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Micropenis Associated or Not with Cryptorchidism in the Endocrinology Department of Yopougon University Hospital in Ivory Coast: Epidemiological, Clinical, Paraclinical and Therapeutic Aspects

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Open Journal of Endocrine and Metabolic Diseases 2024年第3期14卷 75-85页

作者： Adélaïde Hue Kossi Kodjo Michèle Fotso Jacko Abodo Department of Endocrinology Diabetology at Yopougon University Hospital Abidjan Ivory Coast Internal Medicine and Endocrinology Department of Sylvanus Olympio University Hospital Lomé Togo

Background: Congenital malformations such as micropenis and cryptorchidism do not have immediate dramatic consequences. However, the diagnosis is often unknown at birth, and therefore late. In Ivory Coast, there are few studies on cryptorchidism and micropenis. We conducted this study to identify the epidemiological, clinical, etiological and therapeutic characteristics of the micropenis associated or not with cryptorchidism at Yopougon University Hospital. Methods: We conducted a retrospective descriptive study in the Department of Endocrinology-Diabetology of the Yopougon University Hospital carried out over 13 years from January 2005 to December 2018. All patients were included regardless of the presence of a micropenis associated or not with cryptorchidism in the clinical or paraclinical examination. results: A total of 14 micropenis were reported associated in 6 cases with cryptorchidism. It was unilateral cryptorchidism in 4 patients or 66.66% of cases. The average age of affected patients was 21.32 years with extremes ranging from 10 months to 48 years. The reason for consultation was micropenis in 12 out of 14 cases or 85.75%. The associated signs apart from cryptorchidism were obesity in 42.86% of cases, gynecomastia in 35.71% of cases. The aetiology was dominated by idiopathic causes. Treatment with testosterone enanthate was more effective in pre-pubertal children than in adults. Conclusion: The diagnosis of micropenis associated or not with cryptorchidism is late because of the frustrations, taboos and psycho-social states that it causes. However, drug treatment is effective when treatment is started early.

关键词： Micropenis Cryptorchidism Hospital Environment Ivory Coast

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Design and Sizing of an Ecological Wastewater Treatment System in a School Environment: A Case Study of Ndiebene Gandiol 1 School

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Journal of Water resource and Protection 2024年第1期16卷 41-57页

作者： Falilou Coundoul Abdou Khafor Ndiaye Abdoulaye Deme David de la Varga Polytechnic Institute of Saint-Louis Gaston Berger University Saint-Louis Senegal Applied Sciences and Technologies Training and research Unit Gaston Berger University Saint-Louis Senegal laboratory of Chemical-Physical and Chemical Engineering I University of A Coru&ntildea A Coru&ntildea Spain

The primary objective of this study was to design and size a sustainable sanitation solution for the Ndiebene Gandiol 1 school located in the eponymous commune in northern Senegal. Field investigations led to the collection of wastewater samples. Their analysis revealed specific pollutant loads, including loads of BOD5 3.6966 kgO2/day and COD of 12.8775 kgO2/day, which were central to the design phase. Following a rigorous assessment of the existing sanitation infrastructure, constructed wetland (CWs) emerged as the most appropriate ecological solution. This system, valued for its ability to effectively remove contaminants, was tailored to the specific needs of the site. Consequently, the final design of the filter extends over 217.16 m2, divided into two cells of 108.58 m2 each, with dimensions of 12.77 m in length and 8.5 m in width. The depth of the filtering medium is approximately 0.60 m, meeting the standards while ensuring maximized purification. Typha, an indigenous and prolific plant known for its purification abilities, was selected as the filtering agent. Concurrently, non-crushed gravel was chosen for its proven filtration capacity. This study is the result of a combination of scientific rigor and design expertise. It provides a holistic view of sanitation for Ndiebene Gandiol. The technical specifications and dimensions of the constructed wetland filter embody an approach that marries indepth analysis and practical application, all aimed at delivering an effective and long-lasting solution to the local sanitation challenges. By integrating precise scientific data with sanitation design expertise, this study delivers a holistic solution for Ndiebene Gandiol. The detailed dimensions and specifications of the constructed wetland filter reflect a methodology that combines meticulous analysis with practical adaptation, aiming to provide an effective and sustainable response to the challenges of rural and school san

关键词： Water review Hydraulic Engineering Water Treatment Agricultural Irrigation Sanitation Engineering Environment

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Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose maria martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑Garcia laura Morales‑Fernandez Javier Garcia‑Bella Jose manuel Benitez‑del‑Castillo Julian Garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(Preduction was found after treatment in the corneal staining score(Preduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

