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Assessment of Some Secondary Metabolites, Minerals and Alcohol Content of Noni Juice Obtained by Fermentation of Morinda citrifolia L. Fruit from Senegal

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American Journal of Plant Sciences 2024年第7期15卷 577-588页

作者： Ndèye Adiara Ndiaye ma.e ndew mba.e Lahat Niang Modou Dieng Nicolas Cyrille Ayessou Ndeye Coumba Kane Touré Laboratory of Microbiology Graduate School Polytechnique (ESP)-UCAD Dakar Senegal Department of Chemical engineering and Applied Biology Graduate School Polytechnique (ESP)-UCAD Dakar Senegal Water Energy Environment and Industrial Processes Laboratory (LE3PI) Graduate School Polytechnique (ESP)-UCAD Dakar Senegal University Sine Saloum el Hadj Ibrahima Niass (USSeIN) Kaolack Senegal

The fruit of Morinda citrifolia L., commonly known as noni, has an extensive history of use as a food and traditional medicine around the world. Adding value to Morinda citrifolia L. products, particularly the fruit, could be one way of building resilience in vulnerable farming households. The aim of this study was to determine the secondary metabolite and mineral composition of noni juice obtained by fermenting the fruit of Morinda citrifolia L. Fruits were collected in August 2022 from the local field in Thiès region, West of Senegal. extraction yields were determined and the secondary metabolites were determined using conventional analytical methods. Calcium, magnesium, iron, sodium and potassium were determined by atomic absorption spectrophotometer coupled with a CCD detector. The results show that an average fruit mass (503.2 ± 110.96 g) consists of 171.44 ± 50.01 g pulp and 34.06 ± 10.35 g seeds. The traditional extraction yield of noni juice is 16.46% after three weeks of fermentation. The contents of total polyphenols, flavonoids and tannins obtained in noni are 608.97 ± 4.53 mg eAG/100mL, 7.78 ± 0.01 mg eQ/100mL and 0.191 ± 0.01 mg eC/100mL respectively. The ethanol content of noni varies from 3.57 to 5.23 mL/100mL during extraction. Noni has a high calcium content with a concentration of 383.79 ± 33.23 mg/L. This is followed by a good concentration of magnesium, potassium and sodium, at 278.47 ± 26.30, 187.43 ± 10.7 and 155.95 ± 28.66 mg/L respectively. Noni also has an iron content of 202.15 ± 0.05 mg/L.

关键词： Morinda citrifolia L. Juice Alcohol Total Phenols Flavonoids Tannins Minerals

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Button Cell Ingestion in Infants: A Report of Five Cases

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Journal of Biosciences and Medicines 2024年第8期12卷 199-209页

作者： Mbène Fall Aminata Diop Nakoulima Khadija Fall Alice Ingabiré Goumba ma.e Aïta Seck Tagouthie Niang madawase Mboup ma.e Diarra mbacké Ibrahima Diallo Meissa ndew Seye Department of Pediatrics Dakar Principal Hospital Dakar Senegal Department of Surgery Dakar Principal Hospital Dakar Senegal Department of Medecine Dakar Principal Hospital Dakar Senegal

Button cell ingestion is a common household accident among infants, often leading to serious complications that require immediate diagnosis and urgent removal. We report five cases of button cell ingestion involving infants aged between 9 and 32 months, including four boys and one girl. The ingestion was accidentally discovered in two infants, while in the other three, it was suspected during play. In three cases, mothers attempted to induce vomiting by giving fluids, but the batteries remained in the digestive tract for 38 hours to 5 days. After confirming the diagnosis, the batteries were removed within 4 to 36 hours. The locations of the cells were the esophagus in two cases, the cardia in one, the stomach in one, and the bowel in one. One case involved a large cell in the esophagus, while the others involved smaller cells. Complications occurred in four cases, including esotracheal fistula, esophageal ulceration, and perforation of the jejunum and caecum. In one case, the digestive mucosa appeared normal upon endoscopy. One patient died.

