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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

Journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： maría Rodriguez-Ayllon Patricio Solis-urra Cristina Arroyo-ávila Miriam álvarez-Ortega Pablo Molina-García Cristina Molina-Hidalgo manuel Gómez-Río Belinda Brown Kirk I.Erickson Irene Esteban-cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and Rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition Research Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of PubMed,Web of Science,PsycINFO,Cochrane Central Register of Controlled Trials,and SPORTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and *** physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment Dementia Exercise PET

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A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Javier Buezo ma.ina.urra.a.fonso cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel marino Victor martinez-Merino Jose F.Moran Institute for Multidisciplinary Research in Applied Biology(ImaB) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced materials and mathematics(inamaT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

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The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children:The ActiveBrains project

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Journal of Sport and Health Science 2023年第2期12卷 175-185页

作者： maría Rodriguez-Ayllon Abel Plaza-Florido Andrea Mendez-Gutierrez Signe Altmäe Patricio Solis-urra Concepción M.Aguilera Andrés Catena Francisco B.Ortega Irene Esteban-cornejo PROFITH“PROmoting FITness and Health through physical activity”research group Sport and Health University Research Institute(iMUDS)Department of Physical and Sports EducationFaculty of Sport SciencesUniversity of GranadaGranada 18071Spain Department of Epidemiology Erasmus University Medical CenterRotterdam 3015 GDthe Netherlands Department of Biochemistry and Molecular Biology Ⅱ School of PharmacyUniversity of GranadaGranada 18071Spain Department of Biochemistry and Molecular Biology Faculty of SciencesUniversity of GranadaGranada 18071Spain Nuclear Medicine Services Virgen de Las Nieves University HospitalGranada 18014Spain Faculty of Education and Social Sciences Universidad Andres BelloViña del Mar 2531015Chile Department of Experimental Psychology School of PsychologyUniversity of GranadaGranada 18011Spain Faculty of Sport and Health Sciences University of JyväskyläJyväskylä40014Finland Department of Bioscience and Nutrition Karolinska InstitutetHuddingeSE 14157Sweden

Background:Emerging research supports the idea that exercise positively affects ***,the mechanisms linking exercise with brain health are largely *** aimed to investigate the effect of exercise on(a)blood biomarkers selected based on previous evidence(brainderived neurotrophic factor,β-hydroxybutyrate(BHB),cathepsin B(CTSB),kynurenine,fibroblast growth factor 21(FGF21),soluble vascular cell adhesion molecule-1(sVCAM-1));and(b)a panel of 92 neurology-related proteins(discovery analysis).We also investigated whether changes in these biomarkers mediate the effects of exercise on brain health(hippocampal structure and function,cognitive performance,and mental health).Methods:We randomized 81 overweight/obese children(10.1±1.1 years,41%girls)into 2 groups:either 20 weeks of aerobic plus resistance exercise or *** biomarkers were assessed using enzyme-linked immunosorbent assay(ELISA)for kynurenine,FGF21,and CTSB;colorimetry forβ-hydroxybutyrate;and Xmap for brain-derived neurotrophic factor and soluble vascular cell adhesion ***92 neurology-related proteins were analyzed by an antibody-based proteomic ***:Our intervention had no significant effect on candidate biomarkers(all p>0.05).In the discovery analysis,a reduction in circulating macrophage scavenger receptor type-I was observed(standardized differences between groups=-0.3,p=0.001).This effect was validated using ELISA methods(standardized difference=-0.3,p=0.01).None of the biomarkers mediated the effects of exercise on brain ***:Our study does not support a chronic effect of exercise on candidate *** observed that while chronic exercise reduced the levels of macrophage scavenger receptor type-Ⅰ,it did not mediate the effects of exercise on brain *** studies should explore the implications of this novel biomarker for overall health.

