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An update on electrostatic powder coating for pharmaceuticals

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Particuology 2017年第2期15卷 1-7页

作者： Qingliang Yang yingliang ma Jesse Zhu Kwok chow Kaiqi Shi Particle Technology Research Centre Department of Chemical and Biochemical Engineering University of Western Ontario London Ontario N6A 589 Canada Powder Pharma Coatings Mississauga Ontario LSR 2Y9 Canada Ningbo Weston Powder Pharma Coatings Co. Ltd. Ningbo Zhejiang 315042 China

Derived from dry powder coating of metals, electrostatic powder coating for pharmaceuticals is a technology for coating drug solid dosage forms. In this technology, coating powders, containing coating polymers, pigments, and other excipients, are directly sprayed onto the surface of the solid dosage forms through an electrostatic gun without using any organic solvent or water. The deposited coating powders are further cured to form a coating film. Electrostatic powder coating technology has many advantages compared to other pharmaceutical coating methods. It can eliminate the limitations caused by the organic solvent in solvent coating such as environmental issues and health problems. And electrostatic powder coating technology also surpasses aqueous coating due to its shorter processing time and less energy consumption, leading to a lower overall cost. Furthermore, the utilization of electrical attraction can promote the movement of coating powders towards the substrate, leading to an enhanced coating powder adhesion and coating efficiency, which make it more promising compared to other dry coating technologies. The objective of this review is to summarize the coating principles, apparatus, and formulations of different electrostatic powder coating technologies, giving their advantages and limitations and also analyzing the future application in the industry for each technology

关键词： Electrostatic powder coating Solid dosage forms Plasticizers Powder adhesion Film formation Curing

The role of adhesion molecules in gastri c ulcer healing

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World Journal of Gastroenterology 1998年第6期4卷 12-13页

作者： chow JYC, ma L and CHO CH

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关键词： stomach ulcer adhesion molecules vascular cell surface adhesion molecul 1 platelet endothelial cell adhesion molecule

Long-Term and Immediate Impacts of Health Emergency and Disaster Risk management(Health-EDRM) Education Interventions in a Rural Chinese Earthquake-Prone Transitional Village

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International Journal of Disaster Risk Science 2018年第3期9卷 319-330页

作者： Emily ying Yang Chan Janice ying-en Ho Zhe Huang Jean Hee Kim Holly Ching Yu Lam Phoebe Pui Wun Chung Carol Ka Po Wong Sida Liu Sharon chow Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Franois-Xavier Bagnoud Center for Health & Human Rights Harvard University Integrated Research on Disaster Risk (IRDR) International Centre of Excellence–CCOUC (ICoE-CCOUC) Wu Zhi Qiao (Bridge to China) Charitable Foundation

ma'an Qiao Village, a Dai and Yi ethnic minority-based community in Sichuan Province, China sustained complete infrastructure devastation during the 2008 Panzhihua earthquake. Health emergency and disaster risk management(Health-EDRM) education intervention programs were implemented in 2010 and 2011. This serial cross-sectional survey study aimed to examine the immediate and long-term impacts of the Health-EDRM interventions in this remote rural community. The findings demonstrate knowledge improvement in areas of water and sanitation, food and nutrition, and disaster preparedness immediately after the Health-EDRM education interventions. Temporal stability of knowledge retention was observed in household hygiene and waste management and smoking beliefs in 2018, 7 years after the *** important findings include knowledge uptake pattern differences of oral rehydration solution(ORS) between earthquake-prone and flood-prone communities. Usage of Internet and mobile technology for accessing disaster-related information was found to be independent of gender and income. Overall, this study demonstrated the knowledge improvement through Health-EDRM education interventions in a remote rural community. Promoting behavioral changes through interventions to raise awareness has the potential to reduce health risks in transitional post-disaster settings. Future programs should aim to identify evidence-based practices and explore how technology can support Health-EDRM education among vulnerable subgroups.

关键词： Earthquake Transitional community Disaster preparedness kit Disaster risk reduction Health emergency and disaster risk management Rural China Sichuan

B Vitamins Supplementation Can Improve Cognitive Functions and may Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets

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Current Medical Science 2021年第5期41卷 847-856页

作者： ying ZHENG Zhi-yong cheN Wen-jun ma Qiu-zhen WANG Hui LiaNG Ai-guo ma Department of Nutrition Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Institute of Nutrition and Health Medical College of Qingdao UniversityQingdao 266021China

Objective:To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase(TK)expression and ***:To test this,we separated 50 rats into five groups that were either fed a standard chow diet(controls)or a high-fat diet(experimental groups HO,HI,H2,and H3).HO group animals received no additional dietary supplementation,while H1 group animals were administered 100 mg/kg body weight(BW)thiamine,100 mg/kg BW riboflavin,and 250 mg/kg BW niacin each day,and group H2 animals received daily doses of 100 mg/kg BW pyridoxine,100 mg/kg BW cobalamin,and 5 mg/kg BW *** in the H3 group received the B vitamin regimens administered to both H1 and H2 each ***:Over time,group HO exhibited greater increases in BW and fat mass relative to other *** spatial and memory capabilities in these animals were evaluated via conditioned taste aversion(CTA)and Morris Water maze(MWM),we found B vitamin treatment was associated with significant improvements relative to untreated HO ***,B vitamin supplementation was associated with elevated TK expression in erythrocytes and hypothalamus of treated animals relative to those in HO(Pmay be a beneficial method for reducing cognitive dysfunction in clinical settings associated with high-fat diets.