关键词： Button Cell Domestic Accident Infant

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Assessment of Some Secondary Metabolites, Minerals and Alcohol Content of Noni Juice Obtained by Fermentation of Morinda citrifolia L. Fruit from Senegal

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American Journal of Plant Sciences（美国植物学期刊） 2024年第7期 577页

作者： Ndèye Adiara Ndiaye ma.e ndew mba.e Lahat Niang Modou Dieng Nicolas Cyrille Ayessou Ndeye Coumba Kane Touré

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management and ma.ernal-Fetal Prognosis of Placental Abruption: A Retrospective Study of 130 Cases

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Open Journal of Obstetrics and Gynecology 2022年第7期12卷 590-598页

作者： Papa malick Ngom Faye marie edouard Gaye Yaye Fatou Sylla mafing Aya Tine marguerite ndew Inzale Mohamed Amine Bentaleb Hajar Fall Khadidja Koné madjiguène Fall Mouhamadou mansour Department of Obstetrics Gynecology Dakar Principal Hospital Dakar Sénégal Gynecological and Obstetrical Clinic Hopital Aristide Le Dantec Dakar Sénégal Department of Neonatology Dakar Principal Hospital Dakar Sénégal Department of Anesthesia Dakar Principal Hospital Dakar Sénégal Resuscitation Service Dakar Principal Hospital Dakar Sénégal

Objective: To describe the epidemiological, clinical and prognostic factors and assess treatment of placental abruption in the obstetrics gynecology department of the Dakar Principal Hospital. Patients and Method: We carried out a retrospective observational study of 130 successive cases of placental abruption, which occurred from January 2015 to December 2017 at the Level 3 ma.ernity Unit of the Dakar Principal Hospital. Data were collected from non-computerized obstetric records and analyzed using excel and epi info software. Results: There were 130 cases of placental abruption, that is a prevalence of 1.5%. The average age of onset of placental abruption was 30 years. The history of hypertension concerned 32.3% of patients, the average gestational age of 32.5 weeks at the time of diagnosis, grade 3 of Sher was found in 48.5% of cases. The outcome of the pregnancy was a caesarean section in 79.2% of cases, the average weight of newborns was 2058 g. The management of the complications required a blood transfusion and intensive care. A haemostasis hysterectomy was performed in 6.2% of cases. Stillbirth rate was 53.7% and ma.ernal mortality was zero. Discussion and Conclusion: Placental abruption, a severe complication of pregnancy, is associated with high perinatal morbidity and mortality linked to the severity of the clinical picture, despite an improved ma.ernal prognosis.

关键词： Placental Abruption Perinatal Mortality ma.ernal Morbidity

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Neonatal Thrombocytopenia at Dakar Principal Hospital

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Advances in Infectious Diseases 2023年第4期13卷 586-595页

作者： Guèye mamadou Wagué Fall Khadija Gadji macoura Diawara Papa Silman Ndoye maguette Nakoulima Aminata Diop Daffé Sokhna Moumi mbacké Ngom Mor Fall Mbène Niang Tagouthie Seye Meissa ndew Fall Bécaye Laboratory Federation Dakar Principal Hospital (DPH) Dakar Senegal Pediatrics Department Dakar Principal Hospital Dakar Senegal Biological Hematology and Oncological Hematology Department (BHOH) National Blood Transfusion Centre (CNTS)/FMPOS Cheikh Anta Diop University Dakar Senegal

