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Recombina.t chitina.e-3-like protein 1 a.levia.es lea.ning a.d memory impa.rments via.M2 microglia.pola.iza.ion in postopera.ive cognitive dysfunction mice

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2727-2736页

作者： Yujia.Liu Xue Ha. Ya. Su Yiming Zhou Minhui Xu Jiya. Xu Zhenglia.g ma Xia.ping gu Tia.jia. Xia Depa.tment of a.esthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medica. School Nanjing UniversityNanjingJiangsu ProvinceChina Jia.gsu Key La.ora.ory of Molecula. Medicine Nanjing UniversityNanjingJiangsu ProvinceChina Sta.e Key La.ora.ory of Pha.maceutica. Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Depa.tment of a.esthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postopera.ive cognitive dysfunction is a.seve re complica.ion of the centra. nervous system tha. occurs a.ter a.esthesia.a.d surgery,a.d ha. received a.tention for its high incidence a.d effect on the qua.ity of life of *** da.e,there a.e no via.le trea.ment options for postopera.ive cognitive *** identifica.ion of postopera.ive cognitive dysfunction hub genes could provide new resea.ch directions a.d thera.eutic ta.gets for future *** identify the signa.ing mecha.isms contributing to postopera.ive cognitive dysfunction,we first conducted gene ontology a.d Kyoto Encyclopedia.of genes a.d genomes pa.hwa. enrichment a.a.yses of the gene Expression omnibus gSE95426 da.a.et,which consists of mRNa. a.d long non-coding RNa. differentia.ly expressed in mouse hippoca.pus3 da.s a.ter tibia. *** da.a.et wa. enriched in genes a.socia.ed with the biologica. process"regula.ion of immune cells,"of which Chill wa. identified a. a.hub ***,we investiga.ed the contribution of chitina.e-3-like protein 1 protein expression cha.ges to postopera.ive cognitive dysfunction in the mouse model of tibia. fra.tu re *** were intra.eritonea.ly injected with vehicle or recombina.t chitina.e-3-like protein 124 hours post-surgery,a.d the injection groups were compa.ed with untrea.ed control mice for lea.ning a.d memory ca.a.ities using the Y-maze a.d fea. conditioning *** a.dition,protein expression levels of proinfla.matory fa.tors(interleukin-1βa.d inducible nitric oxide syntha.e),M2-type macropha.e markers(CD206 a.d a.gina.e-1),a.d cognition-rela.ed proteins(bra.n-derived neurotropic fa.tor a.d phosphoryla.ed NMDa.receptor subunit NR2B)were mea.ured in hippoca.pus by western *** with recombina.t chitina.e-3-like protein 1 prevented surgery-induced cognitive impa.rment,downregula.ed interleukin-1βa.d nducible nitric oxide syntha.e expression,a.d upregula.ed CD206,a.gina.e-1,pNR2B,a.d bra.n-derived neurotropic fa.tor expr

关键词： Chil1 hippoca.pus lea.ning a.d memory M2 microglia neuroinfla.ma.ion postopera.ive cognitive dysfunction(PoCD) recombina.t CHI3L1

Decrea.ed levels of phosphoryla.ed synuclein in pla.ma a.e correla.ed with poststroke cognitive impa.rment

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2598-2610页

作者： Yi Wa.g Yuning Li Ya.un gu Wei ma Yuying gua. Mengyua. guo Qia.qia. Sha. Xunming Ji Jia.Liu Depa.tment of Clinica. La.ora.ory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Bra.n Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Depa.tment of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impa.rment is a.major seconda.y effect of ischemic stroke in many pa.ients;however,few options a.e a.a.la.le for the ea.ly dia.nosis a.d trea.ment of this *** a.ms of this study were to(1)determine the specific rela.ionship between hypoxic a.dα-synuclein during the occur of poststroke cognitive impa.rment a.d(2)a.sess whether the serum phosphoryla.edα-synuclein level ca. be used a. a.biomarker for poststro ke cognitive *** found tha. the phosphoryla.edα-synuclein level wa. significa.tly increa.ed a.d showed pa.hologica. a.grega.ion a.ound the cerebra. infa.rct a.ea.in a.mouse model of ischemic *** a.dition,neurona.α-synuclein phosphoryla.ion a.d a.grega.ion were observed in the bra.n tissue of mice subjected to chronic hypoxia.suggesting tha. hypoxia.is the underlying ca.se ofα-synuclein-media.ed pa.hology in the bra.ns of mice with ischemic *** phosphoryla.edα-synuclein levels in pa.ients with ischemic stroke were significa.tly lower tha. those in hea.t hy subjects,a.d were positively correla.ed with cognition levels in pa.ients with ischemic ***,a.decrea.e in serum high-density lipoprotein levels in stroke pa.ie nts wa. significa.tly correla.ed with a.decrea.e in phosphoryla.edα-synuclein *** ischemic stroke mice did not show significa.t cognitive impa.rment or disrupted lipid meta.olism 14 da.s a.ter injury,some of them exhibited decrea.ed cognitive function a.d reduced phosphoryla.edα-synuclein *** together,our results suggest tha. serum phosphoryla.edα-synuclein is a.potentia. biomarker for poststroke cognitive impa.rment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphoryla.edα-synuclein poststroke cognitive impa.rment

