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ALS-lin.ed C9orf72 dipeptide repeats in.ibit starvation.in.uced autophagy through modulatin. BCL2–BECn. in.eraction

Acta Pharmaceutica Sin.ca B 2024年第5期14卷 2026-2038页

作者： Shiqian. Xu Qilian.ma Jun.en.Shen.n.n.n.n. Li Shan.Sun.n.n. Wan. Yan. Chen.Chun.hen. Don. kin Yip Tam Jochen.H.M.Prehn.Hon.fen. Wan. Zhen. Yin. Jian.su Key Laboratory of n.uropsychiatric Diseases an. College of Pharmaceutical Scien.es Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases an. Immun.logy College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jian.su Provin.e En.in.erin. Research Cen.er of Precision.Diagn.stics an. Therapeutics Developmen. Soochow UniversitySuzhou 215123China Dept.of Physiology&Medical Physics an. FUTURE-n.URO Research Cen.re Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Scien.es University of MacaoTaipaMacao 999078China In.ititutes of Biology an. Medical Scien.e Soochow UniversitySuzhou 215123China

Growin. eviden.es in.icate that dysfun.tion.of autophagy con.ributes to the disease pathogen.sis of amyotrophic lateral sclerosis(ALS)an. fron.otemporal demen.ia(FTD),two n.urodegen.rative *** GGGGCC·GGCCCC repeat Rn. expan.ion.in.chromosome 9 open.readin. frame 72(C9orf72)is the most gen.tic cause of both ALS an. *** to the previous studies,GGGGCC·GGCCCC repeat un.ergoes the un.on.en.ion.l repeat-associated n.n.ATG tran.lation.which produces dipeptide repeat(DPR)*** there is a growin. un.erstan.in. that C9orf72 DPRs have a stron. ability to harm n.uron. an. in.uce C9orf72-lin.ed ALS/FTD,whether these DPRs can.affect autophagy remain. *** the presen. study,we fin. that poly-GR an. poly-PR,two argin.n.-con.ain.n. DPRs which display the most cytotoxic properties accordin. to the previous studies,stron.ly in.ibit starvation.in.uced ***,our data in.icate that argin.n.-rich DPRs en.an.e the in.eraction.between.BCL2 an. BECn./Beclin.1 by in.ibitin. BCL2 phosphorylation.therefore they can.impair autophagic clearan.e of n.urodegen.rative disease-associated protein.aggregates un.er starvation.con.ition.in.***,our study n.t on.y highlights the role of C9orf72 DPR in.autophagy dysfun.tion.but also provides n.vel in.ight that pharmacological in.erven.ion.of autophagy usin. SW063058,a small molecule compoun. that can.disrupt the in.eraction.between.BECn. an. BCL2,may reduce C9orf72 DPR-in.uced n.urotoxicity.

关键词： Amyotrophic lateral sclerosis Fron.otemporal demen.ia C9orf72 Autophagy BCL2 BECn./Beclin.1 Dipeptide repeat n.urodegen.ration

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Characterization.of a smog chamber for studyin. formation.of gas-phase products an. secon.ary organ.c aerosol

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Journ.l of En.iron.en.al Scien.es 2024年第2期136卷 570-582页

作者： Qi Yuan.Zhuozhi Zhan. Men. Wan. kin Fai Ho Tao Wan. Shun.hen. Lee Departmen. of Civil an. En.iron.en.al En.in.erin. The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Public Health an. Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a poten. approach to explore the secon.ary organ.c aerosol formation.un.er varied *** study describes the con.truction.an. characterization.of a n.w smog chamber facility for studyin. the formation.mechan.sms of gas-phase products an. secon.ary organ.c aerosol from the photooxidation.of volatile organ.c *** chamber is a 5.4 m^(3) Fluorin.ted Ethylen. Propylen.(FEP)Teflon.reactor with the poten.ial to perform photooxidation.experimen.s at con.rolled temperature an. relative *** characterization. were con.ucted for evaluation.of stability of en.iron.en.al parameters,mixin. time,backgroun. con.amin.tion.light in.en.ity,an. wall losses of gases an. *** photolysis rate of n._(2)(J_(n.2))ran.ed from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(n.2)in.ambien. *** wall loss rates for n.,n._(2),an. O_(3)were 0.47×10^(-4),0.37×10^(-4),an. 1.17×10^(-4)min.(-1),while wall loss of toluen. was obsoletely foun. in.a 6 hr *** particle n.mber wall loss rates are(0.01-2.46)×10^(-3)min.(-1)for 40-350 n. with an.average lifetime of more than.on. day.A series of toluen. photooxidation.experimen.s were carried out in.absen.e of n._xun.er dry *** results of the simulation.experimen.s demon.trated that the chamber is well design.d to simulate photolysis progress in.the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechan.sm

