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Particuology 2011年第6期9卷 589-597页

作者： chao Y. ma Xue z. Wang Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Leeds LS2 9JT UK

Near infrared spectroscopy （NIR） is now probably the most popular process analytical technology （PAT） for pharmaceutical and some other industries. However, unlike mid-IR, NIR is known to have difficulties in monitoring crystallization or precipitation processes because the existence of solids could cause distortion of the spectra. This phenomenon, seen as unfavorable previously, is however an indication that NIR spectra contain rich information about both solids and liquids, giving the possibility of using the same instrument for multiple property characterization. In this study, transflectance NIR calibration data was obtained using solutions and slurries of varied solution concentration, particle size, solid concentration and temperature. The data was used to build calibration models for prediction of the multiple properties of both phases. Predictive models were developed for this challenging application using an approach that combines genetic algorithm （ga） and support vector machine （SVM）. ga is used for wavelength selection and SVM for mode building. The new ga-SVM approach is shown to outperform other methods including ga-PLS （partial least squares） and traditional SVM. NIR is thus successfully applied to monitoring seeded and unseeded cooling crystallization processes of L-glutamic acid.

关键词： Process analytical technology Near infrared spectroscopy Support vector machine Genetic algorithm Wavelength selection cooling crystallization

The high level language for system specification: A model-driven approach to systems engineering

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International Journal of Modeling, Simulation, and Scientific computing 2016年第1期7卷 180-214页

作者： Hamzat olanrewaju Aliyu oumar maıga mamadou Kaba Traore School of Information and communication Technology Federal University of Technology Minna Gidan-Kwanu campus MinnaNigeria Universit´e des Sciences des Techniques et des Technologies BamakoMali LIMoS cNRS UMR 6158 Universite Blaise Pascal Clermont-FerrandFrance

We present HiLLS(High Level Language for System Specification),a graphical formalism that allows to specify Discrete Event System(DES)models for analysis using methodologies like simulation,formal methods and ***’syntax is built from the integration of concepts from System Theory and Software Engineering aided by simple concrete notations to describe the structural and behavioral aspects of *** paper provides the syntax of HiLLS and its simulation semantics which is based on the Discrete Event System Specification(DEVS)*** DEVS-based Modeling and Simulation(M&S)perspective,HiLLS is a platform-independent visual language with generic expressions that can serve as a front-end for most existing DEVS-based simulation environments with the aid of Model-Driven Engineering(MDE)*** also suggests ways to fill some gaps in existing DEVS-based visual formalisms that inhibit complete specification of the behavior of complex *** provide a case study to illustrate the core features of the language.

关键词： HiLLS modeling and simulation integrated formalism DEVS object-z

Predicting factors for the need of extracorporeal membrane oxygenation for suicide attempts by cardiac medication:a single-center cohort study

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World Journal of Emergency Medicine 2022年第4期13卷 283-289页

作者： David Vandroux Thomas Aujoulat Bernard-Alex gaüzère Bérénice Puech Bertrand Guihard olivier martinet Intensive care Unit Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance cardiosurgical Intensive care Unit Dupuytren II HospitalUniversity Teaching Hospital of Limoges87042 LimogesFrance UMR 1094 Neuro-épidémiologie Tropicale University of Limoges87042 LimogesFrance cardiovascular Anesthesia Department Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance Service d’Aide Médicale d’Urgence Félix Guyon HospitalUniversity Teaching Hospital of La Réunion97400 Saint DenisReunion IslandFrance

