evaluating standard and the software Revman 5.1 in Cochrane coordinative net were used to analyze the data. The effective index- es of the results were clinical curative rate, effective- ness of alleviating clinical symptoms and adverse reaction. RESULTS： Thirty-one randomized controlled trials of low quality, involving 3915 patients were system- atically evaluated. Statistical analyses showed that good curative effect was achieved in both the group using Duhuojisheng Tang alone and with combined therapies. CONCLUSION： Using Duhuojisheng Tang alone or combined with other therapies can effectively im- prove pain, leg-raising height and other clinical symptoms of patients with prolapse of lumbar in- tervertebral disc. Due to low methodological quali- ty of the articles, no exact recommendations can be made.

关键词： Intervertebral disc displacement Ran-domized controlled trials Review DuhuojishengTang

High Power SiGe X-Band (8～10GHz) Heterojunction Bipolar Transistors and Amplifiers

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Journal of Semiconductors 2006年第2期27卷 270-275页

作者： ma Zhenqiang Wang Guogong Jiang Ningyue Ponchak G E Alterovitz S A Department of Electrical and Computer Engineering University of Wisconsin-Madison Madison WI 53706 USA NASA-Glenn Research Center Cleveland OH 44135 USA

Limited by increased parasitics and thermal effects as device size increases, current commercial SiGe power HBTs are difficult to operate at X-band （8--12GHz） frequencies with adequate power added efficiencies at high power levels. We find that, by changing the heterostructure and doping profile of SiGe HBTs, their power gain can be significantly improved without resorting to substantial lateral scaling. Furthermore,employing a common-base configuration with a proper doping profile instead of a common-emitter configuration improves the power gain characteristics of SiGe HBTs,thus permitting these devices to be efficiently operated at X-band frequencies. In this paper,we report the results of SiGe power HBTs and MMIC power amplifiers operating at 8 *** 10GHz,a 22.5dBm （178mW） RF output power with a concurrent gain of 7.32dB is measured at the peak power-added efficiency of 20.0%, and a maximum RF output power of 24.0dBm （250mW） is achieved from a 20 emitter finger SiGe power HBT. The demonstration of a single-stage X-band medium-power linear MMIC power amplifier is also realized at 8GHz. Employing a 10-emitter finger SiGe HBT and on-chip input and output matching passive components, a linear gain of 9.7dB, a maximum output power of 23.4dBm,and peak power add- ed efficiency of 16% are achieved from the power amplifier. The MMIC exhibits very low distortion with 3rd order intermodulation （im） suppression C/I of -13dBc at an output power of 21,2dBm and over 20dBm 3^rd order output intercept point （OIP3）.

关键词：晶体管放大器基极发射极掺杂

Effect of Tangnaikang on TGF-β_1-induced transdifferentiation of human renal tubular epithelial HK-2 cells

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Journal of Traditional Chinese Medicine 2013年第3期33卷 388-393页

作者： Lixia Yang Xinhuan ma Tao Cheng Tonghua Liu Lili Wu Wen Sun margetts Peter Joseph Central Laboratory of Gansu Province Academy of Traditional Chinese Medicine Pharmacy Department Gansu Province Hospital of Traditional Chinese Medicine Institute of Traditional Chinese Medicine Information Gansu Province Academy of Traditional Chinese Medicine Science and Technology Department Beijing University of Traditional Chinese Medicine Department of Nephrology St. Joseph's Hospital of McMaster University

