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Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim maíra Benchimol Danielle Storck-Tonon Anderson S.Bueno Isabel l.Jones Gilmar Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOlIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams landbridge local extinctions Species-area relationships Species diversity Tropical forests

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legacy of herbicides in water from Hailun City,Northeast China:Occurrence,source,and ecological risk assessment

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Journal of Environmental Sciences 2024年第11期145卷 50-63页

作者： Jun ma Wenjie Ren Hongzhe Wang Jiayin Song Junfeng Jia Hong Chen Changyin Tan Ying Teng School of Geographic Sciences Hunan Normal UniversityChangsha 410081China Key laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China College of materials and Chemistry Tongren UniversityTongren 554300China

Herbicides(HBCs)are extensively used in modern ***,their potential negative impacts on environmental media have emerged as a significant environmental *** this study,we employed positivematrix factorization(PMF)to identify the potential sources of ***,we utilized amulti-matrix ecological riskmodel to assess the risks associated with HBCs in both surface water and groundwater in the black soil region of Northeast *** findings revealed that the levels of15HBCs in surface water and groundwater ranged from585.84 to 6466.96 ng/l and 4.80 to 11,774.64 ng/l,*** PMF results indicated that surface runoff and erosion accounted for 50%of the total HBCs in water,serving as the primary *** tested HBCs exhibited acute risk values within acceptable *** risk index for the∑15HBCs was categorized as“moderate risk”in 31%of the surface waters and 13%of the ***,4%of the groundwater sampling sites reached the“high risk”*** chronic risk quotient of∑15HBCs in surface water and groundwater was 92%and 62%at the“high risk”level,***,noncarcinogenic HBCs contributed more significantly to the ecotoxicology of the aquatic system than carcinogenic *** study provides comprehensive information on the legacy of HBCs in water bodies and emphasizes the potential risks posed by HBCs to aquatic *** results obtained from this study could help relevant management authorities in developing and implementing effective regulations tomitigate the ecological and environmental risks associated with HBCs.

关键词： Herbicide Surface and groundwater Source apportionment Ecological risk assessment

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THE WEIGHTED KATO SQUARE ROOT PROBlEMOF EllIPTIC OPEraTORS HAVING A BMOANTI-SYMMETRICPART

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Acta mathematica Scientia 2024年第2期44卷 532-550页

作者：马文贤杨四辈 School of mathematics and Statistics Gansu Key Laboratory of Applied Mathematics and Complex SystemsLanzhou UniversityLanzhou730000China

let n≥2 and let l be a second-order elliptic operator of divergence form with coefficients consisting of both an elliptic symmetric part and a BMO anti-symmetric part in ℝ^(n).In this article,we consider the weighted Kato square root problem for *** precisely,we prove that the square root l^(1/2)satisfies the weighted l^(p)estimates||l^(1/2)(f)||l_(ω)^p(R^(n))≤C||■f||l_(ω)^p(R^(n);R^(n))for any p∈(1,∞)andω∈Ap(ℝ^(n))(the class of Muckenhoupt weights),and that||■f||l_(ω)^p(R^(n);R^(n))≤C||l^(1/2)(f)||l_(ω)^p(R^(n))for any p∈(1,2+ε)andω∈Ap(ℝ^(n))∩RH_(2+ε/p),(R^(n))(the class of reverse Hölder weights),whereε∈(0,∞)is a constant depending only on n and the operator l,and where(2+ε/p)'denotes the Hölder conjugate exponent of 2+ε/***,for any given q∈(2,∞),we give a sufficient condition to obtain that||■f||l_(ω)^p(R^(n);R^(n))≤C||l^(1/2)(f)||l_(ω)^p(R^(n))for any p∈(1,q)andω∈A_(p)(R^(n))∩pRH_(q/p),(R^(n)).As an application,we prove that when the coefficient matrix A that appears in l satisfies the small BMO condition,the Riesz transform∇l^(−1/2)is bounded on l_(ω)^(p)(ℝ^(n))for any given p∈(1,∞)andω∈Ap(ℝ^(n)).Furthermore,applications to the weighted l^(2)-regularity problem with the Dirichlet or the Neumann boundary condition are also given.

