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Progression of intervention-focused research for Gulf War illness

Military Medical Research 2020年第1期7卷 104-121页

作者： Jeremy E.Chester ma.hga. rowneki William Van Doren Drew A.Helmer War Related Illness and Injury Study Center Veterans Affairs New Jersey Healthcare System385 Tremont AvenueEast OrangeNJ 07018USA War Related Illness and Injury Study Center Veterans AffairsMedicalCenter50lrvingSt.WashingtonDCNW20422USA Rutgers University New Jersey Medical School185 South Orange AvenueNewarkNJ 07103USA

The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle ***-related exposures to toxic substances such as pesticides,nerve agents,pyridostigmine bromide(PB),smoke from burning oil wells,and petrochemicals may have contributed to medical illness in as many as 250,000 of those American *** cluster of chronic symptoms,now referred to as Gulf War Illness(GWI),has been studied by many researchers over the past two *** over$500 million has been spent on GWI research,to date,no cures or condition-specific treatments have been discovered,and the exact pathophysiology remains *** the 2007 National Institute of Health(NIH)Roadmap for Medical Research model as a reference framework,we reviewed studies of interventions involving GWI patients to assess the progress of treatment-related GWI *** GWI clinical trial studies reviewed involved investigations of existing interventions that have shown efficacy in other diseases with analogous *** reviewing the published and ongoing registered clinical trials for cognitivebehavioral therapy,exercise therapy,acupuncture,coenzyme Q10(CoQ10),mifepristone,and carnosine in GWI patients,we identified only four treatments(cognitive-behavioral therapy,exercise therapy,CoQ10,and mifepristone)that have progressed beyond a phase II *** conclude that progress in the scientific study of therapies for GWI has not followed the NIH Roadmap for Medical Research *** of a standard case definition,prioritized GWI research funding for the characterization of the pathophysiology of the condition,and rapid replication and adaptation of early phase,single site clinical trials could substantially advance research progress and treatment discovery for this condition.

关键词： Gulf War illness Chronic multisymptom illness Gulf War veterans Gulf War syndrome Persian Gulf War Cognitive-behavioral therapy Exercise therapy Acupuncture Coenzyme Q10 Mifepristone Carnosine Mindfulness-based stress reduction

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