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Flexibility of Metal-Organic Framework Tunable by Crystal Size at the Micrometer to Submillimeter Scale for Efficient Xylene Isomer Separation

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Research 2019年第1期2019卷 433-441页

作者： Xiao Yang Hao-Long Zhou Chun-Ting He Zong-Wen mo Jia-Wen Ye Xiao-Ming Chen Jie-Peng Zhang moE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

Understanding,controlling,and utilizing the flexibility of adsorbents are of great importance and *** with conventional solid materials,downsizing to the nanoscale is emerging as a possible strategy for controlling the flexibility of porous coordination polymers(or metal-organic frameworks).We report a unique flexibility controllable by crystal size at the micrometer to submillimeter *** removal transforms[Cu_(2)(pypz)_(2)]·0.5p-xylene(maF-36,Hpypz=4-(1H-pyrazol-4-yl)pyridine)with one-dimensional channels toα-[Cu_(2)(pypz)_(2)]with discrete small cavities,and further heating gives a nonporous isomerβ-[Cu_(2)(pypz)_(2)].Both isomers can adsorb p-xylene to give[Cu_(2)(pypz)_(2)]·0.5p-xylene,meaning the coexistence of guest-driven flexibility and shape-memory *** phase transition temperature fromα-[Cu_(2)(pypz)_(2)]toβ-[Cu_(2)(pypz)_(2)]decreased from~270℃ to~150℃ by increasing the crystal size from the micrometer to the submillimeter scale,ca.2-3 orders larger than those of other size-dependent ***-crystal X-ray diffraction showed coordination bond reconstitution and chirality inversion mechanisms for the phase transition,which provides a sufficiently high energy barrier to stabilize the metastable phase without the need of downsizing to the *** virtue of the crystalline molecular imprinting and gate-opening effects,α-[Cu_(2)(pypz)_(2)]andβ-[Cu_(2)(pypz)_(2)]show unprecedentedly high p-xylene selectivities of 16 and 51,respectively,as well as ultrafast adsorption kinetics(<2 minutes),for xylene isomers.

关键词： isomers coordination adsorbent

Full length cDNA cloning and expression analysis of annexinA2 gene from deer antler tissue

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Journal of Forestry Research 2014年第4期25卷 953-957页

作者： li Hao Xianghong Xiao Heping li College of Wildlife Resource Northeast Forestry University

ANXA2（AnnexinA2）, a calcium-dependent phospholipid bind- ing protein, is involved in various ca2＋-related biological activities. In the present study, full-length cDNA of ANXA2 was isolated from the velvet antler tip tissue of sika deer （Cervus nippon hortulomm）; the amino acid sequence and gene expression was analyzed by using bioinformatics and real-time reverse transcdptase polymerase chain reaction （RT-PCR） techniques. Nucleotide sequence analysis reveals that the full-length cDNA of the ANXA2 gene was 1372 bp, of which 1020 bp was in the opan-reading frame （OR.F） encoding 339 amino acids; its relative mo- lecular weight was 38.3 kDa; and isoelectrie point was 6.72. Sequence analysis indicates that the protein includes four conserved tan- dem-duplication ANX domains. The gene-aceession nucleotide sequence number in GenBank is JX315571. Expression analysis by RT-PCR re- veals that ANXA2 gene expression has a significant positive correlation with the antler-tissue mineralization process, indicating that this gene may play an important role in the regulation of antler-tissue mineraliza- tion.

关键词： velvet antler AnnexinA2 (ANXA2) gene cDNA library clone real-time quantitative RT-PCR

STUDY OF COMPOSITE MEMBRANE OF CELLULOSE ACETATE OR POLYVINYL ALCOHOL BLENDED WITH METHYLMETHACRYLATE-ACRYliC ACID COPOLYMER FOR PERVAPORATION SEPARATION

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Chinese Journal of Polymer Science 1999年第3期17卷 299-302页

作者： Huan-lin Chen Jun Tan mo-e liu Chang-luo Zhu Department of Chemical Engineering, Zhejiang University, Hangzhou 310027, China Department of Chemical Engineering Zhejiang University Hangzhou 310027 China

In this paper, methylmethacrylate-acrylic acid Mma-AA hydrophilic and hydrophobic copolymers were prepared by copolymerization for preparing membrane materials. The composite membrane of cellulose acetate (ca) blended with Mma-AA hydrophobic copolymer was used for the separation of methanol from pentane-methanol mixture. When the methanol concentration was only 1 wt%, the permeate flux still maintained at 350 g/m(2)h and separation factor was as big as 800. The composite membrane of PVA (polyvinyl alcohol) blended with Mma-AA hydrophilic copolymer was used for the separation of ethanol-water mixture. The permeate flux was increased to 975 g/m(2)h at 74 degrees C and the separation factor reached 3000 at 25 degrees C. The PVA/Mma-AA blended membrane surface modified by ammonia plasma was also investigated for separating ethanol-water mixture. Both permeate flux and separation factor of the membrane was improved. However, there was no obvious difference of plasma treatment time in the interval of 20 similar to 40 min.