关键词： elliptic operator Kato square root problem Muckenhoupt weight Riesz transform reverse Hölder inequality

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Effect of Different Morphologies Induced by Solvent on ZIF-67 Derived Co@NC for Catalytic Phenol Hydrogenation

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分子催化（中英文） 2024年第5期38卷 399-408,I0001页

作者： WANG Dong-wei ma Zhan-wei lI Jing FENG Hu-lin HU Bin State Key laboratory of low Carbon Catalysis and Carbon Dioxide Utilization State Key Laboratory for Oxo Synthesis and Selective OxidationLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Fujian Zijin Mining and Metallurgy Testing Technology Co. Ltd.Longyan364200China

The Co@NC catalysts with different morphologies were prepared by two step process,solvent control growth and pyrolysis *** polyhedral Co@NC-67P-450 catalyst has a relatively high CoNx content and exhibits excellent phenol hydrogenation activity(conversion 96.9%)at 160℃,3 MPa,which is higher than that of leaf shaped Co@NC-67l-450 catalyst(conversion 75.4%).We demonstrated Co_(3)O_(4)was reduced to the Co^(0)during the ***,CoNx species contribute to the superior hydrogenation activity of *** Co-based catalysts can be easily recovered through the magnetic separation and performed the high stability.

关键词： metal organic frameworks Co-based catalyst morphology phenol hydrogenation

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Cancer immunotherapy with envelopedself-amplifying mRNA CARG-2020 thatmodulates Il-12,Il-17 and PD-l1 pathways toprevent tumor recurrence

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Acta Pharmaceutica Sinica B 2024年第1期14卷 335-349页

作者： Ju Chen Bhaskara Reddy madina Elham Ahmadi Timur Olegovich Yarovinsky marie marthe Krady Eileen Victoria Meehan Isabella China Wang Xiaoyang Ye Elise Pitmon Xian-Yong ma Bijan Almassian Valerian Nakaar Kepeng Wang Department of Immunology School of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA CaroGen Corporation FarmingtonCT 06030USA The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine Foshan Hospital of Traditional Chinese MedicineFoshan 528000China The loomis Chaffee School WindsorCT 06095USA

Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for ***,we describe the application of virus-like vesicles(VlV)for delivery of three immunomodulators alone and in combination,as a promising approach for cancer *** vectors were designed to deliver single chain interleukin(Il)-12,shorthairpin RNA(shRNA)targeting programmed death ligand 1(PD-l1),and a dominant-negative form of Il-17 receptor A(dn-Il17ra)as a single payload or as a combination *** delivery of the VlV vector expressing Il-12 alone,as well as the trivalent vector(designated CARG-2020)eradicated large established ***,only CARG-2020 prevented tumor recurrence and provided long-term survival benefit to the tumor-bearing mice,indicating a benefit of the combined *** abscopal effects of CARG-2020 on the non-injected contralateral tumors,as well as protection from the tumor cell re-challenge,suggest immune-mediated mechanism of protection and establishment of immunological ***,CARG-2020 potently activates Th1 immune mechanisms and inhibits expression of genes related to T cell exhaustion and cancer-promoting *** ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy.

关键词： Virus-like vesicles Oncolytic virus Il-12 Il-17 PD-l1 T cell exhaustion Combination therapy Cancer immunotherapy

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定量评估东亚地区植被对大气变率的反馈

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高原气象 2024年第5期43卷 1234-1248页

作者：马迪吕世华孟宪红赵林李照国马媛媛李美霞中国科学院西北生态环境资源研究院冰冻圈科学与冻土工程重点实验室甘肃兰州730000 成都信息工程大学大气科学学院/高原大气与环境四川省重点实验室四川成都610225 内蒙古乌兰察布市集宁区园林环卫服务中心内蒙古乌兰察布012000

利用统计方法分析了东亚地区植被与大气变率之间的相互关系,并利用平衡反馈分析法(EFA)定量评估了植被对大气的反馈程度。研究发现植被与温度和降水均有明显的相关性,在中高纬度地区植被与温度呈明显的同期正相关,植被与降水存在负相关... 详细信息

利用统计方法分析了东亚地区植被与大气变率之间的相互关系,并利用平衡反馈分析法(EFA)定量评估了植被对大气的反馈程度。研究发现植被与温度和降水均有明显的相关性,在中高纬度地区植被与温度呈明显的同期正相关,植被与降水存在负相关关系。而在中低纬地区植被与降水呈同期正相关,植被与气温呈负相关关系。前期中高纬度植被增加后,会导致后期异常升温。这是由于前期植被覆盖度增加后会遮挡地表积雪,导致地表积雪覆盖度减少,反射率减少,地表吸收更多的太阳辐射,导致异常升温。超前的降水对植被的影响在中低纬度十分明显,这是由于中低纬度地区年平均温度较高,降水是制约植被生长的主要因素。当植被超前降水一个月时,中低纬度地区植被与降水呈正相关,其原因是植被增加会导致局地水汽辐合,蒸发/蒸腾增加,导致降水增加。植被对温度的反馈系数在大兴安岭、贝加尔湖等地区,反馈系数为正,为1~2℃·(0.1FPAR)^(-1),中国南部地区温度反馈系数也为正,但反馈较小,为0.2~1℃·(0.1FPAR)^(-1)。植被对降水的反馈系数噪音较多,在我国华北地区为正的反馈,反馈系数约为1.5cm·mon^(-1)·(0.1FPAR)^(-1)。