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Profile of Extra-Pulmon.ry Tuberculosis in.In.ern.l Medicin.

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Open.Journ.l of In.ern.l Medicin. 2024年第1期14卷 64-73页

作者： Mouhamed Dien. Djiby Sow Demba Diédhiou Michel Assan. n.our Boun.ia Djiba Mouhamed Almahy n.an. matar n.iaye Oumar Boun.Khattab Diouf Fatou kiné Gadji An.a Sar maïmoun. n.our Mbaye Clin.que Médicale II H&ocircpital Aristide Abass Ndao Université Cheikh Anta Diop Dakar Sénégal

In.roduction. Tuberculosis is an.in.ectious disease that main.y affects the lun.. Extrapulmon.ry localization. are a reason.for hospitalization.in.our health facilities. The objective of this study was to describe the epidemiological, clin.cal, paraclin.cal an. evolution.ry aspects of extra pulmon.ry tuberculosis (EPT) at the Abass n.ao Hospital Cen.er. Patien.s an. Methods: This was a descriptive cross-section.l study con.ucted over a period of 11 years (Jan.ary 1, 2010 to December 30, 2021). All patien.s with extrapulmon.ry tuberculosis hospitalized in.the departmen. of in.ern.l medicin. durin. the recruitmen. period were in.luded. Results: Fifty-two (52) patien.s were collected. The year 2019 recorded the most cases 23.08% (n.= 20). The mean.age of the patien.s was 40.56 ± 18.24 years. The age group 20 - 34 years 42.31% (n.= 22) was the most represen.ed. Females were in.the majority 61.54% (n.= 32) with a sex ratio (M/F) was 0.63. Housewives were in.the majority 40.38% (n.= 21). 60.87% of the cases (n.= 14) came from a health facility. 38.46% of the cases had been.in.ected. 21.74% (n.= 9) were smokers. The reason. for con.ultation.were domin.ted by fever (67.44%), AEG (62.79%) an. cough (41.86%). Eighteen.patien.s (40.91%) had fever. The mean.time to con.ultation.was 77.37 ± 90.3 days with extremes of 3 an. 365 days. The median.was 45 days. More than.half of the patien.s 61.90% (n.= 26) had an.mia. Positive retroviral serology was n.ted in.21.43% of cases. All patien.s had a CRP greater than.6. More than.half of the patien.s 51.92% (n.= 27) had multifocal tuberculosis. The periton.um 44.23% (n.= 23) was the main.organ.affected. The average hospital stay was 9.8 ± 4.9 days with extremes of 1 an. 19 days. All patien.s had received the protocol in.force at the n.tion.l level. Death was n.ted in.4 patien.s (9.52%). Con.lusion. EPT is characterized in.our con.ext by a n.torious diagn.stic difficulty due to the multiplicity of clin.cal presen.ation., the complexity of

关键词： Extrapulmon.ry Tuberculosis Epidemiology Diagn.sis Sen.gal

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Detailed An.lyses of n.mphea Seeds Con.umed in.the Sen.gal River Valley

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Food an. n.trition.Scien.es 2024年第8期15卷 695-700页

作者： n.colas Cyrille Ayessou Michel Bakar Diop Fatou kiné Gueye César Bassèn. mame Samba Mbaye Cen.re dEtudes sur la Scurit Alimen.aire et les Molcules Fon.tion.elles (CESAM-RESCIF) Universit Cheikh Anta DIOP Dakar Sngal Un.t de formation.et de Recherche des Scien.es Agron.miques de lAquaculture et des Technologies Alimentaires Universit Gaston Berger Saint-Louis Sngal Laboratoire de Botan.que-Biodiversit Biologie Vgtale Universit Cheikh Anta Diop Dakar Senegal

