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Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease

Animal Models and Experimental Medicine 2024年第2期7卷 166-178页

作者： Xuecui Yin Lin Dong Xiaohan Wang Zhenzhen Qin Yuying ma Xiaofei Ke Ya Li Qingde Wang Yang mi Quanjun Lyu Xia Xu Pengyuan Zheng Youcai Tang Department of Internal Medicine the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Pediatrics the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Clinical Nutrition the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Advanced Drug Preparation Technologies Ministry of Education of ChinaCo-innovation Center of Henan Province for New drug R&D and Preclinical SafetySchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of Pediatrics GastroenterologyHenan Key Laboratory of Rehabilitation MedicineHenan Joint International Research Laboratory of Chronic Liver Injury and Henan Provincial Outstanding Overseas Scientists Chronic Liver Injury Studiothe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Background:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases *** stellate cells(HSCs)are the major effector cells of liver *** contain abundant lipid droplets(LDs)in their cytoplasm during *** 5(PLIN 5)is a LD surface-associated protein that plays a crucial role in lipid ***,little is known about the role of PLIN 5 in HSC ***:PLIN 5 was overexpressed in HSCs of Sprague–Dawley rats by lentivirus *** the same time,PLIN 5 gene knockout mice were constructed and fed with a high-fat diet(HFD)for 20 weeks to study the role of PLIN 5 in *** corresponding reagent kits were used to measure TG,GSH,Caspase 3 activity,ATP level,and mitochondrial DNA copy *** analysis of mice liver tissue metabolism was performed based on UPLC-MS/***,mitochondrial function,cell proliferation,and apoptosis-related genes and proteins were detected by western blotting and ***:Overexpression of PLIN 5 in activated HSCs led to a decrease in ATP levels in mitochondria,inhibition of cell proliferation,and a significant increase in cell apoptosis through AMPK *** addition,compared with the HFD-fed C57BL/6J mice,PLIN 5 knockout mice fed with HFD showed reduced liver fat deposition,decreased LD abundance and size,and reduced liver ***:These findings highlight the unique regulatory role of PLIN 5 in HSCs and the role of PLIN 5 in the fibrosis process of NAFLD.

关键词： AMPK apoptosis hepatic stellate cell liver fibrosis perilipin 5

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Artificial Bear Bile:A Novel Approach to Balancing Medical Requirements and Animal Welfare

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Engineering 2024年第7期38卷 100-112页

作者： Yong Li Yuhong Huang Nan Feng Heping Zhang Jing Qu Shuanggang ma Yunbao Liu Jiang Li Shaofeng Xu Ling Wang mi Zhang Jie Cai Weiping Wang Ru Feng Hang Yu Bo Yu Dailiang Liang Heping Qin Suxiang Luo Yanfen Li Meifeng Li Ruihua Wang Chen ma Yan Wang Xiaobo Cen Xiaoxian Xu Boli Zhang Xiaoliang Wang Shishan Yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250China Zhongshan Belling Biotechnology Co. Ltd.Zhongshan 528437China Zhongshan Anshi Biopharmaceutical Co. Ltd.Zhongshan 528437China WestChina-Frontier Pharma Tech Co. Ltd.Chengdu 610041China Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine(TCM)for over 13 ***,the current practice of obtaining it through bear farming is under scrutiny for its adverse impact on bear ***,we present a new approach for creating artificial bear bile(ABB)as a high-quality and sustainable alternative to natural bear *** study addresses the scientific challenges of creating bear bile alternatives through interdisciplinary collaborations across various fields,including resources,chemistry,biology,medicine,pharmacology,and TCM.A comprehensive efficacy assessment system that bridges the gap between TCM and modern medical terminology has been established,allowing for the systematic screening of therapeutic *** the utilization of chemical synthesis and enzyme engineering technologies,our research has achieved the environmentally friendly,large-scale production of bear bile therapeutic compounds,as well as the optimization and recomposition of ABB *** resulting ABB not only closely resembles natural bear bile in its composition but also offers advantages such as consistent product quality,availability of raw materials,and independence from threatened or wild *** preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effects from ABB and those from commercially available drained bear bile(DBB).Furthermore,preclinical toxicological assessment and phase I clinical trials show that the safety of ABB is on par with that of the currently used *** innovative strategy can serve as a new research paradigm for developing alternatives for other endangered TCMs,thereby strengthening the integrity and sustainability of TCM.

