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CCL5 as a potential immunotherapeutic target in triple-negative breast cancer

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Cellular & Molecular Immunology 2013年第4期10卷 303-310页

作者： Dandan Lv Yan Zhang ha-Jeong Kim Lixing Zhang Xiaojing ma Sheng Yushou Center of Cell Biology and Immunology School of Life Science and Biotechnology Shanghai Jiaotong University Shanghai China Department of Microbiology and Immunology Weill Cornell Medical College New York NY USA

Breast cancer （BC） is a leading cause of mortality among women in the world. To date, a number of molecules have been established as disease status indicators and therapeutic targets. The best known among them are estrogen receptor-α （ER-α）, progesterone receptor （PR） and H ER-2/neu. About 15%-20% BC patients do not respond effectively to thera pies targeting these classes of tumor-promoting factors. Thus, additional targets are strongly and urgently sought after in therapy for human BCs negative for ER, PR and HER-2, the so-called triple-negative BC （TNBC）. Recent clinical work has revealed that CC chemokine ligand 5 （CCL5） is strongly associated with the progression of BC, particularly TNBC. How CCL5 contributes to the development of TN BC is not well understood. Experimental animal studies have begun to address the mechanistic issue. In this article, we will review the clinical and laboratory work in this area that has led to our own hypothesis that targeting CCL5 in TNBCs will have favorable therapeutic outcomes with minimal adverse impact on the general physiology.

关键词： triple negative breast cancer CCL5 myeloid derived suppressor cell immunotherapy

Visible-to-near-infrared photodetector based on graphene–MoTe2–graphene heterostructure

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Chinese Physics B 2019年第11期28卷 354-359页

作者： Rui-Xue Hu Xin-Li ma Chun-ha An Jing Liu State Key Laboratory of Precision Measurement Technology and Instrument School of Precision Instruments and Opto-electronics EngineeringTianjin UniversityTianjin 300072China

Graphene and transition metal dichalcogenides(TMDs), two-dimensional materials, have been investigated wildely in recent years. As a member of the TMD family, MoTe2 possesses a suitable bandgap of ~1.0 eV for near infrared(NIR)photodetection. Here we stack the MoTe2 flake with two graphene flakes of high carrier mobility to form a graphene–MoTe2–graphene heterostructure. It exhibits high photo-response to a broad spectrum range from 500 nm to 1300 nm. The photoresponsivity is calculated to be 1.6 A/W for the 750-nm light under 2 V/0 V drain–source/gate bias, and 154 ma/W for the 1100-nm light under 0.5 V/60 V drain–source/gate bias. Besides, the polarity of the photocurrent under zero Vds can be efficiently tuned by the back gate voltage to satisfy different applications. Finally, we fabricate a vertical graphene–MoTe2–graphene heterostructure which shows improved photoresponsivity of 3.3 A/W to visible light.

关键词： two-dimensional materials van der Waals heterostructure transition metal dichalcogenides(TMDs) graphene photodetector

Papillary cystadenoma of the parotid gland: A case report

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World Journal of Clinical Cases 2019年第3期7卷 366-372页

作者： Li Wang Shi-Kun Zhang Ying ma Patrick K ha Zhi-Ming Wang Department of Oral and maxillofacial Surgery Shengjing Hospital of China Medical University Department of Pathology Shengjing Hospital of China Medical University Division of Head and Neck Oncologic and Endocrine Surgery Department of Otolaryngology-Head and Neck Surgery University of California-San Francisco

BACKGROUND Papillary cystadenoma is a rare benign epithelial tumor of the salivary gland,which is characterized by papillary structures and oncocytic cells with rich eosinophilic cytoplasm. We found only one case of papillary cystadenoma in nearly 700 cases of salivary gland tumors. Our case was initially mistaken for a tumor of the right temporomandibular joint(TMJ) capsule rather than of parotid gland origin. Preoperative magnetic resonance imaging(MRI) and computed tomography(CT) should be carefully studied, which allows for appropriate preoperative counseling and operative *** SUMmaRY Here, we report an unusual case of a 54-year-old woman with a parotid gland papillary cystadenoma(PGPC) that was misdiagnosed as a tumor of the right TMJ capsule. She was initially admitted to our hospital due to a mass anterior to her right ear inadvertently found 5 d ago. Preoperative CT and MRI revealed a well circumscribed tumor that was attached to the right TMJ capsule. The patient underwent a resection through an incision for TMJ, but evaluation of an intraoperative frozen section revealed a benign tumor of the parotid gland. Then we removed part of the parotid gland above the temporal facial trunk. The facial nerve was preserved. Postoperative histopathological findings revealed that the tumor was PGPC. No additional treatment was performed. There was no recurrence during a 20-mo follow-up *** The integrity of the interstitial space around the condyle in MRI or CT should be carefully evaluated for parotid gland or TMJ tumors.