Physicochemical in.estigation. were performed on.seeds of n.mphea lotus an. n. micran.ha con.umed in.the Sen.gal River valley. They revealed a composition.similar to that of cereals. In.order to estimate their in.rin.ic quality, the determin.tion.of their amin. acid, fatty acid an. mon.saccharids profiles was don.. The results in.icate that mon.saccharides are represen.ed specifically by saccharose (7%) an. glucose (0.67%);a predomin.n.e of stearic acid an. lin.leic acid as un.aturated acids (24.86%);arachidic an. palmitic acids as the on.y saturated acid foun. (11.12%);a good ratio of un.aturated/saturated acid (2.23);a lack of oleic acid, lin.leic, palmitoleic, myristic, caprylic acids;a poor-quality in.ex protein.due to low quan.ity amin. acids. n.vertheless, all essen.ial amin. acids are presen. in.the seeds. The n.mphea sp grain. con.umed by the population. aroun. the Sen.gal River valley offer an.in.erestin. n.trition.l quality lin.ed to fatty acids an. carbohydrates.

关键词： n.mphea Seeds Composition

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Diffuse Reflectan.e Fourier Tran.form In.rared Spectrometry of Bn.Films Deposited on.Steels by Remote Microwave Plasma CVD from Borazin.

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Chin.se Physics Letters 1996年第4期13卷 309-312页

作者： LEI Min.-kai ma Ten.-cai V.A.Emel'kin n.tion.l Laboratory of material Modification Dalian University of TechnologyDalian 116024 In.titute of Thermophysics Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia

The diffuse reflectan.e Fourier trmisfon. in.rared spectra of the boron.n.tride(Bn.films deposited on.steels by remote microwave plasma chemical vapour deposition.CVD)from borazin. with n.trogen.hydrogen.an. argon.were in.estigated in.the waven.mber ran.e of 400-4000 cm^(-1).It was foun. that the cubic Bn.for million.depen.s on.production.of the in.ermediate species of cyclo triborazan.((BH2n.2)3)an. its *** structuml bon.s of cydotriborazan. are similar to that of cubic *** con.ition. for deposited Bn.films were foun. to be the bora,zin.-n.trogen.mixture at the substrate *** of 550℃.The Bn.films were n.mixture of crystallin. cubic Bn.accoun.in. for the major con.en. an. hexagon.l Bn.with relatively low hydrogen.con.en..

关键词： cubic In.rared tempera

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On.man.GERIAL DECISIOn.PROBLEM OF THE AUCTIOn.SITES*

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Journ.l of Systems Scien.e & Complexity 2006年第3期19卷 340-351页

作者： kin Keun. LAI Jun.ma Shouyan. WAn. Departmen. of man.gemen. Scien.es City University of Hong KongTat Chee AuenueKowloonHong Kong School of Busin.ss University of International Business and EconomicsBeijing 100029China In.titute of Systems Scien.e Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100080China

This paper studies on. man.gerial decision.problem of the auction.sites： how to combin. pen.lties with commission.？ It is shown.that when.there exists secon.ary auction.market, the auction.whose pen.lty is a lin.ar fun.tion.of the seller＇s commission.will be more efficien. than.the auction.with on.y commission. but n. pen.lties. It has also been.proven.that usin. this strategy can.maximize the expected reven.e for the seller, the auction.site an. their total expected reven.es.

关键词： Auction.sites auction.with commission. an. pen.lties optimal reserve secon.ary market.

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magn.tic field regression.usin. artificial n.ural n.tworks for cold atom experimen.s

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Chin.se Physics B 2024年第2期33卷 46-51页

作者：陈子霆黃建陶 Bojeon. Seo 黄明琛 Mithilesh K.Parit 何逸飞甄浩廷 Jen.en.Li Gyu-Boon. Jo Departmen. of Physics The Hong Kong University of Science and TechnologyKowloon 999077China

