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Food Science and Human Wellness 2024年第5期13卷 2601-2616页

作者： Xiaoli Li Runhui ma Zhijing Ni Wei Wang Kiran Thakur Jianguo Zhang Zhaojun Wei School of Biological Science and Engineering North Minzu UniversityYinchuan 750021China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China School of Public Health Anhui University of Science and TechnologyHuainan 232001China

With an aim to comprehend the precise regulatory mechanism of dioscin against endometrial carcinoma(EC),we firstly extracted the components from Polygonatum sibiricum followed by identification and structural *** anti-EC activity of dioscin was initially determined based on the inhibition of ishikawa cell proliferation and tumor *** high-throughput sequencing data indicated that dioscin not only promoted apoptosis,including decrease of poly ADP-ribose polymerase(PARP)and B-cell lymphoma-2(Bcl-2)and increase of c-PARP and Bcl-2-associcated agonist of cell death(Bad),but also induced autophagy,including increase of autophagic lysosomes and LC3ii/LC3i *** exploration suggested that dioscin induced autophagy and apoptosis through inhibition of Pi3K/AKT/mTOR signaling ***,the dioscin-regulated p53 pathway was mainly involved in autophagy ***,inhibition of ishikawa cell autophagy was linked to dioscin-induced *** data suggest the immense potential of dioscin for the development of functional food for EC and related medical application.

关键词： Dioscin ishikawa cell Apoptosis Autophagy Pi3K/AKT p53

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Liquid metal in prohibiting polysulfides shuttling in metal sulfides anode for sodium-ion batteries

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Journal of Energy Chemistry 2024年第9期96卷 559-567页

作者： Xiaobo Zheng Xinwei Guan Xuan Cheng Xiaoning Li Yang Fu Yitong Li Zhi Zheng Weikong Pang Xun Xu Peng Li Tianyi ma institute for Superconducting&Electronic materials Australian Institute for Innovative MaterialsUniversity of WollongongWollongongNSW 2522Australia School of Science RMIT UniversityMelbourneVIC 3000Australia CSiRO manufacturing ClaytonVIC 3168Australia

Metal sulfides are a class of promising anode materials for sodium-ion batteries(SiBs)owing to their high theoretical specific ***,the reactant products(polysulfides)could dissolve into electrolyte,shuttle across separator,and react with sodium anode,leading to severe capacity loss and safety ***,for the first time,gallium(ga)-based liquid metal(LM)alloy is incorporated with MoS_(2)nanosheets to work as an anode in *** electron-rich,ultrahigh electrical conductivity,and self-healing properties of LM endow the heterostructured MoS_(2)-LM with highly improved conductivity and electrode ***,LM is demonstrated to have excellent capability for the adsorption of polysulfides(e.g.,Na_(2)S,Na_(2)S_(6),and S_(8))and subsequent catalytic conversion of Na_(2)***,the MoS_(2)-LM electrode exhibits superior ion diffusion kinetics and long cycling performance in SiBs and even in lithium/potassium-ion battery(LiB/PiB)systems,far better than those electrodes with conventional binders(polyvinylidene difluoride(PVDF)and sodium carboxymethyl cellulose(CMC)).This work provides a unique material design concept based on ga-based liquid metal alloy for metal sulfide anodes in rechargeable battery systems and beyond.

关键词： galnSn liquid metal alloy MoS_(2) Polysulfides shuttle effects Catalytic conversion Sodium-ion batteries

An unexpected stereochemical effect of thio-substituted Asp in native chemical ligation

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Chinese Chemical Letters 2024年第8期35卷 278-281页

作者： Min Fu Pan He Sen Zhou Wenqiang Liu Bo ma Shiying Shang Yaohao Li Ruihan Wang Zhongping Tan State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Center of Pharmaceutical Technology School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chemical Engineering College Hebei Normal University of Science and TechnologyQinhuangdao 066600China

This study presents an unexpected finding that the cis isomer ofβ-thio-Asp exhibits higher ligation ac-tivity than the trans *** discovery sheds light on the intricate nature of native chemical ligation and highlight... 详细信息

