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Effects of histamine hlR-h4R-agonist on the airway epithelium of rabbits

Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 367-370页

作者： Naushad A Dilkash Trivendra Tripathi Aijaz Ahmed Khan Mohd Shahid haris M Khan ma.h.atullah siddiqui Rahat Ali Khan Department of Anatomy Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University

Objective:To explore the exact role of histamine receptors in respiratory ***: The cohort comprised of six groups(group I control and groupⅡ—Ⅳtreated) containing five rabbits in each ***-group received vehicle(sterile distilled water) and treated groups received subcutaneous histamine(100μg/kg,b.i.d.),and h1R-agonist(hTMT),h2R-agonist (amthamine),h3R-agonist(R-(-)-α-methylhistamine) and h4R-agonist(clobenpropit) each in a dose of 10μg/kg,*** 30 subsequent *** completion of treatment,animals were euthanized and perfused with 10% buffered *** tissue blocks of trachea and lungs were processed for paraffin *** were recorded in sample photomicrographs taken from 10μm *** and eosin stained ***:It was observed that trachea and bronchi from histamine,h1R and h4R groups had only patches of hyperplastic and hypertrophied epithelium and in general,cells in the affected region were taller heaped up. The bronchiolar epithelia from all treated groups showed hypertrophy and hyperplasia throughout with most of the cells having rounded profile and appeared to bud out from the basal cells. Conclusions:It is concluded that histamine receptors on induction via its specific agonist can induce hypertrophy,hyperplasia of respiratory tract epithelia suggesting its role akin to growth stimulating factor and warranting further long-term study.

关键词： Rabbit Airway epithelium histamine receptors-agonist hyperplasia hypertrophy

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1例Ehlers-danlos VIA患者赖氨酸羟化酶基因新突变致赖氨酸羟化酶活性下降

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世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 20-20页

作者： Walker L.C. Overstreet M.A. siddiqui A. h.N. Yeowell 阎小宁 Duke University Medical Center Box 3135 Durham NC 27710 United States Dr.

The clinical diagnosis of a patient with the phenotype of EhlersDanlos syndrome type VI was confirmed biochemically by the severely diminished level of lysyl hydroxylase (Lh) activity in the patient’s skin fibroblasts. A novel homozygous mutation, a single base change of T1360 →G in exon 13 of the Lh1 gene, predicted to result in W446G, was identified in the patient’s full-length cDNA. This was confirmed in genomic DNA from both the patient and her parents, who were heterozygous for the mutation. This mutation was introduced into an Lh1-pAcGP67 baculoviral construct and expressed, in parallel with normal Lh1, in an insect cell system. The loss of Lh activity in the mutated recombinant construct confirmed the pathogenicity of this mutation. Although not in the major catalytic site, this mutation occurs in a highly conserved region of the Lh1 gene and may contribute to loss of activity by interfering with normal folding of the enzyme.

关键词：赖氨酸羟化酶突变体生化检验保存区纤维母细胞纯合子接触反应重组体临床诊断杆状病毒

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Current systematic reviews and meta-analyses of COVID-19

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World Journal of Virology 2021年第4期10卷 182-208页

作者： mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S siddiqui David Zheng mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam mahmoud Mohamed Ismail Omran mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States Department of Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt(IDCARE)Cairo 11221Outside of the USEgypt Department of Medicine Division of NephrologyUniversity of Tennessee Health Science CenterKnoxville CityTN 38103United States Department of Medical St.George's UniversityWest Indies 38901Grenada Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11221Egypt Department of Oncology Broomfiled HospitalMid and South Essex NHS Foundation TrustESSEXChelmsford 12422United Kingdom Department of Critical Care Unit Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States

BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million *** the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of *** To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be *** We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS *** included studies were extracted from Embase,Medline,and Cochrane *** publication timeframe of included studies ranged between January 01,2020,to October 30,*** that were published in languages other than English were not considered for this systematic *** finalized full-text articles are freely accessible in the public *** Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 *** inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 *** screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and ***,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stro

关键词： Systematic review Meta-analyses COVID-19 Review Coronavirinae

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卒中介入治疗培训指南：国际多学会共识文件

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国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K hoh B Bambakidis N Khalessi AA Woo h Riina h siddiqui A hirsch JA Chong W Rice h Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng hQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A higashi T hirohata M hyodo A Ito Y Kawanishi M Kiyosue h Kobayashi E Kobayashi S Kuwayama N matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi h Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami h Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF heck DV hetts SW hussain MS Klucznik RP Leslie-mawzi TM mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic Neuroradiology (WFITN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive Neurologic Therapy (ESMINT) Nice France Japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Americana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

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