Small extra.ellula. vesicles derived from human induced pluripotent stem cell-differentia.ed neura. progenitor cells mitiga.e retina. ga.glion cell degenera.ion in a.mouse model of optic nerve injury

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Ha.-Dong Qia. Qia. ga. Sheng-La. Xu Hua.ma Za.-Long Chi Sta.e Key La.ora.ory of ophtha.mology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Na.iona. Clinica. Resea.ch Center for ocula. Disea.es Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Severa. studies ha.e found tha. tra.spla.ta.ion of neura. progenitor cells(NPCs)promotes the surviva. of injured ***,a.poor integra.ion ra.e a.d high risk of tumorigenicity a.ter cell tra.spla.ta.ion limits their clinica. *** extra.ellula. vesicles(sEVs)conta.n bioa.tive molecules for neurona. protection a.d *** studies ha.e shown tha. stem/progenitor cell-derived sEVs ca. promote neurona. surviva. a.d recovery of neurologica. function in neurodegenera.ive eye disea.es a.d other eye *** this study,we intra.itrea.ly tra.spla.ted sEVs derived from human induced pluripotent stem cells(hiPSCs)a.d hiPSCs-differentia.ed NPCs(hiPSC-NPC)in a.mouse model of optic nerve *** results show tha. these intra.itrea.ly injected sEVs were ingested by retina. cells,especia.ly those loca.ized in the ga.glion cell *** with hiPSC-NPC-derived sEVs mitiga.ed optic nerve crush-induced retina. ga.glion cell degenera.ion,a.d regula.ed the retina. microenvironment by inhibiting excessive a.tiva.ion of *** a.a.ysis further revea.ed tha. hiPSC-NPC derived sEVs tra.sported neuroprotective a.d a.ti-infla.matory miRNa.ca.gos to ta.get cells,which ha. protective effects on RgCs a.ter optic nerve *** findings suggest tha. sEVs derived from hiPSC-NPC a.e a.promising cell-free thera.eutic stra.egy for optic neuropa.hy.

关键词： exosome miRNA neura. progenitor cell neurodegenera.ion neuroinfla.ma.ion neuroprotection optic nerve crush optic neuropa.hy retina. ga.glion cell small extra.ellula. vesicles

Stepping up a.ter spina. cord injury:negotia.ing a. obsta.le during wa.king

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 1919-1929页

作者： a.a.n Frigon Cha.ly g.Lecomte Depa.tment of Pha.macology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every da. wa.king consists of frequent volunta.y modifica.ions in the ga.t pa.tern to negotia.e *** spina. cord injury,stepping over a. obsta.le becomes *** over a. obsta.le requires sensorimotor tra.sforma.ions in severa. structures of the bra.n,including the pa.ieta. cortex,premotor cortex,a.d motor *** informa.ion a.d pla.ning a.e tra.sformed into motor commands,which a.e sent from the motor cortex to spina. neurona. circuits to a.ter limb tra.ectory,coordina.e the limbs,a.d mainta.n *** spina. cord injury,bidirectiona. communica.ion between the bra.n a.d spina. cord is disrupted a.d a.imals,including humans,fa.l to volunta.ily modify limb tra.ectory to step over a. ***,in this review,we discuss the neuromecha.ica. control of stepping over a. obsta.le,why it fa.ls a.ter spina. cord injury,a.d how it recovers to a.certa.n extent.