关键词： Brain development Childhood MRI Physical activity Proteomic

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Bayesian optimization for active flow control

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Acta Mechanica Sinica 2021年第12期37卷 1786-1798页

作者： Antoine B.Blanchard Guy Y.cornejo maceda Dewei Fan Yiqing Li Yu Zhou Bernd R.Noack Themistoklis P.Sapsis Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Universit′e Paris-Saclay CNRSLaboratoire Interdisciplinaire des Sciences du Num′erique91400 OrsayFrance Center for Turbulence Control Harbin Institute of TechnologyShenzhen 518058China School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen 518058China

A key question in flow control is that of the design of optimal controllers when the control space is high-dimensional and the experimental or computational budget is *** address this formidable challenge using a particular flavor of machine learning and present the first application of Bayesian optimization to the design of open-loop controllers for fluid *** consider a range of acquisition functions,including the recently introduced output-informed criteria of Blanchard and Sapsis(2021),and evaluate performance of the Bayesian algorithm in two iconic configurations for active flow control:computationally,with drag reduction in the fluidic pinball;and experimentally,with mixing enhancement in a turbulent *** these flows,we find that Bayesian optimization identifies optimal controllers at a fraction of the cost of other optimization strategies considered in previous *** optimization also provides,as a by-product of the optimization,a surrogate model for the latent cost function,which can be leveraged to paint a complete picture of the control *** proposed methodology can be used to design open-loop controllers for virtually any complex flow and,therefore,has significant implications for active flow control at an industrial scale.

关键词： Bayesian optimization Flow control Drag reduction Turbulence

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Tumor invasion front in oral squamous cell carcinoma

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World Journal of Clinical Cases 2022年第28期10卷 10387-10390页

作者： Juan Carlos Cuevas-González maria Veronica Cuevas-González Leon Francisco Espinosa-Cristobal Alejandro Donohue cornejo Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32320ChihuahuaMexico Faculty of Health Sciences Valle de las Palmas Universidad Autonoma de Baja CaliforniaTijuana 21480Baja CaliforniaMexico

Oral squamous cell carcinoma is a neoplasm that originates from the epithelial *** is usually more frequent between the fifth and sixth decades of life,and more than 90% of carcinomas of the oral cavity are squamous cell *** is an invasive neoplasia with a significant recurrence rate;40% of patients present with metastases in the cervical lymph nodes at the time of *** tumor invasion front is a characteristic of tumor growth,which can be infiltrative or *** histopathological parameters examined include the number of mitoses,depth of the tumor,invasion pattern,degree of keratinization,and nuclear *** the pathologist,these parameters are routinely evaluated but are not reported to the treating physician in all cases,which we consider to be useful information when determining the therapeutic route.

关键词： Oral squamous cell carcinoma Invasive neoplasia Therapeutic route Life Tumor growth Pleomorphism

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Detection of dengue virus serotype 3 in Cajamarca,Peru:Molecular diagnosis and clinical characteristics

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 456-462页

作者： Miguel Angel Aguilar-Luis Hugo Carrillo-Ng Sungmin Kym Wilmer Silva-Caso Eduardo Verne Luis J.del Valle Jorge Bazán-mayra Victor Zavaleta-Gavidia Daniel cornejo-Pacherres Yordi Tarazona-Castro Ronald Aquino-Ortega Angela cornejo-Tapia Juana del Valle-Mendoza School of Medicine Research and Innovation Center of the Faculty of Health SciencesUniversidad Peruana de Ciencias AplicadasLimaPeru Laboratorio de Biologia Molecular Instituto de Investigación NutricionalLimaPeru Facultad de Medicina Alberto Hurtado Universidad Peruana Cayetano HerediaLimaPeru Division of Infectious Diseases Department of Internal MedicineChungnam National University School of MedicineDaejeonRepublic of Korea Barcelona Research Center for Multiscale Science and Engineering Departament d'Enginyeria QuímicaEEBEUniversitat Politècnica de Catalunya(UPC)BarcelonaSpain Laboratorio Regional de Cajamarca Dirección Regional de Salud de Cajamarca(DIRESA)CajamarcaPeru