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Therapeutic Effectiveness of Leukocyte-and Platelet-rich Fibrin for Diabetic Foot Ulcers:A retrospective Study

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Current Medical Science 2024年第3期44卷 568-577页

作者： Fen WANG Xiao-ling ZHANG Jing ZHANG Song GONG Jing TAO Hui XIANG Xiao-qing FU Xu-na BIAN Xue-feng YU An-hui XU Cheng-la YI Shi-ying SHAO Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Branch of National Clinical research Center for Metabolic Diseases Wuhan430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Trauma Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Diabetic foot ulcer(DFU)is one of the most serious complications of ***-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich *** study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical *** Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2018 to 2019 in Tongji Hospital were *** clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2 days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was *** Totally,26 patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)*** severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2–6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2–*** initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)*** median number of L-PRF doses was 3(2,5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh *** overall wound-healing rate was 1.47(0.63,3.29)cm3/week,and the healing rate was faster in the first 2 weeks than in the remaining *** treatment did not change the percentage of complete epithelialization or healing *** Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for D

关键词： diabetic foot ulcer autologous platelet-rich plasma leukocyte-and platelet-rich fibrin standard of care percentage volume reduction

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响应面法优化火绒草中总黄酮与总酚酸的提取工艺研究

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草地学报 2024年第3期32卷 935-944页

作者：意如乐格根图王志军胡日查百岁塞西雅拉图内蒙古农业大学草原与资源环境学院农业农村部饲草栽培、加工与高效利用重点实验室内蒙古呼和浩特010019 克什克腾旗林业和草原局内蒙古赤峰025300 克什克腾旗绿色驿站环境保护监测站内蒙古赤峰025300

为探究野生火绒草(Leontopodium leontopodioides(Wild.)Beauv)总黄酮与总酚酸最佳提取工艺及抗氧化活性,本试验采用快速溶剂萃取法探索萃取温度、循环次数、加热时间及萃取压力对火绒草总黄酮、总酚酸提取含量的影响,通过单因素试验和... 详细信息

为探究野生火绒草(Leontopodium leontopodioides(Wild.)Beauv)总黄酮与总酚酸最佳提取工艺及抗氧化活性,本试验采用快速溶剂萃取法探索萃取温度、循环次数、加热时间及萃取压力对火绒草总黄酮、总酚酸提取含量的影响,通过单因素试验和响应面设计法确定了活性物质的最佳提取工艺。结果表明:当使用70%乙醇提取火绒草中总黄酮时最佳提取工艺为:萃取温度93℃,循环次数3次,加热时间20 min,萃取压力102 bar,提取含量为(45.45±0.36)mg·g^(-1);总酚酸最佳提取工艺为:萃取温度90℃,循环次数3次,加热时间19 min,萃取压力97 bar,提取含量为(23.52±0.34)mg·g^(-1)。火绒草总黄酮提取液对DPPH自由基和ABTS自由基的IC_(50)为0.012 mg·mL^(-1)和0.356 mg·mL^(-1),具有一定的还原力。本研究可为火绒草活性物质的提取工艺及加工利用提供可靠的理论依据和详实的科学参考。

关键词：火绒草总黄酮总酚酸快速溶剂萃取响应面法优化抗氧化活性

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Gentiana macrophylla Pall.:a review of the basic source,traditional use,chemical components,pharmacological activities and quality control

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Traditional Medicine research 2024年第12期9卷 13-30页

作者： Qi-Er Mu Yi-Sa A Yan-Qiu Bai Chu-la Sa College of Mongolian Medicine Inner Mongolian Medical UniversityJinshan Economic and Technological Development ZoneTumote Left BannerHohhot 010110China

Gentiana macrophylla Pall.(***),whose genus and family belong to the Gentianaceae and *** main distribution centers of *** resources were the Loess Plateau and the eastern Qinghai-Tibet Plateau in ***,as a traditional medicine,has a long history and was used in different ethnic *** roots were used in traditional Chinese medicine,which had the effect of anti-inflammatory,anti-rheumatism,antiviral,promote blood circulation,eliminate swelling and pain,while its flowers were used in traditional Mongolian medicine,which had the effect of removing“Xieriwusu”(“Xieriwusu”means rheumatism),antiviral,reducing *** previous studies,it could be found that there were more than forty components isolated and identified from *** main chemical components were iridoids,flavonoids,triterpenoids,steroids,phenylpropanoids,and *** terpenoid components represented by gentiopicroside and Loganic acid were the main components of the root of ***,which had anti-inflammatory,antioxidant,hepatoprotective,analgesic,antibacterial and promote gastrointestinal tract *** flower mainly contains isoorientin and isovitexin as the representative of *** have anti-tumor,liver protection,heart protection,inhibition of acetylcholinesterase and inhibition of *** could be seen from previous studies that the research on *** was mainly focused on the root,and the flower was rarely *** was reported that the experimental data of the anti-inflammatory and anti-tumor effects of *** flowers show that its curative effect was very ***,the flowers of the flower of *** can be used as potential medicinal parts for *** that flavonoids are mostly found in flowers and exhibit a range of functions,it is possible to investigate the flowers in order to learn more about ***’s potential medical *** on botanical books,Chi

