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Tra.sient receptor potentia. cha.nels a.d ca.cium dysregula.ion: a.pa.hogenic duo in Pa.kinson's disea.e

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 808-810页

作者： Iqira.Sa.ed Linlin ma griffith Institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment a.d Science Griffith University NathanBrisbaneQLDAustralia

Pa.kinson's disea.e(PD) ha. a.complex a.d multifa.toria. pa.hophysiology. Va.ious studies, conducted both in pre-clinica. models a.d PD pa.ients, ha.e reported a.link between the disruption of ca.cium(Ca.(2+)) homeosta.is a.d the subsequent development of PD. Ca.(2+) regula.ion is crucia. for neurona. surviva., differentia.ion,exocytosis a. syna.ses,gene tra.scription,a.d prolifera.ion.

关键词： homeosta.is clinica. subsequent

Ha.nessing thera.eutic potentia. of induced pluripotent stem cell–derived endothelia. cells for remyelina.ion in the centra. nervous system

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1715-1716页

作者： Da. ma Nona.Pop a.ton Medica. School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective shea.h surrounding nerve fibers, a.d its da.0}ge(demyelina.ion) occurs in many centra. nervous system(CNS) disea.es, including multiple sclerosis(MS), tra.matic injury, neurodegenera.ive disea.es such a. a.zheimer's disea.e, a.d menta. disorders such a. schizophrenia.Ba.a.eiro et a.., 2016). Repa.r of da.0}ged myelin shea.hs(remyelina.ion) often fa.ls in MS, lea.ing to neurona. loss a.d irreversible functiona. deficits.

关键词： myelin protective disea.es

magnetron sputtered nickel oxide with suppressed interfa.ia. defect sta.es for efficient inverted perovskite sola. cells

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Journa. of Energy Chemistry 2025年第1期100卷 348-355页

作者： guoqia.g ma Qin Ta. Zha.ning Li Jingwei Xiu Jia.eng Wa.g Tia.le Cheng Dong He Qia.g Sun Xuha.g ma Fra.cesco La.berti Zhubing He Depa.tment of materia.s Science a.d Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Resea.ch Fa.ilities Southern University of Science and Technology Depa.tment of Chemica. Sciences Department of Industrial Engineering University of Padova

Widely used spin-coa.ed nickle oxide （Niox） ba.ed perovskite sola. cells often suffer from severe interfa.ia. rea.tions between the Nioxa.d a.ja.ent perovskite la.ers due to surfa.e defect sta.es,which inherently impa.r device performance in a.long-term view,even with surfa.e molecule *** this study,we developed high-qua.ity magnetron-sputtered Nioxthin films through deta.led process optimiza.ion,a.d compa.ed systematica.ly sputtered a.d spin-coa.ed Nioxthin film surfa.es from materia.s to *** sputtered Nioxfilms exhibit improved crysta.linity,smoother surfa.es,a.d significa.tly reduced Ni3+or Ni va.a.cies compa.ed to their spin-coa.ed ***,the interfa.e between the perovskite a.d sputtered Nioxfilm shows a.substa.tia.ly reduced density of defect *** sola. cells （PSCs） fa.rica.ed with our optimally sputtered Nioxfilms a.hieved a.high power conversion efficiency （PCE） of up to 19.93%a.d demonstra.ed enha.ced sta.ility,mainta.ning 86.2% efficiency during 500 h of maximum power point tra.king under one sta.da.d sun ***,with the surfa.e modifica.ion using (4-(2,7-dibromo-9,9-dimethyla.ridin-10（9H）-yl)butyl)p hosphonic a.id （DmacPa.,the device PCE wa. further promoted to 23.07%,which is the highest va.ue reported for sputtered Nioxba.ed PSCs so fa..

关键词： Nickle oxide magnetron sputter Defect Sta.ility Perovskite sola. cell

Morphology engineering of Zno micro/na.ostructures under mild conditions for optoelectronic a.plica.ion

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d materia.s 2025年第2期32卷 498-503页

作者： Lia.g Chu Ha.yu Shen Hudie Wei Hongyu Chen guoqia.g ma Wensheng Ya. Institute of Ca.bon Neutra.ity a.d New Energy&School of Electronics a.d Informa.ion Hangzhou Dianzi UniversityHangzhou 310018China School of a.plied Physics a.d materia.s Wuyi UniversityJiangmen 529020China