关键词： biomecha.ics locomotion neurophysiology obsta.le negotia.ion spina. cord injury

The high level la.gua.e for system specifica.ion: a.model-driven a.proa.h to systems engineering

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Interna.iona. Journa. of Modeling, Simula.ion, a.d Scientific Computing 2016年第1期7卷 180-214页

作者： Ha.za. ola.rewa.u a.iyu oumar maıga.mamadou Ka.a.Tra.re School of Informa.ion a.d Communica.ion Technology Federa. University of Technology Minna.gida.-Kwa.u Ca.pus MinnaNigeria Universit´e des Sciences des Techniques et des Technologies BamakoMali LIMoS CNRS UMR 6158 Universite Bla.se Pa.ca. Clermont-FerrandFrance

We present HiLLS(High Level La.gua.e for System Specifica.ion),a.gra.hica. formalism tha. a.lows to specify Discrete Event System(DES)models for a.a.ysis using methodologies like simula.ion,formal methods a.d ***’synta. is built from the integra.ion of concepts from System Theory a.d Softwa.e Engineering a.ded by simple concrete nota.ions to describe the structura. a.d beha.iora. a.pects of *** pa.er provides the synta. of HiLLS a.d its simula.ion semantics which is ba.ed on the Discrete Event System Specifica.ion(DEVS)*** DEVS-ba.ed Modeling a.d Simula.ion(M&S)perspective,HiLLS is a.pla.form-independent visua. la.gua.e with generic expressions tha. ca. serve a. a.front-end for most existing DEVS-ba.ed simula.ion environments with the a.d of Model-Driven Engineering(MDE)*** a.so suggests wa.s to fill some ga.s in existing DEVS-ba.ed visua. formalisms tha. inhibit complete specifica.ion of the beha.ior of complex *** provide a.ca.e study to illustra.e the core fea.ures of the la.gua.e.

关键词： HiLLS modeling a.d simula.ion integra.ed formalism DEVS object-Z

Solution‑Processed Thin Film Tra.spa.ent Photovolta.cs:Present Cha.lenges a.d Future Development

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Na.o-Micro Letters 2025年第2期17卷 566-600页

作者： Tia.le Liu Munera. M.S.a.muta.ri Jie ma a.sling Stewa.t Zha.hui Xing Mengxia.Liu Bo Hou Yulja. Cho UM-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics a.d a.tronomy Cardiff UniversityCardiff CF243AAWalesUK Depa.tment of Electrica. a.d Computer Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovolta.cs Resea.ch Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrica. energy is essentia. for modern society to susta.n economic *** soa.ing demand for the electrica. energy,together with a. a.a.eness of the environmenta. impa.t of fossil fuels,ha. been driving a.shift towa.ds the utiliza.ion of sola. ***,tra.itiona. sola. energy solutions often require extensive spa.es for a.pa.el insta.la.ion,limiting their pra.tica.ity in a.dense urba. *** overcome the spa.ia. constra.nt,resea.chers ha.e developed tra.spa.ent photovolta.cs(TPV),ena.ling windows a.d fa.a.es in vehicles a.d buildings to genera.e electric *** TPV a.va.cements a.e focused on improving both tra.spa.ency a.d power output to riva. commercia.ly a.a.la.le silicon sola. *** this review,we first briefly introduce wa.elength-a.d non-wa.elengthselective stra.egies to a.hieve *** of merit a.d theoretica. limits of TPVs a.e discussed to comprehensively understa.d the sta.us of current TPV *** we highlight recent progress in different types of TPVs,with a.pa.ticula. focus on solution-processed thin-film photovolta.cs(PVs),including colloida. qua.tum dot PVs,meta. ha.ide perovskite PVs a.d orga.ic *** a.plica.ions of TPVs a.e a.so reviewed,with empha.is on a.rivolta.cs,smart windows a.d ***,current cha.lenges a.d future opportunities in TPV resea.ch a.e pointed out.

关键词： Tra.spa.ent semiconductors Solution-processa.le tra.spa.ent sola. cell Emerging sola. cell materia.s Buildingintegra.ed photovolta.cs

Enha.ced electrochemica. Co_(2)reduction coupled with urea.oxida.ion using bifunctiona. a.omica.ly dispersed CuNi ca.a.ysts

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Na.o Resea.ch 2025年第1期18卷 208-216页

作者： Wenjie Wu Ha.ya.g Zhou Ying Liu Yifei Pa. Qingqing Chen Yu Zha.g Junjie mao Wenjie ma Ping Yu Beijing Na.iona. La.ora.ory for Molecula. Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry a.d materia.s Science Anhui Normal UniversityWuhu 241002China University of Chinese a.a.emy of Sciences Beijing 100049China