Neonatal thrombocytopenia accounts for 20% of neonates hospitalized in the neonatal intensive care unit (NICU) at DPH. The etiologies are multiple, but bacterial infection is the third leading cause of neonatal mortality worldwide. We therefore set out to assess the frequency of neonatal thrombocytopenia associated or not with bacterial infection in the NICU. We conducted a retrospective and prospective study with the DPH NICU, over 10 months (August 2018 and April 2019). Thrombocytopenia encountered in the NICUs, were the subject of research into bacteriological, inflammatory, and epidemiological parameters using Inlog laboratory data processing software. During this period, 1280 babies were hospitalized, 94 of whom underwent thrombocytopenia, corresponding to 7.34%, with a sex ratio of 0.92. The number of babies presenting with thrombocytopenia during the first week of hospitalization was 72, accounting for 76.6%. The clinical context was usually low birth weight in 30.8% of cases and perinatal asphyxia (25%). Thrombocytopenia ranged from 2000 to 137,000 with an average of 69,520/mm3. Among these thrombocytopenias, 64 cases (68%) were below 100,000 mm3 and 44 cases had a CRP >5 mg/l. A total of 30 bacteria were isolated, including 23 enterobacteria, 2 Streptococci, and 1 Acinetobacter. Among these enterobacteria, 14 were multidrug-resistant (MDR). Thrombocytopenia associated with a multidrug-resistant bacterial infection is a real challenging management.

关键词： Neonatal Thrombocytopenia Bacterial Infection enterobacteria Newborns

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Bacteremia in Subjects with Sickle Cell Disease: High Rate of Gram-Negative Isolates in the West African Context!

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Journal of Biosciences and Medicines 2023年第2期11卷 15-29页

作者： Papa Silman Diawara Sokhna Moumy Daffe mamadou Wague Gueye Khadija Fall Moustapha Diop Aminata Diop Nakoulima Tagoutie Niang Mbene Fall Alice Ingabire Mor Ngom maguette Ndoye Nata Dieng Bécaye Fall macoura Gadji Meissa ndew Seye Pape Samba Ba Yankhoba Diop Federation of Laboratories Dakar Principal Hospital Dakar Senegal Pediatrics Department Dakar Principal Hospital Dakar Senegal Infectious Diseases Department Dakar Principal Hospital Dakar Senegal Hematology Department Dakar Principal Hospital Dakar Senegal Department of Biological Hematology & Oncology-Hematology (HBOH) National Blood Transfusion Center (CNTS)/FMPOS-UCAD Dakar Senegal

Background: Sickle cell disease is one of the most common monogenic diseases in the world, affecting approxima.ely 70 million people, 80% in sub-Saharan Africa and 1 in 10 in Senegal. Sickle cell anemia causes functional asplenia (associated with repeated thrombosis of splenic vessels), resulting in increased susceptibility to infection. However, several studies have reported differences in the spectrum of bacterial infections in malaria-endemic areas. Therefore, we proposed to conduct a study to determine the rate of positive blood cultures and the bacteriological spectrum in sickle cell patients. ma.erials and Method: This is a descriptive cross-sectional study of blood culture samples from patients who received a request for hemoglobin electrophoresis as part of their treatment at the Principal’s hospital in Dakar. The study took place from January 2008 to December 2021. For each patient, we collect demographic information, including age, gender, and the service from which the analysis request originated. Data were collected in the laboratory’s computer system and entered into Microsoft excel (2007). Statistical analyzes were performed using epi-Info 7 software. Results: Our study included 1419 patients. The most common types of hemoglobin profiles were: normal profile (n = 1025), AS profile (n = 283), SS profile (n = 104), SC profile (n = 7). This corresponds to the proportions of 72%, 20%, 0.5% and 7.5% for the profiles Normal, AS, SC and SS. The ma.e proportion was 61.1%, 61.5%, 57.1, respectively %, 55.8% for Normal, SA, SC, and SS profiles. A total of 19,090 individual blood culture bottles were collected from 1419 impatient patients as follows: Normal profile (n = 18,042 bottles), AS profile (n = 677 culture bottles), SS profile (n = 362 bottles). The majority of blood culture orders come from pediatric services, accounting for 70% of the total number of orders. Of 19,090 vials examined in this current study, 19.6% developed a positive blood culture. Overal

关键词： Sickle Cell Disease Senegal Bacteremia Blood Culture Infection

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Neonatal Thrombocytopenia at Dakar Principal Hospital

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Advances in Infectious Diseases（传染病进展） 2023年第4期

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