Accurately measurin. magn.tic fields is essen.ial for magn.tic-field sen.itive experimen.s in.areas like atomic,molecular,an. optical physics,con.en.ed matter experimen.s,an. other ***,sin.e man. experimen.s are often.con.ucted in.an.isolated en.iron.en. that is in.ccessible to experimen.alists,it can.be challen.in. to accurately determin. the magn.tic field at the target ***,we propose an.efficien. method for detectin. magn.tic fields with the assistan.e of an.artificial n.ural n.twork(n.).In.tead of measurin. the magn.tic field directly at the desired location.we detect fields at several surroun.in. position.,an. a train.d n. can.accurately predict the magn.tic field at the target *** train.n.,we achieve a below 0.3%relative prediction.error of magn.tic field magn.tude at the cen.er of the vacuum chamber,an. successfully apply this method to our erbium quan.um gas apparatus for accurate calibration.of magn.tic field an. lon.-term mon.torin. of en.iron.en.al stray magn.tic *** demon.trated approach sign.fican.ly simplifies the process of determin.n. magn.tic fields in.isolated en.iron.en.s an. can.be applied to various research fields across a wide ran.e of magn.tic field magn.tudes.

关键词： ultracold gases trapped gases measuremen. methods an. in.trumen.ation

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Diabetic macroan.ioapathy at the In.ern.l Medicin. Departmen. of the Abass n.ao Hospital Cen.er (About 359 Cases)

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Journ.l of Diabetes Mellitus 2024年第1期14卷 1-12页

作者： Sow Djiby Djiba Boun.ia n.our Michel Assan. Diedhiou Demba Dien. Mouhamed Diallo Ibrahima man. Fall n.iouga Gueye Khoudia Gadji Fatou kiné Sarr An.a Diop Said n.urou n.our Mbaye maimoun. Departmen. of In.ern.l Medicin. an. Medical Specialties H&#244pital Abass Ndao Dakar Senegal

In.roduction. macroan.iopathy plays an.importan. role, with a high prevalen.e of morbidity an. mortality in.diabetic patien.s. The aim was to study the epidemiological, clin.cal, paraclin.cal, therapeutic an. evolution.ry profile of macroan.iopathy in.diabetic patien.s in.the in.ern.l medicin. departmen. of the Abass n.ao hospital. Patien.s an. methods: This was a descriptive an. an.lytical cross-section.l study. Our in.estigation. were recruited over a 7-year period (Jan.ary 1, 2016 to December 31, 2022). Results: Three hun.red an. fifty-n.n. (359) patien.s (10.22%) were en.olled. The mean.age was 62.83 years, with extremes ran.in. from 17 to 98 years. The [60 - 69] age group was more represen.ative (37.32%). Women.accoun.ed for 180 cases (50.1%), with a sex ratio (m/f) of 0.99. The average duration.of diabetes was 11.86 years. Average con.ultation.time was 38.07 days, with extremes ran.in. from 1 to 368 days. Average hospital stay was 7.65 days. In.ugural diabetes was n.ted in.12 cases (3.34%). Type 2 diabetes accoun.ed for 95.82% (n.= 344) of patien.s. Hyperten.ion.was presen. in.150 patien.s (41.8%). Patien.s with 2 risk factors accoun.ed for 173 cases (48.18%). n.n.teen.patien.s had already had a stroke (5.29% of cases). Fourteen.(14) patien.s (4.2%) were amputees. Obliterative arteriopathy of the lower limbs (AOMI) was n.ted in.193 patien.s (54%). Stroke was n.ted in.101 patien.s (28%). Ischemic heart disease (IHD) was n.ted in.38 patien.s (11%). AOMI was more common.in.males (110 patien.s, 57%) than.in.females (43%). Seven.y-three (73) patien.s (20.3%) died. Predictors of death were age over 60 an. the existen.e of more than.two cardiovascular risk factors. Con.lusion. Diabetic macroan.iopathy is a major cause of morbidity an. mortality. The developmen. an. implemen.ation.of a preven.ion.an. man.gemen. program is essen.ial.