OBJECTIVE： To explore the function of Tangnai- kang （TNK） in the prevention and treatment of re- nal interstitial fibrosis through transdifferentiation of the human renal tubular epithelial cell line HK-2 induced bytransforming growth factor-β1 （TGF-β1）. METHODS： HK-2 cells cultured in dulbecco＇s modi- fied eagle medium/F12 （1：1） with 10% fetal calf se- rum were divided into six groups： blank control group, TGF-β1 group （TGF-β1 10 ng/mL）, serum con- trol group （TGF-β1 10 ng/mL ＋ 10% serum）, treat- ment group 1 （TGF-β1 10 ng/mL ＋ 5% TNK serum）, treatment group 2 （TGF-β1 10 ng/mL＋10% TNK se-rum）, and treatment group 3 （TGF-β1 10 ng/mL＋ 20% TNK serum）. Cell proliferation was detected by 4,5-Dimethylthiazol-2-yl）-2,5-diphenyltetrazoliu m bromide assay. Expression of a-smooth muscle ac- tin （a-Sma） and E-cadherin were observed by im- munohistochemical assay. The contents of collagen Ⅰ （Col Ⅰ）, collagen Ⅲ（ColⅢ）, and fibronectin （FN） in the culture medium supernatant were detected by ELISA. RESULTS： E-cadherin was expressed and α-Sma was not expressed in normal HK-2 cells. In HK-2 cells cultured with TGF-β1, α-Sma expression signifi- cantly increased, HK-2 cells significantly proliferat- ed, and secretion of Col Ⅰ, Col Ⅲ, and FN significantly increased compared with the blank control group （all P〈0.05）. In the HK-2 cells cultured with TGF-β1 and TNK serum, the expression of α-Sma signifi- cantly decreased, the expression of E-cadherin sig- nificantly increased, and the cell proliferation and the secretion of Col Ⅰ, Col Ⅲ and FN were significant- ly inhibited compared with the TGF-β1 group （all P〈 0.05. CONCLUSION： TNK can inhibit cell proliferation and reduce secretion of Col Ⅰ, Col Ⅲ, and *** in- dicates that TNK can inhibit transdifferentiation of human renal tubular epithelial cells induced by TGF-β1, with the effect of preventing and treating renal interstitial fibrosis.

关键词： Transforming growth factor beta 1 Epi-thelial cells Cell proliferation Cell Transdifferentia-tion Tangnaikang

一种以企业为主导的“产学研”集成创新模式——基于合作关系与控制权视角的建模分析

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科学学研究 2014年第1期32卷 130-139页

作者：马家喜金新元温州大学瓯江学院浙江温州325035

有效的"产学研"合作技术创新模式是有力提升企业技术能力与创新能力的核心途径之一;同时也是高校提升自身科研成果转化率的关键。从创新的类型、主体以及创新过程中资源与能力优化配置的角度出发,归纳出两种典型"产学研"合作技术创新模... 详细信息

有效的"产学研"合作技术创新模式是有力提升企业技术能力与创新能力的核心途径之一;同时也是高校提升自身科研成果转化率的关键。从创新的类型、主体以及创新过程中资源与能力优化配置的角度出发,归纳出两种典型"产学研"合作技术创新模式:以高校为主导兴建的企业模式以及以企业为主导的集成创新模式,并着重对后一种创新模式进行了分析。在此模式下,鉴于控制权与合作关系是影响创新效应的两个核心变量;将高校-企业合作关系分成两类:长期合作关系与短期合作关系,将控制权类型分为两种类型:集中控制与分散控制。在此基础上,着眼于"产学研"合作创新过程:企业从契约提供、合作创新过程的有效组织及产业竞争的系统维度,以动态博弈与委托-代理等理论为工具,建立了一个三阶段动态博弈模型,分别得出了短期合作关系下集中控制、短期合作关系下分散控制、长期合作关系下集中控制、长期合作关系下分散控制四种不同情形的子博弈完美纳什均衡解,并对每种情形及其博弈结果进行了细化分析。最后,从双边关系的类型、控制权类型以及委托-代理效应三个不同维度,从静态与动态两个方面比较分析了创新的知识投入、工资、产量、价格、利润等均衡变量的差异性。

关键词： “产学研” 创新模式动态博弈委托-代理合作关系控制权

制度变迁与草地退化的关联性分析——以锡林郭勒盟为例

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农业现代化研究 2015年第5期36卷 803-810页

作者：马梅乔光华内蒙古农业大学经济管理学院内蒙古呼和浩特010019 内蒙古自治区教育厅畜牧业经济重点研究基地内蒙古呼和浩特010019

通过对内蒙古改革开放以来草地制度变迁进行系统梳理,采用锡林郭勒盟1981-2013年数据,分析其草地退化的演化轨迹,探究草地退化与产权制度和政策之间的关联性。研究表明:从1978-2000年,锡林郭勒盟牲畜数量持续增加,牧民收入大幅提高,然... 详细信息

