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Supplementation of alanine improves biomass accumulation and lipid production of Chlorella pyrenoidosa by increasing the respiratory and metabolic processes

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Journal of Oceanology and limnology 2024年第2期42卷 570-579页

作者： Yongfu lI Tianze ZHAO Wei SUN Ruiwen GAO Guangyuan ma Jiangsu Province Engineering Research Center for marine Bioresources Sustainable Utilization Key Laboratory of Marine Hazards ForecastingMinistry of Natural ResourcesHohai UniversityNanjing 210098China College of Oceanography Hohai UniversityNanjing 210098China Jiangsu Innovation Center of marine Bioresources Jiangsu Coast Development Group Co.Ltd.Nanjing 210019China

The function of exogenous alanine(Ala)in regulating biomass accumulation,lipid production,photosynthesis,and respiration in Chlorella pyrenoidosa was *** shows that the supplementation of Ala increased *** biomass and lipid production in an 8-d batch *** concentration of 10 mmol/l of Ala was optimum and increased the microalgal cell biomass and lipid content by 39.3%and 21.4%,respectively,compared with that in the control(0-mmol/l Ala).Ala supplementation reduced photosynthetic activity while boosting respiratory activity and pyruvate levels,indicating that *** used exogenous Ala for biomass accumulation through the respiratory metabolic *** accelerated respiratory metabolism due to Ala supplementation elevated the substrate pool and improved the lipogenic gene expression,promoting lipid production at *** study provided a novel method for increasing biomass accumulation and lipid production and elucidated the role of Ala in regulating lipid production.

关键词： alanine Chlorella pyrenoidosa lipid respiration lipogenic gene

Advances in the research and application of neurokinin-1 receptor antagonists

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 91-105页

作者： Xiangyu HONG Junjie ma Shanshan ZHENG Guangyu ZHAO Caiyun FU College of life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou310018China

Recently,the substance P(SP)/neurokinin-1 receptor(NK-1R)system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019(COVId-19).Besides,studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical *** findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential broad-spectrum antitumor *** review updates the latest potential and applications of NK-1R antagonists in the treatment of human diseases and cancers,as well as the underlying ***,the strategies to improve the bioavailability and efficacy of NK-1R antagonist drugs are summarized,such as solid dispersion systems,nanonization,and *** a radiopharmaceutical therapeutic,the NK-1R antagonist aprepitant was originally developed as radioligand receptor to target NK-1R-overexpressing ***,combining NK-1R antagonists with other drugs can produce a synergistic effect,thereby enhancing the therapeutic effect,alleviating the symptoms,and improving patients’quality of life in several diseases and cancers.

关键词： Neurokinin-1 receptor(NK-1R)antagonist Pathophysiological disorder Tumor target Bioavailability Nanoencapsulation Synergistic therapy

Universal insertion of molecules in ionic compounds under pressure

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National Science Review 2024年第1期11卷 120-128页

作者： Feng Peng Yanming ma Chris J.Pickard Hanyu liu maosheng Miao College of Physics and Electronic Information Luoyang Normal University department of Chemistry and Biochemistry California State University Northridge State Key laboratory of Superhard materials & Key laboratory of material Simulation Methods and Software of Ministry of Education College of Physics Jilin University International Center of Future Science Jilin University department of materials Science & Metallurgy University of Cambridge Advanced Institute for materials Research Tohoku University department of Earth Science University of California Santa Barbara

Using first-principles calculations and crystal structure search methods, we found that many covalently bonded molecules such as H2, N2, CO2, NH3, H2O and CH4may react with NaC l, a prototype ionic solid,and form stable compounds under pressure while retaining their molecular structure. These molecules,despite whether they are homonuclear or heteronuclear, polar or non-polar, small or large, do not show strong chemical interactions with surrounding Na and Cl ions. In contrast, the most stable molecule among all examples, N2, is found to transform into cyclo-N5-anions while reacting with NaC l under high pressures. It provides a new route to synthesize pentazolates, which are promising green energy materials with high energy density. Our work demonstrates a unique and universal hybridization propensity of covalently bonded molecules and solid compounds under pressure. This surprising miscibility suggests possible mixing regions between the molecular and rock layers in the interiors of large planets.

关键词： molecule-solid hybrid materials high-pressure crystal structure prediction density functional theory planet interior

Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers

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Journal of Environmental Sciences 2024年第3期137卷 181-194页

作者： Yuqing ma Bo Wang Xiaodi li Shuo Wang Wen Wang Yongzhen Peng National Engineering laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China

Anammox is widely considered as the most cost-effective and sustainable process for nitrogen ***,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater *** this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of *** using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 *** long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,*** eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/l and the nitrogen removal efficiency being 90.5%in Phase *** in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and ***,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial ***,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment.