关键词： B vitamins obesity conditioned taste aversion Morris water maze cognition transketolase

High-member low-dimensional Sn-based perovskite solar cells

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Science China chemistry 2023年第2期66卷 459-465页

作者： Hansheng Li Zihao Zang Qi Wei Xianyuan Jiang Mingyu ma Zengshan Xing Jingtian Wang Danni Yu Fei Wang Wenjia Zhou Kam Sing Wong Philip C.Y.chow Yuanyuan Zhou Zhijun Ning School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China Department of Physics Hong Kong University of Science and TechnologyHong Kong999077China Department of Mechanical Engineering The University of Hong KongHong Kong999077China Department of Physics Hong Kong Baptist UniversityHong Kong999077China

Sn-based perovskites are promising thin-film photovoltaic materials for their ideal bandgap and the eco-friendliness of Sn,but the performance of Sn-based perovskite solar cells is hindered by the short carrier diffusion length and large defect density in nominally-synthesized Sn-based perovskite *** we demonstrate that a long carrier diffusion length is achievable in quasi-2D Sn-based perovskite films consisting of high-member low-dimensional Ruddlesden-Popper(RP)phases with a preferred crystal orientation *** key to the film synthesis is the use of a molecular additive formed by phenylethylammonium cations and optimally mixed halide-pseudohalide anions,which favorably tailors the quasi-2D Sn-based perovskite crystallization *** high-member RP film structure effectively enhances device short-circuit current density,giving rise to an increased power conversion efficiency(PCE)of 14.6%.The resulting device demonstrates a near-unity shelf stability upon1,000 h in nitrogen.A high reproductivity is also achieved with a count of 50 devices showing PCEs within a narrow range from minimum 13.0%to maximum 14.6%.

关键词： Sn-based perovskite lead-free perovskite solar cells low-dimensional structure optoelectronics device

基于FOXO3a/Nrf2信号通路探讨尿毒症骨骼肌自噬的分子机制

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重庆医科大学学报 2024年第8期49卷 986-993页

作者：马娟郭银雪胡茂蓉贵州中医药大学第一附属医院肾内科贵阳550002

目的:探讨叉头盒(forkhead box,FOX)O蛋白3a(forkhead box O3a,FOXO3a)/转录因子NF-E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)信号通路的调节尿毒症骨骼肌自噬的机制。方法:24只小鼠随机分为假手术组(Sham组)、慢性肾病(chronic kidney disease,CKD)组和CKD+AST-120(AST)组,每组8只。通过5/6肾切除术建立CKD模型。在肾切除术后4周,CKD+AST组小鼠给予含AST-120粉末(尿毒毒素的木炭吸附剂)饮食,持续8周。透射电子显微镜观察腓肠肌组织中的自噬溶酶体。C2C12小鼠成肌细胞分为对照(Control,Con)组、硫酸吲哚酚(indophenol sulfate,IS)组、IS+si-FOXO3a组。实时RT-PCR和蛋白质印迹法分析FOXO3a表达情况。Giemsa染色对C2C12肌管直径进行量化。结果:与CKD组相比,CKD+AST组血清IS水平和腓肠肌组织中FOXO3a表达、自噬溶酶体的数量明显降低(Piated protein 1,KEAP1)表达明显升高(P<0.05),和NRF2表达明显降低(P<0.05)。AST治疗逆转了CKD小鼠腓肠肌组织中这些蛋白的变化。si-NRF2逆转了FOXO3a敲低对自噬流量的抑制作用。结论:IS可能通过持续刺激FOXO3a-KEAP1-NRF2轴促进骨骼肌过度自噬,参与尿毒症少肌症的发病机制。

关键词：叉头盒O蛋白3a 转录因子NF-E2相关因子2 尿毒症骨骼肌自噬

铁代谢在有氧运动改善动脉粥样硬化小鼠心肌细胞凋亡中的作用机制研究

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中华物理医学与康复杂志 2024年第1期46卷 7-12页

作者：刘西花马甜甜秦芳于子夫高杰山东中医药大学附属医院济南250014 山东中医药大学康复医学院济南250355 山东省妇幼保健院妇幼健康发展研究中心济南250014

目的探讨铁代谢在有氧运动改善动脉粥样硬化(AS)小鼠心肌细胞凋亡中的作用机制。方法选取8周龄雄性ApoE^(-/-)基因敲除小鼠,采用随机数字表法将其分为对照组、模型组及有氧运动组,每组9只小鼠。模型组及有氧运动组小鼠均给予"西方类型"... 详细信息