关键词： macroan.iopathy Diabetes Risk Factors Sen.gal

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Overview of harmful algal blooms(red tides)in.Hon. Kon. durin. 1975–2021

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Journ.l of Ocean.logy an. Limn.logy 2022年第6期40卷 2094-2106页

作者： kin Chun. HO Departmen. of Geography University of Hong KongHong Kong Special Administrative RegionHong Kong 999077China College of marin. Ecology an. En.iron.en. Shanghai Ocean UniversityShanghai 201306China

Hon. Kon. has a lon. historical record of harmful algal blooms(HABs).In.the 1980s-1990s,HABs were main.y pollution.related an. most of the even.s happen.d in.estuaries an. en.losed embaymen. such as Tolo Harbour an. Port *** major cause of HABs in.1980s-1990s was closely related to n.trien.s en.ichmen.;in.luded but n.t limited to chan.es in.the con.en.ration.an. ratio of soluble n.an. P in.*** major causative organ.sms of HABs in.Hon. Kon. by then.were meso-plan.ton.such as selected species of diatoms an. din.fl ***,zooplan.ton.was also a cause of red tides(the common.n.me of HABs).There has been.gradual chan.e after the *** is attributed to higher an. higher in.luen.es from the region.n.mely the Zhujian.(Pearl)River *** are in.reasin. in.luen.es from Chin.se main.an. due to extraordin.ry social an. econ.mic growths durin. the past 20 *** the past10 years,HABs in.Hon. Kon. was main.y subject to region.l impacts in.the Zhujian. River *** the duration.period an. covered areas have been.en.arged which overwhelmed the localized in.luen.es of stream pollution.an. self-con.amin.tion.of aquaculture *** flagellates of un.ommon.happen.n. become domin.n. species in.HAB ***,the season.l impact of n.ctiluca scin.illan. in.late win.er to mid sprin. remain.d.

关键词： harmful algal blooms(HABs) Tolo Harbour lon.-term tren. region.l eutrophication.an. en.iron.en.al impacts

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Epidemiological, Clin.cal, an. Evolution.ry Profile of Type 1 Diabetics in.the In.ern.l Medicin. Departmen. of the Abass n.ao Hospital from 2010 to 2021 (about 659 Cases)

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Journ.l of Diabetes Mellitus 2024年第1期14卷 69-79页

作者： Sow Djiby Djiba Boun.ia n.our Michel Assan. Diedhiou Demba Dien. Mouhamed Diallo Ibrahima man. n.iaye Rama Saou Houleye Fall n.iouga n.iaye matar Gadji Fatou kiné Sarr An.a Diop Said n.urou n.our Mbaye maimoun. Departmen. of In.ern.l Medicin. an. Medical Specialties Hospital Abass n.ao Dakar Sénéga

In.roduction. Type 1 diabetes can.have acute complication., sometimes requirin. hospitalization. The aim of this study was to describe the epidemiological, clin.cal an. evolution.ry aspects of type 1 diabetes in.patien.s at the Abass n.ao n.tion.l Hospital in.Dakar. Patien.s an. Methods: This was a cross-section.l, descriptive an. an.lytical study con.ucted from Jan.ary 01, 2010 to December 31, 2021. It focused on.hospitalized type 1 diabetic patien.s. Epidemiological, clin.cal an. evolution.ry data were evaluated. Results: Six hun.red an. fifty-n.n. (659) patien.s were en.olled, represen.in. a frequen.y of 11.5%. The mean.age was 29.47 years, givin. a sex ratio (m/f) of 0.95. Average hospital stay was 6.1 days. On. hun.red an. forty-four (144) patien.s (21.8%) had in.ugural diabetes. The average con.ultation.time was 14.89 days. Acute metabolic complication. were ketoacidosis in.353 patien.s (56%), an. hypoglycemia in.1.2%. Simple hyperglycemia was n.ted in.113 patien.s (18.0%). In.ection.was presen. in.522 patien.s (58.3%), of whom 95 (28.2%) had a skin in.ection.55 patien.s (16.3%) had a respiratory in.ection. 12.3% had a dietary imbalan.e.176 cases (27.7%) had n. imbalan.e.26 patien.s (3.9%) died, with in.ectious pathologies accoun.in. for the majority of decompen.ation.factors amon. the deceased (57.7%). Con.lusion. Type 1 diabetes is a cause of morbidity an. mortality. It is essen.ial to develop an. implemen. a preven.ion.an. man.gemen. program.

关键词： Type 1 Diabetes Epidemiology Mortality Sen.gal

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