BAcKGRoUND:Severe poisoning due to the overdosing of cardiac drugs can lead to cardiovascular *** order to decrease the mortality rate,the most severe patients should be transferred as quickly as possible to an extracorporeal membrane oxygenation(EcMo)***,the predictive factors showing the need for venous-arterial EcMo(VA-EcMo)had never been ***:A retrospective,descriptive,and single-center cohort *** consecutive patients admitted in the largest IcU of Reunion Island(Indian ocean)between January 2013 and September 2018 for beta-blockers(BB),calcium channel blockers(ccB),renin-angiotensin-aldosterone system blockers,digoxin or anti-arrythmic intentional poisonings were *** implementation was the primary ***:A total of 49 consecutive admissions were *** patients had EcMo,39 patients did not have *** patients in EcMo group died,while no patients in the conventional group *** most relevant EcMo-associated factors were pulse pressure and heart rate at first medical contact and pulse pressure,heart rate,arterial lactate concentration,liver enzymes and left ventricular ejection fraction(LVEF)at *** pulse pressure at first medical contact and LVEF were significant after logistic ***:A transfer to an EcMo center should be considered for a pulse pressurecal contact or LVEFon admission to IcU.

关键词： Extracorporeal membrane oxygenation Implementation cardiac medication overdose Predicting factor

Long-term monitoring of the recruitment and dynamics of large wood in Kamienica Stream, Polish carpathians

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Journal of Mountain Science 2020年第6期17卷 1281-1293页

作者： Pawel MIKUS Bartlomiej WYzga Institute of Nature conservation Polish Academy of Sciencesal.Mickiewicza 3331-120 KrakowPoland

Studies presenting long-term observations of the recruitment and mobility of large wood in mountain watercourses are scarce,but they can considerably contribute to the knowledge of river/riparian forest interactions and the assessment of flood hazard resulting from wood mobility during *** dieback of riparian forest along the headwater course of Kamienica Stream in the Polish carpathians,caused by bark beetle infestation of spruce trees,has raised concerns about potential increases of large wood recruitment to the stream and of the flood hazard to downstream valley *** october 2009,429 trees growing along three sections of the stream were tagged with numbered metal plates and monitored over 10 years to determine the timing and causes of their delivery to the channel and the lengths of their displacement during individual flood ***,in 2012 the mode of location of wood deposits and a degree of wood decay were determined in the second-to fourth-order stream *** monitoring of tagged trees indicated that trees were recruited to the channel during highintensity meteorological and hydrological events,mostly as a result of bank erosion during floods or *** 22%of tagged trees recruited to the channel during 10 years,the rate of turnover of the riparian trees was estimated at 45 *** the riparian area is overgrown with trees with ages up to^160 years,the rate evidences substantial intensification of large wood recruitment to the channel in the recent *** of large wood inventory and the 10-year-long monitoring of tagged trees indicated variable mobility of large wood along the upper course of the *** mobility was negligible in the second-order stream reach,very small in the third-order reach,and greater,but still limited in the fourth-order *** is transported longer distances only during major ***,the advanced state of decay of most pieces leads to their disintegration during floods,pr

关键词： Large wood Wood dynamics Wood monitoring Wood inventory Wood recruitment Polish carpathians

Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone c-1305

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Journal of Pharmaceutical Analysis 2020年第4期10卷 376-384页

作者： Agnieszka Potega Dorota zelaszczyk zofia mazerska Department of Pharmaceutical Technology and Biochemistry Faculty of ChemistryGdansk University of TechnologyGabriela Narutowicza St.11/12Gdansk80-233Poland Department of organic chemistry Faculty of PharmacyJagiellonian UniversityMedyczna St.9Krakow30-688Poland

5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone(c-1305)is a promising antitumor compound developed in our laboratory.A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at ***,the aim of the current work was to predict oxidative pathways of c-1305 that would reflect its phase I *** multi-tool analysis of c-1305 metabolism included electrochemical conversion and in silico sites of metabolism predictions in relation to liver microsomal *** the framework of the first approach,an electrochemical cell was coupled on-line to an electrospray ionization mass *** effluent of the electrochemical cell was also injected onto a liquid chromatography column for the separation of different products formed prior to mass spectrometry *** silico studies were performed using MetaSite *** microsomal incubation was employed as a reference *** found that c-1305 underwent electrochemical oxidation primarily on the dialkylaminoalkylamino *** unknown N-dealkylated and hydroxylated c-1305 products have been *** electrochemical system was also able to simulate oxygenation *** pattern of c-1305 metabolism has been predicted using in silico *** proposed strategies showed high agreement in relation to the generated metabolic products of ***,we conclude that they can be considered as simple alternatives to enzymatic assays,affording time and cost efficiency.