通过对内蒙古改革开放以来草地制度变迁进行系统梳理,采用锡林郭勒盟1981-2013年数据,分析其草地退化的演化轨迹,探究草地退化与产权制度和政策之间的关联性。研究表明:从1978-2000年,锡林郭勒盟牲畜数量持续增加,牧民收入大幅提高,然而草地退化面积增加,牧草质量下降,退化问题严重,这主要由于草畜承包时间上的错位及草地公有与牲畜私有产权之间的矛盾造成;从2000-2010年,退化面积下降,退化态势得到遏制和扭转,但由于"草畜平衡"测定标准的局限性及禁牧补贴偏低出现了一些不良现象;2011年至今,退化总体趋势得到遏制,且区域整体呈好转态势,但草原生态保护补助奖励制度存在禁牧周期短、补助标准固定化的缺陷。草地退化与产权制度和政策有极强的关联性,针对各阶段草地制度与政策的缺陷,结合国内外草地治理经验,提出以下对策建议:制定草地承包制度期限的长期性;建立基于草地生态系统功能最优的"草畜平衡"制度;实行生态补偿制度的长期性;加大生态补贴力度,并建立动态性和市场化的补贴标准;以及提高草地政策的监督管理力度。

关键词：制度变迁草地退化草畜双承包关联性分析锡林郭勒盟

Effect of dendritic cell/cytokine-induced killer cell immunobiological cancer therapy combined with adjuvant chemotherapy in patients with triple-negative breast cancer

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The Chinese-German Journal of Clinical Oncology 2015年第1期14卷 37-41页

作者： Ranran Zhang Wanqing Xie Tao Han Yongye Liu Zhaozhe Liu Fang Guo Yaling Han Zhenyu Ding Yinghui Sun Dongchu ma Xiaodong Xie Liaoning Medical University Department of Oncology Cancer center General Hospital of Shenyang Military Region Molecular Biology Laboratory of Traditional Chinese Medicine The Basic Medical College of Liaoning University of Traditional Chinese Medicine Department of Experimental Medicine Cancer center General Hospital of Shenyang Military Region

Objective The aim of the present study was to investigate the effect of dendritic cell(DC)/cytokine-induced killer cell(CIK) immunobiological cancer therapy in patients with triple-negative breast cancer(TNBC) who underwent adjuvant chemotherapy. Methods From January 2010 to October 2013, 120 patients with postoperative TNBC were recruited and included in the study. Patients were enrolled in one of two groups according to whether they accepted DC/CIK immunobiological cancer therapy during adjuvant chemotherapy; the patients in the DC/CIK group underwent adjuvant chemotherapy combined with DC/CIK immunobiological cancer therapy, and the control group underwent adjuvant chemotherapy alone. When six cycles of adjuvant chemotherapy and six cycles of DC/CIK immunobiological cancer therapy had been completed, differences between the two groups with regard to quality of life(Qo L), immunological indicators(CD3, CD4, CD8, and NK cell levels), disease-free survival(DFS), and side effects of chemotherapy and DC/CIK treatment were *** In the DC/CIK group, the proportion of NK cells and CD3+ and CD4+ T-cell subgroups significantly increased, and the proportion of CD8+ cells decreased when they were compared before and after DC/CIK therapy(P improved in the patients treated with chemotherapy plus DC/CIK therapy compared with the patients treated with chemotherapy alone, and the difference between groups was significant(P ed with the control group, and was not associated with any obvious side effects. Therefore, DC/CIK therapy is a safe and effective method for the treatment of TNBC.

关键词： triple-negative breast cancer (TNBC) cytokine-induced killer cell (CIK) dendritic cell (DC) side effect quality of life (QoL)

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店坪矿切顶卸压无煤柱开采设计方案研究

山西焦煤科技 2016年第10期40卷 41-44页

作者：马俊生山西焦煤集团公司安监局山西太原030024

介绍了店坪煤矿5-200工作面的总体情况,根据预留巷道周围的地质条件,通过对中国矿业大学(北京)切顶卸压理论的研究,经过一系列理论计算及方案论证,决定采用切顶卸压沿空留巷无煤柱技术开采方案,并设计了切顶留巷顶板预裂爆破参数,提出... 详细信息

