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Oxidative stress in N88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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Neural Regeneration Research 2023年第8期18卷 1719-1720页

作者： Vítor costa Vitor Teixeira i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal ICBAS Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

Notes on the 2^(nd) China-US-Europe Young Leaders Exchange Program

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International Understanding 2015年第4期 61-64页

作者： marco costa Jingjing ma

From September 8th to 17th,the Chinese Association for International Understanding held the 2nd China-US-Europe Young Leaders Exchange Program.I had the honour to take part in a so rich program of meetings,seminars,le... 详细信息

关键词： opportunity guided extraordinary Notes political tourist initiative young mutual seminar

Prenatal and postnatal drug exposure:focus on persistent central effects

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Neural Regeneration Research 2023年第8期18卷 1697-1702页

作者： Giulia costa Alexia E.Pollack Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Clinical studies indicate significant use of prescription,nonprescription and social/recreational drugs by women during pregnancy;however,limited knowledge exists about the detrimental effects that this practice may have on the developing central nervous system of the ***,few experimental and clinical data are available on how gestational exposure could exacerbate the effects of the same or a different drug consumed by the offspring later in *** present review summarizes recent findings on the central toxicity elicited by several classes of drugs,administered prenatally and postnatally in experimental animals and humans,focusing on prescription and nonprescription analgesics,anti-inflammatory agents,alcohol and nicotine.

关键词： 3 4-methylenedioxymethamphetamine acetaminophen alcohol chlorpyrifos dexamethasone ibuprofen methadone neuroinflammation neurotoxicity nicotine

Structure,stability,catalytic activity,and polarizabilities of small iridium clusters

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Chinese Physics B 2018年第6期27卷 225-230页

作者： Francisco E Jorge José R da costa Venaancio Unidade Academica dc Ffsica Universidade Federal de Campina Grande 58429-900 Campina Grande Brazil Departamento de Ffsica Universidade Federal do Espfrito Santo 29060-900 Vitoria Brazil

At the second order Douglas–Kroll–Hess（DKH2） level, the B3 PW91 functional in conjunction with the relativistic all-electron basis set of valence triple zeta quality plus polarization functions are employed to compute bond lengths, dissociation energies, vertical ionization potentials, and the highest occupied molecular orbital-lowest unoccupied molecular orbital energy gaps of the small iridium clusters（Irn, n≤8）. These results are compared with the experimental and theoretical data available in the literature. Our results confirm the theoretical predictions made by Feng et al. about the catalytic activities of the Ir4 and Ir6 clusters. From the optimized geometries, DKH2 calculations of static electric mean dipole polarizabilities and polarizability anisotropies are also carried out. It is the first time that the polarizabilities of small iridium clusters have been studied. For n≤4, the mean dipole polarizabilities per atom present an odd–even oscillatory behavior,whereas from Ir5 to Ir8, they decrease with the cluster size increasing. The dependence of the polarizability anisotropy on the structure symmetry of the iridium cluster is verified.

关键词： B3PW91 functional all-electron basis sets DKH2 calculations iridium clusters polarizabilities

Automorphism Groups of Pseudo-real Riemann Surfaces of Low Genus

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Acta mathematica Sinica,English Series 2014年第1期30卷 11-22页

作者： Emilio BUJALANCE Antonio F.costa Departamento de matemáticas Fundamentales Facultad de CienciasUNEDSenda del rey928040 MadridSpain

A pseudo-real Riemann surface admits anticonformal automorphisms but no anticonformal *** obtain the classifcation of actions and groups of automorphisms of pseudo-real Riemann surfaces of genera 2,3 and *** instance the automorphism group of a pseudo-real Riemann surface of genus 4 is eitherC4orC8or the Fro¨benius group of order 20,and in the case ofC4there are exactly two possible topological *** MK P R,g be the set of surfaces in the moduli space MK g corresponding to pseudo-real Riemann *** obtain the equisymmetric stratifcation of MK P R,g for generag=2,3,4,and as a consequence we have that MK P R,gis connected forg=2,3 but MK P R,4has three connected components.

关键词： Riemann surface automorphism anticonformal automorphism moduli space

Novel experimental techniques to assess the time-dependent deformations of geosynthetics under soil confinement

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第2期13卷 410-419页

作者： Carina maia Lins costa Jorge Gabriel Zornberg Department of Civil Engineering Federal University of Rio Grande do NorteAv.Senador Salgado Filho 3000NatalRio Grande do Norte59078-970Brazil Department of Civil Architectural and Environmental Engineering The University of Texas at Austin301 E.Dean KeetonAustinTX78712-0280USA

A new experimental approach to assess the impact of soil confinement on the long-term behavior of geosynthetics is presented in this *** experimental technique described herein includes a novel laboratory apparatus and the use of different types of tests that allow generation of experimental data suitable for evaluation of the time-dependent behavior of geosynthetics under soil *** soil-geosynthetic interaction equipment involves a rigid box capable of accommodating a cubic soil mass under plane strain conditions.A geosynthetic specimen placed horizontally at the mid-height of the soil mass is subjected to sustained vertical pressures that,in turn,induce reinforcement axial loads applied from the soil to the *** previously reported studies on geosynthetic behavior under soil confinement,the equipment was found to be particularly *** minor setup modifications,not only interaction tests but also in-isolation geosynthetic stress relaxation tests and soil-only tests under a constant strain rate can be conducted using the same ***,the time histories of the reinforcement loads and corresponding strains are generated throughout the *** from typical tests conducted using sand and a polypropylene woven geotextile are presented to illustrate the proposed experimental *** testing procedure was found to provide adequate measurements during tests,including good repeatability of test *** soilegeosynthetic interaction tests were found to lead to increasing geotextile strains with time and decreasing reinforcement tension with *** test results highlighted the importance of measuring not only the time history of displacements but also that of reinforcement loads during *** approach of using different types of tests to analyze the soilegeosynthetic interaction behavior is an innovation that provides relevant insight into the impact of soil confinement on the time-dependent deformations of geos