关键词： Gentiana macrophylla Pall basic source chemical component pharmacological activity quality control

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Etiological Agent, Pathogenesis, Diagnosis, Treatment, Measures for Prevention and Control of Caseous Lymphadenitis Disease in the Small Ruminants with Special reference to Sheep

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Journal of Biosciences and Medicines 2024年第5期12卷 154-170页

作者： Eréndira de la Fuente mancera Abel Ciprian Carrasco Susana Mendoza Elvira Facultad de Estudios Superiores Cuautitlá n Universidad Nacional Aut&#243noma de M&#233xico M&#233xico City M&#233xico

Caseous lymphadenitis (CL) is a chronic infectious disease caused by Corynebacterium pseudotuberculosis (C. pseudotuberculosis) that is transmitted mainly by contact with contaminated exudate wounds. Caseous lymphadenitis affects different species of animals and is considered an occupational zoonotic disease. CL is responsible for important economic losses in the small ruminant industry, which include decreased production, damaged quality of milk and wool, reproductive disorders, total or partial confiscation of carcasses, and depreciation of the skin. Caseous lymphadenitis disease can present in two clinical pictures: a skin or superficial picture and a visceral or deep picture. The presumptive diagnosis of CL in the skin is based on the exploration of superficial lymph nodes. These have little value in diagnosing visceral CL, where the main sign is emaciation. The prevention and control of CL involve identifying the skin condition and debriding the abscesses. In addition to the treatment of superficial lesions, the animal facilities must be repaired and adapted. To avoid exposure of negative herds to CL, new animals must be subjected to observation to identify any of the clinical manifestations. Another form of control is vaccination, though only some countries have commercial vaccines. General information on the etiological agent and its characteristics can be used to improve the understanding of this disease.

关键词： Abscess CMNR Corynebacterium pseudotuberculosis Goat CL Lymph Nodes Pseudotuberculosis Sheep

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Effect of Nanostructures Addition and Enhancement of Poly (Vinylidene Difluoride) (PVDF) Energy Harvesting

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materials Sciences and Applications 2024年第7期15卷 228-244页

作者： Omar Peña-Oliveras Brenda Javier-Boodhan Anthony la Santa Juan Gonzalez-Sanchez Division of Science Technology and Engineering Universidad Ana G. Mndez Carolina Campus Carolina Puerto Rico Department of Electronics University of Puerto Rico Bayamon Campus Bayamon Puerto Rico

With concerns in energy crisis and global warming, researchers are actively investigating alternative energy renewable solutions. Among the various methods, piezoelectric transduction stands out due to its impressive electromechanical coupling factor and coefficient. As a result, piezoelectric energy harvesting has garnered significant attention from the scientific community. In this study, we explored methods to enhance the piezoelectric properties of polyvinylidene fluoride (PVDF) through two distinct approaches. The first approach involved applying external high voltages at various stages during the mixture reaction. The goal was to determine whether this voltage application could alter or enhance PVDF’s piezoelectric conformation by improving the alignment of polarized dipoles. In the second part of our study, we investigated the effects of incorporating various nanostructures (including Iron Oxide, magnesium Oxide, and Zinc Oxide) into PVDF. To analyze changes in PVDF’s crystalline structure, we utilized Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD) techniques. Additionally, we measured the electric polarization of samples using a Precision LC Meter and examined the morphology of nanofibers through Scanning Electron Microscopy (SEM).