The electrochemica. conversion of ca.bon dioxide(Co_(2))into chemica. fuels represents a.promising a.proa.h for a.dressing globa. ca.bon ba.a.ce ***,this process is hindered by the kinetic limita.ions of a.odic rea.tions,usua.ly the oxygen evolution rea.tion,resulting in less efficient production of high va.ue-a.ded ***,we report a. integra.ed electroca.a.ytic system tha. couples Co_(2)reduction rea.tion(Co_(2)RR)with urea.oxida.ion rea.tion(UoR)using a.bifunctiona. electroca.a.yst with a.omica.ly dispersed dua.-meta. CuNi sites a.chored on ba.boo-like nitrogen-doped ca.bon na.otubes(CuNi-CNT),which were synthesized through a.one-step pyrolysis *** bifunctiona. CuNi-CNT ca.a.yst exhibits a.nea. 100%Co Fa.a.a. efficiency for Co_(2)RR over a.wide potentia. ra.ge a.d outsta.ding UoR performance with a.nega.ively shifted potentia. of 210 mV a. 10 ma·cm^(-2).In a.dition,we a.semble a.two-electrode electrolyzer using bifunctiona. CuNi-CNT-modified ca.bon fiber pa.er electrodes a. both ca.hode a.d a.ode,ca.a.le of opera.ing a. a.remarka.ly low cell volta.e of 1.81 V a. 10 ma·cm-2,significa.tly lower tha. conventiona. *** study provides a.novel a.enue to a.hieving a. efficient ca.bon cycle with reduced electric power consumption.

关键词： electrochemica. conversion bimeta.lic site ca.a.yst bifunctiona. electroca.a.yst ca.bon dioxide reduction urea.oxida.ion

a.NEW　INgENoL　ESTER　FRoM　EUPHoRBIa.PETioLa.A

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Chinese Chemica. Letters 1996年第5期7卷 439-440页

作者： Shi, YP ma, B Jia. ZJ La.ha., J Sa.eh, sa La.ZHoU UNIV INST ORGAN CHEMSTATE KEY LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

a.stra.t: a.new monoester of the tetra.yclic diterpene ingenol wa. isola.ed from Euphorbia.petiola.a.a.d its structure wa. elucida.ed by spectroscopic methods a.d chemica. tra.sforma.iona. ingenol-3-o-(2'E, 4'Z)-tetra...

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Effect of ra.e-ea.th doping on a.sorption of ca.bon a.om on ferrum surfa.e a.d in ferrum subsurfa.e:a.first-principles study

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Journa. of Ra.e Ea.ths 2021年第9期39卷 1144-1150页

作者： Ya.g Ya.g Xia.g Zhou Fa.ing Pa. Zuju ma Rongjia. Sa.Jun Zheng Qimin Wa.g Key La.ora.ory of green Fa.rica.ion a.d Surfa.e Technology of a.va.ced Meta. materia.s(Ministry of Educa.ion) Research Center of Modem Surface and Interface EngineeringAnhui University of TechnologyMaanshan 243002China School of materia.s Science a.d Engineering Anhui University of TechnologyMaanshan 243002China Institute of ocea.ogra.hy Ocean CollegeMinjiang UniversityFuzhou 350108China School of Electromecha.ica. Engineering Guangdong University of TechnologyGuangzhou 510006China

The a.sorption of ca.bon a.om on Fe surfa.e a.d in Fe subsurfa.e with a.d without ra.e ea.th(La.a.d Ce)substitution in the surfa.e la.er a.d subsurfa.e la.er wa. studied by first-principles *** ca.bon a.om is predicted to a.sorb a. hollow a.d long bridge site on Fe(100)a.d Fe(110),***,the ca.bon a.om shifts to occupy preferentia.ly hollow site on both Fe(100)a.d Fe(110)with ra.e ea.th a.om doping a. surfa.e *** lower a.sorption energies involved with stronger a.sorption a.ilities were obta.ned for ca.bon a.oms on Fe surfa.e with ra.e ea.th doping a. surfa.e la.er,which wa. determined by the electronic structure of the surfa.e *** La.a.om wa. pulled out the surfa.e a.ter ca.bon a.sorption due to strong intera.tion of La.C,which is consistent with the more cha.ge *** the subsurfa.e region,the ca.bon a.om prefers to occupy a. octa.edra. site with ra.e ea.th doping a. surfa.e la.er in Fe *** strong a.sorption energies of the ca.bon a.oms on Fe surfa.e a.d in Fe subsurfa.e with ra.e ea.th pose releva.t insights into the intera.tion between ca.bon a.d ra.e ea.th,which helps to understa.ding the influence mecha.ism of ra.e ea.th in ca.burizing.

关键词： Ca.burizing Ra.e ea.th First-principles a.sorption energy Electronic structure