关键词： Native chemical ligation Stereochemistry Ligation activity β-Thio-Asp intramolecular hydrogen bond

Polyphyllin Ⅰ enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth via downregulating the Wnt/β-catenin pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 251-259页

作者： CHANG Junli ZHAO Fulai SUN Xingyuan ma Xiaoping ZHAO Peng ZHOU Chujie SHi Binhao GU Wenchao WANG Yongjun YANG Yanping Spine Disease institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Diagnostic and interventional Radiology University of TsukubaIbaraki 315-0114Japan

OBJECTiVE:To investigate the synergistic effects of polyphyllin Ⅰ(PPⅠ)combined with tumor necrosis factorrelated apoptosis-inducing ligand(TRAiL)on the growth of osteosarcoma cells through downregulating the Wnt/β-catenin signaling ***:Cell viability,apoptosis and cell cycle distribution were examined using cell counting kit-8 and flow cytometry *** morphology of cancer cells was observed with inverted phase contrast *** migration and invasion abilities were examined by xCELLigence real time cell analysis DP system and transwell *** expressions of poly(adenosine diphosphate-ribose)polymerase,C-Myc,Cyclin B1,cyclin-dependent kinases 1,N-cadherin,Vimentin,Active-β-catenin,β-catenin,p-glycogen synthase kinase 3β(GSK-3β)and GSK-3βwere determined by Western blotting ***:PPⅠ sensitized TRAiL-induced decrease of viability,migration and invasion,as well as increase of apoptosis and cell cycle arrest of MG-63 and U-2 OS osteosarcoma *** synergistic effect of PPⅠwith TRAiL in inhibiting the growth of osteosarcoma cells was at least partially realized through the inactivation of Wnt/β-catenin signaling ***:The combination of PPⅠ and TRAiL is potentially a novel treatment strategy of osteosarcoma.

关键词： osteosarcoma tumor necrosis factor-related apoptosis-inducing ligand Wnt signaling pathway beta-catenin polyphyllinⅠ

Regulation effects of water and nitrogen on yield,water,and nitrogen use efficiency of wolfberry

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Journal of Arid Land 2024年第1期16卷 29-45页

作者： gaO Yalin Qi Guangping ma Yanlin YiN Minhua WANG Jinghai WANG Chen TiAN Rongrong XiAO Feng LU Qiang WANG Jianjun College of Water Conservancy and Hydropower Engineering Gansu Agricultural UniversityLanzhou 730070China Jingtaichuan Electric Power irrigation Water Resource Utilization Center in gansu Province Baiyin 730900China

Wolfberry(Lycium barbarum L.)is important for health care and ecological ***,it faces problems of low productivity and resource utilization during *** reasonable models for water and nitrogen management is important for solving these *** on field trials in 2021 and 2022,this study analyzed the effects of controlling soil water and nitrogen application levels on wolfberry height,stem diameter,crown width,yield,and water(WUE)and nitrogen use efficiency(NUE).The upper and lower limits of soil water were controlled by the percentage of soil water content to field water capacity(θ_(f)),and four water levels,i.e.,adequate irrigation(W0,75%-85%θ_(f)),mild water deficit(W1,65%-75%θ_(f)),moderate water deficit(W2,55%-65%θ_(f)),and severe water deficit(W3,45%-55%θ_(f))were used,and three nitrogen application levels,i.e.,no nitrogen(N0,0 kg/hm^(2)),low nitrogen(N1,150 kg/hm^(2)),medium nitrogen(N2,300 kg/hm^(2)),and high nitrogen(N3,450 kg/hm^(2))were *** results showed that irrigation and nitrogen application significantly affected plant height,stem diameter,and crown width of wolfberry at different growth stages(Pir maximum values were observed in W1N2,W0N2,and W1N3 *** weight per plant and yield of wolfberry first increased and then decreased with increasing nitrogen application under the same water *** weight per hundred grains and dry weight percentage increased with increasing nitrogen application under W0 ***,under other water treatments,the values first increased and then decreased with increasing nitrogen *** and its component of wolfberry first increased and then decreased as water deficit increased under the same nitrogen *** water use efficiency(iWUE,8.46 kg/(hm^(2)·mm)),WUE(6.83 kg/(hm^(2)·mm)),partial factor productivity of nitrogen(PFPN,2.56 kg/kg),and NUE(14.29 kg/kg)reached their highest values in W2N2,W1N2,W1N2,and W1N1 treatments.R