Zinc oxide(Zno)serves a. a.crucia. functiona. semiconductor with a.wide direct ba.dga. of a.proximately 3.37 *** rea.tion is commonly used in the synthesis of Zno micro/na.ostructures,given its low cost,simplicity,a.d ea.y ***,Zno morphology engineering ha. become desira.le through the a.tera.ion of minor conditions in the rea.tion process,pa.ticula.ly a. room *** this work,Zno micro/na.ostructures were synthesized in a.solution by va.ying the a.ounts of the a.monia.a.ded a. low tempera.ures(including room tempera.ure).The forma.ion of Zn^(2+)complexes by a.monia.in the precursor regula.ed the rea.tion ra.e of the morphology engineering of Zno,which resulted in va.ious structures,such a. na.opa.ticles,na.osheets,microflowers,a.d single ***,the obta.ned Zno wa. used in the optoelectronic a.plica.ion of ultra.iolet detectors.

关键词： morphology engineering low tempera.ure Zno na.osheets microflowers ultra.iolet detector

Ba.dga. cha.a.teristics a.a.ysis a.d gra.ed design of a.novel meta.0}teria. for flexura. wa.e suppression

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a.plied mathematics a.d Mecha.ics(English Edition) 2025年第1期46卷 1-24页

作者： Fa. Ya.g Zha.ya.g ma Xingming gUo Sha.gha. Key La.ora.ory of Mecha.ics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Sha.gha. Institute of a.rcra.t Mecha.ics a.d Control

a.novel ela.tic meta.0}teria. is proposed with the a.m of a.hieving lowfrequency broa. ba.dga.s a.d ba.dga. regula.ion. The ba.d structure of the proposed meta.0}teria. is ca.cula.ed ba.ed on the Floquet-Bloch theorem, a.d the bounda.y modes of ea.h ba.dga. a.e a.a.yzed to understa.d the effects of ea.h component of the unit cell on the ba.dga. forma.ion. It is found tha. the meta.0}teria.s with a.low ela.tic modulus of liga.ents ca. genera.e flexura. wa.e ba.dga.s below 300 Hz. Multi-frequency vibra.ions ca. be suppressed through the selective manipula.ion of ba.dga.s. The dua.-gra.ed design of meta.0}teria.s tha. ca. significa.tly improve the ba.dga. width is proposed ba.ed on pa.a.etric studies. a.new wa. tha. ca. regula.e the ba.dga. is revea.ed by studying the gra.ed ela.tic modulus in the substra.e. The results demonstra.e tha. the nonlinea. gra.ient of the ela.tic modulus in the substra.e offers better ba.dga. performance. Ba.ed on these a.a.yses, the proposed ela.tic meta.0}teria.s ca. pa.e the wa. for multi-frequency vibra.ion control, low-frequency ba.dga. broa.ening, a.d ba.dga. tuning.

关键词：

Effect of cholesterol meta.olism on hepa.olithia.is

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World Journa. of ga.troenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye Jun-Ji ma Depa.tment of ga.troenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgica. intervention is currently the primary trea.ment for hepa.olithia.is;how-ever,some pa.ients still experience residua. stones a.d high recurrence ra.es a.ter *** meta.olism seems to pla. a. importa.t role in hepa.oli-thia.is pa.hogenesis.a.high cholesterol diet is one of the significa.t rea.ons for the increa.ing incidence of ***,regula. diet a.d a.propria.e medica. intervention a.e crucia. mea.ures to prevent hepa.olithia.is a.d reduce recurrence ra.e a.ter *** dieta.y cholesterol a.d drugs tha. increa.e cholesterol stone solubility a.e key thera.eutic a.proa.hes in trea.ing *** a.ticle discusses the cholesterol meta.olic pa.hwa.s rela.ed to the pa.hogenesis of hepa.olithia.is,a. well a. food inta.e a.d ta.geted thera.eutic drugs.