介绍了店坪煤矿5-200工作面的总体情况,根据预留巷道周围的地质条件,通过对中国矿业大学(北京)切顶卸压理论的研究,经过一系列理论计算及方案论证,决定采用切顶卸压沿空留巷无煤柱技术开采方案,并设计了切顶留巷顶板预裂爆破参数,提出了切顶卸压沿空留巷无煤柱开采设计方案;已在店坪煤矿5-200采煤工作面推广应用,取得了阶段性的良好效果、较好的安全评价和经济效益。

关键词：切顶卸压沿空留巷无煤柱开采预裂爆破

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动态能力、即兴能力与竞争优势关系研究

外国经济与管理 2015年第11期37卷 25-37页

作者：马鸿佳宋春华葛宝山吉林大学管理学院吉林长春130022

近年来,动态能力逐渐成为创业研究领域的焦点之一,同时,学者们也开始探索创业领域中即兴能力的相关问题,但鲜有研究提出动态能力、即兴能力与竞争优势关系的异同。本文依据184份有效问卷,分别探究了动态能力、即兴能力与竞争优势的关系... 详细信息

近年来,动态能力逐渐成为创业研究领域的焦点之一,同时,学者们也开始探索创业领域中即兴能力的相关问题,但鲜有研究提出动态能力、即兴能力与竞争优势关系的异同。本文依据184份有效问卷,分别探究了动态能力、即兴能力与竞争优势的关系以及环境动态性对它们之间关系的作用机理。研究得出如下结论:在没有调节因素时,动态能力和即兴能力均与新创企业竞争优势呈现正相关关系;在加入环境动态性这一调节变量后,样本被分为"低动态环境"和"高动态环境"两组,在"低动态环境"下,即兴能力与动态能力均对竞争优势有正向的影响作用,但相比即兴能力而言,动态能力起到主要影响作用;在"高动态环境"下,即兴能力对提升企业竞争优势起到了主要作用,而动态能力对企业竞争优势的作用不显著。本研究在理论上深化了动态能力理论相关研究,同时也阐明了尚未被广泛关注的即兴能力的重要性,在实践中也对中国企业有一定参考价值,即企业在注重动态能力培育的同时,也不要忽视即兴能力为企业带来的作用。

关键词：动态能力(DC) 即兴能力(IC) 竞争优势(CA) 环境动态性(ed)

4周1900m高原训练对男子短距离自行车运动员无氧代谢能力的影响

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中国体育科技 2013年第4期49卷 60-67页

作者：马国强李之俊梁效忠倪大海上海体育学院运动科学学院上海200438 上海体育科学研究所上海200030 上海体育职业学院上海201100

目的:探讨4周1 900m高原训练对短距离自行车运动员无氧代谢能力的影响。方法:上海自行车队7名男子场地自行车短距离运动员进行为期4周的海拔1 900m高原训练。每周训练安排相同,包括公路有氧课5节、场地专项课4节、身体力量课2节,训练负... 详细信息

目的:探讨4周1 900m高原训练对短距离自行车运动员无氧代谢能力的影响。方法:上海自行车队7名男子场地自行车短距离运动员进行为期4周的海拔1 900m高原训练。每周训练安排相同,包括公路有氧课5节、场地专项课4节、身体力量课2节,训练负荷逐渐增加,第4周减量调整。分别在高原训练前、后相同时间测试空腹体成分,进行15s最大频率、最大功率测试,以及45s×2组(间歇20min)功率维持能力测试,选取时间点测试HR和BLa,并计算15s分段功率;分别在高原训练前、结束后和结束2周后采静脉血测试血常规、T、C,高原训练1周后相同方法加测血常规。结果:1)高原训练后运动员体重、体脂%、骨骼肌质量和脂肪质量没有显著变化(P>0.05);2)高原训练后血红蛋白和红细胞压积分别提高了7.4%和6.9%(P0.05);4)高原训练后两组45s测试中的最大和平均功率均无显著变化(P>0.05),但一、二组间的最大功率下降率和平均功率下降率分别降低40.5%和51.8%(P<0.01),且第一组结束后3min、第二组开始前和第二组结束后3min的血乳酸分别降低了11.2%、21.2%和9.5%(P<0.01),而20min间歇期内的乳酸消除率明显提高。结论:4周1 900m高原训练未对自行车短距离运动员的最大频率和最大功率产生显著影响,但以糖酵解代谢供能为主的重复做功和做功维持能力,以及疲劳消除能力均有所提高。

关键词：自行车短距离运动员高原训练无氧代谢能力