关键词： blended membranes Mma-AA copolymers pervaporation separation of mixed solvents

Hepatocellular carcinoma masquerading as a bleeding gastric ulcer: A case report and a review of the surgical management

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World Journal of Gastroenterology 2007年第33期13卷 4523-4525页

作者： Johnny ca Ong Pierce KH Chow Weng-Hoong Chan Alex YF Chung Choon Hua Thng Wai-Keong Wong Department of General Surgery Singapore General Hospital Singapore 169608 Singapore Department of Oncologic Radiology National Cancer Centre Singapore Singapore

Hepatocellular carcinoma (HCC) is a common malignancyworldwide. While bleeding from the gastrointestinal tract(BGIT) has a well known association with HCC, suchcases are mainly due to gastric and esophageal *** as a result of invasion of the gastrointestinal tractby HCC is extremely rare and is reportedly associatedwith very poor prognosis. We describe a 67-year-oldmale who presented with BGIT. Endoscopy showed thesite of bleeding to be from a gastric ulcer, but endoscopictherapy failed to control the bleeding and emergencysurgery was required. At surgery, the ulcer was found tohave arisen from direct invasion of the gastrointestinaltract by HCC of the left lobe. Control of the bleedingwas achieved by surgical resection of the HCC en-bloc with the lesser curve of the stomach. The patientremains alive 33 mo after surgery. Direct invasion of thegastrointestinal tract by HCC giving rise to BGIT is veryuncommon. Surgical resection may offer significantlybetter survival over non-surgical therapy, especially if thepatient is a good surgical candidate and has adequatefunctional liver reserves. Prognosis is not uniformly grave.

关键词： Hepatocellular carcinoma Gastrointestinal bleeding Stomach invasion Hepatectomy

基于席夫碱反应的氧化葡聚糖/胺化羧甲基壳聚糖双组分水凝胶粘合剂

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中国组织工程研究 2018年第22期22卷 3527-3532页

作者：李丹丹莫秀梅东华大学化学化工与生物工程学院上海市201620

背景:基于席夫碱反应的双交联水凝胶粘合剂,具有一定的网络结构和更好的生物相容性,黏结强度也更高,在组织工程和临床医学中具有很好的应用前景。目的:通过席夫碱反应制备氧化葡聚糖/胺化羧甲基壳聚糖双组分水凝胶粘合剂,并进行表征。方... 详细信息

背景:基于席夫碱反应的双交联水凝胶粘合剂,具有一定的网络结构和更好的生物相容性,黏结强度也更高,在组织工程和临床医学中具有很好的应用前景。目的:通过席夫碱反应制备氧化葡聚糖/胺化羧甲基壳聚糖双组分水凝胶粘合剂,并进行表征。方法:利用高碘酸钠对葡聚糖进行氧化处理,利用乙二胺对羧甲基壳聚糖进行胺化处理;在室温条件下,通过席夫碱反应制备氧化葡聚糖/胺化羧甲基壳聚糖水凝胶粘合剂。利用红外吸收光谱表征氧化葡聚糖和胺化羧甲基壳聚糖的结构,利用分光光度计法测定氧化葡聚糖碘残留量,利用气相色谱法测定胺化羧甲基壳聚糖乙二胺残留量。根据行业标准,利用万能试验机检测氧化葡聚糖/羧甲基壳聚糖与氧化葡聚糖/胺化羧甲基壳聚糖水凝胶粘合剂的搭接-剪切拉伸承载强度、T-剥离拉伸承载强度、拉伸强度。结果与结论:(1)红外光谱显示,与葡聚糖相比,氧化葡聚糖的峰强度下降,同时在1 733 cm-1处出现一个新的吸收峰,对应于半缩醛结构;羧甲基壳聚糖本身具有胺基,在3 358 cm-1处宽峰对应于胺基与羟基的伸缩振动,胺化羧甲基壳聚糖在3 358 cm-1吸收峰大幅度增强;(2)氧化葡聚糖的氧化度为73.42%,碘残留量为138.58μg/g;胺化羧甲基壳聚糖胺基含量为0.636 9 mmol/L,无乙二胺残留;(3)氧化葡聚糖/胺化羧甲基壳聚糖水凝胶粘合剂的搭接-剪切拉伸承载强度、T-剥离拉伸承载强度和拉伸强度较氧化葡聚糖/羧甲基壳聚糖水凝胶粘合剂分别增大47.48%、17.54%和76.42%,增幅明显;(4)结果表明,氧化葡聚糖/胺化羧甲基壳聚糖水凝胶粘合剂具有较高的搭接-剪切拉伸承载强度、T-剥离拉伸承载强度和拉伸强度。