Objective:To describe and molecularly characterize an outbreak of dengue virus(DENV)infection in Cajamarca,an Andean region in ***:A total of 359 serum samples from patients with acute febrile illness were assessed for the presence of DENV via RT-PCR,ELISA NS1,Ig M and Ig G in Cajamarca,Peru from January 2017 to June *** evaluation of the different diagnostic tests and their applicability was ***:Dengue virus was detected in 24.7%of samples by ***,serological analysis detected 30.3%positive cases via ELISA NS1 antigen,16.7%via ELISA Ig G and 9.7%via ELISA Ig *** of the cases corresponded to DENV-3(77.5%).The use of RT-PCR performed better in primary infections(Pination of NS1 and Ig M performed better than the other assays in detecting primary(92.5%)and secondary infections(96.6%).The most frequent symptoms associated with fever were headaches,myalgias,and arthralgias across all ***:We report an important outbreak of dengue infection caused by DENV-3 in Cajamarca,*** findings encourage the use of NS1 antigen and Ig M *** findings demonstrate an increasing expansion of DENV-3 in Peru and highlight the importance of molecular diagnosis and serotype characterization among the clinically defined dengue cases to strengthen the Peruvian epidemiological surveillance.

关键词： Dengue DENV Arbovirus Diagnosis Peru

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T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets

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World Journal of Gastroenterology 2014年第46期20卷 17416-17425页

作者： Luis A Videla Virginia Fernández Pamela cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileIndependencia 1027SantiagoChile School of Medical Technology Faculty of MedicineDiego Portales UniversityEjército 141SantiagoChile

AIM: To investigate the redox dependency and promotion of downstream targets in thyroid hormone (T3)-induced AMP-activated protein kinase (AMPK) signaling as cellular energy sensor to limit metabolic stresses in the l... 详细信息

关键词： Liver Thyroid hormone N-acetylcysteine AMP-activated protein kinase Fatty acid oxidation

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Journal of Sport and Health Science 2021年第4期10卷 447-453页

作者： Kate Parker Anna Timperio Jo Salmon Karen Villanueva Helen Brown Irene Esteban-cornejo Veronica Cabanas-Sánchez José Castro-Pinero David Sánchez-Oliva OscarL.Veiga School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition(IPAN)Deakin UniversityGeelongVIC 3220Australia Centre for Urban Research School of Global Urban and Social StudiesRMIT UniversityMelbourneVIC 3000Australia Center for Cognitive and Brain Health Department of PsychologyNortheastern UniversityBostonMA 02115USA PROmoting FITness and Health through physical activity(PROFITH)research group Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18010Spain Department of Physical Education Sports and Human MovementAutonomous University of MadridMadrid 28049Spain Research Centre in Physical Activity Health and Leisure(CIAFEL)Faculty of SportUniversity of PortoPorto 4099-002Portugal Department of Physical Education Faculty of Education SciencesUniversity of CadizPuerto Real 11003Spain Biomedical Research and Innovation Institute of Cadiz(INiBICA) Cadiz 11003Spain

Background:Children and adolescents can be distinguished by different typologies(clusters) of physical activity and sedentary *** physical activity and sedentary behaviors change over time within different typologies is not *** study examined longitudinal changes in physical activity and sedentary time among children and adolescents with different baseline typologies of activity-related ***:In this longitudinal study(3 annual time points) of children(n=600,age=9.2±0.4 years(mean±SD),50.3% girls) and adolescents(n=1037,age=13.6±1.7 years,48.4% girls),participants were recruited in Spain in *** class analyses identified typologies based on self-reported screen,educational,social and relaxing sedentary behaviors,active travel,muscle strengthening activity,and sport at *** each typology,linear mixed growth models explored longitudinal changes in accelerometer-derived moderate-to-vigorous physical activity and sedentary time,as well as time by class ***:Three typologies were identified among children( "social screenies",12.8%;"exercisers",61.5%;and "non-sporty active commuters",25.7%) and among adolescents "active screenies",43.5%;"active academics",35.0%;and "non-sporty active commuters",21.5%) at *** time increased within each typology among children and adolescents,with no significant differences between *** changes in physical activity were found in any typology among *** adolescents,physical activity declined within all typologies,with "non-sporty active commuters" declining significantly more than "active screenies" over 3 ***:These results support the need for interveation to promote physical activity and prevent increases in sedentary time during childhood and *** characterized as "non-sporty active commuters" may require specific interventions to maintain their physical activity over time.