目的探讨铁代谢在有氧运动改善动脉粥样硬化(AS)小鼠心肌细胞凋亡中的作用机制。方法选取8周龄雄性ApoE^(-/-)基因敲除小鼠,采用随机数字表法将其分为对照组、模型组及有氧运动组,每组9只小鼠。模型组及有氧运动组小鼠均给予"西方类型"膳食饲料喂养12周以制作AS动物模型,有氧运动组小鼠在制模期间同时进行有氧运动干预,持续训练12周,对照组小鼠则给予正常饲料喂养。于训练12周后采用TUNEL染色法检测各组小鼠心肌细胞凋亡情况;采用免疫组化技术检测各组小鼠心肌组织中铁蛋白重链1(FTH1)、谷胱甘肽过氧化物酶4(GPX4)表达;采用Western blot技术检测各组小鼠心肌组织中FTH1、GPX4蛋白水平;采用普鲁士蓝染色检测各组小鼠心肌组织中铁沉积情况;通过试剂盒检测各组小鼠心肌组织中铁、丙二醛(MDA)及谷胱甘肽过氧化物酶(GSH-PX)含量。结果TUNEL染色结果显示模型组出现明显心肌细胞凋亡,有氧运动组心肌凋亡情况较模型组明显减轻。普鲁士蓝染色显示模型组心肌出现明显铁沉积现象,而有氧运动组铁沉积情况较模型组明显减轻。免疫组化检测显示模型组FTH1及GPX4表达量均较对照组降低,有氧运动组上述指标表达量均较模型组明显升高。Western blot检测显示有氧运动组FTH1、GPX4蛋白水平均较模型组明显升高,且心肌组织中的铁及MDA含量明显低于模型组,GSH-PX含量显著高于模型组。结论有氧运动能显著改善AS小鼠心肌细胞凋亡,其作用机制可能与有氧运动改善心肌组织铁代谢、降低氧化应激水平及抑制铁超载有关。

关键词：有氧运动动脉粥样硬化心肌组织铁代谢凋亡

Injectivity radius bound of Ricci flow with positive Ricci curvature and applications

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Frontiers of mathematics in China 2013年第5期8卷 1129-1137页

作者： Li ma Anqiang ZHU Zhongyuan Institute of mathematics and Department of mathematics Henan Normal University Xinxiang 453007 China Department of mathematics Wuhan University Wuhan 430072 China

We study the injectivity radius bound for 3-d Ricci flow with bounded curvature. As applications, we show the long time existence of the Ricci flow with positive Ricci curvature and with curvature decay condition at i... 详细信息

关键词： Injectivity radius bound Ricci flow positive Ricci curvature global solution

B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 174-183页

作者： ying ZHENG Ai-guo ma Ming-ci ZHENG Qiu-zhen WANG Hui LiaNG Xiu-xia HAN Evert G.Schouten Department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Institute of Human Nutrition Medical College of Qingdao UniversityQingdao 266021China Department of Pediatrics Guilin Medical College Affiliated HospitalGuilin 541001China Division of Human Nutrition Wageningen UniversityWageningen 6700 EVThe Netherland

B vitamins are enzyme cofactors that play an important role in energy *** aim of this study was to elucidate whether B vitamin administration can reduce body weight(BW)gain by improving energy metabolism-related enzyme activities in rats fed on a highfat *** rats were randomly assigned to one of the following five groups:control group(C),including rats fed on standard rat chow;four treatment groups(H0,H1,H2,and H3),in which rats were fed on a high-fat *** in the H1 group were treated daily with 100 mg/kg BW thiamine(VB1),100 mg/kg BW riboflavin(VB2),and 250 mg/kg BW niacin(VPP);rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine(VB6),100 mg/kg BW cobalamin(VB12),and 5 mg/kg BW folate(FA);and rats in the H3 group were treated daily with all of the B vitamins administered to the H1 and H2 *** 12 weeks,the BW gains from the initial value were 154.5±58.4 g and 159.1±53.0 g in the H1 and C groups,respectively,which were significantly less than the changes in the H0 group(285.2±14.8 g,P〈0.05).In the H0 group,the plasma total cholesterol(CHO)and triglyceride(TG)levels were 1.59±0.30 mmol/L and 1.55±0.40 mmol/L,respectively,which were significantly greater than those in the H1 group(1.19±0.18 mmol/L and 0.76±0.34 mmol/L,respectively,P〈0.05).The activities of transketolase(TK),glutathione reductase,and Na^+/K^+adenosine triphosphatase were significantly increased in the B vitamin-treated groups and were significantly greater than those in the H0 group(P〈0.05).Furthermore,the glucose-6-phosphate dehydrogenase,pyruvic acid kinase,and succinate dehydrogenase activities also were increased after treatment with B *** with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats,thus possibly providing potential benefits to humans.

关键词： B vitamins obesity body weight gain enzyme activities rats