关键词： water deficit growth characteristics yield water and nitrogen use efficiency principal component analysis

Hierarchically Structured Nb_(2)O_5 Microflowers with Enhanced Capacity and Fast-Charging Capability for Flexible Planar Sodium ion Micro-Supercapacitors

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Nano-Micro Letters 2024年第4期16卷 97-109页

作者： Jiaxin ma Jieqiong Qin Shuanghao Zheng Yinghua Fu Liping Chi Yaguang Li Cong Dong Bin Li Feifei Xing Haodong Shi Zhong‑Shuai Wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China School of materials Science and Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China College of Science Henan Agricultural UniversityNo.63 Agricultural RoadZhengzhou 450002People’s Republic of China Dalian National Laboratory for Clean Energy Chinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049People’s Republic of China Hebei Key Lab of Optic‑Electronic information and materials The College of Physics Science and TechnologyInstitute of Life Science and Green DevelopmentHebei UniversityBaoding 071002People’s Republic of China

Planar Na ion micro-supercapacitors(NiMSCs) that offer both high energy density and power density are deemed to a promising class of miniaturized power sources for wearable and portable microelectron-ics. Nevertheless, the development of NiMSCs are hugely impeded by the low capacity and sluggish Na ion kinetics in the negative ***, we demonstrate a novel carbon-coated Nb_(2)O_5 microflower with a hierarchical structure composed of vertically intercrossed and porous nanosheets, boosting Na ion storage performance. The unique structural merits, including uniform carbon coating, ultrathin nanosheets and abun-dant pores, endow the Nb_(2)O_5 microflower with highly reversible Na ion storage capacity of 245 mah g^(-1) at 0.25 C and excellent rate *** from high capacity and fast charging of Nb_(2)O_5 microflower, the planar NiMSCs consisted of Nb_(2)O_5 negative electrode and activated car-bon positive electrode deliver high areal energy density of 60.7 μWh cm^(-2),considerable voltage window of 3.5 V and extraordinary cyclability. Therefore, this work exploits a structural design strategy towards electrode materials for application in NiMSCs, holding great promise for flexible microelectronics.

关键词： Nb_(2)O_5 nanosheets Microflowers Sodium ion micro-supercapacitors Flexibility Energy storage

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： TAO Lei DOU Renjie CHEN Xueming CAO Yu DAi Zhen HU Ziyan ma Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (iBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of iBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. in this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eiF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. in conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for iBD.

关键词： Oroxyloside ER stress PPARγ Colitis

Clinical practice guidelines for full-cycle standardized management of bone health in breast cancer patients

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Cancer innovation 2024年第1期3卷 1-28页

作者： Committee of Full-cycle Standardized management of Bone Health in Breast Cancer Patients Fei ma 不详 Department of Medical Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Bone health management for breast cancer spans the entire cycle of patient care,including the prevention and treatment of bone loss caused by early breast cancer treatment,the adjuvant application of bone-modifying agents to improve prognosis,and the diagnosis and treatment of advanced bone *** good bone health management means formulating appropriate treatment strategies and dealing with adverse drug reactions,and will help to improve patients'quality of life and survival *** Breast Cancer Expert Committee of the National Cancer Center for Quality Control organized relevant experts to conduct an in-depth discussion on the full-cycle management of breast cancer bone health based on evidence-based medicine,and put forward reasonable suggestions to guide clinicians to better deal with health issues in bone health clinics.