关键词： Antitumor triazoloacridinone P450-catalyzed reactions Electrochemistry/mass spectrometry In silico metabolism Prediction Liver microsomal assay

Nanomechanics of Fiber-like Nanomaterials

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Journal of materials Science & Technology 2001年第3期17卷 303-305页

作者： z.L. Wang School of materials Science and Engineering, Georgia Institute of Technology, Atlanta, ga 30332-0245, USA E-mail: zhong.wang@mse.gatech.edu Georgia Inst Technol Sch Mat Sci & Engn Atlanta GA 30332 USA

Property characterization of nanomaterials is challenged by the small size of the structure be-cause of the difficulties in manipulation Here we demonstrate a novel approach that allows a direct measurement of the mechanical properties of individual nanotube-like structures by in-situ transmission electron microscopy (TEM). The technique is powerful in a way that it can directly correlate the atomic-scale microstructure of the carbon nanotube with its physical properties, providing a one-to-one correspondence in structure-property characterization Applications of the technique will be demonstrated on mechanical properties, the electron field emission and the ballistic quantum conductance in individual nanotubes.

关键词： Nanomechanics of Fiber-like Nanomaterials

Evidence for fine-scale habitat specialisation in an invasive weed

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Journal of Plant Ecology 2018年第2期11卷 189-199页

作者： Daniel z.Atwater Rebecca A.Fletcher christopher c.Dickinson Andrew H.Paterson Jacob N.Barney Virginia Tech Department of Plant PathologyPhysiology and Weed Science435 Old Glade RoadBlacksburgVA 24061USA University of Georgia Plant Genome Mapping Laboratory111 Riverbend RoadAthensGA 30606USA

Aims As an exotic species colonises a new continent,it must overcome enormous environmental variation in its introduced *** adaptation of introduced species has frequently been observed at the continent scale,particularly in response to latitudinal climatic ***,significant environmental heterogeneity can also exist at the landscape scale.A small number of studies have provided evidence that introduced species may also be capable of phenotypic and genetic differentiation at much smaller spatial *** example,previously we found US agricultural and non-agricultural populations of Sorghum halepense(Johnsongrass)to be phenotypically and genetically *** this study,we inves-tigated whether this phenotypic differentiation of agricultural and non-agricultural populations of *** is the result of fine-scale local *** We surveyed a nationally collected *** germplasm panel and also collected neighbouring agricultural and non-agricultural sub-populations of *** at four sites throughout Western Virginia,USA,raising seedlings in common conditions mimicking both agricultural and non-agricultural *** Findings At the national scale,we found evidence of habitat differentiation but not ***,at the local scale,we found evi-dence of specialisation in two of the four local populations to non-agricultural habitat,but no evidence of specialisation to agricultural *** results show that local specialisation is a possible,but not guaranteed consequence of kilometre-scale habitat heterogen-eity in invasive *** finding contributes to a growing aware-ness of the importance of fine-scale local adaptation in the ecology and management of introduced and weedy species.

关键词： Johnsongrass local adaptation rapid evolution Sorghum halepense(L.)