关键词：葡聚糖类壳聚糖水凝胶组织工程生物材料席夫碱葡聚糖羧甲基壳聚糖黏结强度

电感耦合等离子体原子发射光谱法测定硅铝钡合金中7种主次量元素

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冶金分析 2006年第5期26卷 44-47页

作者：莫庆军济南钢铁集团总公司山东济南250101

应用电感耦合等离子体原子发射光谱(ICP-AES)法对硅铝钡合金中的主次量元素Si,Al,Ba,Fe,ca,Mn,Cu进行同时测定。样品(100mg)于聚四氟乙烯密封罐中,用2mL盐酸(1+1)、3mL硝酸(1+1)和1mL氢氟酸在室温下溶解,20min后加入15mL硼酸溶液除氟,... 详细信息

应用电感耦合等离子体原子发射光谱(ICP-AES)法对硅铝钡合金中的主次量元素Si,Al,Ba,Fe,ca,Mn,Cu进行同时测定。样品(100mg)于聚四氟乙烯密封罐中,用2mL盐酸(1+1)、3mL硝酸(1+1)和1mL氢氟酸在室温下溶解,20min后加入15mL硼酸溶液除氟,试液经过滤后,用于ICP-AES测定。通过对溶样方法和电感耦合等离子体原子发射光谱仪分析参数的优化,以及对影响分析结果准确度的因素进行校正,方法的准确度得到提高。应用本法测定国家标准参考物质其结果与认定值一致,加标回收率为98.1%～104.7%,RSD小于4%。

关键词：电感耦合等离子体原子发射光谱法(ICP-AES) 硅铝钡合金元素分析

canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species

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Journal of Pharmaceutical Analysis 2023年第11期13卷 1309-1325页

作者： Hui-Nan Zhang Meng Zhang Wen Tian Wei Quan Fan Song Shao-Yuan liu Xiao-Xiao liu Dan mo Yang Sun Yuan-Yuan Gao Wen Ye Ying-Da Feng Chang-Yang Xing Chen Ye Lei Zhou Jing-Ru Meng Wei cao Xiao-Qiang li Department of Health management Second Affiliated HospitalFourth Military Medical UniversityXi'an710038China Department of Pharmacology School of PharmacyFourth Military Medical UniversityXi'an710032China Key Laboratory of Gastrointestinal Pharmacology of Chinese materia Medica of the State Administration of Traditional Chinese Medicine School of PharmacyFourth Military Medical UniversityXi'an710032China Shaanxi Key Laboratory of“Qin Medicine”Research and Development Shaanxi Administration of Traditional Chinese MedicineXi'an710032China Institute of materia Medica School of PharmacyFourth Military Medical UniversityXi'an710032China Department of Ultrasound Diagnostics Second Affiliated HospitalFourth Military Medical UniversityXi'an710038China Department of Pharmacy School of Chemistry&PharmacyNorthwest A&F UniversityYanglingShaanxi712100China