关键词： bone health bone-modifying drugs breast cancer guidelines

Neutral color and self-healable electrochromic system based on Cui/Cu and i_(3)^(-)/i^(-)conversions

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Nano Research 2024年第5期17卷 4437-4443页

作者： Junsen Zhong Bingkun Huang Kunjie Yang Zuju ma Lingyu Du Ning Luo Fengjiao Tang Chuanxin Hou Fuyi Jiang Litao Kang College of Environment and materials Engineering Yantai UniversityYantai 264005China School of Energy and Power Engineering Shandong UniversityJinan 250061China Shandong Laboratory of Advanced materials and Green manufacturing(Yantai) Yantai 264001China

The electrochromic(EC)mechanisms of inorganic materials are usually based on reversible cation insertion/extraction or metal deposition/dissolution,which are plagued by ion trapping and dendrite growth,*** this paper,a novel conversion-type electrochromic mechanism is proposed,by making good use of the Cui/Cu redox *** Cui-based electrochromic system shows a neutral color switching from transparent and dim *** simply increasing the bleaching voltage,i_(3)^(-)/i^(-)redox couple can be further *** generated i_(3)^(-)will readily react with Cu,effectively improving the conversion reversibility and thereby rejuvenating the degraded electrochromic *** to the well-designed electrode and the self-healing ability,this conversion electrochromic system achieves rapid response times(tcoloring:23 s,tbleaching:6 s),decant optical modulation amplitude(26.4%),high coloration efficiency(86.15 cm^(2)·C^(-1)),admirable cyclic durability(without performance degradation after 480 cycles)and excellent optical memory ability(transmittance variationircuit storage).The establishment of this conversion-type electrochromism may inspire the exploration of novel electrochromic materials and devices.

关键词： electrochromic Cui conversion reaction self-healing neutral color

Electron delocalization-enhanced sulfur reduction kinetics on an MXene-derived heterostructured electrocatalyst

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Nano Research 2024年第8期17卷 7153-7162页

作者： Yunmeng Li Yinze Zuo Xiang Li Yongzheng Zhang Cheng ma Xiaomin Cheng Jian Wang Jitong Wang Hongzhen Lin Licheng Ling State Key Laboratory of Chemical Engineering Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education)East China University of Science and TechnologyShanghai 200237China institute of New Energy materials and Engineering College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Specially Functional Polymeric materials and Related Technology(Ministry of Education) School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China i-Lab&CAS Key Laboratory of Nanophotonic materials and Device Suzhou institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China Helmholtz institute Ulm(HiU) D89081 UlmGermany

Lithium-sulfur(Li-S)batteries mainly rely on the reversible electrochemical reaction of between lithium ions(Li^(+))and sulfur species to achieve energy storage and conversion,therefore,increasing the number of free Li^(+)and improving the Li^(+)diffusion kinetics will effectively enhance the cell ***,Mo-based MXene heterostructure(MoS_(2)@Mo_(2)C)was developed by partial vulcanization of Mo_(2)C MXene,in which the introduction of similar valence S into Mo-based MXene(Mo_(2)C)can create an electron delocalization *** theoretical simulations and electrochemical characterisation,it is demonstrated that the MoS_(2)@Mo_(2)C heterojunction can effectively promote ion desolvation,increase the amount of free Li^(+),and accelerate Li^(+)transport for more efficient polysulfide *** addition,the MoS_(2)@Mo_(2)C material is also capable of accelerating the oxidation and reduction of polysulfides through its sufficient defects and vacancies to further enhance the catalytic ***,the Li-S battery with the designed MoS_(2)@Mo_(2)C electrocatalyst performed for 500 cycles at 1 C and still maintained the ideal capacity(664.7 mah·g^(−1)),and excellent rate performance(567.6 mah·g^(−1)at 5 C).Under the extreme conditions of high loading,the cell maintained an excellent capacity of 775.6 mah·g^(−1)after 100 *** also retained 838.4 mah·g^(−1)for 70 cycles at a low temperature of 0℃,and demonstrated a low decay rate(0.063%).These results indicate that the delocalized electrons effectively accelerate the catalytic conversion of lithium polysulfide,which is more practical for enhancing the behaviour of Li-S batteries.

关键词： delocalized electron lithium sulfur batteries MXene-based heterostructures catalytic desolvation multi-catalytic sites