关键词：定量评估平衡反馈分析法反馈植被

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Attenuation of the Activation of NlRP3 Inflammasome in Fibroblast like Synoviocytes of Rheumatoid Arthritis by Baicalin through Regulating the let-7i-3p/PI3K/Akt/NF-κB Signaling Axis

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Medicinal Plant 2024年第2期15卷 69-73,76页

作者： Wei ZHANG li WANG Yuxin YANG Rui ma li WANG ling HUANG Qiaofeng WAN Department of Pathogenic Biology and Immunology School of Basic MedicineNingxia Medical UniversityYinchuan 750004China Department of Rheumatology Ningxia Medical University General HospitalYinchuan 750003China School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004China

[Objectives]To study the effect and mechanism of baicalin on the activation of NlRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFlS-ra).[Methods]To confirm that baicalin alleviated the activation of NlRP3 inflammasome in HFlS-ra,the expression of NlRP3 before and after baicalin treatment was observed by *** blot was used to detect the protein expression of p-PI3K,p-Akt,NF-κB p65,NlRP3,ASC and caspase-1 after baicalin treatment for 48 h,and the contents of Il-1 and Il-18 in the supernatents were detected by *** order to explore the mechanism of baicalin alleviating the activation of NlRP3 inflammasome,the corresponding relationship between let-7i-3p and PIK3CA was verified by double luciferin and Westen blot *** expression of let-7i-3p and PI3K before and after baicalin intervention was detected by ***-7i-3p interference was used to verify whether baicalin mitigated the activation of enhanced NlRP3 inflammasome.[Results]Baicalin(50 and 100 mg/l)significantly reduced the activation of NlRP3 inflammasome,inhibited the protein expressions of p-PI3K,p-Akt,NF-κB p65,NlRP3,ASC and caspase-1,and the secretion of Il-1 and ***-7i-3p and PIK3CA had a targeted correspondence,and baicalin up-regulated the expression of let-7i-3p and down-regulated the expression of *** attenuated the activation of NlRP3 inflammasome enhanced by let-7i-3p interference.[Conclusions]Baicalin can up-regulate let-7i-3p expression,inhibit PI3K/Akt/NF-κB signal transduction,and thus reduce the activation of NlRP3 inflammasome in HFlS-ra.

关键词： Baicalin Rheumatoid arthritis Human fibroblast like synoviocytes of rheumatoid arthritis NlRP3 inflammasome miRNA Dual-luciferase

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GH625镍基高温合金化学抛光工艺

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电镀与涂饰 2024年第4期43卷 79-86页

作者：马宁张峻山沈阳航空航天大学机电工程学院辽宁沈阳110136

[目的]化学抛光是高温合金化学铣切的关键步骤之一,能够去除高温合金表面的微观不平整缺陷,令其满足航空航天、石油化工等领域对零件表面高品质的要求。[方法]通过正交试验和单因素实验研究了抛光液配方和工艺参数对GH625高温合金化学... 详细信息

[目的]化学抛光是高温合金化学铣切的关键步骤之一,能够去除高温合金表面的微观不平整缺陷,令其满足航空航天、石油化工等领域对零件表面高品质的要求。[方法]通过正交试验和单因素实验研究了抛光液配方和工艺参数对GH625高温合金化学抛光速率和表面粗糙度的影响。[结果]GH625高温合金化学抛光的较佳配方和工艺条件为:盐酸100 g/l,硝酸170 g/l,氢氟酸90 g/l,Fe^(3+)170 g/l,温度50℃,时间5 min,试片水平放置。在该条件下化学抛光后,GH625高温合金表面变得平整均匀而富有金属光泽,表面粗糙度ra从初始的10.3μm降至1.1μm。[结论]本文的研究结果可为GH625高温合金的化学抛光提供参考。

关键词：镍基高温合金化学抛光表面粗糙度材料去除速率

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维持性血液透析患者合并导管相关性血流感染预后的危险因素分析

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中华危重病急救医学 2024年第2期36卷 183-188页