Structural & magnetic characterizations of NiLizn Nanoferrites Synthesized by co-precipitation Method

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Journal of materials Science & Technology 2011年第11期27卷 991-995页

作者： D.N. Rohadiana z.A.z. Jamal S.B. Jamaludin M.F. Bari J. Adnan Sustainable Engineering Research cluster Universiti Malaysia Perlis School of Microelectronic Engineering Universiti Malaysia Perlis

Synthesis of ***（0.5-x）Fe204 nanoparticles with x=0, 0.1, 0.2, 0.3, 0.4 and 0.5 were realized via coprecipitation method. X-ray diffraction （XRD） and vibrating sample magnetometer （VSM） measurements were performed on the samples to determine the characteristics of the crystal structures and the magnetic properties of the samples, respectively. The spinel phase structures of the samples were confirmed by XRD analysis. Patterns of decreased lattice parameter and increased crystallite size values were observed by increasing the Li concentration at longer synthesis reaction periods. Similarly, for the magnetic properties, both the saturation magnetization （Ms） and coercivity （Hc） were found to vary with increasing patterns at higher Li doping levels and longer synthesis reaction periods. The results and mechanisms concerned were discussed.

关键词： Lithium nickel zinc ferrite co-precipitation crystal structure magnetic properties

Experimental and theoretical investigation of zinc diffusion in N-gaSb

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chinese Science Bulletin 2010年第23期55卷 2489-2496页

作者： YE Hong TANG LiangLiang ma YuLong Department of Thermal Science and Energy Engineering University of Science and Technology of China Hefei 230027 China

zinc diffusion process in N-gaSb was studied with excessive,appropriate and insufficient quantity of diffusion source (zinc pellets).Kink-and-tail type zinc concentration profiles obtained with appropriate zinc pellets quantity were successfully simulated using the assumption that the vacancy mechanism mediated by V0ga and kick-out mechanism mediated by I+ga take effect at the same *** is found out that for diffusion temperature from 460°c to 500°c,the zinc surface concentration of the diffused samples has nearly no change and the logarithmic value of the zinc surface diffusion coefficient is linear with the reciprocal value of diffusion temperature;when the diffusion temperature is constant,both the zinc surface concentration and diffusion coefficient do not change with diffusion time.

关键词：扩散实验锌浓度锑化镓表面扩散系数扩散温度扩散时间扩散过程配置文件

Element diffusion ability in metasomatic agents and its effect on chemical characteristics of metasomatized peridotites

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Science china Earth Sciences 2006年第9期49卷 926-937页

作者： Y S o’Reilly GEMoc ARc National Key centre Department of Earth and Planetary Sciences Macquarie University Sydney N.S.W. 2109 Australia

Detailed in situ LM-IcPMS researches on the composite xenoliths from Yingfengling volcano of Leizhou Peninsula, South china, indicate that most incompatible trace elements of clino- pyroxenes in composite xenoliths decrease spatially from pyroxenites to distal lherzolites, and com- patible elements and HREE increase steeply. The increasing and decreasing rate is distinct for dif- ferent trace elements, which give rise to element chromatographic fractionation within metasomatized lherzolites. The element chromatographic fractionation result actually from the difference in element diffusive rate in melts or fluids percolating through wall-rock lherzolites. Based on element variation profiles in composite xenoliths this study indicates that Sr, Nb, La and ce have the highest diffusive mobility, MREE-HREE are moderate, and zr, Hf, Ti, ga and Sc are very low in most cases. Higher diffusive rates of LREE than HREE would enlarge the REE fractionation of metasomatized peridotites, and lower diffusive rate of zr, Hf and Ti relative to neighbor REEs with similar incompatibility would cause the relative depletion of these elements in metasomatized peridotites. Trace elements com- monly have a higher diffusive rate in fluid-rich infiltrating melt, which will weaken element chroma- tographic fractionation during the metasomatism. The range of mantle metasomatism caused by sili- cate melt intrusion is very limited, generally within tens of centimeters wide. The width of metasoma- tized wall-rock peridotites near the pyroxenite or horblendite veins was strictly controlled by both melt volume and chemical characteristics.

关键词： composite xenolith, metasomatism, chromatographic fractionation, diffusive rate, Leizhou Peninsula.