关键词： Artificial bear bile Chemical profile Formula optimization Pharmacodynamic consistency Preclinical toxicological assessment

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Compressive performance of innovative reinforced pillars in closed/abandoned mines

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Journal of Central South University 2024年第8期31卷 2780-2793页

作者： Li, Jian Bai, Jin-wen Feng, Guo-rui Wang, Shan-yong Zhao, Hong-chao mi, Jia-chen Pan, Rui-kai Shi, Xu-dong ma, Jun-biao College of mining Engineering Taiyuan University of Technology Taiyuan China Key Laboratory of Shanxi Province for mine Rock Strata Control and Disaster Prevention Taiyuan University of Technology Taiyuan China Shanxi-Zheda Institute of Advanced materials and Chemical Engineering Taiyuan China Priority Research Centre for Geotechnical Science and Engineering School of Engineering The University of Newcastle Callaghan Australia School of Geology and mining Engineering Xinjiang University Urumqi China Department of mining Engineering Shanxi Institute of Energy Jinzhong China

Pillar is closely related to the stability and reliability of underground spaces in closed/abandoned mines. The present research introduced a new technique to strengthen square cement mortar columns via fiber-reinforced polymer (FRP) strips to verify the strengthening effect of FRP on pillars. Compared to a fully wrapped FRP jacket, the advantages of FRP strip are cost-effective and easy-to-construct. A series of compression tests as well as theoretical analysis were carried out to explore the mechanical behavior of square cement mortar specimens partially strengthened with FRP strips. The results verified the effectiveness of FRP strips in enhancing the stress and strain of cement mortar. Different from unconfined cement mortar specimens, these FRP-strengthened cement mortar specimens are featured with the double-peaked behaviors, mainly attributed to the stress state transformation from a one-dimensional to a three-dimensional stress state. It also indicated that the enhancement of stress increased with the FRP strip width. Moreover, the brittle-ductile transition ductile failure characteristics were also observed in FRP-confined cement mortar specimens. The ultimate ductility of the cement mortar specimen decreases gradually with the growth of the FRP strip width. The main contribution of this research is to enrich the strengthening techniques for residual pillars.

关键词： brittle-ductile transition double-peaked behaviors fiber-reinforced polymer partially strengthening uniaxial compression

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Metallurgical performance evaluation of space-weathered Chang’e-5 lunar soil

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International Journal of minerals,Metallurgy and materials 2024年第6期31卷 1241-1248页

作者： Chen Li Wenhui ma Yang Li Kuixian Wei Center for Lunar and Planetary Sciences Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China

Space metallurgy is an interdisciplinary field that combines planetary space science and metallurgical *** involves systematic and theoretical engineering technology for utilizing planetary resources in ***,space metallurgy on the Moon is challenging because the lunar surface has experienced space weathering due to the lack of atmosphere and magnetic field,making the mi-crostructure of lunar soil differ from that of minerals on the *** this study,scanning electron microscopy and transmission electron microscopy analyses were performed on Chang’e-5 powder lunar soil *** microstructural characteristics of the lunar soil may drastically change its metallurgical *** main special structure of lunar soil minerals include the nanophase iron formed by the impact of micrometeorites,the amorphous layer caused by solar wind injection,and radiation tracks modified by high-energy particle rays inside mineral *** nanophase iron presents a wide distribution,which may have a great impact on the electromagnetic prop-erties of lunar *** ions injected by solar wind may promote the hydrogen reduction *** widely distributed amorph-ous layer and impact glass can promote the melting and diffusion process of lunar ***,although high-energy events on the lun-ar surface transform the lunar soil,they also increase the chemical activity of the lunar *** is a property that earth samples and tradi-tional simulated lunar soil *** application of space metallurgy requires comprehensive consideration of the unique physical and chemical properties of lunar soil.