关键词： Poly (Vinylidene Fluoride) (PVDF) Energy Harvesting Electrospinning Nanoparticles ZnO MgO Fe3O4

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Epicardial adipose tissue in obesity with heart failure with preserved ejection fraction: Cardiovascular magnetic resonance biomarker study

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World Journal of Cardiology 2024年第3期16卷 149-160页

作者： Ju-Wei Shao Bing-Hua Chen Kamil Abu-Shaban Ahmad Baiyasi Lian-Ming Wu Jing ma Department of Radiology The Affiliated Hospital of Yunnan UniversityKunming 650021Yunnan ProvinceChina Department of Radiology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Radiology University of Toledo College of MedicineToledoOH 43623United States Department of Radiology Wayne State University School of MedicineDetroitMI 48201United States Department of Endocrinology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

BACKGROUND Obesity has become a serious public health issue,significantly elevating the risk of various *** is a well-established contributor to Heart failure with preserved ejection fraction(HFpEF).Evaluating HFpEF in obesity is *** adipose tissue(EAT)has emerged as a valuable tool for validating prognostic biomarkers and guiding treatment ***,assessing EAT is of paramount *** magnetic resonance(CMR)imaging is acknowledged as the gold standard for analyzing cardiac function and *** hope to use CMR to assess EAT as a bioimaging marker to evaluate HFpEF in obese *** To assess the diagnostic utility of CMR for evaluating heart failure with preserved ejection fraction[HFpEF;left ventricular(LV)ejection fraction≥50%]by measuring the epicardial adipose tissue(EAT)volumes and EAT mass in obese *** Sixty-two obese patients were divided into two groups for a case-control study based on whether or not they had heart failure with *** two groups were defined as HFpEF+and HFpEF-.LV geometry,global systolic function,EAT volumes and EAT mass of all subjects were obtained using cine magnetic resonance *** Forty-five patients of HFpEF-group and seventeen patients of HFpEF+group were *** mass index(g/m2)of HFpEF+group was higher than HFpEF-group(Pmass,EAT mass index and the ratio of EAT/[left atrial(la)left-right(LR)diameter]were higher compared to HFpEF-group(Priate analysis,Higher EAT/la LR diameter ratio was associated with higher odds ratio of *** EAT/la LR diameter ratio is highly associated with HFpEF in obese *** is plausible that there may be utility in CMR for assessing obese patients for HFpEF using EAT/la LR diameter ratio as a diagnostic *** prospective studies,are needed to validate these proof-of-concept findings.

关键词： Heart failure with preserved ejection fraction Epicardial adipose tissue Obesity Cardiac magnetic resonance

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Petrology of Spinel-Lherzolite Xenoliths from mazéléand Others Northen Xenoliths Localities of Cameroon Volcanic Line: Exchange reactions and Equilibrium State

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Open Journal of Geology 2024年第5期14卷 629-653页

作者： Nguihdama Dagwai Kamgang Pierre Mbowou Gbambié Isaac Bertrand Chazot Gilles Ngounouno Ismaïla Department of Life and Earth Sciences Higher Teachers&#8217 Training College University of Maroua Maroua Cameroon Department of Earth Sciences Faculty of Science University of Yaound&#233 1 Yaound&#233 Cameroon Department of Mineral Prospecting and Exploration Technologies School of Geology and Mining Engineering University of Ngaoundere Meiganga Cameroon Ocean Geosciences laboratory European University Institute of the Sea (IUEM) Brest France

The alkaline volcanism of the Cameroon Volcanic Line in its northern domain has raised many fresh enclaves of peridotites. The samples selected come from five (05) different localities (Liri, in the plateau of Kapsiki, mazélé in the NE of Ngaoundéré, Tello and Ganguiré in the SE of Ngaoundéré and Likok, locality located in the west of Ngaoundé). The peridotite enclaves of the above localities show restricted mineralogical variation. Most are four-phase spinel-lherzolites, indicating that this is the main lithology that forms the lithospheric mantle below the shallow zone. No traces of garnet or primary plagioclase were detected, which strongly limits the depth range from which the rock fragments were sampled. The textures and the wide equilibrium temperatures (884˚C - 1115˚C) indicate also entrainment of lherzolite xenoliths from shallow depths within the lithosphere and the presence of mantle diapirism. The exchange reactions and equilibrium state established in this work make it possible to characterize the chemical composition of the upper mantle of each region and test the equilibrium state of the phases between them. Variations of major oxides and incompatible elemental concentrations in clinopyroxene indicate a primary control by partial melting. The absence of typical “metasomatic” minerals, low equilibration temperatures and enriched LreE patterns indicate that the upper mantle below septentrional crust of Cameroun underwent an event of cryptic metasomatic enrichment prior to partial melting. The distinctive chemical features, LreE enrichment, strong U, Ce and Pr, depletion relative to Ba, Nb, la, Pb, and T, fractionation of Zr and Hf and therefore ligh high Zr/Hf ratio, low la/Yb, Nb/la and Ti/Eu are all results of interaction of refractory peridotite residues with carbonatite melts.

关键词： Xenoliths Upper mantle Northern region Adamawa Cameroon Volcanic Line Exchange reaction

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