关键词： Enrichment Anammox biomass Bio-carriers Partial denitrification mainstream wastewater

In-situ construction of PdOl electrolyte with dual-reinforced stable interface for high-voltage lithium metal batteries

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Science China Chemistry 2024年第5期67卷 1664-1671页

作者： Yingkang Wu Yuzhou Bai Wujie dong Xue Wang Wenqin ma Fuqiang Huang State Key lab of Metal matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China

In-situ polymerized electrolytes significantly enhance the interfacial compatibility of lithium metal batteries(lMBs). Typically,in-situ polymerized 1,3-dioxolane(PdOl) exhibits low interfacial resistance, yet still suffers from low ionic conductivity and a narrow electrochemical stability window(ESW). Here, an ultra-stable PdOl-based polymer electrolyte is developed by incorporating plasticizers of tetramethylene sulfone(TMS) and fluorinated ethylene carbonate(FEC) into the 3d cross-linked network, achieving a significant enhancement in the transport capacity and efficiency of li-ion. The ionic conductivity reaches3.63×10^(-4)S cm^(-1)even at room temperature, and the transference number(tli^(+)) is even higher at 0.85. Furthermore, the ESW of this electrolyte can be increased to 4.5 V with the addition of TMS, which forms a thin and robust antioxidant cathode-electrolyte interface(CEI) on the surface of high-voltage liCoO_(2). FEC generates an inorganic-rich solid-electrolyte interface(SEI) on the li anode, which effectively inhibits the growth of lithium dendrites. Benefiting from the aforementioned advantages, the highvoltage lithium metal battery demonstrates outstanding long-cycle stability, with 93.2% capacity retention after 200 cycles. This work offers a straightforward and accessible method for the practical implementation of high energy density in-situ polymerized solid-state lMBs.

关键词： solid polymer electrolyte in-situ polymerization PdOl high-voltage lMBs

A Self-sensing TSA-actuated Anthropomorphic Robot Hand

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Journal of Bionic Engineering 2024年第3期21卷 1174-1190页

作者： Chanchan Xu Shuai dong Yifan ma Jingwei Zhan Yucheng Wang Xiaojie Wang Institute of Intelligent machines Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China CAS Key laboratory of Mechanical Behavior and design of materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei230026China Institutes of Physical Science and Information Technology Anhui UniversityHefei230601China

This paper introduces a self-sensing anthropomorphic robot hand driven by Twisted String Actuators(TSAs).The use of TSAs provides several advantages such as muscle-like structures,high transmission ratios,large output forces,high efficiency,compactness,inherent compliance,and the ability to transmit power over ***,conventional sensors used in TSA-actuated robotic hands increase stiffness,mass,volume,and complexity,making feedback control *** address this issue,a novel self-sensing approach is proposed using strain-sensing string based on Conductive Polymer Composite(CPC).By measuring the resistance changes in the strain-sensing string,the bending angle of the robot hand's fingers can be estimated,enabling closed-loop control without external *** developed self-sensing anthropomorphic robot hand comprises a 3d-printed structure with five fingers,a palm,five self-sensing TSAs,and a 3d-printed *** studies validate the self-sensing properties of the TSA and the anthropomorphic robot ***,a real-time Virtual Reality(VR)monitoring system is implemented for visualizing and monitoring the robot hand's movements using its self-sensing *** research contributes valuable insights and advancements to the field of intelligent prosthetics and robotic end grippers.

关键词： Anthropomorphic robot hand Twisted string actuator Self-sensing Conductive polymer composite Virtual reality monitoring

An approach for formation design and flight performance prediction based on aerodynamic formation unit:Energy-saving considerations

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Chinese Journal of Aeronautics 2024年第3期37卷 77-91页

作者： Nanxuan QIAO Tielin ma Xiangsheng WANG Jie WANG Jingcheng FU Pu XUE School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Institute of Unmanned System Beihang UniversityBeijing 100191China Key laboratory of Advanced Technology of Intelligent Unmanned Flight System Ministry of Industry and Information TechnologyBeijing 100191China School of Transportation Science and Engineering Beihang UniversityBeijing 102206China Beijing Institute of Space long march Vehicle Beijing 100076China

The performance improvement of swarm drones through aerodynamic shape optimization may be challenging due to folded size constraints imposed by the specific launch ***,fixed-wing aircraft swarms can benefit from formation flight in terms of energy *** study introduces the concept of the"aerodynamic formation unit",which consists of two or three aircraft that form an inseparable unit of the *** the Unmanned Aerial Vehicle(UAV)distribution and wingtip vortex interference in the formation,two typical aerodynamic formation units are optimized by the variable-fidelity aerodynamic optimization method based on space *** aerodynamic characteristics of the formation UAVs that affect flight performance,such as lift-to-drag ratio(l/d ratio)and static stability are analyzed by Computational Fluid dynamics(CFd)*** l/d ratio(cruising condition)of the following aircraft can be increased by 22.8%and 57.5%in the optimal units that involve two and three aircraft ***,this study conducts several CFd simulations for multi-aircraft formations formed by the units,which show that the average l/d ratio of the formation can be improved by more than 19%.These results verify the feasibility and effectiveness of the"aerodynamic formation unit"concept and the optimization framework for formation parameters.