关键词： Geosynthetics Geotextile Creep Stress relaxation Reinforced soil Long-term deformation

Numerical simulation of non-Darcian flow through a porous medium

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Particuology 2009年第3期7卷 193-198页

作者： Duoxing Yang Yipeng Yang V.A.F. costa Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Crustul Dynamics Chinese Earthquake Administration Beijing 100085 China Ministry of Environmentul Protection of the People's Republic of China. Beijing 100035 China Departamento de Engenharia Mecenica. Universidade de Aveiro Campus Universiterio de Santiago 3810-193 Aveiro Portugal

This work reports on fluid flow in a fluid-saturated porous medium, accounting for the boundary and inertial effects in the momentum equation. The flow is simulated by Brinkman-Forchheimer-extended Darcy formulation （DFB）, using maC （marker And Cell） and Chorin pressure iteration method. The method is validated by comparison with analytic results. The effect of Reynolds number, Darcy number, porosity and viscosity ratio on velocity is investigated. As a result, it is found that Darcy number has a decisive influence on pressure as well as velocity, and the effect of viscosity ratio on velocity is very strong given the Darcy number. Additional key findings include unreasonable choice of effective viscosity can involve loss of important physical information.

关键词： maC Pressure Darcy law Porous media Permeability Viscosity ratio

The effect of ethanol fuel dilution on oil performance and MoDTC tribofilms formation and composition

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Friction 2024年第9期12卷 2108-2125页

作者： Juan RUIZ-ACERO Felipe KESSLER Henara costa Tiago COUSSEAU Polytechnic School Universidade de São PauloSão Paulo 05508-030Brazil School of Food and Chemistry Universidade Federal do Rio GrandeRio Grande 96203-000Brazil School of Engineering Universidade Federal do Rio GrandeRio Grande 96203-900Brazil Mechanical Engineering Department Univ.Tecnológica Federal do ParanáCuritiba 81280-340Brazil University of Newcastle CallaghanSW 2308Australia

Ethanol has emerged as a promising alternative to fossil fuels,but its use can lead to significant dilution in lubricants,particularly during cold start or heavy *** dilution can affect the performance of additives,including friction modifiers like molybdenum dithiocarbamate(MoDTC),which are designed to reduce friction under extreme contact *** research suggests that ethanol may impact the performance of MoDTC,prompting this study’s goal to investigate the effects of ethanol on MoDTC tribofilms and their friction response under boundary lubrication ***,reciprocating tribological tests were performed with fully formulated lubricants containing MoDTC with varying ethanol *** results indicate that a critical ethanol dilution level inhibits friction reduction by MoDTC activation,resulting in friction coefficients(COFs)similar to the base *** tested with simple mixtures of polyalphaolefin(PAO)+MoDTC showed increased COFs with added *** of tested surfaces using Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),and X-ray absorption spectroscopy near the edge structure(XANES)revealed the presence of sulfates,MoO_(3),MoS_(2),and MoS_(x)O_(y)compounds in the tribofilms formed on the surfaces,with and without ethanol diluted in the ***,the addition of ethanol increased the sulfates and MoO_(3)content of the tribofilms at the expense of friction-reducing compounds such as MoS_(2)and MoS_(x)O_(y).These findings suggest that ethanol dilution in lubricants containing MoDTC creates an oxygen-rich interfacial medium that favors the formation of compounds with insufficient friction-reducing capabilities.

关键词： molybdenum dithiocarbamate(MoDTC) ethanol tribofilm friction modifier additive lubricant

Tailored surface textures to increase friction-A review

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Friction 2022年第9期10卷 1285-1304页

作者： Henara L.costa Jörg SCHILLE Andreas ROSENKRANZ School of Engineering Surface Engineering GroupUniversidade Federal do Rio GrandeRio Grande 96203900Brazil University of Applied Sciences Mittweida Laserinstitut Hochschule Mittweida 09648Germany Department of Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiago 8370459Chile

Surface textures with micro-scale feature dimensions still hold great potential to enhance the frictional performance of tribological *** from the ability of surface texturing to reduce friction,surface textures can also be used to intentionally increase friction in various applications that rely on friction for their adequate ***,this review aims at presenting the state-of-the-art regarding textured surfaces for high-friction *** a brief general introduction,the recent trends and future paths in laser surface texturing are ***,the potential of surface textures to increase friction in different applications including adhesion,movement transmission and control,biomimetic applications,and road-tire contacts is critically *** emphasis in this section is laid on the involved mechanisms responsible for friction ***,current short-comings and future research directions are pointed out thus emphasizing the great potential of(laser-based)surface texturing methods for innovations in modern surface engineering.

关键词： surface texturing tribology laser processing friction increase