关键词： Papillary cystadenoma Parotid gland Temporomandibular joint Case report

Non-expansive mappings and Iterative Methods in Uniformly Convex Banach Spaces

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Acta mathematica Sinica,English Series 2004年第5期20卷 829-836页

作者： ha|YunZHOU Dept.ofmath. ShijiazhuangMechanicalEngineeringCollegeShijiazhuang050003P.R.China

In this article,we will investigate the properties of iterative sequence for non-expansive mappings and present several strong and weak convergence results of successive approximations to fixed points of non-expansive mappings in uniformly convex Banach *** results presented in this article generalize and improve various ones concerned with constructive techniques for the fixed points of non-expansive mappings.

关键词： Non-expansive mapping mann and lshikawa iteration schemes Convergence theorem Uniformly convex Banach space

A novel electrolytic-manganese-residues-and-serpentine-based composite(S-EMR) for enhanced Cd(Ⅱ) and Pb(Ⅱ) adsorption in aquatic environment

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Rare Metals 2023年第1期42卷 346-358页

作者： Meng-Yu ma Xuan Ke Yan-Chang Liu Zhi-hao ha Ting Wang Jia Li Fan Zhang Tian C.Zhang College of Resources and Environmental Science South-Central Minzu UniversityWuhan430074China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan430074China College of Engineering University of Nebraska-LincolnOmahaNE68182USA

Electrolytic manganese residue(EMR) is the waste slag generated from the electrolysis manganese *** a promising exploitable adsorbent,EMR has become a hot research ***,EMR’s low adsorption capacity has limited its applications as an efficient *** this study,the EMR was mixed with serpentine and calcined(at 800℃ for 2 h) to prepare a composite adsorbent(S-EMR) with its specific surface area of 11.998 m^(2)·g^(-1)(increased compared to the original EMR) and improved adsorption capacities for Cd^(2+)(98.05 mg·g^(-1)) and Pb^(2+)(565.81 mg·g^(-1)).Kinetic studies have shown that the pseudo-first-order kinetics(PSO)model could best describe the adsorption kinetics of S-EMR for Cd^(2+)/Pb^(2+),implying that the chemisorption process is the rate-limiting *** effects of different interfering ions on S-EMR’ s adsorption for Cd^(2+)/Pb^(2+)may be due to the difference in their *** of response surface methodology tests showed that pH had the highest influence on adsorption,and the removal efficiency of S-EMR reached 99.92% for Cd(Ⅱ) and 94.00%for Pb(Ⅱ).X-ray photoelectron spectroscopy(XPS) analyses revealed that chemical precipitation was the predominant mechanism for Cd^(2+)/Pb^(2+)removal,and the adsorption mechanisms were associated with ion exchange and electrostatic *** results showed that S-EMR could be used as an effective adsorbent for the removal of Cd(Ⅱ)/Pb(Ⅱ) from water bodies,rendering dual benefits of pollution control and resource recovery.

关键词： Cadmium Lead Electrolytic manganese residue Serpentine Heavy metals

Effects of material and Dimension on TCF,Frequency,and Q of Radial Contour Mode AlN-on-Si MEMS Resonators

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Journal of Electronic Science and Technology 2021年第4期19卷 319-334页

作者： Thi Dep ha with the Faculty of Electronics Technology Industrial University of Ho Chi Minh CityHo Chi Minh City 70000