The canonical transient receptor potential channel(TRPC)proteins form ca^(2+)-permeable cation channels that are involved in various heart ***,the roles of specific TRPC proteins in myocardial ischemia/reperfusion(I/R)injury remain poorly *** observed that TRPC1 and TRPC6 were highly expressed in the area at risk(AAR)in a coronary artery ligation induced I/R ***1/mice exhibited improved cardiac function,lower serum Troponin T and serum creatine kinase level,smaller infarct volume,less fibrotic scars,and fewer apoptotic cells after myocardial-I/R than wild-type or Trpc6/***-specific knockdown of Trpc1 using adeno-associated virus 9 mitigated myocardial I/R ***,Trpc1 deficiency protected adult mouse ventricular myocytes(AMVMs)and HL-1 cells from death during hypoxia/reoxygenation(H/R)***-sequencing-based transcriptome analysis revealed differential expression of genes related to reactive oxygen species(ROS)generation in Trpc1/*** these genes,oxoglutarate dehydrogenase-like(Ogdhl)was markedly ***,Trpc1 deficiency impaired the calcineurin(caN)/nuclear factorkappa B(NF-kB)signaling pathway in *** of this pathway inhibited Ogdhl upregulation and ROS generation in HL-1 cells under H/R *** immunoprecipitation assays confirmed NF-kB binding to the Ogdhl *** cardioprotective effect of Trpc1 deficiency was canceled out by overexpression of NF-kB and Ogdhl in *** conclusion,our findings reveal that TRPC1 is upregulated in the AAR following myocardial I/R,leading to increased ca^(2+) influx into associated ***,this upregulates Ogdhl expression through the caN/NF-kB signaling pathway,ultimately exacerbating ROS production and aggravating myocardial I/R injury.

关键词： TRPC1 Myocardial ischemia/reperfusion Reactive oxygen species OGDHL

Cell Mechanics Regulates Cellular Uptake of Graphene Quantum dot for Specifically Targeting cancer Stem Cells

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医用生物力学 2019年第A1期34卷 127-128页

作者： Xi Chen Kai Tang Jinghua Sun Yadi Fan Zhipeng Xu mo Yang Youhua Tan The Hong Kong Polytechnic University

cancer stem cells(CSCs)are the driving force for sustainable tumor growth and metastasis and responsible for drug resistance and cancer ***-based drug delivery has been demonstrated to be effective in combating tumor ***,it has been challenging to selectively eliminate CSCs due to the lack of a general signature for a spectrum of *** is known that CSCs from various types of cancer show lower stiffness compared to *** remains unclear whether low stiffness in CSCs influences cellular uptake in nanoparticle-based drug delivery and thus the chemotherapy *** quantum dot(GQD)is emerging as a promising carrier material in delivering anti-cancer *** found that breast CSCs were softer than conventional cancer cells,which were further softer compared to healthy breast tissue ***,soft CSCs uptook more GQD than conventional cancer cells,while stiff breast cancer cells with relatively low stiffness uptook more GQD than healthy breast *** cells by pharmacologically inhibiting actomyosin activity using either siRNA or actomyosin inhibitors significantly enhanced the cellular uptake of GQD in breast cancer cells but not CSCs,while stiffening cells by activating actomyosin using ca-MLCK/ROCK or actomyosin activators considerably suppressed the nanoparticle uptake in both cancer cells and *** could specifically target CSC because of low cell stiffness of CSC in breast cancer cell line MCF-7 and *** regulating cell stiffness reflected that decreasing breast cancer cell stiffness by inhibiting actomyosin activity using blebbistatin could promote GQD *** versa,stiffening cancer cell by activating actomyosin decreased GQD *** attachment of anti-cancer drug doxorubicin did not alter the trend of GQD uptake in neither soften nor stiffen cancer *** activity regulates cellular uptake ofGQD might through clathrin and caveolin-mediated *** cells

关键词： cell mechanics cancer stem cells nanoparticle endocytosis

Sintering of doped, Nanocrystalline CeO_2 Powders Prepared under Hydrothermal Conditions

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Journal of materials Science & Technology 1995年第6期11卷 429-434页

作者： Yanchun ZHOU(Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110015, China)M.N.Rahaman (Ceramic Engineering Department, University of Missouri-Rolla, Rolla, mo 65401, USA) Inst of metal Research Chinese Acad of Sciences Shenyang China

Nanocrystalline CeO2 powders (particle size ≈10-15 nm), doped with up to 20 at.-% of Mg,ca or Y were prepared by chemical precipitation under hydrothermal conditions. The particle size and shape of the powders change slightly with the dopant concentrations. The the of the dopants on the sintering of the compacted powders was investigated during heating at a constant rate of 10℃/min. The elemental composition and the concentration of the dopant has significant efFect on the densification and grain growth. Compared to undoped CeO2, the dopants produce a shift in the densification curve to higher temperatures. For the same dopant concentration and under identical sintering conditions, the ca doped samples reach nearly full density with the smallest grain size (≈50 nm), however, the Mg doped sample has the lowest density (≈95% of the theoretical) with the largest grain size (≈1 μm)

关键词： Brook TGA Nanocrystalline CeO2 Powders Prepared under Hydrothermal Conditions Sintering of doped