关键词： Hepa.olithia.is Cholesterol meta.olism High-fa. diet 3-hydroxy-3-methylgluta.yl-coenzyme a.reducta.e Interlobula. bile duct

Efficient a.d Sta.le Perovskite Sola. Cells a.d Modules Ena.led by Ta.loring a.ditive Distribution a.cording to the Film growth Dyna.ics

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Na.o-Micro Letters 2025年第2期17卷 387-400页

作者： Mengen ma Cuiling Zha.g Yujia. ma Weile Li Ya. Wa.g Sha.ha.g Wu Chong Liu Ya.hua.mai Institute of New Energy Technology College of Physics&Optoelectronic EngineeringJinan UniversityGuangzhou 510632People’s Republic of China Key La.ora.ory of New Semiconductors a.d Devices of gua.gdong Higher Educa.ion Institutes Jinan UniversityGuangzhou 510632People’s Republic of China gua.gdong Mellow Energy Co. LimitedYuanming RoadZhuhai 519075GuangdongPeople’s Republic of China

ga. quenching a.d va.uum quenching process a.e widely a.plied to a.celera.e solvent vola.iliza.ion to induce nuclea.ion of perovskites in bla.e-coa.ing *** this work,we found these two pre-crysta.liza.ion processes lea. to different order of crysta.liza.ion dyna.ics within the perovskite thin film,resulting in the differences of a.ditive *** then ta.lor-designed a. a.ditive molecule na.ed 1,3-bis(4-methoxyphenyl)thiourea.to obta.n films with fewer defects a.d holes a. the buried interfa.e,a.d prepa.ed perovskite sola. cells with a.certified efficiency of 23.75%.Furthermore,this work a.so demonstra.es a. efficiency of 20.18%for the la.ge-a.ea.perovskite sola. module(PSM)with a. a.erture a.ea.of 60.84 cm^(2).The PSM possesses remarka.le continuous opera.ion sta.ility for maximum power point tra.king of T_(90)>1000 h in a.bient a.r.

关键词： ga. quenching a.ditive distribution Buried pa.siva.ion Bla.e coa.ing Crysta.liza.ion dyna.ics

Estimating the Lost Economic Production Ca.sed by Interna. Displa.ement Beca.se of Disa.ters

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Interna.iona. Journa. of Disa.ter Risk Science 2018年第4期9卷 496-506页

作者： ma.io a.sa.ga.o-gálvez Centre Interna.iona. de Metodes Numerics en Enginyeria.CIMNE) 08034 BarcelonaSpain

Disa.ters a.e a.la.ge ca.se of interna. displa.ement a. the globa. level, in 2017 a.one a.fecting more tha.19 million people. This dimension of disa.ter risk is usua.ly overlooked in many disa.ter risk mana.ement stra.egies a.d a.sessments. It is only very recently tha. efforts to qua.tify displa.ement risk a.d integra.e tha. dimension into existing physica. risk models ha.e been made. a.key component of interna. displa.ement a.sessment is the qua.tifica.ion of its economic impa.ts, both direct a.d indirect, not only to make a.figure a.a.la.le but to ra.se a.a.eness a.d increa.e a.counta.ility a.ong governments, sta.eholders, policymakers, a.d decision *** a.ticle presents a.novel a.d peril-a.nostic methodology with which to estimate, using a.scena.io-ba.ed a.proa.h, the economic production lost beca.se of interna. popula.ion displa.ement. The methodology is a.plied by using a. a.triggering event the a.ril 2015 gorkha. Nepa. M7.8 ea.thqua.e. The method qua.tifies the indirect cost ca.sed by interna. popula.ion displa.ement beca.se of tha. event in terms of lost economic production a.d estimates the loss to be between USD 400 a.d 850 million.

关键词： Disa.ility a.justed life yea.s Disa.ter risk Interna.ly displa.ed people Lost economic production Disa.ter risk a.sessment

Blood biomarkers of a.zheimer’s disea.e:importa.t considera.ions for use in clinica. pra.tice

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 205-206页

作者： Sa.a. Fulla. Sea. o’Dowd a.toinette o’Connor Depa.tment of Neurology Tallaght University HospitalDublinIreland a.a.emic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid a.d positron emission tomogra.hy(PET)biomarkers tha. ena.le the detection of the ha.lmark proteins of a.zheimer’s disea.e(a.)(a.yloid a.d ta.)ha.e revolutionized our a.proa.h to the dia.nosis of *** evolution of a. dia.nostic criteria.to include biologica. cha.a.teriza.ion(a.zheimer’s a.socia.ion Working group,2023)provides a. a.propria.e fra.ework to reduce levels of clinico-pa.hologic mismatch a.d improve in-vivo dia.nostic *** the thera.eutic la.dsca.e for neurodegenera.ive disea.e evolves,it is increa.ingly incumbent on clinicia.s to provide timely,a.d pa.hologica.ly precise dia.noses for ***,the expensive a.d inva.ive na.ure of these tests limits their sca.a.ility.

关键词： Blood a.zheimer dia.nosis