This paper investigates the effects of material and dimension parameters on the frequency splitting,frequency drift,and quality factor(Q)of aluminium nitride(AlN)-on-n-doped/pure silicon(Si)microelectromechanical systems(MEMS)disk resonators through analysis and *** parameters include the crystallographic orientation,dopant,substrate thickness,and *** resonators operate in the elliptical,higher order,and flexural *** simulation results show that i)the turnover points of the resonators exist at 55°C,-50°C,40°C,and-10°C for n-doped silicon with the doping concentration of 2×1019 cm-3 and the Si thickness of 3.5μm,and these points are shifted with the substrate thickness and mode variations;ii)compared with pure Si,the modal-frequency splitting for n-doped Si is higher and increases from 5%to 10%for all studied modes;iii)Q of the resonators depends on the temperature and ***,the turnover,modal-frequency splitting,and Q of the resonators depend on the thickness and material of the substrate and the *** work offers an analysis and design platform for high-performance MEMS gyroscopes as well as oscillators in terms of the temperature compensation by n-doped Si.

关键词： Anisotropic contour mode doping gyroscope microelectromechanical systems(MEMS)resonator piezoelectric temperature coefficient of frequency(TCF) temperature compensation thin-film piezoelectric-on-substrate(TPoS)

Current state-of-the-art review of footwear–ground friction

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Friction 2024年第10期12卷 2188-2204页

作者： David REBENDA Tomáš SÁha Footwear Research Centre University InstituteTomas Bata University in ZlinZlin 76001Czech Republic Faculty of Mechanical Engineering Brno University of TechnologyBron 61600Czech Republic

The most important role of footwear is to ensure safe,functional walking,and foot *** the proper functionality of not only the work shoes,the anti-slip behavior of the shoe under various conditions and environments plays an important role in the prevention of slips,trips,falls,and consequent *** article is intended to review the current understanding of the frictional mechanisms between shoe outsoles and various counterfaces that impact the evaluation of outsole *** research focuses on the mechanisms driving outsole friction on different ground surfaces or the definition and description of parameters that influence outsole ***,the review discusses the effect of various surface contaminants on footwear ***,challenges and outlooks in the field of footwear outsoles are briefly mentioned.

关键词： shoe outsole composite slipperiness coefficient of friction(COF) adhesion safe walk

Effects of Mirazid~ and myrrh volatile oil on adult Fasciola gigantica under laboratory conditions

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 875-884页

作者： AM massoud ha Shalaby RM El Khateeb MS mahmoud ma Kutkat Tropical Medicine Department Faculty of MedicineAl-Azhar University Parasitology and Animal Diseases Department National Research CenterGizaEgypt Poultry Diseases Department National Research CenterGizaEgypt

Objective:To evaluate the effects of Mirazid and myrrh volatile oil on adult Fasciola gigantica(***) under laboratory ***:The effects of oleoresin extract of myrrh(Mirazid) and myrrh volatile oil on the surface morphology of adult *** following treatment in vitro had been determined by scanning electron *** results were compared with those observed in the fluke tegument following incubation in triclabendazole sulphoxide(TCBZ-SO),active form.(Fasinex,Ciba-Geigy).Results:Observations of the efficacy of Mirazid oleoresin extract and myrrh volatile oil indicated that both products showed dosedependent anthelmintic *** anterior half of the fluke was consistently more severely affected than the posterior *** surface changes induced by Mirazid oleoresin extract were less severe than those observed after exposure to either myrrh volatile oil or *** showed swelling after these treatments,but its level and blebbing were much greater with myrrh volatile oil;in which patches of tegumental sloughing were observed in the apical cone and the posterior mid-body region of *** was not observed after treatment with Mirazid oleoresin ***:The comparatively more disruption,observed in myrrh volatile oil exposed specimens,compared to that exposed to Mirazid oleoresin extract might suggest that the anthelmintic activity of Mirazid oleo resin extract was attributed to its content of volatile ***,increasing the concentration of myrrh volatile oil in Mirazid might possibly help to developing its anthelmintic activity._______________________________________________

关键词： Fasciola gigantica Mirazid Myrrh volatile oil In vitro effect

Some remarks on the genericity of unique range sets for meromorphic functions

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Science China mathematics 2005年第z1期48卷 262-267页

作者： ha Huy Khoai Institute of mathematics 18 Hoang Quoc Viet 10307HanoiVietnam

In this paper we relate the study of unique range sets for meromorphic functions (URSM) with the hyperbolic hypersurfaces and give some remarks on the genericity of unique range sets for meromorphic functions.

关键词： unique range set for meromorphic functions, hyperbolic surface.