关键词： Behavior change Physical activity Sedentary behavior Typologies Youth

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Clinicopathological and oncological significance of persistent prostate-specific antigen after radical prostatectomy:A systematic review and meta-analysis

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Asian Journal of Urology 2023年第3期10卷 317-328页

作者： Shulin Wu Sharron X.Lin Kristine M.cornejo Rory K.Crotty Michael L.Blute Douglas M.Dahl Chin-Lee Wu Department of Urology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Pathology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Objective:To investigate the association of persistently elevated prostate-specific antigen(PSA)after radical prostatectomy(RP)with clinicopathological features and long-term oncological prognosis for the development of a potential management ***:A systematic literature search was performed using PubMed and Web of Science up to June 2021 to identify the eligible studies focusing on understanding the impact of persistent PSA in patients who underwent RP for localized prostate ***-analyses were performed on parameters with available ***:A total of 32 RP studies were identified,of which 11 included 26719 patients with consecutive cohorts and the remaining 21 comprised 24177 patients with cohorts carrying specific *** the 11 studies with consecutive cohorts,the incidence of persistent PSA varied between 3.1%and 34.6%with a median of 11.0%.Meta-analyses revealed patients with persistent PSA consistently showed unfavorable clinicopathological features and a more than 3.5-fold risk of poorer biochemical recurrence,metastasis,and prostate cancer-specific mortality prognosis independently,when compared to patients with undetectable ***,cases with persistent PSA in different specific patient cohorts with a higher risk of prostate cancer also showed a trend of worse ***:We found that the frequency of persistent PSA was about 11.0%in consecutive RP *** PSA was significantly associated with unfavorable clinicopathological characteristics and worse oncological *** with persistent PSA after RP may benefit from early salvage treatment to delay or prevent biochemical recurrence,improving oncological outcomes for these *** prospective randomized controlled trials are warranted to understand optimal systemic therapy in these patients.

关键词： Prostate cancer Radical prostatectomy Persistent prostatespecific antigen Prognosis Salvage Systematic review Meta-analysis

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Balanced Scorecard and Efficiency: Design and Empirical Validation of a Strategic map in the University by Means of DEA

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American Journal of Operations Research 2013年第1期3卷 30-52页

作者： Teresa García Valderrama Vanesa Rodríguez cornejo Daniel Revuelta Bordoy Departmentof Finance and Accounting University of Cádiz Cádiz Spain

The principal objective of the research reported in this article is to validate a Balanced Scorecard (BSC) model and a Strategic map for the University by studying the relationships of efficiency between its dimensions. Subsequently, the validation is completed by establishing hypotheses of efficiency relationships between the perspectives proposed, employing Data Envelopment Analysis (DEA). Empirical evidence has been obtained on the validity of the proposed BSC for a unit of academic management in the university. The first contribution of this work is the establishment of a framework of analysis of the hypothetical cause-effect relationships in the BSC in university institutions. The second contribution is to obtain the determining factors of the performance in this type of institution and, therefore, the Strategic map. Specifically, these factors are: the participation of teaching staff in innovation activities;the number of doctorate-level staff;the academic subjects and credits in the Virtual Campus;and the scores in the surveys of student satisfaction. With respect to research, the determining factors of the performance are: the research sexennials;the funding obtained from contracts with companies;the number of research projects obtained;their financing;and the participation of teachers in these projects.

关键词： Balanced Scorecard Efficiency Data Envelopment Analysis University

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