关键词： Formation flight CFd Aerodynamic formation unit Wingtip vortices Foldable tandem-wing aircraft

Formation mechanism of Fe-based amorphous powders produced by spark erosion

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Journal of materials Science & Technology 2024年第3期170卷 33-46页

作者： Chekai liu Ran li Jiazi Bi ding ma Xiaobin liu Tao Zhang School of materials Science and Engineering Key Laboratory of Aerospace Materials and Performance(Ministry of Education)Beihang UniversityBeijing 100191China

Spark erosion is a convenient,flexible,and low-cost method to quickly produce fine powders of metals,alloys,and semiconductors in size ranging from nearly a hundred micrometers to submicrometer by repetitive spark *** to the complexity of the powder-forming journey,normally accompanied by high temperature,high pressure,decomposition,diffusion and rapid quenching caused by discharge plasma,the mechanisms of powder formation and possible contaminant infiltration are still controversial,posing a significant challenge to control particle size and chemical composition of the powder produced by this *** this study,Fe-based amorphous powders in different particle-size distributions with high sphericity were fabricated by spark erosion under different discharge-energy *** max-imum particle size of the resultant powders can be correlated with discharge parameters,crater depth,and crater radius,respectively.A multi-ring-breakup model is proposed to reveal the particle-size distribution of the powder formed from the electrode melt under a single-pulse ***,a dielectric-element infiltration model is provided to quantitatively evaluate the infiltration mass ratio of the contaminant elements,stemming from the decomposed products of dielectric liquid,in the resultant powder with different particle *** models verified through the experimental data are significant for the development of high-performance fine Fe-based amorphous powder with controlled particle size and chemical composition.

关键词： Amorphous alloy Particle Spark erosion Infiltration Modeling

Three-dimensional breast cancer tumor models based on natural hydrogels:a review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 736-755页

作者： Yan SHU Bing lI Hailin ma Jiaqi lIU Yuen Yee CHENG Xiangqin lI Tianqing lIU Chuwei YANG Xiao ma Kedong SONG State Key laboratory of Fine Chemicals Dalian R&D Center for Stem Cell and Tissue EngineeringDalian University of TechnologyDalian116024China Institute for Biomedical materials and devices Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia Emergency Center The Second Hospital of Dalian Medical UniversityDalian116023China department of Anesthesia The First Affiliated Hospital of Dalian Medical UniversityDalian116011China

Breast cancer is the most common cancer in women and one of the d.a.l.est cancers *** to the distribution of tumor tissue,breast cancer can be divided into invasive and non-invasive *** cancer cells in invasive breast cancer pass through the breast and through the immune system or systemic circulation to different parts of the body,forming metastatic breast *** resistance and distant metastasis are the main causes of death from breast *** on breast cancer has attracted extensive attention from *** vitro construction of tumor models by tissue engineering methods is a common tool for studying cancer mechanisms and anticancer drug *** tumor microenvironment consists of cancer cells and various types of stromal cells,including fibroblasts,endothelial cells,mesenchymal cells,and immune cells embedded in the extracellular *** extracellular matrix contains fibrin proteins(such as types Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅵ,and Ⅹ collagen and elastin)and glycoproteins(such as proteoglycan,laminin,and fibronectin),which are involved in cell signaling and binding of growth *** current traditional two-dimensional(2d)tumor models are limited by the growth environment and often cannot accurately reproduce the heterogeneity and complexity of tumor tissues in ***,in recent years,research on three-dimensional(3d)tumor models has grad.a.l. increased,especially 3d bioprinting models with high precision and *** with a 2d model,the 3d environment can better simulate the complex extracellular matrix components and structures in the tumor ***-dimensional models are often used as a bridge between 2d cellular level experiments and animal *** matrix,gelatin,sodium alginate,and other natural materials are widely used in the construction of tumor models because of their excellent biocompatibility and non-immune ***,we review various natural scaffold materials and con

关键词： Breast cancer Tumor microenvironment 3d tumor model decellularized extracellular matrix Natural scaffold materials