作者：陈彩合马淑燕黄文辉甘肃中医药大学第一临床医学院兰州730000 甘肃省人民医院肾病科兰州730000

目的分析维持性血液透析(MHD)患者非住院期间发生导管相关性血流感染(CRBSI)的病原菌分布特征及影响预后的危险因素。方法采用回顾性对照研究,选择2020年1月至2023年5月在甘肃省人民医院肾病科因非住院期间发生CRBSI收治的34例以半永久... 详细信息

目的分析维持性血液透析(MHD)患者非住院期间发生导管相关性血流感染(CRBSI)的病原菌分布特征及影响预后的危险因素。方法采用回顾性对照研究,选择2020年1月至2023年5月在甘肃省人民医院肾病科因非住院期间发生CRBSI收治的34例以半永久导管为通路进行MHD的病例为研究对象。分析MHD患者非住院期间发生CRBSI的病原菌分布特点;所有患者入院后积极给予抗感染治疗,通过电子病历系统收集患者的一般资料、实验室检查指标及住院期间预后情况。根据住院期间的治疗结果将患者分为预后不良组(14例)和预后良好组(20例),采用单因素和多因素logistic回归分析影响患者预后的危险因素,并绘制受试者工作特征曲线(ROC曲线)评估其对预后的预测价值。结果34例患者中共分离出28株病原菌,其中革兰阳性菌25株,葡萄球菌属为最多见病原菌,占总数的82.15%,金黄色葡萄球菌16株(57.15%),包括耐甲氧西林金黄色葡萄球菌(MRSA)6株(21.43%),表皮葡萄球菌7株(25.00%),包括耐甲氧西林表皮葡萄球菌(MRSE)3株(10.71%);革兰阴性菌3株,铜绿假单胞菌、大肠埃希菌、鲍曼不动杆菌各1株。单因素分析显示,MHD合并CRBSI患者预后不良组发热时间比预后良好组明显延长〔d:8.50(3.75,45.00)比2.50(1.00,4.75),PlU)均明显高于预后良好组〔ESR(mm/1 h):82.36±24.98比56.95±35.65,CRP(mg/l):123.45±74.10比67.35±55.22,GlU(mmol/l):8.74±3.66比6.42±1.95,均Plogistic回归分析显示,血清CRP为MHD合并CRBSI患者预后不良的独立危险因素〔优势比(OR)=1.020,95%可信区间(95%CI)为1.002~1.038,P=0.025〕。ROC曲线分析显示,血清CRP预测MHD合并CRBSI患者预后不良的曲线下面积(AUC)为0.711;最佳截断值为104.65 mg/l时,敏感度64.3%,特异度为85.0%,说明其具有较好的预测价值。结论MHD患者非住院期间发生CRBSI时,主要以革兰阳性菌感染为主;且其预后不良主要与较高的血清CRP水平有关;血清CRP水平能有效筛选MHD合并CRBSI患者预后不良的高危人群。

关键词：维持性血液透析导管相关性血流感染预后危险因素

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非洲猪瘟病毒DP71l蛋白原核表达及其多克隆抗体制备

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中国兽医科学 2024年第9期54卷 1216-1223页

作者：李志煜马旭升马永华郑海学甘肃农业大学动物医学院甘肃兰州730070 中国农业科学院兰州兽医研究所兰州大学动物医学与生物安全学院动物疫病防控全国重点实验室甘肃兰州730000

为深入研究非洲猪瘟病毒(ASFV)DP71l蛋白的生物学功能,根据非洲猪瘟病毒ASFVCN/GS/2018DP71l基因序列设计特异性引物,通过扩增DP71l基因并克隆到原核表达载体pET28a(+)后转入大肠杆菌Bl21(DE3)诱导表达,通过SDS-PAGE、Western-blot进行... 详细信息

为深入研究非洲猪瘟病毒(ASFV)DP71l蛋白的生物学功能,根据非洲猪瘟病毒ASFVCN/GS/2018DP71l基因序列设计特异性引物,通过扩增DP71l基因并克隆到原核表达载体pET28a(+)后转入大肠杆菌Bl21(DE3)诱导表达,通过SDS-PAGE、Western-blot进行鉴定,并以纯化出的重组DP71l蛋白免疫BAlB/c小鼠,制备多克隆抗体,间接ElISA测定多克隆抗体效价,Western-blot鉴定多克隆抗体的特异性。结果显示,重组DP71l蛋白以可溶物和包涵体两种形式表达;间接ElISA测得多克隆抗体血清效价为1∶64000;Western-blot结果显示,该抗体能特异性识别DP71l蛋白。结论:成功地表达了DP71l重组蛋白,制备了多克隆抗体,为深入研究DP71l蛋白生物学功能奠定了基础。

关键词：非洲猪瘟 DP71l蛋白原核表达多克隆抗体

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