关键词： space metallurgy Chang’e-5 lunar soil space weathering metallurgical performance

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Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang Fu Yanyan Lin mingzhen Bai Jia Yao Chongfei Huang Long Gao Ningning mi Haidong ma Liang Tian Ping Yue Yong Zhang Jinduo zhang Yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo Meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal *** study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by mass spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome maintenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids

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minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou Cai-Ling Li Hua Zhang Bao-Jun Suo Yu-Xin Zhang Xin-Lu Ren Yu-Xin Wang Chang-min mi Ling-Ling ma Li-Ya Zhou Xue-Li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple ***,the search for new alternative drugs has become one of the research *** recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(***)infection,but the systematic evaluation of its role remains *** To explore the efficacy,safety,and compliance of minocycline in eradicating *** *** We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on *** eradication with minocycline-containing regimens as per the inclusion and exclusion *** eradication rates of *** were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were *** The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall *** eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol *** overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse *** of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and

关键词： Helicobacter pylori minocycline Eradication Safety Resistance

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陕西地区健康人群血栓弹力图参考区间的建立

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西安交通大学学报（医学版） 2024年第4期45卷 663-668页

作者：黄露杰马捷王咪闫芳西安交通大学医学部电镜室陕西西安710061 西安市第三医院输血科陕西西安710018

目的建立陕西地区健康人群血栓弹力图(TEG)的参考区间,为临床精准输血工作服务。方法依据《临床实验室检验项目参考区间的制定》(WS/T 402-2012)的标准方法,采集386例陕西地区入选者的外周静脉血,分别运用血凝仪测定常规凝血纤溶指标... 详细信息

目的建立陕西地区健康人群血栓弹力图(TEG)的参考区间,为临床精准输血工作服务。方法依据《临床实验室检验项目参考区间的制定》(WS/T 402-2012)的标准方法,采集386例陕西地区入选者的外周静脉血,分别运用血凝仪测定常规凝血纤溶指标(PT、APTT、TT、FiB、FDP、DD)和TEG检测以下各项参数(R、K、Angle、ma、LY30、CI),并以95%CI确定TEG各项参数的参考区间。结果 386例健康志愿者常规凝血纤溶指标均正常。所有入选者TEG数据与TEG生产商提供的各项指标的参考区间相比,其中7.2%(28/386)被诊断为凝血病,检测特异性仅为44%(170/386)。此外,R减小者188例(48.7%),K增大者28例(7.3%),Angle减小者12例(3.1%)。男性与女性的R、ma和CI差异明显(Pma:49.5~69.3,LY30:0~8.0,CI:-3.2~3.6;女性R:2.7~9.2,K:1.2~3.4,Angle:46.2~72.5,ma:49.5~69.3,LY30:0~8.0,CI:-3.2~3.6。结论陕西地区健康人群TEG参考区间与生产商提供的参考区间存在明显差异。本研究建立的TEG参考区间更为适应本地区人群的临床凝血特征,可更好地应用于临床诊疗服务。

关键词：陕西地区血栓弹力图(TEG) 参考范围健康人群

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连续流选择性加氢技术研究进展

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有机化学 2024年第5期44卷 1445-1457页

作者：密思怡马隆龙刘建国东南大学-蒙纳士大学苏州联合研究生院江苏苏州215000 东南大学能源与环境学院南京210096

流动氢化技术是合成制备精细化学品的重要手段,在制备药物中间体及生产高值化学品方面占比极大.非均相催化氢化法具有优良的经济环保性,通过使用负载型催化剂能有效减少污染物排放,提高底物转化率以及选择性.详细介绍了按催化剂负载方... 详细信息

流动氢化技术是合成制备精细化学品的重要手段,在制备药物中间体及生产高值化学品方面占比极大.非均相催化氢化法具有优良的经济环保性,通过使用负载型催化剂能有效减少污染物排放,提高底物转化率以及选择性.详细介绍了按催化剂负载方式分类的微反应器类型以及常用的固体催化剂,阐述了连续流技术在不同官能团催化氢化领域中取得的进展.在此基础上概述了作为十大新兴化学技术之一的流动化学,在催化加氢应用上具有极大远景,连续、自动化和智能化技术是制药和化学工业的未来.

关键词：氢化多相催化流动化学微反应器

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RuO_(2)/TiO_(2)/MXene with multi-heterojunctions coating on carbon cloth for high-activity chlorine evolution reaction at large current densities

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Nano Research 2024年第6期17卷 4764-4772页

作者： Yuhao Duan Liuxu Wei Chenyu Cai Junbao mi Fuyuan Cao Jiaze Chen Xiaolong Li Xiujiang Pang Bin Li Lei Wang Key Laboratory of Eco-chemical Engineering Ministry of EducationInternational Science and Technology Cooperation Base of Eco-chemical Engineering and Green ManufacturingCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042China

The chlorine evolution reaction(CER)is a crucial step in the production of chlorine gas and active chlorine by chlor-alkali ***,the endeavor to fabricate electrodes capable of yielding high current density at minimal overpotential remains a central challenge in advancing the realm of chlorine evolution ***,we grow TiO_(2)and RuO_(2)on MXene@carbon cloth(CC)through the favorable affinity and induced deposition effect between the surface functional groups of MXene and the metal.A self-supported electrode(RuTiO_(2)/MXene@CC)with strong binding at the electrocatalyst-support interface and weak adhesion at electrocatalyst-bubble interface is *** RuTiO_(2)/MXene@CC can reduce the electron density of RuO_(2)by regulating the electron redistribution at the heterogeneous interface,thus enhancing the adsorption of Cl−.RuTiO_(2)/MXene@CC could achieve a high current density of 1000 ma·cm^(−2)at a small overpotential of 220 mV,superior to commercial dimensionally stable anodes(DSA).This study provides a new strategy for constructing efficient CER catalysts at high current density.

关键词： chlorine evolution reaction high current density MXene TiO_(2) RuO_(2)

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基于电力系统分区惯量估计的储能容量配置策略

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电力自动化设备 2024年第7期44卷 13-20页

作者：米阳王沛林周杰马思源李东东上海电力大学电气工程学院上海200090

针对大规模新能源接入导致电力系统惯量水平下降,提出了一种基于分区惯量估计的储能容量配置策略。基于传统电力系统的惯量机理分析,建立了含新能源电力系统的等效惯量模型和风光储能虚拟惯量模型。运用谱聚类对电力系统进行分区解决惯... 详细信息

针对大规模新能源接入导致电力系统惯量水平下降,提出了一种基于分区惯量估计的储能容量配置策略。基于传统电力系统的惯量机理分析,建立了含新能源电力系统的等效惯量模型和风光储能虚拟惯量模型。运用谱聚类对电力系统进行分区解决惯量空间分布不均影响估计精度问题,并基于皮尔逊相关系数确定测量节点。运用差值法对分区后系统的各个区域进行惯量估计,进而利用分区惯量估计结果设计电力系统储能容量配置策略。在DIgSLIENT/PowerFactory中搭建含风机的IEEE 10机39节点模型进行仿真验证。仿真结果表明所提方法可以减小惯量估计误差,基于惯量估计结果可以对储能容量进行合理配置,保证储能系统实现快速调频和提供虚拟惯量支撑。

关键词：惯量估计系统分区谱聚类差值法储能容量配置策略

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